메뉴 건너뛰기




Volumn 26, Issue 2 A, 2006, Pages 1077-1084

Cancer genetics of sporadic colorectal cancer: BRAF and PI3KCA mutations, their impact on signaling and novel targeted therapies

Author keywords

BRAF; BRAF inhibitors; Colorectal cancer (CRC); KRAS; Microarrays; Mutated gene signature; PI3KCA; Review

Indexed keywords

B RAF KINASE;

EID: 33645812174     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (22)

References (51)
  • 1
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumourigenesis
    • Fearon ER and Vogelstein B: A genetic model for colorectal tumourigenesis. Cell 67: 759-767, 1990.
    • (1990) Cell , vol.67 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 2
    • 0033400418 scopus 로고    scopus 로고
    • Genetic pathways in colorectal and other cancers
    • Ilyas M, Straub J, Tomlinson IP and Bodmer WF: Genetic pathways in colorectal and other cancers (Review). Eur J Cancer 14: 1986-2002, 1999.
    • (1999) Eur J Cancer , vol.14 , pp. 1986-2002
    • Ilyas, M.1    Straub, J.2    Tomlinson, I.P.3    Bodmer, W.F.4
  • 3
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell OR, Cox C et al: Mutations of the BRAF gene in human cancer. Nature 417: 949-954, 2002.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, O.R.2    Cox, C.3
  • 4
    • 22144452507 scopus 로고    scopus 로고
    • The prevalence of PIK3CA mutations in gastric and colon cancer
    • Velho S, Oliveira C, Ferreira A et al: The prevalence of PIK3CA mutations in gastric and colon cancer. Eur J Cancer 41: 1649-1654, 2005.
    • (2005) Eur J Cancer , vol.41 , pp. 1649-1654
    • Velho, S.1    Oliveira, C.2    Ferreira, A.3
  • 9
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC: The phosphoinositide 3-kinase pathway (Review). Science 296: 1655-1657, 2002.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 10
    • 0035813230 scopus 로고    scopus 로고
    • Identification of tyrosine phosphorylation sites on 3-phosphoinositide- dependent protein kinase-1 and their role in regulating kinase activity
    • Park J, Hill MM, Hess D, Brazil DP, Hofsteenge J and Hemmings BA: Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity. J Biol Chem 276: 37459-37471, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 37459-37471
    • Park, J.1    Hill, M.M.2    Hess, D.3    Brazil, D.P.4    Hofsteenge, J.5    Hemmings, B.A.6
  • 11
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241, 1997.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 13
    • 0344441258 scopus 로고    scopus 로고
    • Inhibition of Akt kinase signalling and activation of forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells
    • Ciechomska I, Pyrzynska B, Kazmierczak P and Kaminska B: Inhibition of Akt kinase signalling and activation of forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. Oncogene 22: 7617-7627, 2003.
    • (2003) Oncogene , vol.22 , pp. 7617-7627
    • Ciechomska, I.1    Pyrzynska, B.2    Kazmierczak, P.3    Kaminska, B.4
  • 14
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers PF, Medema RH, Lammers JW, Koenderman L and Coffer PJ: Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10: 1201-1204, 2000.
    • (2000) Curr Biol , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medema, R.H.2    Lammers, J.W.3    Koenderman, L.4    Coffer, P.J.5
  • 15
    • 0035957951 scopus 로고    scopus 로고
    • Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt
    • Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB and Pfeffer LM: Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem 276: 13756-13761, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 13756-13761
    • Yang, C.H.1    Murti, A.2    Pfeffer, S.R.3    Kim, J.G.4    Donner, D.B.5    Pfeffer, L.M.6
  • 16
    • 0032491579 scopus 로고    scopus 로고
    • Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
    • Muise-Helmericks RC, Grimes HL, Bellacosa A, Malstrom SE, Tsichlis PN and Rosen N: Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 275: 29864-29872, 1998.
    • (1998) J Biol Chem , vol.275 , pp. 29864-29872
    • Muise-Helmericks, R.C.1    Grimes, H.L.2    Bellacosa, A.3    Malstrom, S.E.4    Tsichlis, P.N.5    Rosen, N.6
  • 18
    • 0035949699 scopus 로고    scopus 로고
