Molecular genetics of bipolar disorder

Genes, Brain and Behavior

Volumn 5, Issue 1, 2006, Pages 85-95

  Hayden, E P ^a   Nurnberger Jr , J I ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Association studies; Bipolar disorder; Linkage analysis; Molecular genetics

Indexed keywords

4 AMINOBUTYRIC ACID; ADENYLATE CYCLASE; ADRENALIN; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; GUANINE NUCLEOTIDE BINDING PROTEIN; IMIPRAMINE; LITHIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE CELL ADHESION MOLECULE; PROTEIN BCL 2; PURINE RECEPTOR; SEROTONIN 2A RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HIGH TEMPERATURE REQUIREMENT PROTEIN A 4; MESSENGER RNA; SERINE PROTEINASE; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

BIPOLAR DISORDER; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME 16; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 2; CHROMOSOME 20; CHROMOSOME 21; CHROMOSOME 22; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME 9; CHROMOSOME ANALYSIS; DEPRESSION; DRUG EFFECT; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE SEQUENCE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SCREENING; HAPLOTYPE; HUMAN; MAJOR AFFECTIVE DISORDER; MAJOR DEPRESSION; MOLECULAR GENETICS; MOOD DISORDER; NONHUMAN; PANIC; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; X CHROMOSOME; ANIMAL BEHAVIOR; AVERSIVE BEHAVIOR; CHROMOSOME 11P; CHROMOSOME 12Q; CHROMOSOME 13Q; CHROMOSOME 16P; CHROMOSOME 16Q; CHROMOSOME 18P; CHROMOSOME 18Q; CHROMOSOME 21Q; CHROMOSOME 22Q; CHROMOSOME 2P; CHROMOSOME 4P; CHROMOSOME 4Q; CHROMOSOME 6Q; CHROMOSOME 8Q; CHROMOSOME XQ; CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SLEEP DISORDER; GENETIC ANALYSIS; GENETIC ASSOCIATION; HETEROZYGOTE; LINKAGE ANALYSIS; PREFRONTAL CORTEX; SLEEP DEPRIVATION; UPREGULATION;

ANIMALS; BIPOLAR DISORDER; CHROMOSOMES, HUMAN; CHROMOSOMES, HUMAN, X; DISEASE MODELS, ANIMAL; HUMANS; LINKAGE (GENETICS); MICE; MICE, KNOCKOUT;

ANIMALIA;

EID: 33645081719     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2005.00138.x     Document Type: Review

References (109)

1. Adams L.J. Mitchell P.B. Fielder S.L. Rosso A. Donald J.A. Schofield P.R. 1998 A susceptibility locus for bipolar affective disorder on chromosome 4q35 Am J Hum Genet 62 1084 1091
2. Amberlas A. 1979 Psychologically stressful events in the precipitation of manic episodes Br J Psychiatry 135 15 21
3. American Psychiatric Association. 1994 Diagnostic and Statistical Manual of Mental Disorders 4th edn Author Washington, DC
4. Anguelova M. Benkelfat C. Turecki G. 2003 A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter. I. Affective disorders Mol Psychiatry 8 574 591
5. Arai M. Itokawa M. Yamada K. Toyota T. Arai M. Haga S. Ujike H. Sora I Ikeda K. Yoshikawa T. 2004 Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals Biol Psychiatry 55 804 810.
