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Volumn 79, Issue 1-2, 2005, Pages 172-179

Rasagiline: Neurodegeneration neuroprotection, and mitochondrial permeability transition

Author keywords

Bcl 2 family members; Caspase 3; Propargyl moiety; Protein kinase C; Rasagiline; SHSY5Y neuroblastoma cells

Indexed keywords

ALPHA SECRETASE; AMPHETAMINE; AMYLOID PRECURSOR PROTEIN; ANTIPARKINSON AGENT; CASPASE 3; CHOLINESTERASE; FAS ANTIGEN; LADOSTIGIL; LEVODOPA; METHAMPHETAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MONOAMINE OXIDASE B INHIBITOR; NEUROTOXIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C; RASAGILINE; SELEGILINE; UNCLASSIFIED DRUG;

EID: 12244296145     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20350     Document Type: Conference Paper
Times cited : (163)

References (77)
  • 1
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams JM, Cory S. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281:1322-1326.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 2
    • 0037189081 scopus 로고    scopus 로고
    • An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells
    • Akao Y, Maruyama W, Yi H, Shamoto-Nagai M, Youdim MBH, Naoi M. 2002a. An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells. Neurosci Lett 326:105-108.
    • (2002) Neurosci Lett , vol.326 , pp. 105-108
    • Akao, Y.1    Maruyama, W.2    Yi, H.3    Shamoto-Nagai, M.4    Youdim, M.B.H.5    Naoi, M.6
  • 3
    • 0036677312 scopus 로고    scopus 로고
    • Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan
    • Akao Y, Maruyama W, Shimizu S, Yi H, Nakagawa Y, Shamoto-Nagai M, Youdim MB, Tsujimoto Y, Naoi M. 2002b. Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan. J Neurochem 82:913-923.
    • (2002) J Neurochem , vol.82 , pp. 913-923
    • Akao, Y.1    Maruyama, W.2    Shimizu, S.3    Yi, H.4    Nakagawa, Y.5    Shamoto-Nagai, M.6    Youdim, M.B.7    Tsujimoto, Y.8    Naoi, M.9
  • 4
    • 1542317394 scopus 로고    scopus 로고
    • Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline
    • Bar-Am OB, Amit T, Youdim MB. 2004a. Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline. Neurosci Lett 355:169-172.
    • (2004) Neurosci Lett , vol.355 , pp. 169-172
    • Bar-Am, O.B.1    Amit, T.2    Youdim, M.B.3
  • 5
    • 2642529309 scopus 로고    scopus 로고
    • Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo
    • Bar-Am O, Yogev-Falach M, Amit T, Sagi Y, Youdim MB. 2004b. Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo. J Neurochem 89:1119-1125.
    • (2004) J Neurochem , vol.89 , pp. 1119-1125
    • Bar-Am, O.1    Yogev-Falach, M.2    Amit, T.3    Sagi, Y.4    Youdim, M.B.5
  • 6
    • 0141649550 scopus 로고    scopus 로고
    • The adenine nucleotide translocator: A new potential chemotherapeutic target
    • Belzacq AS, Brenner C. 2003. The adenine nucleotide translocator: a new potential chemotherapeutic target. Curr Drug Targets 7:517-524.
    • (2003) Curr Drug Targets , vol.7 , pp. 517-524
    • Belzacq, A.S.1    Brenner, C.2
  • 9
    • 2342547676 scopus 로고    scopus 로고
    • Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease
    • Blandini F, Armentero MT, Fancellu R, Blaugrund E, Nappi G. 2004. Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease. Exp Neurol 187:455-459.
    • (2004) Exp Neurol , vol.187 , pp. 455-459
    • Blandini, F.1    Armentero, M.T.2    Fancellu, R.3    Blaugrund, E.4    Nappi, G.5
  • 11
    • 0030921730 scopus 로고    scopus 로고
    • Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive upregulation of protein kinase C
    • Caputi A, Barindelli S, Pastorino L, Cimino M, Buxbaum JD, Cattabeni F, Di Luca M. 1997. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive upregulation of protein kinase C. J Neurochem 68:2523-2529.
