Mechanism of Anionic Conduction across ClC

Biophysical Journal

Volumn 86, Issue 2, 2004, Pages 836-845

  Cohen, Jordi ^a   Schulten, Klaus ^a,b  

^a University of Illinois at Urbana Champaign   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; CHLORIDE; CHLORIDE CHANNEL; MEMBRANE PROTEIN; PROTEIN CIC; UNCLASSIFIED DRUG;

ARTICLE; CHLORIDE TRANSPORT; CRYSTAL STRUCTURE; DYNAMICS; ENERGY; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTON TRANSPORT; VERTEBRATE;

VERTEBRATA;

EID: 1142291714     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(04)74159-4     Document Type: Article

References (39)

1. Accardi, A., and M. Pusch. 2003. Conformal changes in the pore of CLC-0. J. Gen. Physiol. 122:277-293.
2. Åqvist, J., H. Luecke, F. A. Quiocho, and A. Warshel. 1991, Dipoles localized at helix termini of protein stabilize charges. Proc. Natl. Acad. Sci. USA. 88:2026-2030.
3. Åqvist, J., and V. Luzhkov. 2000. Ion permeation mechanism of the potassium channel. Nature. 404:881-884.
4. + channel in a bilayer membrane. Biophys. J. 78:2900-2917.
5. + channel. Nature. 414:73-77.
6. - channel. J. Gen. Physiol. 108:237-250.
7. + conduction and selectivity. Science. 280:69-77.
8. Dutzler, R., E. B. Campbell, M. Cadene, B. T. Chait, and R. MacKinnon. 2002. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature. 415:287-294.
9. Dutzler, R., E. B. Campbell, and R. MacKinnon. 2003. Gating the selectivity filter in ClC chloride channels. Science. 300:108-112.
10. Fahlke, C. 2001. Ion permeation and selectivity in ClC-type chloride channels. Am. J. Physiol. Ren. Physiol. 280:F748-F757.
11. Fahlke, C., H. Yu, C. L. Beck, T. R. Rhodes, and J. A. L. George. 1997. Pore-forming segments in voltage-gated chloride channels. Nature. 390:529-532.
12. Ferroni, S., C. Marchini, M. Nobile, and C. Rapisarda. 1997. Characterization of an inwardly rectifying chloride conductance expressed by cultured rat cortical astrocytes, Glia. 21:217-227.
13. Friedrich, T., T. Breiderhoff, and T. J. Jentsch. 1999. Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents. J. Biol. Chem. 274:896-902.
14. Fu, D., A. Libson, L. J. W. Miercke, C. Weitzman, P. Nollert, J. Krucinski, and R. M. Stroud. 2000. Structure of a glycerol conducting channel and the basis for its selectivity. Science. 290:481-486.
15. Grayson, P., E. Tajkhorshid, and K. Schulten. 2003. Mechanisms of selectivity in channels and enzymes studied with interactive molecular dynamics. Biophys. J. 85:36-48.
16. Gullingsrud, J., R. Braun, and K. Schulten. 1999. Reconstructing potentials of mean force through time series analysis of steered molecular dynamics simulations. J. Comp. Phys. 151:190-211.
17. Hille, B. 1992. Ionic Channels of Excitable Membranes, 2nd Ed. Sinauer Associates, Sunderland, MA.
18. Iyer, R., T. M. Iverson, A. Accardi, and C. Miller. 2002. A biological role for prokaryotic ClC chloride channels. Nature. 419:715-718.
19. Jentsch, T. J., T. Friedrich, A. Schriever, and H. Yamada. 1999. The ClC chloride channel family. Pflug. Arch. Eur. J. Physiol. 437:783-795.
20. Jiang, Y., A. Lee, J. Chen, M. Cadene, B. T. Chait, and R. MacKinnon. 2002. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417:515-522.
21. + channel. Nature. 423:33-41.
