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Volumn 2, Issue 2, 2006, Pages 80-85

Oncogenic parallels in Alzheimer disease

Author keywords

Alzheimer disease; Apoptosis; Cell cycle; Cyclin dependent kinase; Oncogenesis; Oxidative stress; Presenilin 1

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN C; CYCLIN D; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; CYCLINE; KI 67 ANTIGEN; MYC PROTEIN; PROTEIN CDC42; PROTEIN P105; PROTEIN P107; PROTEIN P16; PROTEIN P21; PROTEIN P25; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 33645681674     PISSN: 17451183     EISSN: 17451191     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (70)
  • 1
    • 0031614624 scopus 로고    scopus 로고
    • Alzheimer disease
    • Smith MA (1998) Alzheimer disease. Int Rev Neurobiol 42:1-54.
    • (1998) Int Rev Neurobiol , vol.42 , pp. 1-54
    • Smith, M.A.1
  • 2
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr CJ (1994) G1 phase progression: cycling on cue. Cell 79:551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 3
    • 0034237405 scopus 로고    scopus 로고
    • Activation of oncogenic pathways in degenerating neurons in Alzheimer disease
    • Zhu X, Raina AK, Boux H et al. (2000) Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Int J Dev Neurosci 18:433-437.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 433-437
    • Zhu, X.1    Raina, A.K.2    Boux, H.3
  • 4
    • 0033782845 scopus 로고    scopus 로고
    • Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease
    • Zhu X, Rottkamp CA, Boux H et al. (2000) Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 59:880-888.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 880-888
    • Zhu, X.1    Rottkamp, C.A.2    Boux, H.3
  • 5
    • 0033636620 scopus 로고    scopus 로고
    • Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease
    • Zhu X, Rottkamp CA, Raina AK et al. (2000) Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Neurobiol Aging 21:807-813.
    • (2000) Neurobiol Aging , vol.21 , pp. 807-813
    • Zhu, X.1    Rottkamp, C.A.2    Raina, A.K.3
  • 7
    • 0034661784 scopus 로고    scopus 로고
    • Cyclin toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease
    • Raina AK, Zhu X, Rottkamp CA et al. (2000) Cyclin toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J Neurosci Res 61:128-133.
    • (2000) J Neurosci Res , vol.61 , pp. 128-133
    • Raina, A.K.1    Zhu, X.2    Rottkamp, C.A.3
  • 8
    • 0029070087 scopus 로고
    • Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders
    • Smith TW, Lippa CF (1995) Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders. J Neuropathol Exp Neurol 54:297-303.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 297-303
    • Smith, T.W.1    Lippa, C.F.2
  • 9
    • 0029066704 scopus 로고
    • Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease
    • Arendt T, Holzer M, Grossmann A, Zedlick D, Bruckner MK (1995) Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease. Neuroscience 68:5-18.
    • (1995) Neuroscience , vol.68 , pp. 5-18
    • Arendt, T.1    Holzer, M.2    Grossmann, A.3    Zedlick, D.4    Bruckner, M.K.5
  • 10
    • 0030454478 scopus 로고    scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease
    • Arendt T, Rodel L, Gartner U, Holzer M (1996) Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport 7:3047-3049.
    • (1996) Neuroreport , vol.7 , pp. 3047-3049
    • Arendt, T.1    Rodel, L.2    Gartner, U.3    Holzer, M.4
  • 11
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I, Jicha G, Rosado M, Dickson DW (1997) Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J Neurosci 17:3588-3598.
    • (1997) J Neurosci , vol.17 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 12
    • 0030062245 scopus 로고    scopus 로고
    • Mitotic mechanisms in Alzheimer's disease?
    • Vincent I, Rosado M, Davies P (1996) Mitotic mechanisms in Alzheimer's disease? J Cell Biol 132:413-425.