    • (1997) J Neurochem , vol.68 , pp. 2523-2529
    • Caputi, A.1    Barindelli, S.2    Pastorino, L.3    Cimino, M.4    Buxbaum, J.D.5    Cattabeni, F.6    Di Luca, M.7
  • 13
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: Regulator of the cellular life-or-death switch
    • Cory S, Adams JM. 2002. The Bcl2 family: regulator of the cellular life-or-death switch. Nat Rev Cancer 2:647-656.
    • (2002) Nat Rev Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 14
    • 0030982798 scopus 로고    scopus 로고
    • Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons
    • Durkin JP, Tremblay R, Chakravarthy B, Mealing G, Morley P, Small D, Song D. 1997. Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons. J Neurochem 68:1400-1412.
    • (1997) J Neurochem , vol.68 , pp. 1400-1412
    • Durkin, J.P.1    Tremblay, R.2    Chakravarthy, B.3    Mealing, G.4    Morley, P.5    Small, D.6    Song, D.7
  • 15
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • Evan G, Littlewood T. 1998. A matter of life and cell death. Science 28:1317-1322.
    • (1998) Science , vol.28 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 16
    • 0032498811 scopus 로고    scopus 로고
    • Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor
    • Finberg JP, Takeshima T, Johnston JM, Commissiong JW. 1998. Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor. Neuroreport 9:703-707.
    • (1998) Neuroreport , vol.9 , pp. 703-707
    • Finberg, J.P.1    Takeshima, T.2    Johnston, J.M.3    Commissiong, J.W.4
  • 17
    • 0036914093 scopus 로고    scopus 로고
    • Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours
    • Finberg JP, Youdim MB, 2002. Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours. Neuropharmacology 43:1110-1118.
    • (2002) Neuropharmacology , vol.43 , pp. 1110-1118
    • Finberg, J.P.1    Youdim, M.B.2
  • 18
    • 0036478989 scopus 로고    scopus 로고
    • The permeability transition pore complex: Another view
    • Halestrap AP, McStay GP, Clarke SJ. 2002. The permeability transition pore complex: another view. Biochimie 84:153-166.
    • (2002) Biochimie , vol.84 , pp. 153-166
    • Halestrap, A.P.1    McStay, G.P.2    Clarke, S.J.3
  • 19
    • 0022553361 scopus 로고
    • Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells
    • Hama T, Huang KP, Guroff G. 1986. Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells. Proc Natl Acad Sci USA 83:2353-2357.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2353-2357
    • Hama, T.1    Huang, K.P.2    Guroff, G.3
  • 20
    • 0347693127 scopus 로고    scopus 로고
    • Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line
    • Hsieh YC, Jao HC, Yang RC, Hsu HK, Hsu C. 2003. Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line. Shock 19:582-587.
    • (2003) Shock , vol.19 , pp. 582-587
    • Hsieh, Y.C.1    Jao, H.C.2    Yang, R.C.3    Hsu, H.K.4    Hsu, C.5
  • 21
    • 0032999575 scopus 로고    scopus 로고
    • Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse
    • Huang W, Chen Y, Shohami E, Weinstock M. 1999. Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse. Eur J Pharmacol 366:127-135.
    • (1999) Eur J Pharmacol , vol.366 , pp. 127-135
    • Huang, W.1    Chen, Y.2    Shohami, E.3    Weinstock, M.4
  • 23
    • 0033955608 scopus 로고    scopus 로고
    • Cell death mechanisms in Parkinson's disease
    • Jellinger KA. 2000. Cell death mechanisms in Parkinson's disease. J Neural Transm 107:1-29.
    • (2000) J Neural Transm , vol.107 , pp. 1-29
    • Jellinger, K.A.1
  • 24
    • 0029240533 scopus 로고
    • Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy
    • Jin LW, Saitoh T. 1995. Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy. Drugs Aging 6:136-149.
