Three Potential Susceptibility Loci Shown by a Genome-Wide Scan for Regions Influencing the Age at Onset of Mania

American Journal of Psychiatry

Volumn 161, Issue 4, 2004, Pages 625-630

  Faraone, Stephen V ^a   Glatt, Stephen J ^b   Su, Jessica ^b   Tsuang, Ming T ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHROMOSOME; CLINICAL FEATURE; FEMALE; GENETIC LINKAGE; GENOME; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MANIA; ONSET AGE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGE OF ONSET; BIPOLAR DISORDER; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 15; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; POINT MUTATION;

EID: 1842533141     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.161.4.625     Document Type: Article

References (54)

1. Cardno AG, Marshall EJ, Coid B, Macdonald AM, Ribchester TR, Davies NJ, Venturi P, Jones LA, Lewis SW, Sham PC, Gottesman II, Farmer AE, McGuffin P, Reveley AM, Murray RM: Heritability estimates for psychotic disorders. Arch Gen Psychiatry 1999; 56:162-168
2. Tsuang MT, Faraone SV: The genetic epidemiology of bipolar disorder, in Bipolar Disorders: 100 Years After Manic-Depressive Insanity. Edited by Marneros A, Angst J. Zurich, Kluwer Academic, 2000, pp 231-242
3. Berrettini WH: Molecular linkage studies of bipolar disorders. Bipolar Disord 2001; 3:276-283
4. Badner J, Gershon E: Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7:405-411
5. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, et al: Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am J Hum Genet 2003; 73:49-62
6. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 3rd ed. New York, New York State Psychiatric Institute, Biometrics Research, 1978
7. Faraone SV, Blehar M, Pepple J, Moldin S, Norton J, Nurnberger JI, Malaspina D, Kaufmann CA, Reich T, Cloninger CR, DePaulo JR, Berg K, Gershon ES, Kirch DG, Tsuang MT: Diagnostic accuracy and confusability analyses: an application to the Diagnostic Interview for Genetic Studies. Psychol Med 1996; 26:401-410
8. Smeraldi E, Negri F, Heimbuch RC, Kidd KK: Familial patterns and possible modes of inheritance of primary affective disorders. J Affect Disord 1981; 3:173-182
9. Spence MA, Flodman PL, Sadovnick AD, Bailey-Wilson JE, Ameli H, Remick RA: Bipolar disorder: evidence for a major locus. Am J Med Genet 1995; 60:370-376
10. Radhakrishna U, Senol S, Herken H, Gucuyener K, Gehrig C, Blouin JL, Akarsu NA, Antonarakis SE: An apparently dominant bipolar affective disorder (BPAD) locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree. Eur J Hum Genet 2001; 9:39-44
11. Pauls DL, Bailey JN, Carter AS, Allen CR, Egeland JA: Complex segregation analyses of old order Amish families ascertained through bipolar I individuals. Am J Med Genet 1995; 60:290-297
12. Cox N, Reich T, Rice J, Elston R, Schober J, Keats B: Segregation and linkage analyses of bipolar and major depressive illnesses in multigenerational pedigrees. J Psychiatr Res 1989; 23:109-123
13. Faraone SV, Glatt SJ, Tsuang MT: The genetics of pediatric-onset bipolar disorder. Biol Psychiatry 2003; 53:970-977
14. Biederman J, Mick E, Faraone SV, Spencer T, Wilens TE, Wozniak J: Pediatric mania: a developmental subtype of bipolar disorder? Biol Psychiatry 2000; 48:458-466
15. Sax KW, Strakowski SM, Keck PE Jr, McElroy SL, West SA, Bourne ML, Larson ER: Comparison of patients with early-, typical-, and late-onset affective psychosis. Am J Psychiatry 1997; 154:1299-1301
16. Grigoroiu-Serbanescu M, Martinez M, Nothen MM, Grinberg M, Sima D, Propping P, Marinescu E, Hrestic M: Different familial transmission patterns in bipolar I disorder with onset before and after age 25. Am J Med Genet 2001; 105:765-773