    • AKT plays a central role in tumourigenesis
    • Testa JR and Bellacosa A: AKT plays a central role in tumourigenesis (Review). Proc Natl Acad Sci USA 98: 10983-10985, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10983-10985
    • Testa, J.R.1    Bellacosa, A.2
  • 19
  • 20
    • 1242307944 scopus 로고    scopus 로고
    • Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma
    • Khaleghpour K, Li Y, Banville D, Yu Z and Shen SH: Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis 25: 241-248, 2004.
    • (2004) Carcinogenesis , vol.25 , pp. 241-248
    • Khaleghpour, K.1    Li, Y.2    Banville, D.3    Yu, Z.4    Shen, S.H.5
  • 21
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • Di Cristofano A, Pesce B, Cordon-Cardo C and Pandolfi PP: Pten is essential for embryonic development and tumour suppression. Nat Genet 19: 348-355, 1998.
    • (1998) Nat Genet , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 24
    • 0036898614 scopus 로고    scopus 로고
    • Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma
    • Semba S, Itoh N, Ito M, Youssef EM, Harada M, Moriya T, Kimura W and Yamakawa M: Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. Clin Cancer Res 8: 3824-3831, 2002.
    • (2002) Clin Cancer Res , vol.8 , pp. 3824-3831
    • Semba, S.1    Itoh, N.2    Ito, M.3    Youssef, E.M.4    Harada, M.5    Moriya, T.6    Kimura, W.7    Yamakawa, M.8
  • 25
    • 27944496435 scopus 로고    scopus 로고
    • The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis
    • Jun 3; Epub ahead of print
    • Bar J, Lukaschuk N, Zalcenstein A, Wilder S, Seger R and Oren M: The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. Cell Death Differ Jun 3; Epub ahead of print, 2005.
    • (2005) Cell Death Differ
    • Bar, J.1    Lukaschuk, N.2    Zalcenstein, A.3    Wilder, S.4    Seger, R.5    Oren, M.6
  • 27
    • 0034675919 scopus 로고    scopus 로고
    • Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
    • Zhang BH and Guan KL: Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J 19: 5429-5439, 2000.
    • (2000) EMBO J , vol.19 , pp. 5429-5439
    • Zhang, B.H.1    Guan, K.L.2
  • 31
    • 0035328521 scopus 로고    scopus 로고
    • Active Ras induces heterodimerization of cRaf and BRaf
    • Weber CK, Slupsky JR, Kalmes HA and Rapp UR: Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res 61: 3595-3598, 2001.
    • (2001) Cancer Res , vol.61 , pp. 3595-3598
    • Weber, C.K.1    Slupsky, J.R.2    Kalmes, H.A.3    Rapp, U.R.4
  • 33
    • 0035393498 scopus 로고    scopus 로고
    • Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells
    • Dai Y, Yu C, Singh V, Tang L, Wang Z, McInistry R, Dent P and Grant S: Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells. Cancer Res 67: 5106-5115, 2001.
    • (2001) Cancer Res , vol.67 , pp. 5106-5115
    • Dai, Y.1    Yu, C.2    Singh, V.3    Tang, L.4    Wang, Z.5    McInistry, R.6    Dent, P.7    Grant, S.8
  • 34
    • 0035328521 scopus 로고    scopus 로고
    • Active Ras induces heterodimerization of cRaf and BRaf
    • Weber CK, Slupsky JR, Kalmes HA and Rapp UR: Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res 61: 3595-3598, 2001.
    • (2001) Cancer Res , vol.61 , pp. 3595-3598
    • Weber, C.K.1    Slupsky, J.R.2    Kalmes, H.A.3    Rapp, U.R.4
  • 35
    • 20344365798 scopus 로고    scopus 로고
    • BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms
    • Ikehara N, Semba S, Sakashita M, Aoyama N, Kasuga M and Yokozaki H: BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. Int J Cancer 115: 943-950, 2005.
    • (2005) Int J Cancer , vol.115 , pp. 943-950
    • Ikehara, N.1    Semba, S.2    Sakashita, M.3    Aoyama, N.4    Kasuga, M.5    Yokozaki, H.6
  • 37
    • 4444315579 scopus 로고    scopus 로고
    • Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK
    • Li W, Zhu T and Guan KL: Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem 279: 37398-37406, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 37398-37406
    • Li, W.1    Zhu, T.2    Guan, K.L.3
  • 38
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL: Ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689, 1989.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 39
