Endophenotypes in bipolar disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 114, Issue 4, 2002, Pages 391-406

  Lenox, Robert H ^a   Gould, Todd D ^a   Manji, Husseini K ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Biological marker; Circadian rhythms; Genetics; Subclinical trait; Vulnerability marker

Indexed keywords

BIOLOGICAL MARKER; CHOLINERGIC RECEPTOR STIMULATING AGENT; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; PSYCHOSTIMULANT AGENT;

ANIMAL MODEL; ARTICLE; BEHAVIOR; CIRCADIAN RHYTHM; ENDOPHENOTYPE; ENZYME INHIBITION; EVENT RELATED POTENTIAL; GENE LOCUS; GENETIC CONSERVATION; GENETIC DISORDER; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC MARKER; GENETIC MODEL; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; HORMONE RELEASE; MANIC DEPRESSIVE PSYCHOSIS; MONONUCLEAR CELL; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; SLEEP DEPRIVATION; SLEEP WAKING CYCLE; WHITE MATTER;

ANIMALS; BIPOLAR DISORDER; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CENTRAL NERVOUS SYSTEM STIMULANTS; CIRCADIAN RHYTHM; EVENT-RELATED POTENTIALS, P300; GENETIC PREDISPOSITION TO DISEASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; LEUKOCYTES, MONONUCLEAR; LITHIUM; PHENOTYPE; SIGNAL TRANSDUCTION; SLEEP DEPRIVATION;

ANIMALIA;

EID: 0037042065     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.10360     Document Type: Article

References (238)

1. Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons
2. Familial leukoencephalopathy in bipolar disorder
3. A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus
4. Autosomal recessive inheritance of affective disorders in families of responders to lithium prophylaxis?
5. Disease gene search goes big science
6. Stopping time: The genetics of fly and mouse circadian clocks
7. T2 hyperintensities in bipolar disorder: Magnetic resonance imaging comparison and literature meta-analysis
8. Antidepressant-induced mania and cycle acceleration: A controversy revisited
9. Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients
10. The dexamethasone suppression test and depression. Approaches to the use of a laboratory test in psychiatry
11. Autorhythmometry in manic-depressives
12. Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex
13. Effects of the rate of discontinuing lithium maintenance treatment in bipolar disorders
14. Effects of lithium treatment and its discontinuation on suicidal behavior in bipolar manic-depressive disorders
15. A serum shock induces circadian gene expression in mammalian tissue culture cells
16. Genetic linkage between X-chromosome markers and bipolar affective illness
17. Tryptophan depletion and its implications for psychiatry
18. Sleep and psychiatric disorders. A meta-analysis
19. The cholinergic rapid eye movement sleep induction test with RS-86. State or trait marker of depression?
20. Sleep deprivation combined with consecutive sleep phase advance as a fast-acting therapy in depression: An open pilot trial in medicated and unmedicated patients
21. Transient depressive relapse induced by catecholamine depletion: Potential phenotypic vulnerability marker?
22. Progress and pitfalls: Bipolar molecular linkage studies
23. On the future of genetic research in bipolar and schizophrenic syndromes
24. Chromosome 18 DNA markers and manic-depressive illness: Evidence for a susceptibility gene
25. A linkage study of bipolar illness
26. P300 in family studies of schizophrenia: Review and critique
27. Temperature rhythm of patients with major affective disorders: Reduced circadian period length
28. A locus for bipolar affective disorder on chromosome 4p
29. Dose-response relationships for resetting of human circadian clock by light
30. Simultaneous study of 24-hour patterns of melatonin and cortisol secretion in depressed patients
31. Late positive component amplitude in schizophrenics and alcoholics in two different paradigms
32. Neuroendocrine regulation in depression. II. Discrimination of depressed from nondepressed patients
33. The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3
34. Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system
35. Gene expression in the brain across the sleepwaking cycle
36. The renaissance of GSK3
37. Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression
38. Behavioral responses to amphetamines in identical twins
39. Genetics of bipolar disorder
40. Stability, precision, and near-24-hour period of the human circadian pacemaker
41. Physostigmine in mania
42. Individual differences in the reinforcing and subjective effects of amphetamine and diazepam
43. Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees
44. Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q
45. Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance
46. Neuroimaging studies of mood disorders
47. Elevated platelet intracellular calcium concentration in bipolar depression
48. The calcium second messenger system in bipolar disorders: Data supporting new research directions
49. Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients
50. Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder
51. A molecular and cellular theory of depression
52. Circadian rhythms and the pharmacology of affective illness
53. Molecular bases for circadian clocks
54. Subcortical signal hyperintensities in bipolar patients detected by MRI
55. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
56. Bipolar affective disorders linked to DNA markers on chromosome 11
57. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder
58. Support for the possible locus on chromosome 4p16 for bipolar affective disorder
59. Lithium prophylaxis of depression in bipolar I, bipolar II, and unipolar patients
60. Schizophrenia: The broken P300 and beyond
61. The relationship between P300 amplitude and regional gray matter volumes depends upon the attentional system engaged
62. Natural history and preventative treatment of recurrent mood disorders
63. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
64. Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23
65. The cholinergic agonist RS 86: A pharmacopsychological study
66. Sleep electroencephalographic coherence abnormalities in individuals at high risk for depression: A pilot study
67. Role of the CLOCK protein in the mammalian circadian mechanism
68. Inbred rat strain comparisons indicate different sites of action for cocaine and amphetamine locomotor stimulant effects
69. Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategies
70. Physostigmine alters onset but not duration of REM sleep in man
71. Successful separation of depressed, normal, and insomniac subjects by EEG sleep data
72. Age-related changes in sleep in depressed and normal subjects
73. Antidepressant discontinuation-related mania: Critical prospective observation and theoretical implications in bipolar disorder
74. Long latency event-related components of the auditory evoked potential in dementia
75. Evidence that the pathophysiology of depression and the mechanism of drug action of antidepressant drugs both involve alterations in circadian rhthyms
76. The Wnt signaling pathway in bipolar disorder
77. Signaling networks in the pathophysiology and treatment of mood disorders