    • (1995) Drugs Aging , vol.6 , pp. 136-149
    • Jin, L.W.1    Saitoh, T.2
  • 25
    • 0038164796 scopus 로고    scopus 로고
    • Effects of FK506 on the translocation of protein kinase C and CaM kinase II in the gerbil hippocampal CA1 neurons
    • Katsura K, Kurihara J, Hiraide T, Takahashi K, Kato H, Katayama Y. 2003. Effects of FK506 on the translocation of protein kinase C and CaM kinase II in the gerbil hippocampal CA1 neurons. Neurol Res 25:522-527.
    • (2003) Neurol Res , vol.25 , pp. 522-527
    • Katsura, K.1    Kurihara, J.2    Hiraide, T.3    Takahashi, K.4    Kato, H.5    Katayama, Y.6
  • 26
    • 0027444597 scopus 로고
    • AVP-induced activation of MAP kinase in vascular smooth muscle cells is mediated through protein kinase C
    • Kribben A, Wieder ED, Li X, van Putten V, Granot Y, Schrier RW, Nemenoff RA. 1993. AVP-induced activation of MAP kinase in vascular smooth muscle cells is mediated through protein kinase C. Am J Physiol 265:939-945.
    • (1993) Am J Physiol , vol.265 , pp. 939-945
    • Kribben, A.1    Wieder, E.D.2    Li, X.3    Van Putten, V.4    Granot, Y.5    Schrier, R.W.6    Nemenoff, R.A.7
  • 27
    • 0032693398 scopus 로고    scopus 로고
    • Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation
    • Lin L, Georgievska B, Mattsson A, Isacson O. 1999. Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation. Proc Natl Acad Sci USA 96:12108-12113.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12108-12113
    • Lin, L.1    Georgievska, B.2    Mattsson, A.3    Isacson, O.4
  • 28
    • 0035341268 scopus 로고    scopus 로고
    • How protein kinase C activation protects nerve cells from oxidative stress-induced cell death
    • Maher P. 2001. How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. J Neurosci 21:2929-2938.
    • (2001) J Neurosci , vol.21 , pp. 2929-2938
    • Maher, P.1
  • 29
    • 0034525891 scopus 로고    scopus 로고
    • Neurotoxins induce apoptosis in dopamine neurons: Protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022
    • Maruyama W, Akao Y, Youdim MB, Naoi M. 2000. Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022. J Neural Transm Suppl 60:171-186.
    • (2000) J Neural Transm Suppl , vol.60 , pp. 171-186
    • Maruyama, W.1    Akao, Y.2    Youdim, M.B.3    Naoi, M.4
  • 30
    • 0034884148 scopus 로고    scopus 로고
    • Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3 phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol
    • Maruyama W, Akao Y, Youdim MB, Boulton AA, Davis BA, Naoi M. 2001b. Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3 phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol. J Neurochem 78:727-735.
    • (2001) J Neurochem , vol.78 , pp. 727-735
    • Maruyama, W.1    Akao, Y.2    Youdim, M.B.3    Boulton, A.A.4    Davis, B.A.5    Naoi, M.6
  • 31
    • 0034928655 scopus 로고    scopus 로고
    • Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: Suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine
    • Maruyama W, Boulton AA, Davis BA, Dostert P, Naoi M. 2001a. Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine. J Neural Transm 108:11-24.
    • (2001) J Neural Transm , vol.108 , pp. 11-24
    • Maruyama, W.1    Boulton, A.A.2    Davis, B.A.3    Dostert, P.4    Naoi, M.5
  • 32
    • 0346848857 scopus 로고    scopus 로고
    • N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor
    • Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Yodim M, Furukawa S, Nabeshima T, Naoi M. 2004. N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor. Neurochem Int 44:393-400.