6. Badenhop R.F. Moses M.J. Scimone A. Adams L.J. Kwok J.B.J. Jones A.M. Davison G. Evans M.R. Kirkby K. Hewitt J.E. Donald J.A. Mitchell P.B. & Schofield P.R. 2003 Genetic refinement and physical mapping of a 2.3 Mb probable disease region associated with a bipolar affective disorder susceptibility locus on chromosome 4q35 Am J Med Genet Part B (Neuropsychiatr Genet) 117B 23 32
7. Badner J.A. Gershon E.S. 2002 Meta-analysis of whole genome linkage scans of bipolar disorder and schizophrenia Mol Psychiatry 7 405 411
8. Barden N. Harvey M. Shink E. Tremblay M. Gagne B. Raymond C. Labbe M. St-Onge L. Stadler H. Sillaber I. Paez-Pereda Holsboer F. 2004 Identification and characterisation of a gene predisposing to both bipolar and unipolar affective disorders Am J Med Genet Part B (Neuropsychiatr Genet) 130B 122
9. Baron M. 2002 Manic-depression genes and the new millennium: poised for discovery Mol Psychiatry 7 342 358
10. Barrett T.B. Hauger R.L. Kennedy J.L. Sadovnick A.D. Remick R.A. Keck P.E. McElroy S.L. Alexander M. Shaw S.H. Kelsoe J.R. 2003 Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene in associated with bipolar disorder Mol Psychiatry 8 546 557
11. Berrettini W.H. 2003 Chromosome 18p11 in bipolar disorder and schizophrenia Am J Med Genet Part B (Neuropsychiatr Genet) 122B 6
12. Berrettini W.H. Golden L.R. Martinez M.M. et al. 1991 A bipolar pedigree series for genomic mapping of disease genes: diagnostic and analytic considerations Psychiatr Genet 2 125 160
13. Berrettini W.H. Ferraro T.N. Goldin L.R. Weeks D.E. Detera-Wadleigh S. Nurnberger J.I., Jr Gershon E.S. 1994 Chromosome 18 DNA markers and manic depressive illness: evidence for a susceptibility gene Proc Natl Acad Sci USA 91 5918 5921
14. Bertelsen A. Harvald B. Hauge M. 1977 A Danish twin study of manic-depressive disorders Br J Psychiatry 130 330 351
15. Blackwood D.H. He L. Morris S.W. McLean A. Whitton C. Thomson M. Walker M.T. Woodburn K. Sharp C.M. Wright A.F. Shibasaki Y. St Clair D.M. Poreous D.J. Muir W.J. 1996 A locus for bipolar disorder on chromosome 4p Nat Genet 12 427 430
16. Cardno A.G. Marshall E.J. Coid B. Macdonald A.M. Ribchester T.R. Davies N.J. Venturi P. Jones L.A. Lewis S.W. Sham P.C. Gottesman I.I. Farmer A.E. McGuffin P. Reveley A.M. Murray R.M. 1999 Heritability estimates for psychotic disorders Arch Gen Psychiatry 56 162 168
17. Caspi A. Sugden K. Moffitt T.E. Taylor A. Craig I.W. Harrington H. McClay J. Mill J. Martin J. Braithwaite A. Poulton R. 2003 Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 386 389
18. Chen A.C.H. Shirayama Y. Shin K.H. Neve R.L. Duman R.S. 2001 Expression of the camp response element binding protein (CREB) in hippocampus produces an antidepressant effect Biol Psychiatry 49 753 762
19. Chen Y.S. Akula N. Detera-Wadleigh S.D. Schulze T.G. Thomas J. Potash J.B. DePaulo J.R. McInnis M.G. Cox N.J. McMahon F.J. 2004 Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33 Mol Psychiatry 9 87 92
20. Cichon S. Schumacher J. Muller D.J. et al. 2001 A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q Hum Mol Genet 10 2933 2944
21. Collier D.A. Stober G. Heils A. Catalano M. di Bella D. Arranz M.J. Murray R.M. Vallada H.P. Bengel D. Muller C.R. Roberts S.W. Smeraldi E. Kirov G. Shap P. Lesch K.P. 1996 A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders Mol Psychiatry 1 453 460
22. Craddock N. Jacobsen N. Franks E. Green E. Elvidge G. Jones I. O'Donovan M. Owen M.J. 1999 Molecular genetic investigation of bipolar disorder in the region of the Darier's disease gene (ATP2A2) on chromosome 12q23-q24.1 Mol Psychiatry 4 S71