78. Comparative efficacy of lithium and amitriptyline in the maintenance treatment of recurrent unipolar depression: A randomised study
79. Linkage findings in bipolar disorder
80. Affective disorders and circadian rhythms
81. The circadian system and the therapeutics of the affective disorders
82. Endogenous and exogenous components in the circadian variation of core body temperature in humans
83. Molecular genetic evidence for heterogeneity in manic depression
84. Further evidence for period lengthening effect of Li+ on circadian rhythms
85. The basic-helix-loophelix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
86. Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay
87. Molecular mechanisms underlying mood stabilization in manic-depressive illness: The phenotype challenge
88. Effects of aging on event-related brain potentials and reaction times in an auditory oddball task
89. A cholinergic-adrenergic hypothesis of mania and depression
90. Is cholinergic sensitivity a genetic marker for the affective disorders?
91. A triarchic model of P300 amplitude
92. Effect of lithium carbonate on circadian periodicity in humans
93. Influence of lithium ions on human circadian rhythms
94. Period lengthening of human circadian rhythms by lithium carbonate, a prophylactic for depressive disorders
95. Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans
96. Lithium and brain signal transduction systems
97. The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain
98. The role of sleep and wakefulness in the genesis of depression and mania
99. The anticholinergic biperiden in depressive disorders
100. Period lengthening and disruption of socially facilitated circadian activity rhythms of goldfish by lithium
101. The amphetamine challenge test correlates with affective lability in healthy volunteers
102. Molecular and cellular mechanisms of cardiac arrhythmias
103. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene
104. Recent progress in the search for genes for bipolar disorder
105. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish
106. Positional cloning of the mouse circadian clock gene
107. A molecular mechanism for the effect of lithium on development
108. Rhythms and the pharmacology of lithium
109. Light responsiveness of a circadian oscillator during lithium and potassium treatment
110. Antimanic drugs stabilize hamster circadian rhythms
111. Phase-advance theories for affective illness
112. Long-term treatment of depression
113. Lithium carbonate and sleep in affective illness
114. The application of EEG sleep for the differential diagnosis of affective disorders
115. Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders
116. Nonparametric simulation-based statistical analyses for bipolar affective disorder locus on chromosome 21q22.3
117. Splitting schizophrenia
118. Psychiatric genetics: Search for phenotypes
119. Lithium
120. From ultradian to infradian rhythms: LH release patterns in vitro
121. Glycogen synthase kinase 3-beta, mood stabilizers, and neuroprotection
122. The 24-hour profile of adrenocorticotropin and cortisol in major depressive illness
123. 24-Hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: Effect of antidepressant treatment
124. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau
125. An amphetamine model of manic depressive illness
126. Post-receptor signaling pathways in the pathophysiology and treatment of mood disorders
127. Signaling: Cellular insights into the pathophysiology of bipolar disorder
128. Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: Therapeutic implications
129. Neuroplasticity and cellular resilience in mood disorders
130. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock
131. Increased G alpha q/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder
132. Reliability of bestestimate diagnosis in genetic linkage studies of major psychoses: Results from the Quebec pedigree studies
133. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia
134. A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees
135. Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series
136. The effect of lithium carbonate on the sleep of depressed patients
137. Absence of linkage between chromosome 11p15 markers and manic-depressive illness in a Belgian pedigree
138. New insights into the mammalian circadian clock
139. Close linkage of bipolar disorder to chromosome 11 markers is excluded in two large Australian pedigrees
140. High levels of Gs alpha in platelets of euthymic patients with bipolar affective disorder
141. Effects of d-amphetamine upon open field behaviour in two inbred strains of mice
142. Nocturnal and circadian body temperatures of depressed outpatients during symptomatic and recovered states
143. A clock for the ages
144. White matter lesions and season of birth of patients with bipolar affective disorder
145. Different effect of desipramine on protein kinase C in platelets between bipolar and major depressive disorders
146. Effects of lithium on second messenger systems in the brain
147. Long-latency auditory eventrelated potentials in schizophrenia and in bipolar and unipolar affective disorder
148. Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients
149. A twin study of cholinergic REM induction
150. Measuring cholinergic sensitivity. I. Arecoline effects in bipolar patients
151. Behavioural disorders: Lessons in linkage
152. Drug-induced mania
153. Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder
154. Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder
155. Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder
156. Human morbid genetics revisited: Relevance of epigenetics
157. Molecular targets of lithium action
158. The P300 wave of the human event-related potential
159. Information processing deficits in relatives of manic depressive patients
160. A functional analysis of circadian pacemakers in nocturnal rodents. IV. Entrainment: Pacemaker as a clock
