Identification of quantitative trait loci for prepulse inhibition in rats

Psychopharmacology

Volumn 165, Issue 3, 2003, Pages 270-279

  Palmer, Abraham A ^a,b   Breen, Laura L ^b   Flodman, Pamela ^c   Conti, Lisa H ^b   Spence, M Anne ^c   Printz, Morton P ^b  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endophenotype; Prepulse inhibition; Psychiatric genetics; Quantitative trait loci; Schizophrenia; Syntenic

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACKCROSSING; BIOCHEMISTRY; BIPOLAR DISORDER; CHROMOSOMAL LOCALIZATION; CHROMOSOME 18; CHROMOSOME STRUCTURE; CONTROLLED STUDY; ENDOPHENOTYPE; FEMALE; GENE CONTROL; GENE IDENTIFICATION; GENE LOCATION; GENE MAPPING; GENETIC DISORDER; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GILLES DE LA TOURETTE SYNDROME; MALE; MENTAL DISEASE; NONHUMAN; PHENOTYPE; POPULATION RISK; PREPULSE INHIBITION; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; SCHIZOPHRENIA;

EID: 0037275569     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-002-1258-0     Document Type: Article

References (65)

1. Baron M (2002) Manic-depression genes and the new millennium: poised for discovery. Mol Psychiatry 7:342-358
2. Bassett AS, McGillivray BC, Jones BD, Pantzar JT (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet 1:799-801
3. Baysal BE, Willett-Brozick JE, Badner JA, Corona W, Ferrell RE, Nimgaonkar VL, Detera-Wadleigh SD (2002) A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family. Neurogenetics 4:43-53
4. Belknap JK, Atkins AL (2001) The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mamm Genome 12:893-899
5. Berrettini WH (2000) Are schizophrenic and bipolar disorders related? A review of family and molecular studies. Biol Psychiatry 48:531-538
6. Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 47:181-188
7. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343
8. Braff DL, Geyer MA, Light GA, Sprock J, Perry W, Cadenhead KS, Swerdlow NR (2001a) Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophr Res 49:171-178
9. Braff DL, Geyer MA, Swerdlow NR (2001b) Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology 156:234-258
10. Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS (2000) Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288:678-682
11. Bullock AE, Slobe BS, Vazquez V, Collins AC (1997) Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response. Behav Neurosci 111:1353-1360
12. Cadenhead KS, Swerdlow NR, Shafer KM, Diaz M, Braff DL (2000) Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. Am J Psychiatry 157:1660-1668
13. Conti LH, Palmer AA, Vanella JJ, Printz MP (2001) Latent inhibition and conditioning in rat strains which show differential prepulse inhibition. Behav Genet 31:325-333
14. Craddock N, Jones I (1999) Genetics of bipolar disorder. J Med Genet 36:585-594
15. Crawley JN (2002) abstract to grant 1Z01MH002179-13 recovered from the CRISP database on Mar 13, 2002, http://crisp.cit.-nih.gov/
16. Darvasi A (1998) Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18:19-24
17. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G, Rollins DY, Moses T, Sanders AR, Karkera JD, Esterling LE, Zeng J, Ferraro TN, Guroff JJ, Kazuba D, Maxwell ME, Nurnberger JI Jr, Gershon ES (1999) A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 96:5604-5609
18. Ellenbroek BA, Geyer MA, Cools AR (1995) The behavior of APOSUS rats in animal models with construct validity for schizophrenia. J Neurosci 15:7604-7611
19. Ferraro TN, Golden GT, Smith GG, Schork NJ, St Jean P, Ballas C, Choi H, Berrettini WH (1997) Mapping murine loci for seizure response to kainic acid. Mamm Genome 8:200-208
20. Fisher SE, Francks C, McCracken JT, McGough JJ, Marlow AJ, MacPhie IL, Newbury DF, Crawford LR, Palmer CG, Woodward JA, Del'Homme M, Cantwell DP, Nelson SF, Monaco AP, Smalley SL (2002) A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet 70:1183-1196