23. DePaulo J.R. 2004 Genetics of bipolar disorder: where do we stand? Am J Psychiatry 161 595 597
24. Depue R.A. Krauss S.P. Spoont M.R. 1987 ) A two-dimensional threshold model of seasonal bipolar affective disorder. In Magnusson D. Oehman A. (eds) Psychopathology: An Interactional PerspectivePersonality, Psychopathology, and Psychotherapy Academic Press Orlando, FL, pp. 95 123
25. Detera-Wadleigh S. Badner J.A. Goldin L.R. Berrettini W.H. Sanders A.R. Rollins D.Y. Moses T. Sanders A.R. Karkera J.D. Esterling L.E. Zeng J. Ferraro T.N. Guroff J.J. Kazuba D. Maxwell M.E. Nurnberger J.I. Jr. Gershon E.S. 1996 Affected sib-pair analysis reveal support of prior evidence for susceptibility locus for bipolar disorder on 21q Am J Hum Genet 58 1279 1285
26. Detera-Wadleigh S.D. Badner J.A. Yoshikawa T. Sanders A.R. Goldin L.R. Turner G. Moses R. Haerian G. Muniec D. Nurnberger J.I. Jr. Gershon E.S. 1997 Initial genome scan of the NIMH Genetics Initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q Am J Med Genet 74 254 262
27. Detera-Wadleigh S.D. Badner J.A. Yoshidawa T. et al. 1999 A high-density genome scan detects evidence for a bipolar disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2 Proc Natl Acad Sci USA 96 5604 5609
28. Dick D.M. Foroud T. Edenberg H.J. Miller M. Bowman E. Rau N.L. DePaulo J.R. McInnis M. Gershon E. McMahon F. Rice J.P. Beirut L.J. Reich T. Nurnberger J.I Jr. 2002 Apparent replication of suggestive linkage on chromosome 16 in the NIMH Genetics Initiative bipolar pedigrees Am J Med Genet (Neuropsychiatr Genet) 114 407 412
29. Dick D.M. Foroud T. Flury L. et al. 2003 Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative Am J Hum Genet 73 107 114
30. Dluzen D.E. Gao X. Story G.M. Anderson L.I. Kucera J. Walro J.M. 2001 Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice Exp Neurol 170 121 128
31. Egeland J.A. Gerhard D.S. Pauls D.L. Sussex J.N. Kidd K.K. Allen C.R. Hostetter A.M. Housman D.E. 1987 Bipolar affective disorders linked to DNA markers on chromosome 11 Nature 325 783 787
32. Ekholm J.M. Pekkarinen P. Pajukanta P. Kieseppa T. Partonen T. Paunio T. Varilo T. Perola M. Lonnqvist J. Peltonen L. 2002 Bipolar disorder susceptibility region on Xq24-q27.1 in Finnish families Mol Psychiatry 7 453 459
33. Ewald H. Flint T. Degn B. Wang A. Vang M. Mors O. Kruse T.A. 1999 A search for a shared segment of a chromosome 10q in patients with bipolar affective disorder from the Faroe Islands Mol Psychiatry 4 S72
34. Faraone S.V. Matise T. Svrakic D. Pepple J. Malaspina D. Suarez B. Hampe C. Zambuto C.T. Schmitt K. Meyer J. Markel P. Lee H. Harkavy Friedman J. Kaufmann C. Cloninger C.R. Tsuang M.T. 1998 Genome scan of European American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium Am J Med Genet 81 290 295
35. Faraone S.V. Glatt S.J. Su J. Tsuang M.T. 2004 Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania Am J Psychiatry 161 625 630
36. Ferguson G.D. Herschman H.R. Storm D.R. 2004 Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice Neuropharmacology 47 604 611
37. Foroud T. Castelluccio P.F. Koller D.L. et al. 2000 Suggestive evidence of a locus on chromosome 10p using the NIMH Genetics Initiative bipolar affective disorder pedigrees Am J Med Genet (Neuropsychiatr Genet) 96 18 23
38. Garner C. McInnes L.A. Service S.K. Spesny M. Fournier E. Leon P. Freimer N.B. 2001 Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov Chain Monte Carlo method Am J Hum Genet 68 1061 1064
39. Gessa G.L. Pani L. Fadda P. Fratta W. 1995 Sleep deprivation in the rat: an animal model of mania Eur Neuropsychopharmacol 5 89 93
