Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis

American Journal of Human Genetics

Volumn 73, Issue 1, 2003, Pages 17-33

  Levinson, Douglas F ^a,d   Levinson, Matthew D ^a   Segurado, Ricardo ^b   Lewis, Cathryn M ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d Department of Psychiatry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CALCULATION; CHROMOSOME; GENE MAPPING; GENETIC LINKAGE; GENOME SCAN META ANALYSIS; GENOTYPE; HUMAN; NONPARAMETRIC TEST; PARENT; PEDIGREE; PRIORITY JOURNAL; PROBABILITY; SAMPLE SIZE; SCHIZOPHRENIA; SCORING SYSTEM; SIBLING; SIMULATION;

EID: 0038003197     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/376548     Document Type: Article

References (21)

1. _ (2002a) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405-411
2. Badner JA, Gershon ES (2002b) Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7. Mol Psychiatry 7:56-66
3. Berrettini WH (2000) Are schizophrenic and bipolar disorders related? A review of family and molecular studies. Biol Psychiatry 48:531-538
4. Dorr D, Rice J, Armstrong C, Reich T, Blehar M (1997) A meta-analysis of chromosome 18 linkage data for bipolar illness. Genet Epidemiol 14:617-622
5. Gill M, Vallada H, Collier D, Sham P, Holmans P, Murray R, McGuffin P, et al (1996) A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22). Am J Med Genet 67:40-45
6. Göring HHH, Terwilliger JD, Blangero J (2001) Large upward bias in estimation of locus-specific effects from genome-wide scans. Am J Hum Genet 69:1357-1369
7. Hauser ER, Boehnke M, Guo SW, Risch N (1996) Affected sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol 13:117-138
8. James JW (1971) Frequency in relatives for an all-or-none trait. Ann Hum Genet 35:47-49
9. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K (2002) A high-resolution recombination map of the human genome. Nat Genet 31:241-247
10. Kruglyak L, Daly M (1998) Linkage thresholds for two-stage genome scans. Am J Hum Genet 62:994-996
11. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363
12. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
13. Levinson DF, Holmans P, Straub RE, Owen MJ, Wildenauer DB, Gejman PV, Pulver AE, Laurent C, Kendler KS, Walsh D, Norton N, Williams NM, Schwab SG, Lerer B, Mowry BJ, Sanders AR, Antonarakis SE, Blouin JL, DeLeuze JF, Mallet J (2000) Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. Am J Hum Genet 67:652-663
14. Levinson DF, Mowry BJ (2000) Genetics of schizophrenia. In: Pfaff DW, Berrettini WH, Maxson SC, Joh TH (eds) Genetic influences on neural and behavioral functions. CRC Press, New York, pp 47-82
15. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, et al (2003) Genome scan meta-analysis of schizophrenia and bipolor disorder, part II: schizophrenia. Am J Hum Genet 73:34-48 (in this issue)
16. North BV, Curtis D, Sham PC (2002) A note on the calculation of empirical P values from Monte Carlo procedures. Am J Hum Genet 71:439-441
17. Risch N (1987) Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 40:1-14
18. _ (1990) Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46:222-228
19. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8 (1996) Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Am J Med Genet 67:580-594
20. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am J Hum Genet 73:49-62 (in this issue)
21. Wise LH, Lanchbury JS, Lewis CM (1999) Meta-analysis of genome searches. Ann Hum Genet 63:263-272