22. Kalé, L., R. Skeel, M. Bhandarkar, R. Brunner, A. Gursoy, N. Krawetz, J. Phillips, A. Shinozaki, K. Varadarajan, and K. Schulten. 1999. NAMD2: greater scalability for parallel molecular dynamics. J. Comp. Phys. 151:283-312.
23. Kumar, S., D. Bouzida, R. H. Swendsen, P. A. Kollman, and J. M. Rosenberg. 1992. The weighted histogram analysis method for free-energy calculations on biomolecules. I. The method. J. Comp. Chem. 13:1011-1021.
24. Laio, A., and V. Torre. 1999. Physical origin of selectivity in ionic channels of biological membranes. Biophys. J. 76:129-148.
25. Lin, C.-W., and T.-Y. Chen. 2003. Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J. Gen. Physiol. 122:147-159.
26. Ludewig, U., T. J. Jentsch, and M. Pusch. 1997. Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions. J. Gen. Physiol. 110:165-171.
27. MacKerell Jr., A. D., D. Bashford, M. Bellott, R. L. Dunbrack Jr., J. Evanseck, M. J. Field, S. Fischer, J. Gao, H. Guo, S. Ha, D. Joseph, L. Kuchnir, K. Kuczera, F. T. K. Lau, C. Mattos, S. Michnick, T. Ngo, D. T. Nguyen, B. Prodhom, I. W. E. Reiher, B. Roux, M. Schlenkrich, J. Smith, R. Stote, J. Straub, M. Watanabe, J. Wiorkiewicz-Kuczera, D. Yin, and M. Karplus. 1998. All-hydrogen empirical potential for molecular modeling and dynamics studies of proteins using the CHARMM22 force field. J. Phys. Chem. B. 102:3586-3616.
28. Maduke, M., C. Miller, and J. A. Mindell. 2000. A decade of ClC chloride channels: structure, mechanism, and many unsettled questions. Annu. Rev. Biophys. Biomol. Struct. 29:411-438.
29. + selectivity filter. Nature. 414:37-41.
30. Pusch, M., U. Ludewig, A. Rehfeldt, and T. J. Jentsch. 1995. Gating of the voltage-dependent chloride channel ClC-0 by the permeant anion. Nature. 373:527-531.
31. Roux, B. 1995. The calculation of the potential of mean force using computer simulations. Comp. Phys. Comm. 91:275-282.
32. Roux, B. 1999. Statistical mechanical equilibrium theory of selective ion channels. Biophys. J. 77:139-153.
33. Rychkov, G. Y., M. Pusch, M. L. Roberts, T. J. Jentsch, and A. H. Bretag. 1998. Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions. J. Gen. Physiol. 111:653-665.
34. Schlenkrich, M., J. Brickmann, A. D. MacKerell, Jr., and M. Karplus. 1996. Empirical potential energy function for phospholipids: criteria for parameter optimization and applications. In Biological Membranes: A Molecular Perspective from Computation and Experiment. K. M. Merz and B. Roux, editors. Birkhauser, Boston, MA. 31-81.
35. Shrivastava, I. H., and M. S. P. Sansom. 2000. Simulations of ion permeation through a potassium channel: molecular dynamics of KcsA in a phospholipid bilayer. Biophys. J. 78:557-570.
36. + in a K channel selectivity filter: a simulation study. Biophys. J. 83:633-645.
37. Stone, J., J. Gullingsrud, P. Grayson, and K. Schulten. 2001. A system for interactive molecular dynamics simulation. In 2001 ACM Symposium on Interactive 3D Graphics. J. F. Hughes and C. H. Séquin, editors. ACM SIGGRAPH, New York. 191-194.
38. Tajkhorshid, E., P. Nollert, M. Ø. Jensen, L. J. W. Miercke, J. O'Connell, R. M. Stroud, and K. Schulten. 2002. Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science. 296:525-530.
39. Traverso, S., L. Elia, and M. Pusch. 2003. Gating competence of constitutively open ClC-0 mutants revealed by the interaction with a small organic inhibitor. J. Gen. Physiol. 122:295-306.