40. Ginns E.I. Ott J. Egeland J.A. Allen C.R. Fann C.S.J. Pauls D.L. Weissenbachoff J. Carulli J.P. Falls K.M. Keith T.P. Paul S.M. 1996 A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish Nat Genet 12 431 435
41. Greenwood T.A. Alexander M. Keck P.E. McElroy S. Sadovnick A.D. Remick R.A. Kelsoe J.R. 2001 Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder Am J Med Genet (Neuropsychiatr Genet) 105 145 151
42. Hattori E. Liu C. Badner J.A. Bonner T.I. Christian S.L. Maheshwari M. Detera-Wadleigh S. Gibbs R.A. Gershon E.S. 2003 Polymorphisms at the G72/G30 locus, on 13q33, are associated with bipolar disorder in two independent pedigree series Am J Hum Genet 72 1131 1140
43. Hofstetter J.R. Trofatter J.A. Kernek K.L. Nurnberger J.I. Mayeda A.R. 2003 New quantitative trait loci for the genetic variance in circadian period of locomotor activity between inbred strains of mice J Biol Rhythms 18 450 462
44. 5 receptor null mutant mice Behav Neurosci 115 1129 1144
45. Itokawa M. Yamada K. Iwayama-Shigeno Y. Ishitsuka Y. Detera-Wadleigh S. Yoshikawa T. 2003 Genetic analysis of a functional GRIN2A promoter (GT) N repeat in bipolar disorder pedigrees in humans Neurosci Lett 345 53 56
46. Ivy A.S. Rodriguez F.G. Garcia C. Chen M.J. Russo-Neustadt A.A. 2003 Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant Pharmacol Biochem Behav 75 81 88
47. Jacobsen N.J.O. Franks E.K.E. Jones I. McCandless F. O'Donovan M.C. Owen M.J. Craddock N. 2001 Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder Mol Psychiatry 6 92 97
48. Johnson S.L. Sandrow D. Meyer B. Winters R. Miller I. Solomon D. Keitner G. 2000 Increases in manic symptoms after life events involving goal attainment J Abnorm Psychol 109 721 727
49. Jones J. Jacobsen N. Green E.K. Elvidge G.P. Owen M.J. Craddock N. 2002 Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's disease Mol Psychiatry 7 424 427
50. Kelsoe J.R. Spence M.A. Loetscher E. Foguet M. Sadovnick A.D. Remick R.A. Flodman P. Khristich J. Mroczkowski-Parker Z. Brown J.L. Masser D. Ungerleider S. Rapaport M.H. Wishart W.L. Luebbert H. 2001 A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22 Proc Natl Acad Sci USA 98 585 590
51. Kernie S.G. Liebl D.J. Parada L.F. 2000 BDNF regulates eating behavior and locomotor activity in mice EMBO J 19 1290 1300
52. Kohen R. Neumaier J.F. Hamblin M.W. Edwards E. 2003 Congenitally learned helpless rats show abnormalities in intracellular signaling Biol Psychiatry 53 520 529
53. Kwapil T.R. Miller M.B. Zinser M.C. Chapman L.J. Chapman J. Eckblad M. 2000 A longitudinal study of high scorers on the hypomanic personality scale J Abnorm Psychol 109 222 226
54. Lachman H.M. Morrow B. Shprintzen R. Veit S. Parsia S.S. Faedda G. Goldbery R. Kucherlapati R. Papolos D.F. 1996 Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome Am J Med Genet (Neuropsychiatr Genet) 67 468 472
55. Lander E. Kruglyak L. 1995 Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results Nat Genet 11 241 247
56. Lenox R.H. Gould T.D. Manji H.K. 2002 Endophenotypes in bipolar disorder Am J Med Genet 114 391 406
57. Levinson D.F. Levinson M.D. Segurado R. Lewis C.M. 2003 Genome scan meta-analysis of schizophrenia and bipolar disorder, part I. Methods and power analysis Am J Hum Genet 73 17 33
58. Lira A. Zhou M. Castanon N. Ansorge M.S. Gordon J.A. Francis J.H. 2003 Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice Biol Psychiatry 54 960 971
