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Volumn 115, Issue 2, 2000, Pages 93-106

The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel

Author keywords

Conductance; Mutagenesis; Nicotinic; Reaction kinetics; Selectivity

Indexed keywords

ACETYLCHOLINE; ALKALI METAL; CATION CHANNEL; CHOLINERGIC RECEPTOR;

EID: 0033813781     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.115.2.93     Document Type: Article
Times cited : (51)

References (44)
  • 9
    • 0024511429 scopus 로고
    • Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel
    • (1989) J. Neurosci. , vol.9 , pp. 884-892
    • Dani, J.A.1
  • 10
  • 17
    • 0033608961 scopus 로고    scopus 로고
    • Arg352 is a major determinant of charge selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel
    • (1999) Biochemistry , vol.38 , pp. 5528-5537
    • Guinamard, R.1    Akabas, M.H.2
  • 18
    • 0007963684 scopus 로고
    • Ionic channels of excitable membranes. Sinauer Associates Inc., Sunderland, MA
    • (1992) , pp. 607
    • Hille, B.1
  • 22
    • 0029593370 scopus 로고
    • Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
    • (1995) Neuron , vol.15 , pp. 1231-1244
    • Karlin, A.1    Akabas, M.H.2
  • 23
    • 0032321487 scopus 로고    scopus 로고
    • Substituted-cysteine-accessibility method
    • Methods in Enzymology. Vol. 293. P.M. Conn, editor. Academic Press, Inc., San Diego, CA
    • (1998) , pp. 123-145
    • Karlin, A.1    Akabas, M.H.2
  • 28
    • 0014481138 scopus 로고
    • Energy of an ion crossing a low dielectric membrane: Solutions to four relevant electrostatic problems
    • (1969) Nature , vol.221 , pp. 844-846
    • Parsegian, A.1
  • 29
    • 0031781630 scopus 로고    scopus 로고
    • State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor: Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit
    • (1998) J. Gen. Physiol. , vol.111 , pp. 717-739
    • Pascual, J.M.1    Karlin, A.2
  • 36
    • 0028355745 scopus 로고
    • Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates
    • (1994) Biochemistry , vol.33 , pp. 6840-6849
    • Stauffer, D.A.1    Karlin, A.2
  • 38
    • 0028921479 scopus 로고
    • Acetylcholine receptor channel imaged in the open state
    • (1995) Nature , vol.373 , pp. 37-43
    • Unwin, N.1
  • 44
    • 0032474432 scopus 로고    scopus 로고
    • Contribution of the beta subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor
    • (1998) Biochemistry , vol.37 , pp. 7952-7964
    • Zhang, H.1    Karlin, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.