17. Faraone SV, Biederman J, Monuteaux MC: Attention deficit hyperactivity disorder with bipolar disorder in girls: further evidence for a familial subtype? J Affect Disord 2001; 64:19-26
18. Faraone SV, Biederman J, Mennin D, Wozniak J, Spencer T: Attention deficit hyperactivity disorder with bipolar disorder: a familial subtype? J Am Acad Child Adolesc Psychiatry 1997; 36: 1378-1387
19. Biederman J, Faraone SV, Wozniak J, Monuteaux MC: Parsing the association between bipolar, conduct, and substance use disorders: a familial risk analysis. Biol Psychiatry 2000; 48: 1037-1044
20. Faraone SV, Biederman J, Mennin D, Russell R: Bipolar and antisocial disorders among relatives of ADHD children: parsing familial subtypes of illness. Am J Med Genet 1998; 81:108-116
21. Omahony E, Corvin A, O'Connell R, Comerford C, Larsen B, Jones R, McCandless F, Kirov G, Cardno AG, Craddock N, Gill M: Sibling pairs with affective disorders: resemblance of demographic and clinical features. Psychol Med 2002; 32:55-61
22. Visscher PM, Yazdi MH, Jackson AD, Schalling M, Lindblad K, Yuan QP, Porteous D, Muir WJ, Blackwood DH: Genetic survival analysis of age-at-onset of bipolar disorder: evidence for anticipation or cohort effect in families. Psychiatr Genet 2001; 11: 129-137
23. Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: a preliminary report. Am J Med Genet 1997; 74: 227-237
24. Stine OC, McMahon FJ, Chen L, Xu J, Meyers DA, MacKinnon DF, Simpson S, McInnis MG, Rice JP, Goate A, Reich T, Edenberg HJ, Foroud T, Nurnberger JI Jr, Detera-Wadleigh SD, Goldin LR, Guroff J, Gershon ES, Blehar MC, DePaulo JR: Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2, 11, 13, 14, and X. Am J Med Genet 1997; 74:263-269
25. Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud T, Nurnberger J Jr, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MC, Reich T: Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12. Am J Med Genet 1997; 74:247-253
26. Edenberg HJ, Foroud T, Conneally PM, Sorbel JJ, Carr K, Crose C, Willig C, Zhao J, Miller M, Bowman E, Mayeda A, Rau NL, Smiley C, Rice JP, Goate A, Reich T, Stine OC, McMahon F, DePaulo JR, Meyers D, Detera-Wadleigh SD, Goldin LR, Gershon ES, Blehar MC, Nurnberger JI Jr: Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. Am J Med Genet 1997; 74:238-246
27. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T (NIMH Genetics Initiative): Diagnostic Interview for Genetic Studies: rationale, unique features, and training. Arch Gen Psychiatry 1994; 51:849-859
28. Maxwell ME: Manual for the FIGS (Family Interview for Genetics Studies). Bethesda, Md, National Institute of Mental Health, Clinical Neurogenetics Branch, Intramural Research Program, March 30, 1992
29. Foroud T, Castelluccio PF, Koller DL, Edenberg HJ, Miller M, Bowman E, Rau NL, Smiley C, Rice JP, Goate A, Armstrong C, Bierut LJ, Reich T, Detera-Wadleigh SD, Goldin LR, Badner JA, Guroff JJ, Gershon ES, McMahon FJ, Simpson S, MacKinnon D, McInnis M, Stine OC, DePaulo JR, Blehar MC, Nurnberger JI Jr: Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees. Am J Med Genet 2000; 96:18-23
30. Detera-Wadleigh SD, Badner JA, Yoshikawa T, Sanders AR, Goldin LR, Turner G, Rollins DY, Moses T, Guroff JJ, Kazuba D, Maxwell ME, Edenberg HJ, Foroud T, Lahiri D, Nurnberger JI Jr, Stine OC, McMahon F, Meyers DA, MacKinnon D, Simpson S, McInnis M, DePaulo JR, Rice J, Goate A, Gershon ES, et al: Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q. Am J Med Genet 1997; 74: 254-262
31. Boehnke M: Allele frequency estimation from data on relatives. Am J Hum Genet 1991; 48:22-25
32. Lander E, Green P: Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 1987; 84:2363-2367
33. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62:1198-1211
34. Blangero J, Williams J, Almasy L: Variance component methods for detecting complex trait loci. Adv Genet 2001; 42:151-181
35. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES: Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996; 58:1347-1363
36. Self SG, Liang KY: Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandardized conditions. J Am Stat Assoc 1987; 82:605-610
37. Lander E, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11:241-247
38. Dick DM, Foroud T, Edenberg HJ, Miller M, Bowman E, Rau NL, DePaulo JR, McInnis M, Gershon E, McMahon F, Rice JP, Bierut LJ, Reich T, Nurnberger JI Jr: Apparent replication of suggestive linkage on chromosome 16 in the NIMH genetics initiative bipolar pedigrees. Am J Med Genet 2002; 114:407-412
39. Bellivier F, Golmard JL, Henry C, Leboyer M, Schurhoff F: Ad-mixture analysis of age at onset in bipolar I affective disorder. Arch Gen Psychiatry 2001; 58:510-512
40. Bellivier F, Leroux M, Henry C, Rayah F, Rouillon F, Laplanche JL, Leboyer M: Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder. Neurosci Lett 2002; 334:17-20
41. Verheyen GR, Del-Favero J, Mendlewicz J, Lindblad K, Van Zand K, Aalbregtse M, Schalling M, Souery D, Van Broeckhoven C: Molecular interpretation of expanded RED products in bipolar disorder by CAG/CTG repeats located at chromosomes 17q and 18q. Neurobiol Dis 1999; 6:424-432
42. Lindblad K, Nylander PO, Zander C, Yuan QP, Stahle L, Engstrom C, Balciuniene J, Pettersson U, Breschel T, McInnis M, Ross CA, Adolfsson R, Schalling M: Two commonly expanded CAG/CTG repeat loci: involvement in affective disorders? Mol Psychiatry 1998; 3:405-410
43. Tsuang MT, Faraone SV: The Genetics of Mood Disorders. Baltimore, Johns Hopkins University Press, 1990
44. Rice J, Reich T, Andreasen NC, Endicott J, Van Eerdewegh M, Fishman R, Hirschfeld RM, Klerman GL: The familial transmission of bipolar illness. Arch Gen Psychiatry 1987; 44:441-447
45. Pauls DL, Morton LA, Egeland JA: Risks of affective illness among first-degree relatives of bipolar I old-order Amish probands. Arch Gen Psychiatry 1992; 49:703-708
46. Strober M, Morrell W, Burroughs J, Lampert C, Danforth H, Freeman R: A family study of bipolar I disorder in adolescence: early onset of symptoms linked to increased familial loading and lithium resistance. J Affect Disord 1988; 15:255-268
47. Neuman R, Geller B, Rice J, Todd R: Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands. J Am Acad Child Adolesc Psychiatry 1997; 36:466-473
48. Wozniak J, Biederman J, Kiely K, Ablon S, Faraone S, Mundy E, Mennin D: Mania-like symptoms suggestive of childhood onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry 1995; 34:867-876
49. Carlson GA, Bromet EJ, Sievers S: Phenomenology and outcome of subjects with early- and adult-onset psychotic mania. Am J Psychiatry 2000; 157:213-219
50. Biederman J, Mick E, Bostic J, Prince J, Daly J, Wilens T, Spencer T, Garcia-Jetton J, Russell R, Wozniak J, Faraone S: The naturalistic course of pharmacologic treatment of children with manic-like symptoms: a systematic chart review. J Clin Psychiatry 1998; 59:628-637
51. Faraone SV, Biederman J, Wozniak J, Mundy E, Mennin D, O'Donnell D: Is comorbidity with ADHD a marker for juvenile onset mania? J Am Acad Child Adolesc Psychiatry 1997; 36: 1046-1055
52. Schurhoff F, Bellivier F, Jouvent R, Mouren-Simeoni MC, Bouvard M, Allilaire JF, Leboyer M: Early and late onset bipolar disorders: two different forms of manic-depressive illness? J Affect Disord 2000; 58:215-221
53. McElroy SL, Keck PE Jr, Pope HG Jr, Hudson JI, Faedda GL, Swann AC: Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania. Am J Psychiatry 1992; 149:1633-1644
54. Todd RD, Neuman R, Geller B, Fox LW, Hickok J: Genetic studies of affective disorders: should we be starting with childhood onset probands? J Am Acad Child Adolesc Psychiatry 1993; 32: 1164-1171