Tissue factor in cancer angiogenesis and metastasis

Current Opinion in Hematology

Volumn 3, Issue 5, 1996, Pages 379-384

  Ruf, Wolfram ^a   Mueller, Barbara M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOPLASTIN;

ANGIOGENESIS; EXTRACELLULAR MATRIX; HUMAN; METASTASIS; METASTASIS POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TUMOR VASCULARIZATION;

EID: 0029806633     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199603050-00008     Document Type: Review

References (34)

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2. Mackman N: Regulation of the tissue factor gene. FASEB J 1995, 9:883-889. A concise review on the regulation of the constitutive and inducible expression of the tissue factor gene.
3. Martin DMA, Boys CWG, Ruf W: Tissue factor: molecular recognition and cofactor function. FASEB J 1995, 9:852-859. A concise review dealing with the structure-function relationships of initiation of coagulation by tissue factor.
4. Fischer EG, Ruf W, Mueller BM: Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells. Cancer Res 1995, 55:1629-1632. This publication demonstrates that tissue factor-induced coagulation is required for metastatic dissemination of melanoma cells in a hematogenous metastasis assay. Inhibition of coagulation at the level of tissue factor, factor Xa, and thrombin abolished metastasis in vivo. Thrombin, but not factor Xa, provided a proliferative signal to the tumor cell, a possible mechanism by which tissue factor expression supports tumor cell survival in vivo.
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8. Drake TA, Ruf W, Morrissey JH, Edgington TS: Functional tissue factor is entirely cell surface expressed on lipopolysaccharide-stimulated human blood monocytes and a constitutively tissue factor-producing neoplastic cell line. J Cell Biol 1989, 109:389-395.
9. 2+ fluxes in response to ligand Vlla binding to tissue factor on a variety of tissue factor-positive cells. These data provide evidence that tissue factor is transmitting outside-in signals and thus directly participates in the modulation of cellular functions.
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33. Bromberg ME, Konigsberg WH, Madison JF, Pawashe A, Garen A: Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci U S A 1995, 92:8205-8209. The deletion of the cytoplasmic domain of tissue factor resulted in the loss of the prometastatic properties of tissue factor. This article thus provides strong evidence that tissue factor supports metastasis through cellular functions that go beyond the activation of the coagulation cascade.
34. Ruf W, Miles DJ, Rehemtulla A, Edgington TS: Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor Vlla protease complex. J Biol Chem 1992, 267:6375-6381.