59. Liu J. Aita V.M. Knowles J.A. Terwilliger J.D. Baltazar R. Grunn A. Loth J.E. Kanyas K. Lerer B. Endicott J. Wang Z. Penchaszadeh G. Gilliam T.C. Baron M. 1999 Search for susceptibility loci in extended pedigrees with bipolar affective disorder Mol Psychiatry 4 S21
60. Liu J. Juo S.H. Dewan A. Grunn A. Tong X. Brito M. Park N. Kanyas K. Lerer B. Endicott J. Penchaszadeh G. Knowles J.A. Ott J. Gilliam T.C. Baron M. 2003 Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12 Mol Psychiatry 8 333 342
61. Liu J. Juo S.H. Terwilliger J.D. Brunn A. Tong X. Brito M. Loth J.E. Kanyas K. Lerer B. Edicott J. Penchaszadeh G. Gilliam T.C. Baron M. 2001 A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22 Am J Med Genet (Neuropsychiatr Genet) 105 189 194
62. Lozano B.E. Johnson S.L. 2001 Can personality traits predict increases in manic and depressive symptoms? J Affect Disord 63 103 111
63. Lyons W.E. Mamounas L.A. Ricaurte G.A. Coppola V. Reid S.W. Bora S.H. Wihler C. Koliatsos V.E. Tessarollo L. 1999 Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities Proc Natl Acad Sci USA 96 15239 15244
64. Massat I. Souery D. Del-Favero J. et al. 2002a Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European multicenter association study of affective disorders Am J Med Genet (Neuropsychiatr Genet) 114 177 185
65. Massat I. Souery D. Del-Favero J. et al. 2002b Excess of allele1 for α3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study Mol Psychiatry 7 201 207
66. Mayeda A. Nurnberger J.I., Jr ( 1998 Melatonin and circadian rhythms in bipolar mood disorder. In Shafii M. Shafii S.L. (eds) Melatonin in Psychiatric and Neoplastic Disorders American Psychiatric Press Washington, DC, pp. 105 123
67. McInnis M.G. MacKinnon D.F. McMahon F.J. Foroud T. Edenberg H.J. Goate A. Detera-Wadleigh S. Stine O.C. Rice J. Blehar M. Reich T. Gershon E. Nurnberger J.I. Simpson S.G. DePaulo J.R. 1999 Evidence for a susceptibility loci for bipolar disorder on the X chromosome Mol Psychiatry 4 S75
68. McInnis M. Lan T.-H. Willour V.L. et al. 2003a Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12 Mol Psychiatry 8 288 298
69. McInnis M. Dick D.M. Willour V.L. et al. 2003b Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health Genetics Initiative bipolar pedigrees Biol Psychiatry 54 1265 1273
70. Meloni R. Leboyer M. Bellivier F. Barbe B. Samolyk D. Allilaire J.F. Mallet J. 1995 Association of manic-depressive illness with tyrosine hydroxylase microsatellite marker Lancet 345 932
71. Mendelwicz J. Rainer J.D. 1977 Adoption study supporting genetic transmission in manic-depressive illness Nature 368 327 329
72. Millar K. Mackie S. Pickard B. Buchanan S. Christie S. Malloy P. Blackwood D. Muir W. Porteous D. 2004 DISC1: progress from discovery towards an understanding Am J Med Genet Part B (Neuropsychiatr Genet) 130B 6
73. Morissette J. Villeneuve A. Bordeleau L. Rochette D. Laberge C. Gagne B. Laprise C. Bouchard G. Plante M. Gobeil L. Shink E. Weissenbach J. Barden N. 1999 Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24 Am J Med Genet (Neuropsychiatr Genet) 88 567 587
74. Mortensen P.B. Pedersen C.B. Melbye M. Mors O. Ewald H. 2003 Individual and familial risk factors for bipolar affective disorders in Denmark Arch Gen Psychiatry 60 1209 1215
75. Muglia P. Petronis A. Mundo E. Lander S. Cate T. Kennedy J.L. 2002 Dopamine D4 receptor and tyrosine hydroylase genes in bipolar disorder: evidence for a role of DRD4 Mol Psychiatry 7 860 866
76. Mundo E. Tharmalingham S. Neves-Pereira M. Dalton E.J. Macciardi F. Parikh S.V. Bolonna A. Kerwin R.W. Arranz M.J. Makoff A.J. Kennedy J.L. 2003 Evidence that the N-methyl- d -aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder Mol Psychiatry 8 241 245