    • (2004) Neurochem Int , vol.44 , pp. 393-400
    • Maruyama, W.1    Nitta, A.2    Shamoto-Nagai, M.3    Hirata, Y.4    Akao, Y.5    Yodim, M.6    Furukawa, S.7    Nabeshima, T.8    Naoi, M.9
  • 33
    • 0345237921 scopus 로고    scopus 로고
    • Antiapoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)- aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor
    • Maruyama W, Weinstock M, Youdim MB, Nagai M, Naoi M. 2003. Antiapoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor. Neurosci Lett 8:233-236.
    • (2003) Neurosci Lett , vol.8 , pp. 233-236
    • Maruyama, W.1    Weinstock, M.2    Youdim, M.B.3    Nagai, M.4    Naoi, M.5
  • 34
    • 0034939146 scopus 로고    scopus 로고
    • Antiapoptotic function of N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022
    • Maruyama W, Youdim MB, Naoi M. 2001c. Antiapoptotic function of N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022. Ann N Y Acad Sci 939:320-329.
    • (2001) Ann N Y Acad Sci , vol.939 , pp. 320-329
    • Maruyama, W.1    Youdim, M.B.2    Naoi, M.3
  • 36
    • 0029666442 scopus 로고    scopus 로고
    • Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease
    • Matsushima H, Shimohama S, Chachin M, Taniguchi T, Kimura J. 1996. Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease. J Neurochem 67:317-323.
    • (1996) J Neurochem , vol.67 , pp. 317-323
    • Matsushima, H.1    Shimohama, S.2    Chachin, M.3    Taniguchi, T.4    Kimura, J.5
  • 37
    • 0035125664 scopus 로고    scopus 로고
    • Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival
    • Middleton, G, Wyatt S, Nikiman N, Davies M, Nabeshima T. 2001. Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival. Development 128:447-457.
    • (2001) Development , vol.128 , pp. 447-457
    • Middleton, G.1    Wyatt, S.2    Nikiman, N.3    Davies, M.4    Nabeshima, T.5
  • 38
    • 0022154427 scopus 로고
    • Tumor-promoting phorbol diester mimics two distinct neurotrophic factors
    • Montz HP, Davis GE, Skaper SD, Manthorpe M, Varon S. 1985. Tumor-promoting phorbol diester mimics two distinct neurotrophic factors. Brain Res 355:150-154.
    • (1985) Brain Res , vol.355 , pp. 150-154
    • Montz, H.P.1    Davis, G.E.2    Skaper, S.D.3    Manthorpe, M.4    Varon, S.5
  • 39
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer MG, Yan Q, Raisman-Vozari R. 2001. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 63:71-124.
    • (2001) Prog Neurobiol , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 40
    • 0034899354 scopus 로고    scopus 로고
    • Future of neuroprotection in Parkinson's disease
    • Naoi M, Maruyama W, 2001. Future of neuroprotection in Parkinson's disease. Parkinsonism Relat Disord 8:139-145.
    • (2001) Parkinsonism Relat Disord , vol.8 , pp. 139-145
    • Naoi, M.1    Maruyama, W.2
  • 41
    • 0023764824 scopus 로고
    • The molecular heterogeneity of protein kinase C and its implications for cellular regulation
    • Nishizuka Y. 1988. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334:661-665.
    • (1988) Nature , vol.334 , pp. 661-665
    • Nishizuka, Y.1
  • 42
    • 0026476297 scopus 로고
    • Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
    • Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. 1992. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258:304-307.
    • (1992) Science , vol.258 , pp. 304-307
    • Nitsch, R.M.1    Slack, B.E.2    Wurtman, R.J.3    Growdon, J.H.4
  • 43
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 44
    • 0033602009 scopus 로고    scopus 로고
    • Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra
    • Parain K, Murer MG, Yan O, Faucheux B, Agid Y, Hirsch E, Raisman Vozari R. 1999. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport 10:557-561.
    • (1999) Neuroreport , vol.10 , pp. 557-561
    • Parain, K.1    Murer, M.G.2    Yan, O.3    Faucheux, B.4    Agid, Y.5    Hirsch, E.6    Raisman Vozari, R.7
  • 45
    • 0036894795 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in early Parkinson disease
    • Parkinson Study Group. 2002. A controlled trial of rasagiline in early Parkinson disease. Arch Neurol 59:1937-1993.