    • 0026052754 scopus 로고
    • GTP hydrolysis mechanisms in ras p21 and in the ras-GAP complex studied by fluorescence measurements on tryptophan mutants
    • Antonny B, Chardin P, Roux M and Chabre M: GTP hydrolysis mechanisms in ras p21 and in the ras-GAP complex studied by fluorescence measurements on tryptophan mutants. Biochemistry 30: 8287-8295, 1991.
    • (1991) Biochemistry , vol.30 , pp. 8287-8295
    • Antonny, B.1    Chardin, P.2    Roux, M.3    Chabre, M.4
  • 40
    • 0029069106 scopus 로고
    • Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme
    • Feng M, Cabrera G, Deshane J, Scanlon KJ and Curiel DT: Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme. Cancer Res 55: 2024-2028, 1995.
    • (1995) Cancer Res , vol.55 , pp. 2024-2028
    • Feng, M.1    Cabrera, G.2    Deshane, J.3    Scanlon, K.J.4    Curiel, D.T.5
  • 41
    • 12944277774 scopus 로고    scopus 로고
    • Liposome formulation improves efficacy against xenografted human tumour lines in nude mice, and alters pharmacokinetics of an antisense oligonucleotide inhibitor of H-ras expression
    • Cooper S, Howard R, Glazer R, Trent K, Leamon CP, Mehta R, Ohashi C, Cowsert L, Monia BP and Dean NM: Liposome formulation improves efficacy against xenografted human tumour lines in nude mice, and alters pharmacokinetics of an antisense oligonucleotide inhibitor of H-ras expression. Proc Am Assoc Cancer Res 39: 417, 1998.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 417
    • Cooper, S.1    Howard, R.2    Glazer, R.3    Trent, K.4    Leamon, C.P.5    Mehta, R.6    Ohashi, C.7    Cowsert, L.8    Monia, B.P.9    Dean, N.M.10
  • 43
    • 0031914004 scopus 로고    scopus 로고
    • Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts
    • Ura H, Obara T, Shudo R, Itoh A, Tanno S, Fujii T, Nishino N and Kohgo Y: Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts. Mol Carcinog 21: 93-99, 1998.
    • (1998) Mol Carcinog , vol.21 , pp. 93-99
    • Ura, H.1    Obara, T.2    Shudo, R.3    Itoh, A.4    Tanno, S.5    Fujii, T.6    Nishino, N.7    Kohgo, Y.8
  • 44
    • 0036284741 scopus 로고    scopus 로고
    • Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line
    • Smith V, Rowlands MG, Barrie E, Workman P and Kelland LR: Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line. Clin Cancer Res 8: 2002-2009, 2002.
    • (2002) Clin Cancer Res , vol.8 , pp. 2002-2009
    • Smith, V.1    Rowlands, M.G.2    Barrie, E.3    Workman, P.4    Kelland, L.R.5
  • 45
    • 0037273848 scopus 로고    scopus 로고
    • Apo2L/TRAIL and its death and decoy receptors (Review)
    • LeBlanc HN and Ashkenazi A: Apo2L/TRAIL and its death and decoy receptors (Review). Cell Death Differ 10: 66-75, 2003.
    • (2003) Cell Death Differ , vol.10 , pp. 66-75
    • LeBlanc, H.N.1    Ashkenazi, A.2
  • 46
    • 20744450585 scopus 로고    scopus 로고
    • Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
    • Drosopoulos KG, Roberts ML, Cermak L, Sasazuki T, Shirasawa S, Andera L and Pintzas A: Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. J Biol Chem 280: 22856-22867, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 22856-22867
    • Drosopoulos, K.G.1    Roberts, M.L.2    Cermak, L.3    Sasazuki, T.4    Shirasawa, S.5    Andera, L.6    Pintzas, A.7
  • 47
    • 2342495721 scopus 로고    scopus 로고
    • Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway
    • Wang Y, Engels IH, Knee DA, Nasoff M, Deveraux QL and Quon KC: Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. Cancer Cell 5: 501-512, 2004.
    • (2004) Cancer Cell , vol.5 , pp. 501-512
    • Wang, Y.1    Engels, I.H.2    Knee, D.A.3    Nasoff, M.4    Deveraux, Q.L.5    Quon, K.C.6
  • 48
  • 49
    • 2442546516 scopus 로고    scopus 로고
    • Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and MEK/ERK signaling pathways
    • Tullai JW, Schaffer ME, Mullenbrock S, Kasif S and Cooper GM: Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and MEK/ERK signaling pathways. J Biol Chem 279: 20167-20177, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 20167-20177
    • Tullai, J.W.1    Schaffer, M.E.2    Mullenbrock, S.3    Kasif, S.4    Cooper, G.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.