21. Garver DL, Holcomb J, Mapua FM, Wilson R, Barnes B (2001) Schizophrenia spectrum disorders: an autosomal-wide scan in multiplex pedigrees. Schizophr Res 52:145-160
22. Gejman PV (2002) abstract to grant 1Z01MH002746-03 recovered from the CRISP database on Mar 13, 2002, http://crisp.cit.-nih.gov/
23. Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology 156:117-154
24. Graham FK (1975) Presidential Address, 1974. The more or less startling effects of weak prestimulation. Psychophysiology 12:238-248
25. Hampson RM, Malloy MP, Mors O, Ewald H, Flannery AV, Morten J, Porteous DJ, Muir WJ, Blackwood DH (1999) Mapping studies on a pericentric inversion (18) (p11.31 q21.1) in a family with both schizophrenia and learning disability. Psychiatr Genet 9:161-163
26. Hitzemann RJ, Bell J, Rasmussen E, McCaughran J (2001) Mapping the genes for the acoustic startle response (ASR) and prepulse inhibition fo the ASR in the BXD recombinant inbred series: effect of high-frequency hearing loss and cochlear pathology. In: Willott F (ed) Handbook of mouse auditory research: from behavior to molecular biology. CRC Press, Boca Raton, pp 441-455
27. Jaworski RL, Jirout M, Closson S, Breen L, Flodman PL, Spence MA, Kren V, Krenova D, Pravenec M, Printz MP (2002) Heart rate and blood pressure quantitative trait loci for the airpuff startle reaction. Hypertension 39:348-352
28. Joober R, Zarate J, Rouleau G, Skamene E, Boksa, P (2002) Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startle. Neuropsychopharmacology, print copy in press (originally published online March 14, 2002, at http://www.acnp.org/citations/Npp031402268)
29. Kilts CD (2001) The changing roles and targets for animal models of schizophrenia. Biol Psychiatry 50:845-855
30. Kline L, Decena E, Hitzemann R, McCaughran J Jr (1998) Acoustic startle, prepulse inhibition, locomotion, and latent inhibition in the neuroleptic-responsive (NR) and neuroleptic-nonresponsive (NNR) lines of mice. Psychopharmacology 139:322-331
31. Lander ES, Botstein D (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199
32. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
33. Le Roy I, Perez-Diaz F, Cherfouh A, Roubertoux PL (1999) Preweanling sensorial and motor development in laboratory mice: quantitative trait loci mapping. Dev Psychobiol 34:139-158
34. Leboyer M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D, Mallet J (1998) Psychiatric genetics: search for phenotypes. Trends Neurosci 21:102-105
35. Logue SF, Owen EH, Rasmussen DL, Wehner JM (1997) Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: implications of genetic background for single gene and quantitative trait loci analyses. Neuroscience 80:1075-1086
36. Maier W, Rietschel M, Lichtermann D, Wildenauer DB (1999) Family and genetic studies on the relationship of schizophrenia to affective disorders. Eur Arch Psychiatr Clin Neurosci 249:57-61
37. McCaughran J Jr, Bell J, Hitzemann R (1999) On the relationships of high-frequency hearing loss and cochlear pathology to the acoustic startle response (ASR) and prepulse inhibition of the ASR in the BXD recombinant inbred series. Behav Genet 29:21-30
38. Merette C, Brassard A, Potvin A, Bouvier H, Rousseau F, Emond C, Bissonnette L, Roy MA, Maziade M, Ott J, Caron C (2000) Significant linkage for Tourette syndrome in a large French Canadian family. Am J Hum Genet 67:1008-1013
39. Misbahuddin A, Placzek MR, Chaudhuri KR, Wood NW, Bhatia KP, Warner TT (2002) A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. Neurology 58:124-126
40. Mors O, Ewald H, Blackwood D, Muir W (1997) Cytogenetic abnormalities on chromosome 18 associated with bipolar affective disorder or schizophrenia. Br J Psychiatry 170:278-280
41. Nancarrow DJ, Levinson DF, Taylor JM, Hayward NK, Walters MK, Lennon DP, Nertney DA, Jones HL, Mahtani MM, Kirby A, Kruglyak L, Brown DM, Crowe RR, Andreasen NC, Black DW, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, Mowry BJ (2000) No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees. Am J Med Genet 96:224-227