    • (1996) J Cell Biol , vol.132 , pp. 413-425
    • Vincent, I.1    Rosado, M.2    Davies, P.3
  • 13
    • 0031685160 scopus 로고    scopus 로고
    • Mitotic phosphoepifopes precede paired helical filaments in Alzheimer's disease
    • Vincent I, Zheng JH, Dickson DW, Kress Y, Davies P (1998) Mitotic phosphoepifopes precede paired helical filaments in Alzheimer's disease. Neurobiol Aging 19:287-296.
    • (1998) Neurobiol Aging , vol.19 , pp. 287-296
    • Vincent, I.1    Zheng, J.H.2    Dickson, D.W.3    Kress, Y.4    Davies, P.5
  • 15
    • 0031043049 scopus 로고    scopus 로고
    • Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions
    • Nagy Z, Esiri MM, Smith AD (1997) Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions. Acta Neuropathol (Bert) 93:294-300.
    • (1997) Acta Neuropathol (Bert) , vol.93 , pp. 294-300
    • Nagy, Z.1    Esiri, M.M.2    Smith, A.D.3
  • 16
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea A, Harris PL, Webster KR, Wahl AF, Smith MA (1997) Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 150:1933-1939.
    • (1997) Am J Pathol , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 17
    • 0033037948 scopus 로고    scopus 로고
    • Re-entry into the cell cycle: A mechanism for neurodegeneration in Alzheimer disease
    • McShea A, Wahl AF, Smith MA (1999) Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease. Med Hypotheses 52:525-527.
    • (1999) Med Hypotheses , vol.52 , pp. 525-527
    • McShea, A.1    Wahl, A.F.2    Smith, M.A.3
  • 18
    • 0033537306 scopus 로고    scopus 로고
    • Signal transduction abnormalities in Alzheimer's disease: Evidence of a pathogenic stimuli
    • McShea A, Zelasko DA, Gerst JL, Smith MA (1999) Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli. Brain Res 815:237-242.
    • (1999) Brain Res , vol.815 , pp. 237-242
    • McShea, A.1    Zelasko, D.A.2    Gerst, J.L.3    Smith, M.A.4
  • 19
    • 0031737550 scopus 로고    scopus 로고
    • Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease
    • Arendt T, Holzer M, Gartner U (1998) Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease. J Neural Transm 105:949-960.
    • (1998) J Neural Transm , vol.105 , pp. 949-960
    • Arendt, T.1    Holzer, M.2    Gartner, U.3
  • 21
    • 0032877585 scopus 로고    scopus 로고
    • Mitotic neurons: A dogma succumbs
    • Raina AK, Takeda A, Smith MA (1999) Mitotic neurons: a dogma succumbs. Exp Neurol 159:248-249.
    • (1999) Exp Neurol , vol.159 , pp. 248-249
    • Raina, A.K.1    Takeda, A.2    Smith, M.A.3
  • 22
    • 0032814262 scopus 로고    scopus 로고
    • Cell cycle events in neurons. Proliferation or death?
    • Zhu X, Raina AK, Smith MA (1999) Cell cycle events in neurons. Proliferation or death? Am J Pathol 155:327-329.
    • (1999) Am J Pathol , vol.155 , pp. 327-329
    • Zhu, X.1    Raina, A.K.2    Smith, M.A.3
  • 23
    • 0035871660 scopus 로고    scopus 로고
    • DNA replication precedes neuronal cell death in Alzheimer's disease
    • Yang Y, Geldmacher DS, Herrup K (2001) DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci 21:2661-2668.
    • (2001) J Neurosci , vol.21 , pp. 2661-2668
    • Yang, Y.1    Geldmacher, D.S.2    Herrup, K.3
  • 24
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • Busser J, Geldmacher DS, Herrup K (1998) Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 18:2801-2807.
    • (1998) J Neurosci , vol.18 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 26
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
    • Grundke-Iqbal I, Iqbal K, Tung YC et al. (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83:4913-4917.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.C.3
  • 27
    • 0021338217 scopus 로고
    • Phosphorylation affects the ability of tau protein to promote microtubule assembly
    • Lindwall G, Cole RD (1984) Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem 259:5301-5305.