77. Nakata K. Ujike H. Sakai A. Uchida N. Nomura A. Imamura T. Katsu T. Tanaka Y. Hamamura T. Kuroda S. 2003 Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder Neurosci Lett 337 17 20
78. Nestler E.J. Gould E. Manji H. Bucan M. Duman R.S. Gershenfeld H.K. Hen R. Koester S. Lederhendler I. Meaney M.J. Robbins T. Winsky L. Zalcman S. 2002 Preclinical models: status of basic research in depression Biol Psychiatry 52 503 528
79. Neves-Pereira M. Mundo E. Muglia P. King N. Macciardi F. Kennedy J.L. 2002 The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study Am J Hum Genet 71 651 655
80. Niculescu A.B. Segal D.S. Kuczenski R. Barrett T. Hauger R.L. Kelsoe J.R. 2000 Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach Physiol Genomics 4 83 91
81. Nurnberger J.I. Jr. Adkins S. Lahiri D.K. Mayeda A. Hu K. Lewy A. Miller A. Bowman E.S. Miller M.J. Rau L. Smiley C. Davis-Singh D. 2000 Melatonin suppression by light in euthymic bipolar and unipolar patients Arch Gen Psychiatry 57 572 579
82. Nurnberger J.I. Jr. Goldin L.R. Gershon E.S. 1994 ) Genetics of psychiatric disorders. In Winokur G. Clayton P.J. (eds) The Medical Basis of Psychiatry 2nd edn W.B. Saunders Philadelphia, PA, pp. 459 492
83. Ohtsuki T. Ishiguro H. Detera-Wadleigh S.D. Toyota T. Shimuzu H. Yamada K. Yoshitsugu K. Hattori E. Yoshikawa T. Arinami T. 2002 Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative bipolar pedigrees Mol Psychiatry 7 954 961
84. Palmer A.A. Breen L.L. Flodman P. Conti L.H. Spence M.A. Printz M.P. 2003 Identification of quantitative trait loci for prepulse inhibition in rats Psychopharmacology 165 270 279
85. Pekkarinen P. Terwilliger J. Bredbacka P.E. Lonnqvist J. Peltonen L. 1995 Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree Genome Res 5 105 115
86. Perry W. Minassian A. Feifel D. Braff D.L. 2001 Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania Biol Psychiatry 50 418 424
87. Porsolt R.D. LePichon M. Jalfre M 1977 Depression: a new animal model sensitive to anti-depressant treatment Nature 266 730 732
88. Porsolt R.D. Lenegre A. McArthur R.A (1991) Pharmacological models of depression In Olivier B. Mos J. Slangen J.L (eds) Animal Models in Psychopharmacology Birkhauser, Basel pp 137 159
89. Potash J.B. Zandi P.P. Willour V.L. Lan T. Huo Y. Avramopoulos D. Shugart Y.Y. MacKinnon D.F. Simpson S.G. McMahon F.J. DePaulo J.R. McInnis M.G. 2003 Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder Am J Psychiatry 160 680 686
90. Preisig M. Bellivier F. Fenton B.T. Baud P. Berney A. Courtet P. Hardy P. Golaz J. Leboyer M. Mallet J. Matthey M.-L. Mouthan D. Neidhart E. Nosten-Bertrand M. Stadelmann-Cubuis E. Guimon J. Ferrero F. Buresi C. Malafosse A. 2000 Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study Am J Psychiatry 157 948 955
91. Ranade S.S. Mansour H. Wood J. Chowdari K.V. Brar L.K. Kupfer D.J. Nimagaonkar V.L. 2003 Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder Am J Med Genet Part B (Neuropsychiatr Genet) 121B 28 34
92. Rotondo A. Mazzanti C. Dell'Osso L. Rucci P. Sullivan P. Bouanani S. Gonnelli C. Goldman D. Cassano G.B. 2002 Catechol O-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder Am J Psychiatry 159 23 29
93. Schumacher J. Abon Jamra R. Freudenberg J. Becker T. Ohlraun S. Otte A.C.J. Tullius M. Kovalenko S. Bogaert A.V.D. Maier W. Rietschel M. Propping P. Nothen M.M. Cichon S. 2004 Examination of G72 and d -amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder Mol Psychiatry 9 203 207
