Separate ion pathways in a Cl-/H+ exchanger

Journal of General Physiology

Volumn 126, Issue 6, 2005, Pages 563-570

  Accardi, Alessio ^a   Walden, Michael ^a   Nguitragool, Wang ^a   Jayaram, Hariharan ^a   Williams, Carole ^a   Miller, Christopher ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; PROTON;

ANIMAL CELL; ARTICLE; CHLORIDE TRANSPORT; CRYSTAL STRUCTURE; ION TRANSPORT; MUTAGENESIS; NONHUMAN; PH; PROTON TRANSPORT; WILD TYPE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CHLORIDE CHANNELS; CHLORIDES; CRYSTALLOGRAPHY; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; PROTON PUMPS;

EID: 28244457359     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200509417     Document Type: Article

References (29)

1. - channels. J. Gen. Physiol. 123:109-119.
2. - channels. Nature. 427:803-807.
3. Ädelroth, P., and P. Brzezinski. 2004. Surface-mediated protontransfer reactions in membrane-bound proteins. Biochim. Biophys. Acta. 1655:102-115.
4. Auer, M., M.J. Kim, M.J. Lemieux, A. Villa, J. Song, X.D. Li, and D.N. Wang. 2001. High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter. Biochemistry. 40:6628-6635.
5. + of the muscle-type ClC chloride channels. J. Gen. Physiol. 118:23-32.
6. 2+ exchanger NCX1.1 measured in transfected HEK cells. Biophys. J. 82:1943-1952.
7. Dutzler, R., E.B. Campbell, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature. 415:287-294.
8. Dutzler, R., E.B. Campbell, and R. MacKinnon. 2003. Gating the selectivity filter in ClC chloride channels. Science. 300:108-112.
9. Estevez, R., B.C. Schroeder, A. Accardi, T.J. Jentsch, and M. Pusch. 2003. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron. 38:47-59.
10. Faraldo-Gomez, J.D., and B. Roux. 2004. Electrostatics of ion stabilization in a ClC chloride channel homologue from Escherichia coli. J. Mol. Biol. 339:981-1000.
11. Foster, J.W. 2004. Escherichia coli acid resistance: tales of an amateur acidophile. Nat. Rev. Microbiol. 2:898-907.
12. Iyer, R., T.M. Iverson, A. Accardi, and C. Miller. 2002. A biological role for prokaryotic ClC chloride channels. Nature. 419:715-718.
13. Jencks, W.P. 1980. The utilization of binding energy in coupled vectorial processes. Adv. Enzymol. Relat. Areas Mol. Biol. 51:75-106.
14. Jentsch, T.J., I. Neagoe, and O. Scheel. 2005. CLC chloride channels and transporters. Curr. Opin. Neurobiol. 15:319-325.
15. Kaback, H.R. 2005. Structure and mechanism of the lactose permease. C. R. Biol. 328:557-567.
16. 2+ exchanger. Nature. 427:544-548.
17. Kida, Y., S. Uchida, H. Miyazaki, S. Sasaki, and F. Marumo. 2001. Localization of mouse CLC-6 and CLC-7 mRNA and their functional complementation of yeast CLC gene mutant. Histochem. Cell Biol. 115:189-194.
18. Knauf, P.A., F.Y. Law, T.W. Leung, A.U. Gehret, and M.L. Perez. 2002. Substrate-dependent reversal of anion transport site orientation in the human red blood cell anion-exchange protein, AE1. Proc. Natl. Acad. Sci. USA. 99:10861-10864.
19. Kornak, U., D. Kasper, M.R. Bosl, E. Kaiser, M. Schweizer, A. Schulz, W. Friedrich, G. Delling, and T.J. Jentsch. 2001. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Cell. 104:205-215.
20. Lobet, S., and R. Dutzler. 2005. Ion binding properties of the CLC chloride selectivity filter. EMBO J. In press.
21. Maloney, P.C. 1994. Bacterial transporters. Curr. Opin. Cell Biol. 6:571-582.
22. Niemeyer, M.I., L.P. Cid, L. Zuniga, M. Catalan, and F.V. Sepulveda. 2003. A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel. J. Physiol. 553:873-879.
23. Pebay-Peyroula, E., C. Dahout-Gonzalez, R. Kahn, V. Trezeguet, G.J. Lauquin, and G. Brandolin. 2003. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature. 426:39-44.
24. Picollo, A., and M. Pusch. 2005. Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature. 436:420-423.
25. Richard, H., and J.W. Foster. 2004. Escherichia coli glutamate- and arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potential. J. Bacteriol. 186:6032-6041.
26. Ruan, Z.S., V. Anantharam, I.T. Crawford, S.V. Ambudkar, S.Y. Rhee, M.J. Allison, and P.C. Maloney. 1992. Identification, purification, and reconstitution of OxlT, the oxalate: formate antiport protein of Oxalobacter formigenes. J. Biol. Chem. 267:10537-10543.
27. Scheel, O., A.A. Zdebik, S. Lourdel, and T.J. Jentsch. 2005. Voltagedependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature. 436:424-427.
28. Terwilliger, T.C. 2000. Maximum-likelihood density modification. Acta Crystallogr. D Biol. Crystallogr. 56(Pt 8):965-972.
29. Yin, J., Z. Kuang, U. Mahankali, and T.L. Beck. 2004. Ion transit pathways and gating in ClC chloride channels. Proteins. 57:414-421.