Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury

Critical Care Medicine

Volumn 31, Issue 1, 2003, Pages 73-79

  Schröder, Ove ^b   Schulte, Klaus Martin ^a   Ostermann, Peter ^b   Röher, Hans Dietrich ^a   Ekkernkamp, Axel ^b   Laun, Reinhold Alexander ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NONE

Author keywords

Cytokine; Genotype; Heat shock protein; HSPA1B; HSPA1L; Inflammatory response; Interleukin 6; Multiple trauma; Organ failure; Outcome; Polymorphism; Survival; Tumor necrosis factor

Indexed keywords

HEAT SHOCK PROTEIN 70; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNOASSAY; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MULTIPLE TRAUMA; NUCLEOTIDE SEQUENCE; OUTCOMES RESEARCH; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RESTRICTION MAPPING; RISK FACTOR; SCORING SYSTEM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GERMANY; HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; SURVIVAL RATE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037248080     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200301000-00011     Document Type: Article

References (31)

1. Faist E, Storck M, Hultner L, et al: Functional analysis of monocyte activity through synthesis patterns of proinflammatory cytokines and neopterin in patients in surgical intensive care. Surgery 1992; 112:562-572
2. Gebhard FPH, Steinbach G, Strecker W, et al: Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg 2000; 135:291-295
3. Pellegrini JD Puyana JC, Lapchak PH, et al: A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality. Shock 1996; 6:389-396
4. Majetschak MFS, Obertacke U, Schroder J, et al: Relation of a TNF gene polymorphism to severe sepsis in trauma patients. Ann Surg 1999; 230:207-214
5. Martin CBC, Haccoun M, Thomachot L, et al: Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 1997; 25:1813-1819
6. Adamik BZM, Wlaszczyk A, Kubler A: Immunological status of septic and trauma patients. I. High tumor necrosis factor alpha serum levels in septic and trauma patients are not responsible for increased mortality; a prognostic value of serum interleukin 6. Arch Immunol Ther Exp 1997; 45:169-175 [published erratum appears in Arch Immunol Ther Exp 1997; 45:350]
7. Stith RD TL: Peripheral endocrine and metabolic responses to centrally administered interleukin-1. Neuroendocrinology 1994; 60:215-224
8. Sanderson KL, Raghupathi R, Saatman KE, et al: Interleukin-1 receptor antagonist attenuates regional neuronal cell death and cognitive dysfunction after experimental brain injury. J Cereb Blood Flow Meta 1999; 19:1118-1125
9. Krohn CD, Reikeras O, Aasen AO: The cytokines IL-1beta and IL-1 receptor antagonist, IL-2 and IL-2 soluble receptor-alpha, IL-6 and IL-6 soluble receptor, TNF-alpha and TNF soluble receptor I, and IL10 in drained and systemic blood after major orthopaedic surgery. Eur J Surg 1999; 165:101-109
10. Molloy RG, Mannick JA, Rodrick ML: Cytokines, sepsis and immunomodulation. Br J Surg 1993; 80:289-297
11. Nast-Kolb DWC, Gippner-Steppert C, Schneider I, et al: Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma 1997; 42:446-454
12. Roumen RM, Redl H, Schlag G, et al: Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma. Crit Care Med 1995; 23:474-480
13. Craig EA, Gross CA: Is hsp70 the cellular thermometer? Trends Biochem Sci 1991; 16:135-140
14. Milner CM, Campbell RD: Polymorphic analysis of the three MHC-linked HSP70 genes. Immunogenetics 1992; 36:357-362
15. Lindquist SCE: The heat-shock proteins. Annu Rev Genet 1988; 22:631-677
16. Young R: Stress proteins and immunology. Annu Rev Immunol 1990; 8:401
17. Suto RSP: A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 1995; 269:1585-1588
18. Song J, Masahiro T, Morimoto RI: Bag1-HSP70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nature Cell Biol 2001; 3:276-282
19. Beere HM, Wolf BB, Cain K, et al: Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nature Cell Biol 2000; 2:469-475
20. Asea A, Kraeft S, Kurt-Jones E, et al: HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000; 6:435-442
21. Chouchane LAS, Baccouche S, Remadi S: Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors. Cancer 1997; 80:1489-1496
22. Mestiri S, Bouaouina N, Ahmed SB, et al: Genetic variation in the tumor necrosis factor-alpha promotor region and in the stress protein hsp70-2: Susceptibility and prognostic implication in breast carcinoma. Cancer 2001; 91:672-678
23. Schulte K, Mewes I, Schulte C, et al: Analysis of the C-509T polymorphism in the TGF-β1 gene promotor in human multinodular goiter and differentiated thyroid cancer. J Clin Endocrinol Metab, In Press
24. Greenspan LMB, Greig H: Abbreviated Injury Scale and Injury Severity Score: A scoring chart. J Trauma 1985; 25:60-64
25. Sauaia A, Moore FA, Moore EE, et al: Early predictors of postinjury multiple organ failure. Arch Surg 1994; 129:39-45
26. Sauaia A, Moore FA, Moore EE, et al: Multiple organ failure can be predicted as early as 12 hours after injury. J Trauma 1998; 45:291-301
27. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
28. Schulte CM, Dignass AU, Goebell H, et al: Genetic factors determine extent of bone loss in inflammatory bowel disease. Gastroenterology 2000; 119:909-920
29. Gebhard F, Pfetsch H, Steinbach G, et al: Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg 2000; 135:291-295
30. Multhoff GML, Winchester CC, Milner CM, et al: Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exp Hematol 1999; 27:1627-1636
31. Xie YCC, Asea A, Auron PE, et al: Heat shock proteins and regulation of cytokine expression. Infect Dis Obstet Gynecol 1999; 7:26-30