161. Glycogen synthase kinase-3: Functions in oncogenesis and development
162. Meta-analysis of P300 normative aging studies
163. Cocaine induced behavioral sensitization: A model for recurrent manic illness
164. Searching high and low: A review of the genetics of bipolar disorder
165. Genome scans for susceptibility genes in bipolar affective disorder
166. A clockwork explosion!
167. Molecular analysis of mammalian circadian rhythms
168. How to preserve the antidepressive effect of sleep deprivation: A comparison of sleep phase advance and sleep phase delay
169. A manic depressive history
170. Lithium inhibits glycogen synthase kinase-3 by competition for magnesium
171. Potentiation of antidepressant medications by phase advance of the sleep-wake cycle
172. Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain
173. Hyperfunctional G proteins in mononuclear leukocytes of patients with mania
174. On the origin of early REM episodes in the sleep of depressed patients: A comparison of three hypotheses
175. Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder
176. Assessment of lineality in bipolar I linkage studies
177. REM sleep induction by physostigmine infusion during sleep
178. The effect of physostigmine on normal human sleep and dreaming
179. Experimental acceleration and slowing of REM sleep ultradian rhythm by cholinergic agonist and antagonist
180. Induction and resetting of REM sleep rhythm in normal man by arecholine: Blockade by scopolamine
181. Scopolamine-induced muscarinic supersensitivity in normal man: Changes in sleep
182. Faster cholinergic REM sleep induction in euthymic patients with primary affective illness
183. Cholinergic regulation of mood and REM sleep: Potential model and marker of vulnerability to affective disorder
184. The association of supersensitive cholinergic REM-induction and affective illness within pedigrees
185. The anatomy of mood disorders - Review of structural neuroimaging studies
186. The functional neuroanatomy of mood disorders
187. Twenty-four-hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects
188. Lithium treatment and prophylaxis in unipolar depression: A meta-analysis
189. Auditory P300 event-related potentials and neuropsychological performance in schizophrenia and bipolar affective disorder
190. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
191. Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery
192. Tolerance and sensitization to the behavioral effects of drugs
193. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect
194. Rat strain differences in open-field behavior and the locomotor stimulating and rewarding effects of amphetamine
195. Neuroimaging in bipolar disorder: What have we learned?
196. A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3
197. Distinct neurophysiological mechanisms for manic and cycloid psychoses: Evidence from a P300 study on manic patients
198. Risk of recurrence following discontinuation of lithium treatment in bipolar disorder
199. Effects of partial sleep deprivation on the diurnal variation of mood and motor activity in major depression
200. Mouse molecular genetic technologies: Promise for psychiatric research
201. Locomotor activity in depressed children and adolescents. I. Circadian dysregulation
202. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
203. Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage study
204. Drug preference and mood in humans: Preference for d-amphetamine and subject characteristics
205. Depression: A disorder of timekeeping?
206. Total sleep deprivation: Clinical and theoretical aspects
207. On the explanation of short REM latencies in depression
208. Periodic fever associated with intermittent rhythmic delta activity: A syndrome of hypothalamic origin?
209. Neuropathology of bipolar disorder
210. MRI findings in patients with affective disorder: A metaanalysis
211. The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome
212. Circadian rhythms in endogenous depression
213. Diurnal variation of mood and the cortisol rhythm in depression and normal states of mind
214. Circadian rhythm genetics: From flies to mice to humans
215. Enhanced protein kinase C activity and translocation in bipolar affective disorder brains
216. Signal transduction abnormalities in bipolar disorder
217. Increased membrane-associated protein kinase C activity and translocation in blood platelets from bipolar affective disorder patients
218. Effects of tetraethylammoniumchloride (TEA), vanadate, and alkali ions on the lateral leaflet movement rhythm of Desmodium motorium (Houtt.)
219. Effects of wakefulness and sleep on depression and mania
220. Rapid cycling in manic-depressives induced by tricyclic antidepressants
221. 48-Hour sleep-wake cycles in manic-depressive illness: Naturalistic observations and sleep deprivation experiments
222. Sleep reduction as a final common pathway in the genesis of mania
223. Lithium lengthens circadian period in a diurnal primate, Saimiri sciureus
224. The effect of co-morbidity and penetrance estimation on the outcome of linkage analysis in a bipolar family
225. Circadian variation in rat brain AP-1 DNA binding activity after cholinergic stimulation: Modulation by lithium
226. Molecular components of the circadian system in Drosophila
227. Sleep deprivation in depression: What do we know, where do we go?
228. Effects of chronic administration and withdrawal of antidepressant agents on circadian activity rhythms in rats
229. Judging a protein by more than its name: GSK-3
230. The biological basis of an antidepressant response to sleep deprivation and relapse: Review and hypothesis
231. Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder
232. Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder
233. Molecular analysis of mammalian timeless