Probing the Ser-Ser-Lys catalytic triad mechanism of peptide amidase: Computational studies of the ground state, transition state, and intermediate

Biochemistry

Volumn 43, Issue 50, 2004, Pages 15657-15672

  Valiña, Anna Liza B ^a   Mazumder Shivakumar, Devleena ^a   Bruice, Thomas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPUTER SIMULATION; CRYSTAL STRUCTURE; ENZYMES; FATTY ACIDS; GROUND STATE; HYDROGEN BONDS; HYDROLYSIS; MOLECULAR DYNAMICS;

AMIDASE SIGNATURE (AS); HYDROLYTIC ENZYME; PEPTIDE AMIDASE (PAM); PEPTIDES; X-RAY STRUCTURES;

POLYPEPTIDES;

AMIDASE; AMIDE; ASPARTIC ACID; CARBONYL DERIVATIVE; HYDROGEN; LYSINE; NITROGEN; PEPTIDE AMIDASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; HYDROGEN BOND; HYDROLYSIS; PH; PRIORITY JOURNAL; PROTON TRANSPORT; X RAY ANALYSIS;

AMIDOHYDROLASES; CATALYSIS; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HYDROGEN BONDING; LYSINE; MODELS, MOLECULAR; SERINE; STENOTROPHOMONAS MALTOPHILIA; SUBSTRATE SPECIFICITY;

EID: 10844250211     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049025r     Document Type: Article

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