    • (1984) J Biol Chem , vol.259 , pp. 5301-5305
    • Lindwall, G.1    Cole, R.D.2
  • 28
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso AC, Grundke-Iqbal I, Iqbal K (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2:783-787.
    • (1996) Nat Med , vol.2 , pp. 783-787
    • Alonso, A.C.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 29
    • 0028143773 scopus 로고
    • Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons
    • Brion JP, Octave JN, Couck AM (1994) Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons. Neuroscience 63:895-909.
    • (1994) Neuroscience , vol.63 , pp. 895-909
    • Brion, J.P.1    Octave, J.N.2    Couck, A.M.3
  • 30
    • 0022257253 scopus 로고
    • Immunologic determinants of tau protein are present in neurofibrillary tangles of Alzheimer's disease
    • Brion JP, Passarier H, Nunez J, Flament-Durand J (1985) Immunologic determinants of tau protein are present in neurofibrillary tangles of Alzheimer's disease. Arch Biol 95:229-235.
    • (1985) Arch Biol , vol.95 , pp. 229-235
    • Brion, J.P.1    Passarier, H.2    Nunez, J.3    Flament-Durand, J.4
  • 31
    • 0026711059 scopus 로고
    • Fetal-type phosphorylation of the tau in paired helical filaments
    • Kanemaru K, Tokio K, Miura R, Titani K, Ihara Y (1992) Fetal-type phosphorylation of the tau in paired helical filaments. J Neurochem 58:1667-1675.
    • (1992) J Neurochem , vol.58 , pp. 1667-1675
    • Kanemaru, K.1    Tokio, K.2    Miura, R.3    Titani, K.4    Ihara, Y.5
  • 32
    • 0027217679 scopus 로고
    • The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development
    • Goedert M, Jakes R, Crowther RA et al. (1993) The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc Natl Acad Sci U S A 90:5066-5070.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5066-5070
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3
  • 33
    • 0028298450 scopus 로고
    • Micro tubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y
    • Pope WB, Lambert MP, Leypold B et al. (1994) Micro tubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. Exp Neurol 126:185-194.
    • (1994) Exp Neurol , vol.126 , pp. 185-194
    • Pope, W.B.1    Lambert, M.P.2    Leypold, B.3
  • 34
    • 20044367108 scopus 로고    scopus 로고
    • Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    • Andorfer C, Acker CM, Kress Y et al. (2005) Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 25:5446-5454.
    • (2005) J Neurosci , vol.25 , pp. 5446-5454
    • Andorfer, C.1    Acker, C.M.2    Kress, Y.3
  • 35
    • 0027246336 scopus 로고
    • Amyloid precursor protein in peripheral mononuclear cells is up-regulated with cell activation
    • Ledoux S, Rebai N, Dagenais A et al. (1993) Amyloid precursor protein in peripheral mononuclear cells is up-regulated with cell activation. J Immunol 150:5566-5575.
    • (1993) J Immunol , vol.150 , pp. 5566-5575
    • Ledoux, S.1    Rebai, N.2    Dagenais, A.3
  • 36
    • 0028295848 scopus 로고
    • Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
    • Suzuki T, Oishi M, Marshak DR et al. (1994) Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. Embo J 13:1114-1122.
    • (1994) Embo J , vol.13 , pp. 1114-1122
    • Suzuki, T.1    Oishi, M.2    Marshak, D.R.3
  • 37
    • 0034708641 scopus 로고    scopus 로고
    • The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons
    • Chen Y, McPhie DL, Hirschberg J, Neve RL (2000) The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J Biol Chem 275:8929-8935.
    • (2000) J Biol Chem , vol.275 , pp. 8929-8935
    • Chen, Y.1    McPhie, D.L.2    Hirschberg, J.3    Neve, R.L.4
  • 38
    • 0034672421 scopus 로고    scopus 로고
    • Alzheimer's disease: A dysfunction of the amyloid precursor protein(1)
    • Neve RL, McPhie DL, Chen Y (2000) Alzheimer's disease: a dysfunction of the amyloid precursor protein(1). Brain Res 886:54-66.