94. Schwab S.G. Hallmayer J. Albus M. Lerer B. Hanses C. Kanyas K. Segman R. Borrman M. Dreikorn B. Lichtermann D. Rietschel M. Trixler M. Maier W. Wildenauer D.B. 1998 Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis Am J Med Genet 81 302 307
95. Segurado R. Detera-Wadleigh S.D. Levinson D.F. et al. 2003 Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder Am J Hum Genet 73 49 62
96. Selcher J.C. Nekrasovo T. Paylor R. Landreth G.E. Sweatt J.D. 2001 Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning Learn Mem 8 11 19
97. Sheehan T.P. Neve R.L. Duman R.S. Russell D.S. 2003 Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septum Biol Psychiatry 54 540 551
98. Sklar P. Gabriel S.B. McInnis M.G. Bennett P. Lim Y.-L. Tsan G. Schaffner S. Kirov G. Jones I. Owen M. Craddock N. DePaulo J.R. Lander E.S. 2002 Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus Mol Psychiatry 7 579 593
99. Souery D. Van Gestel S. Massat I. et al. 2001 Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study Biol Psychiatry 49 405 409
100. Stine O.C. McMahon F.J. Chen L. Xu J. Meyers D.A. MacKinnon D.F. Simpson S. McInnis M.G. Rice J.P. Goate A. Reich T. Edenberg H.J. Foroud T. Nurnberger J.I. Jr. Detera-Wadleigh S.D. Goldin L.R. Guroff J. Gershon E.S. Blehar M.C. DePaulo J.R. 1997 Initial genome screen for bipolar disorder in the NIMH Genetics Initiative pedigrees: chromosomes 2, 11, 13, 14, and X Am J Med Genet (Neuropsychiatr Genet) 74 263 269
101. Straub R.E. Lehner T. Luo Y. Loth J.L. Shao W. Sharpe L. Alexander J.R. Das K. Simon R. Fieve R.R. Lerer B. Endicott J. Ott J. Gilliam C. Baron M. 1994 A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3 Nat Genet 8 291 296
102. Toyota T. Hattori E. Meerabux J. Yamada K. Saito K. Shibuya H. Nankai M. Yoshikawa T. 2002a Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders Am J Med Genet 114 84 92
103. Toyota T. Yamada K. Saito K. Detera-Wadleigh S.D. Yoshikawa T. 2002b Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder Mol Psychiatry 7 450 452
104. Turecki G. Alda M. Grof P. Martin R. Cavazzoni P.A. Duffy A. Maciel P. Rouleau G.A. 1996 No association between chromosome-18 markers and lithium-responsive affective disorders Psychiatry Res 63 17 23
105. Turecki G. Grof P. Grof E. D'Souza V. Lebuis L. Marineau C. Cavazzoni P. Duffy A. Betard C. Zvolsky P. Robertson C. Brewer C. Hudson T.J. Rouleau G.A. Alda M. 2001 Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium Mol Psychiatry 6 570 578
106. Turecki G. Rouleau G.A. Mari J. Joober R. Morgan K. 1997 Lack of association between bipolar disorder and tyrosine hydroxylase: a meta-analysis Am J Med Genet 74 348 352
107. Willour V.L. Zandi P.P. Huo Y. Diggs T.L. Chellis J.L. MacKinnon D.F. Simpson S.G. McMahon F.J. Potash J.B. Gershon E.S. Reich T. Foroud T. Nurnberger J.I. Jr. DePaulo J.R. McIinnis M.G (2003) Genome scan of the fifty-six bipolar pedigrees from the NIMH Genetics Initiative replication sample: Chromosomes 4, 7, 9, 18, 20, and 21 Am J Med Genet B Neuropsychiatr Genet 121 21 27
108. Zandi P.P. Willour V.L. Huo Y. Chellis J. Potash J.B. MacKinnon D.F. Simpson S.G. McMahon F.J. Gershon E.S. Reich T. Foroud T. Nurnberger J.I. Jr. DePaulo J.R. McIinnis M.G. 2003 Genome scan of a second wave of NIMH Genetics Initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X Am J Med Genet Part B (Neuropsychiatr Genet) 119b 69 76
109. Zill P. Malitas P.N. Bondy B. Engel R. Boufidou F. Behrens S. Alevizos B.E. Nikolaou C.K. Christodoulou G.N. 2003 Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients Psychiatr Genet 13 65 69