    • (2002) Arch Neurol , vol.59 , pp. 1937-1993
  • 46
    • 2342655732 scopus 로고    scopus 로고
    • A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease
    • Parkinson Study Group. 2004. A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch Neurol 61:561-566.
    • (2004) Arch Neurol , vol.61 , pp. 561-566
  • 47
    • 0030722499 scopus 로고    scopus 로고
    • In vivo regulation of amyloid precursor protein secretion in rat neocortex by cholinergic activity
    • Rossner S, Ueberham U, Yu J, Kirazov L, Schliebs R, Perez-Polo JR, Bigl V. 1997. In vivo regulation of amyloid precursor protein secretion in rat neocortex by cholinergic activity. Eur Neurosci 9:2125-2134.
    • (1997) Eur Neurosci , vol.9 , pp. 2125-2134
    • Rossner, S.1    Ueberham, U.2    Yu, J.3    Kirazov, L.4    Schliebs, R.5    Perez-Polo, J.R.6    Bigl, V.7
  • 48
    • 0028916836 scopus 로고
    • Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging
    • Roth GS, Joseph JA, Mason RP. 1995. Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging. Trends Neurosci 18:203-206.
    • (1995) Trends Neurosci , vol.18 , pp. 203-206
    • Roth, G.S.1    Joseph, J.A.2    Mason, R.P.3
  • 49
    • 0032566717 scopus 로고    scopus 로고
    • A functional role for mitochondrial protein kinase C alpha in Bcl2 phosphorylation and suppression of apoptosis
    • Ruvolo PP, Deng X, Carr BK, May WS. 1998. A functional role for mitochondrial protein kinase C alpha in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 273:25436-25442.
    • (1998) J Biol Chem , vol.273 , pp. 25436-25442
    • Ruvolo, P.P.1    Deng, X.2    Carr, B.K.3    May, W.S.4
  • 50
    • 0344989342 scopus 로고    scopus 로고
    • Neuroprotective and neurorescue properties of rasagiline and TV3326 in MPTP model of Parkinson's disease
    • Sagi Y, Weinreb O, Weinstock M, Youdim MB. 2001. Neuroprotective and neurorescue properties of rasagiline and TV3326 in MPTP model of Parkinson's disease. Neural Plast 8:197-198.
    • (2001) Neural Plast , vol.8 , pp. 197-198
    • Sagi, Y.1    Weinreb, O.2    Weinstock, M.3    Youdim, M.B.4
  • 51
    • 0038155162 scopus 로고    scopus 로고
    • Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor
    • Sagi Y, Weinstock M, Youdim MB. 2003. Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor. J Neurochem 85:290-297.
    • (2003) J Neurochem , vol.85 , pp. 290-297
    • Sagi, Y.1    Weinstock, M.2    Youdim, M.B.3
  • 52
    • 0034694128 scopus 로고    scopus 로고
    • Effect of experimental treatment on housekeeping gene expression: Validation by real-time, quantitative RT-PCR
    • Schmittgen TD, Zakrajsek BA. 2000. Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR. J Biochem Biophys Methods 46:69-81.
    • (2000) J Biochem Biophys Methods , vol.46 , pp. 69-81
    • Schmittgen, T.D.1    Zakrajsek, B.A.2
  • 53
    • 0037214308 scopus 로고    scopus 로고
    • Protein kinase C activity, translocation, and selective isoform subcellular redistribution in the rat cerebral cortex after in vitro ischemia
    • Selvatici R, Marino S, Piubello C, Radi D, Beani C, Gardini E, Siniscalchi A. 2003. Protein kinase C activity, translocation, and selective isoform subcellular redistribution in the rat cerebral cortex after in vitro ischemia. J Neurosci Res 71:64-71.