    • (2000) Brain Res , vol.886 , pp. 54-66
    • Neve, R.L.1    McPhie, D.L.2    Chen, Y.3
  • 39
    • 0037144438 scopus 로고    scopus 로고
    • Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression
    • Bruni P, Minopoli G, Brancaccio T et al. (2002) Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. J Biol Chem 277:35481-35488.
    • (2002) J Biol Chem , vol.277 , pp. 35481-35488
    • Bruni, P.1    Minopoli, G.2    Brancaccio, T.3
  • 40
    • 0032526423 scopus 로고    scopus 로고
    • Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes
    • McDonald DR, Bamberger ME, Combs CK, Landreth GE (1998) beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J Neurosci 18:4451-4460.
    • (1998) J Neurosci , vol.18 , pp. 4451-4460
    • McDonald, D.R.1    Bamberger, M.E.2    Combs, C.K.3    Landreth, G.E.4
  • 41
    • 0032579949 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia
    • Pyo H, Jou I, Jung S, Hong S, Joe EH (1998) Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia. Neuroreport 9:871-874.
    • (1998) Neuroreport , vol.9 , pp. 871-874
    • Pyo, H.1    Jou, I.2    Jung, S.3    Hong, S.4    Joe, E.H.5
  • 42
    • 0033516567 scopus 로고    scopus 로고
    • Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in B-amyloid-induced neuronal death
    • Giovanni A, Wirtz-Brugger F, Keramaris E, Slack R, Park DS (1999) Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in B-amyloid-induced neuronal death. J Biol Chem 274:19011-19016.
    • (1999) J Biol Chem , vol.274 , pp. 19011-19016
    • Giovanni, A.1    Wirtz-Brugger, F.2    Keramaris, E.3    Slack, R.4    Park, D.S.5
  • 43
    • 17744401440 scopus 로고    scopus 로고
    • Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm
    • Wong PC, Zheng H, Chen H et al. (1997) Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387:288-292.
    • (1997) Nature , vol.387 , pp. 288-292
    • Wong, P.C.1    Zheng, H.2    Chen, H.3
  • 44
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl G, Greenwald I (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398:522-525.
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 45
    • 0033535555 scopus 로고    scopus 로고
    • Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    • Ye Y, Lukinova N, Fortini ME (1999) Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398:525-529.
    • (1999) Nature , vol.398 , pp. 525-529
    • Ye, Y.1    Lukinova, N.2    Fortini, M.E.3
  • 46
    • 0030761059 scopus 로고    scopus 로고
    • Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
    • Li J, Xu M, Zhou H, Ma J, Potter H (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90:917-927.
    • (1997) Cell , vol.90 , pp. 917-927
    • Li, J.1    Xu, M.2    Zhou, H.3    Ma, J.4    Potter, H.5
  • 47
    • 0033637232 scopus 로고    scopus 로고
    • Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest
    • Janicki SM, Stabler SM, Monteiro MJ (2000) Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest. Neurobiol Aging 21:829-836.
    • (2000) Neurobiol Aging , vol.21 , pp. 829-836
    • Janicki, S.M.1    Stabler, S.M.2    Monteiro, M.J.3
  • 48
    • 0035911156 scopus 로고    scopus 로고
    • Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing
    • Soriano S, Kang DE, Fu M et al. (2001) Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J Cell Biol 152:785-794.
    • (2001) J Cell Biol , vol.152 , pp. 785-794
    • Soriano, S.1    Kang, D.E.2    Fu, M.3
  • 49
    • 0037010306 scopus 로고    scopus 로고
    • Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice
    • Yuasa S, Nakajima M, Aizawa H et al. (2002) Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J Neurosci Res 70:501-513.