42. Owen EH, Christensen SC, Paylor R, Wehner JM (1997) Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains. Behav Neurosci 111:292-300
43. Palmer AA, Phillips TJ (2002) Quantitative trait locus (QTL) mapping in mice. In: Lui Y, Lovinger D (eds) Methods for alcohol-related neuroscience research. CRC Press, Boca Raton, pp 1-30
44. Palmer AA, Dulawa SC, Mottiwala AA, Conti LH, Geyer MA, Printz MP (2000) Prepulse startle deficit in the Brown Norway rat: a potential genetic model. Behav Neurosci 114:374-388
45. Paunio T, Ekelund J, Varilo T, Parker A, Hovatta I, Turunen JA, Rinard K, Foti A, Terwilliger JD, Juvonen H, Suvisaari J, Arajarvi R, Suokas J, Partonen T, Lonnqvist J, Meyer J, Peltonen L (2001) Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 10:3037-3048
46. Paylor R, Crawley JN (1997) Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology 132:169-180
47. Perry W, Geyer MA, Braff DL (1999) Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients. Arch Gen Psychiatry 56:277-281
48. Perry W, Minassian A, Feifel D, Braff DL (2001) Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry 50:418-424
49. Phillips TJ, Belknap JK, Hitzemann RJ, Buck KJ, Cunningham CL, Crabbe JC (2002) Harnessing the mouse to unravel the genetics of human disease. Genes Brain Behav 1:14-26
50. Pulver AE (2000) Search for schizophrenia susceptibility genes. Biol Psychiatry 47:221-230
51. Radcliffe RA, Lowe MV, Wehner JM (2000) Confirmation of contextual fear conditioning QTLs by short-term selection. Behav Genet 30:183-191
52. Swerdlow NR, Geyer MA (1998) Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull 24:285-301
53. Swerdlow NR, Geyer MA, Braff DL (2001) Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology 156:194-215
54. The Tourette Syndrome Association International Consortium for Genetics (1999) A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome. Am J Hum Genet 65:1428-1436
55. Tsuang M (2000) Schizophrenia: genes and environment. Biol Psychiatry 47:210-220
56. van Broeckhoven C, Verheyen G (1999) Report of the chromosome 18 workshop. Am J Med Genet 88:263-270
57. von Gontard A, Schaumburg H, Hollmann E, Eiberg H, Rittig S (2001) The genetics of enuresis: a review. J Urol 166:2438-2443
58. Watanabe TK, Bihoreau MT, McCarthy LC, Kiguwa SL, Hishigaki H, Tsuji A, Browne J, Yamasaki Y, Mizoguchi-Miyakita A, Oga K, Ono T, Okuno S, Kanemoto N, Takahashi E, Tomita K, Hayashi H, Adachi M, Webber C, Davis M, Kiel S, Knights C, Smith A, Critcher R, Miller J, Thangarajah T, Day PJR, Hudson JR Jr, Irie Y, Takagi T, Nakamura Y, Goodfellow PN, Lathrop GM, Tanigami A James MR (1999) A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet 22:27-36
59. Weissbecker K, Baxter L, Schwartz J, Sparkes R, Spence MA (1989) Linkage analysis of obsessive compulsive disorder. (abstract) Cytogenet Cell Genet 51:1105
60. Wildenauer DB, Schwab SG, Maier W, Detera-Wadleigh SD (1999) Do schizophrenia and affective disorder share susceptibility genes? Schizophr Res 39:107-111
61. Willott JF, Erway LC (1998) Genetics of age-related hearing loss in mice. IV. Cochlear pathology and hearing loss in 25 BXD recombinant inbred mouse strains. Hearing Res 119:27-36
62. Yeomans JS, Frankland PW (1995) The acoustic startle reflex: neurons and connections. Brain Res Brain Res Rev 21:301-314
63. Yoshikawa T, Kikuchi M, Saito K, Watanabe A, Yamada K, Shibuya H, Nankai M, Kurumaji A, Hattori E, Ishiguro H, Shimizu H, Okubo Y, Toru M, Detera-Wadleigh SD (2001) Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. Mol Psychiatry 6:202-210
64. Zhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR, Tourette Syndrome Association International Consortium for Genetics (2002) Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome. Am J Hum Genet 70:896-904
65. Zheng QY, Johnson KR, Erway LC (1999) Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hearing Res 130:94-107