    • (2003) J Neurosci Res , vol.71 , pp. 64-71
    • Selvatici, R.1    Marino, S.2    Piubello, C.3    Radi, D.4    Beani, C.5    Gardini, E.6    Siniscalchi, A.7
  • 54
    • 0027265320 scopus 로고
    • Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease
    • Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, Taniguchi T. 1993. Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology 43:1407-1413.
    • (1993) Neurology , vol.43 , pp. 1407-1413
    • Shimohama, S.1    Narita, M.2    Matsushima, H.3    Kimura, J.4    Kameyama, M.5    Hagiwara, M.6    Hidaka, H.7    Taniguchi, T.8
  • 55
    • 0027487188 scopus 로고
    • Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts over expressing protein kinase C alpha
    • Slack BE, Nitsch RM, Livneh E, Kunz GM Jr, Breu J, Eldar H, Wurtman RJ. 1993. Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts over expressing protein kinase C alpha. J Biol Chem 268:21097-21101.
    • (1993) J Biol Chem , vol.268 , pp. 21097-21101
    • Slack, B.E.1    Nitsch, R.M.2    Livneh, E.3    Kunz Jr., G.M.4    Breu, J.5    Eldar, H.6    Wurtman, R.J.7
  • 56
    • 0033971901 scopus 로고    scopus 로고
    • Bcl-2 family: Life-or-death switch
    • Tsujimoto Y, Shimizu S. 2000. Bcl-2 family: life-or-death switch. FEBS Lett 466:6-10.
    • (2000) FEBS Lett , vol.466 , pp. 6-10
    • Tsujimoto, Y.1    Shimizu, S.2
  • 57
    • 0032807402 scopus 로고    scopus 로고
    • Studies with rasagiline, a MAO-B inhibitor, in experimental focal ischemia in the rat
    • Speiser Z, Mayk A, Eliash S, Cohen S. 1999. Studies with rasagiline, a MAO-B inhibitor, in experimental focal ischemia in the rat. J Neural Transm 106:593-606.
    • (1999) J Neural Transm , vol.106 , pp. 593-606
    • Speiser, Z.1    Mayk, A.2    Eliash, S.3    Cohen, S.4
  • 59
    • 0033520937 scopus 로고    scopus 로고
    • p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway
    • Tan Y, Ruan HD, Comb MJ. 1999. p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway. J Biol Chem 274:34859-34867.
    • (1999) J Biol Chem , vol.274 , pp. 34859-34867
    • Tan, Y.1    Ruan, H.D.2    Comb, M.J.3
  • 60
    • 0032953646 scopus 로고    scopus 로고
    • Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons
    • Tremblay R, Hewitt K, Lesiuk H, Mealing G, Morley P, Durkin JP. 1999. Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons. J Neurochem 72:102-111.
    • (1999) J Neurochem , vol.72 , pp. 102-111
    • Tremblay, R.1    Hewitt, K.2    Lesiuk, H.3    Mealing, G.4    Morley, P.5    Durkin, J.P.6
  • 61
    • 0034041345 scopus 로고    scopus 로고
    • Pharmacological demonstration of the differential involvement of protein kinase C isoforms in short- and long-term memory formation and retrieval of one-trial avoidance in rats
    • Vianna MR, Barros DM, Silva T, Choi H, Madche C, Rodrigues C, Medina JH, Izquierdo I. 2000. Pharmacological demonstration of the differential involvement of protein kinase C isoforms in short- and long-term memory formation and retrieval of one-trial avoidance in rats. Psychopharmacology 150:77-84.
    • (2000) Psychopharmacology , vol.150 , pp. 77-84
    • Vianna, M.R.1    Barros, D.M.2    Silva, T.3    Choi, H.4    Madche, C.5    Rodrigues, C.6    Medina, J.H.7    Izquierdo, I.8
  • 62
    • 4644225112 scopus 로고    scopus 로고
    • Rasagiline alone and in combination with rituzole prolongs survival in ALS mouse model
    • Waibel S, Reuter A, Malessa S, Blaugrund E, Ludolph AC. 2004. Rasagiline alone and in combination with rituzole prolongs survival in ALS mouse model. J Neurol 251:1080-1084.