    • (2002) J Neurosci Res , vol.70 , pp. 501-513
    • Yuasa, S.1    Nakajima, M.2    Aizawa, H.3
  • 50
    • 0031982670 scopus 로고    scopus 로고
    • Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease
    • Mattson MP, Guo Q, Furukawa K, Pedersen WA (1998) Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J Neurochem 70:1-14.
    • (1998) J Neurochem , vol.70 , pp. 1-14
    • Mattson, M.P.1    Guo, Q.2    Furukawa, K.3    Pedersen, W.A.4
  • 51
    • 10544224542 scopus 로고    scopus 로고
    • Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
    • Wolozin B, Iwasaki K, Vito P et al. (1996) Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 274:1710-1713.
    • (1996) Science , vol.274 , pp. 1710-1713
    • Wolozin, B.1    Iwasaki, K.2    Vito, P.3
  • 52
    • 0030771534 scopus 로고    scopus 로고
    • Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N1411)
    • Janicki S, Monteiro MJ (1997) Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N1411). J Cell Biol 139:485-495.
    • (1997) J Cell Biol , vol.139 , pp. 485-495
    • Janicki, S.1    Monteiro, M.J.2
  • 53
    • 0030614814 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation
    • Slooter AJ, Tang MX, van Duijn CM et al. (1997) Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. Jama 277:818-821.
    • (1997) Jama , vol.277 , pp. 818-821
    • Slooter, A.J.1    Tang, M.X.2    Van Duijn, C.M.3
  • 54
    • 0031848404 scopus 로고    scopus 로고
    • Basement membrane proteins, apolipoprotein e and glycosaminoglycans in pituitary adenomas and their correlation to amyloid
    • Steusloff K, Rocken C, Saeger W (1998) Basement membrane proteins, apolipoprotein E and glycosaminoglycans in pituitary adenomas and their correlation to amyloid. Virchows Arch 433:29-34.
    • (1998) Virchows Arch , vol.433 , pp. 29-34
    • Steusloff, K.1    Rocken, C.2    Saeger, W.3
  • 55
    • 0029018228 scopus 로고
    • In vivo viability of postmitotic Purkinje neurons requires pRb family member function
    • Feddersen RM, Clark HB, Yunis WS, Orr HT (1995) In vivo viability of postmitotic Purkinje neurons requires pRb family member function. Mol Cell Neurosci 6:153-167.
    • (1995) Mol Cell Neurosci , vol.6 , pp. 153-167
    • Feddersen, R.M.1    Clark, H.B.2    Yunis, W.S.3    Orr, H.T.4
  • 56
    • 0033636761 scopus 로고    scopus 로고
    • Cell cycle regulators in neuronal death evoked by excitotoxic stress: Implications for neurodegeneration and its treatment
    • Park DS, Obeidat A, Giovanni A, Greene LA (2000) Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment. Neurobiol Aging 21:771-781.
    • (2000) Neurobiol Aging , vol.21 , pp. 771-781
    • Park, D.S.1    Obeidat, A.2    Giovanni, A.3    Greene, L.A.4
  • 58
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23:134-147.
    • (1997) Free Radic Biol Med , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 59
    • 0032229327 scopus 로고    scopus 로고
    • Reactive oxygen species mediate cellular damage in Alzheimer disease
    • Perry G, Castellani RJ, Hirai K, Smith MA (1998) Reactive oxygen species mediate cellular damage in Alzheimer disease. J Alzheimers Dis 1:45-55.
    • (1998) J Alzheimers Dis , vol.1 , pp. 45-55
    • Perry, G.1    Castellani, R.J.2    Hirai, K.3    Smith, M.A.4
  • 60
    • 0027054448 scopus 로고
    • Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: New insights on the pathophysiological mechanisms of diabetic vascular complications
    • Curcio F, Ceriello A (1992) Decreased cultured endothelial cell proliferation in high glucose medium is reversed by antioxidants: new insights on the pathophysiological mechanisms of diabetic vascular complications. In Vitro Cell Dev Biol 28A:787-790.
