Roles of K149, G352, and H401 in the channel functions of ClC-0: Testing the predictions from theoretical calculations

Journal of General Physiology

Volumn 127, Issue 4, 2006, Pages 435-447

  Zhang, Xiao Dong ^a   Li, Yong ^a   Yu, Wei Ping ^a   Chen, Tsung Yu ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CHLORIDE CHANNEL; LEUCINE; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; ELECTRICITY; HUMAN; HUMAN CELL; MUTATION; NONHUMAN;

AMINO ACID SUBSTITUTION; ANIMALS; CELL MEMBRANE PERMEABILITY; CHLORIDE CHANNELS; ELECTRIC CONDUCTIVITY; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MODELS, THEORETICAL; OOCYTES; POINT MUTATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 33645304847     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200509460     Document Type: Article

References (36)

1. - channels. J. Gen. Physiol. 123:109-119.
2. - channels. Nature. 427:803-807.
3. + exchanger. J. Gen. Physiol. 126:563-570.
4. Bauer, C.K., K. Steinmeyer, J.R. Schwarz, and T.J. Jentsch. 1991. Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA. Proc. Natl. Acad. Sci. USA. 88:11052-11056.
5. Bostick, D.L., and M.L. Berkowitz. 2004. Exterior site occupancy infers chloride-induced proton gating in a prokaryotic homolog of the ClC chloride channel. Biophys. J. 87:1686-1696.
6. + of the muscle-type ClC chloride channels. J. Gen. Physiol. 118:23-32.
7. Chen, M.F., and T.Y. Chen. 2003. Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. J. Gen. Physiol. 122:133-145.
8. Chen, T.Y. 1998. Extracellular zinc ion inhibits ClC-0 chloride channels by facilitating slow gating. J. Gen. Physiol. 112:715-726.
9. Chen, T.Y. 2005. Structure and function of clc channels. Annu. Rev. Physiol. 67:809-839.
10. Chen, T.Y., M.F. Chen, and C.W. Lin. 2003. Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels. J. Gen. Physiol. 122:641-651.
11. - channel. J. Gen. Physiol. 108:237-250.
12. Cohen, J., and K. Schulten. 2004. Mechanism of anionic conduction across ClC. Biophys. J. 86:836-845.
13. Corry, B., M. O'Mara, and S.H. Chung. 2004. Conduction mechanisms of chloride ions in ClC-type channels. Biophys. J. 86:846-860.
14. Dutzler, R., E.B. Campbell, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature. 415:287-294.
15. Dutzler, R., E.B. Campbell, and R. MacKinnon. 2003. Gating the selectivity filter in ClC chloride channels. Science. 300:108-112.
16. Engh, A.M., and M. Maduke. 2005. Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule. J. Gen. Physiol. 125:601-617.
17. Estevez, R., B.C. Schroeder, A. Accardi, T.J. Jentsch, and M. Pusch. 2003. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron. 38:47-59.
18. Faraldo-Gomez, J.D., and B. Roux. 2004. Electrostatics of ion stabilization in a ClC chloride channel homologue from Escherichia coli. J. Mol. Biol. 339:981-1000.
19. Hanke, W., and C. Miller. 1983. Single chloride channels from Torpedo electroplax. Activation by protons. J. Gen. Physiol. 82:25-45.
20. - channels gleaned from human genetic disease and mouse models. Annu. Rev. Physiol. 67:779-807.
21. Karlin, A. 2001. Scam feels the pinch. J. Gen. Physiol. 117:235-238.
22. Lin, C.W., and T.Y. Chen. 2000. Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. J. Gen. Physiol. 116:535-546.
23. Lin, C.W., and T.Y. Chen. 2003. Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J. Gen. Physiol. 122:147-159.
24. Lin, Y.W., C.W. Lin, and T.Y. Chen. 1999. Elimination of the slow gating of ClC-0 chloride channel by a point mutation. J. Gen. Physiol. 114:1-12.
25. Ludewig, U., M. Pusch, and T.J. Jentsch. 1996. Two physically distinct pores in the dimeric ClC-0 chloride channel. Nature. 383:340-343.
26. Maduke, M., C. Miller, and J.A. Mindell. 2000. A decade of CLC chloride channels: structure, mechanism, and many unsettled questions. Annu. Rev. Biophys. Biomol. Struct. 29:411-438.
27. Middleton, R.E., D.J. Pheasant, and C. Miller. 1996. Homodimeric architecture of a ClC-type chloride ion channel. Nature. 383:337-340.
28. Miller, C. 1982. Open-state substructure of single chloride channels from Torpedo electroplax. Philos. Trans. R. Soc. Lond. B Biol. Sci. 299:401-411.
29. Miller, C., and M.M. White. 1984. Dimeric structure of single chloride channels from Torpedo electroplax. Proc. Natl. Acad. Sci. USA. 81:2772-2775.
30. - pores: electrostatic effects of charged residues. Biophys. J. 86:825-835.
31. Pascual, J.M., and A. Karlin. 1998. State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the α subunit. J. Gen. Physiol. 111:717-739.
32. Picollo, A., and M. Pusch. 2005. Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature. 436:420-423.
33. Pusch, M., and T.J. Jentsch. 2005. Unique structure and function of chloride transporting CLC proteins. IEEE Trans Nanobioscience. 4:49-57.
34. Saviane, C., F. Conti, and M. Pusch. 1999. The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia. J. Gen. Physiol. 113:457-468.
35. Scheel, O., A.A. Zdebik, S. Lourdel, and T.J. Jentsch. 2005. Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature. 436:424-427.
36. Wilson, G.G., J.M. Pascual, N. Brooijmans, D. Murray, and A. Karlin. 2000. The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel. J. Gen. Physiol. 115:93-106.