    • (1992) In Vitro Cell Dev Biol , vol.28 , pp. 787-790
    • Curcio, F.1    Ceriello, A.2
  • 61
    • 0028916027 scopus 로고
    • N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells
    • Ferrari G, Yan CY, Greene LA (1995) N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 15:2857-2866.
    • (1995) J Neurosci , vol.15 , pp. 2857-2866
    • Ferrari, G.1    Yan, C.Y.2    Greene, L.A.3
  • 62
    • 0029920323 scopus 로고    scopus 로고
    • Static cytofluorometry and fluorescence morphology of mitochondria and DNA in proliferating fibroblasts
    • Barni S, Sciola L, Spano A, Pippia P (1996) Static cytofluorometry and fluorescence morphology of mitochondria and DNA in proliferating fibroblasts. Biotech Histochem 71:66-70.
    • (1996) Biotech Histochem , vol.71 , pp. 66-70
    • Barni, S.1    Sciola, L.2    Spano, A.3    Pippia, P.4
  • 63
    • 0034923434 scopus 로고    scopus 로고
    • Oxidative damage is the earliest event in Alzheimer disease
    • Nunomura A, Perry G, Aliev G et al. (2001) Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60:759-767.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 759-767
    • Nunomura, A.1    Perry, G.2    Aliev, G.3
  • 64
    • 0031064856 scopus 로고    scopus 로고
    • Developmental changes in calcium content of ultra-structurally distinct subcellular compartments of preimplantation human embryos
    • Sousa M, Barros A, Silva J, Tesarik J (1997) Developmental changes in calcium content of ultra-structurally distinct subcellular compartments of preimplantation human embryos. Mol Hum Reprod 3:83-90.
    • (1997) Mol Hum Reprod , vol.3 , pp. 83-90
    • Sousa, M.1    Barros, A.2    Silva, J.3    Tesarik, J.4
  • 65
    • 0035341254 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer's disease
    • Hirai K, Aliev G, Nunomura A et al. (2001) Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21:3017-3023.
    • (2001) J Neurosci , vol.21 , pp. 3017-3023
    • Hirai, K.1    Aliev, G.2    Nunomura, A.3
  • 66
    • 0032547801 scopus 로고    scopus 로고
    • Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents
    • Park DS, Morris EJ, Padmanabhan J et al. (1998) Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol 143:457-467.
    • (1998) J Cell Biol , vol.143 , pp. 457-467
    • Park, D.S.1    Morris, E.J.2    Padmanabhan, J.3
  • 68
    • 10744227217 scopus 로고    scopus 로고
    • Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease
    • Zhu X, McShea A, Harris PL et al. (2004) Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. J Neurosci Res 75:698-703.
    • (2004) J Neurosci Res , vol.75 , pp. 698-703
    • Zhu, X.1    McShea, A.2    Harris, P.L.3
  • 69
    • 0033516947 scopus 로고    scopus 로고
    • Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation
    • Perry G, Roder H, Nunomura A et al. (1999) Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport 10:2411-2415.
    • (1999) Neuroreport , vol.10 , pp. 2411-2415
    • Perry, G.1    Roder, H.2    Nunomura, A.3
  • 70
    • 24344482275 scopus 로고    scopus 로고
    • Alzheimer disease - A new beginning, or a final exit?
    • Copani A, Nicoletti F, editors. Georgestown, Texas: Landes Bioscience
    • Obrenovich ME, Raina AK, Ogawa O, Atwood CS, Smith MA. Alzheimer disease - a new beginning, or a final exit? In: Copani A, Nicoletti F, editors. The Cell Cycle and Neuronal Cell Death. Georgestown, Texas: Landes Bioscience; 2005. p. 79-93.
    • (2005) The Cell Cycle and Neuronal Cell Death , pp. 79-93
    • Obrenovich, M.E.1    Raina, A.K.2    Ogawa, O.3    Atwood, C.S.4    Smith, M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.