    • (2004) J Neurol , vol.251 , pp. 1080-1084
    • Waibel, S.1    Reuter, A.2    Malessa, S.3    Blaugrund, E.4    Ludolph, A.C.5
  • 63
    • 0028339544 scopus 로고
    • Attenuated protein kinase C activity and translocation in Alzheimer's disease brain
    • Wang HY, Pisano MR, Friedman E. 1994. Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol Aging 15:293-298.
    • (1994) Neurobiol Aging , vol.15 , pp. 293-298
    • Wang, H.Y.1    Pisano, M.R.2    Friedman, E.3
  • 64
    • 6944242126 scopus 로고    scopus 로고
    • Neuroprotection via Bcl-2 PKC interaction
    • Weinreb O, Bar-Am O, Amit T, Youdim MB. 2004. Neuroprotection via Bcl-2 PKC interaction. FSAEB J 18:1471-1473.
    • (2004) FSAEB J , vol.18 , pp. 1471-1473
    • Weinreb, O.1    Bar-Am, O.2    Amit, T.3    Youdim, M.B.4
  • 65
    • 0034525115 scopus 로고    scopus 로고
    • TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease
    • Weinstock M, Bejar C, Wang RH, Poltyrev T, Gross A, Finberg J, Youdim MB. 2000. TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease. J Neural Transm Suppl 60:157-170.
    • (2000) J Neural Transm Suppl , vol.60 , pp. 157-170
    • Weinstock, M.1    Bejar, C.2    Wang, R.H.3    Poltyrev, T.4    Gross, A.5    Finberg, J.6    Youdim, M.B.7
  • 66
    • 0034932067 scopus 로고    scopus 로고
    • Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs
    • Weinstock M, Kirschbaum-Slager N, Lazarovici P, Bejar C, Youdim MB, Shoham S. 2001. Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs. Ann N Y Acad Sci 939:148-161.
    • (2001) Ann N Y Acad Sci , vol.939 , pp. 148-161
    • Weinstock, M.1    Kirschbaum-Slager, N.2    Lazarovici, P.3    Bejar, C.4    Youdim, M.B.5    Shoham, S.6
  • 67
    • 0036121418 scopus 로고    scopus 로고
    • Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression
    • Weinstock M, Poltyrev T, Bejar C, Youdim MB. 2002. Effect of TV3326, a novel monoamine-oxidase cholinesterase inhibitor, in rat models of anxiety and depression. Psychopharmacology (Berl) 160:318-324.
    • (2002) Psychopharmacology (Berl) , vol.160 , pp. 318-324
    • Weinstock, M.1    Poltyrev, T.2    Bejar, C.3    Youdim, M.B.4
  • 68
    • 0038012567 scopus 로고    scopus 로고
    • A novel cholinesterase and brain selective monamine oxidase inhibitor for treatment of dementia co-morbid with depression and parkinson's disease
    • Weinstock M, Poltyrev T, Gross A, Sagi Y, Youdim MB. 2003. A novel cholinesterase and brain selective monamine oxidase inhibitor for treatment of dementia co-morbid with depression and parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 27:555-561.
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 555-561
    • Weinstock, M.1    Poltyrev, T.2    Gross, A.3    Sagi, Y.4    Youdim, M.B.5
  • 69
    • 0036777108 scopus 로고    scopus 로고
    • The involvement of mitogen-activated protein (MAP) kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline
    • Yogev-Falach M, Amit T, Bar-Am O, Sagi Y, Weinstock M, Youdim MB. 2002. The involvement of mitogen-activated protein (MAP) kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline. FASEB J 16:1674-1676.
    • (2002) FASEB J , vol.16 , pp. 1674-1676
    • Yogev-Falach, M.1    Amit, T.2    Bar-Am, O.3    Sagi, Y.4    Weinstock, M.5    Youdim, M.B.6
  • 70
    • 0642303109 scopus 로고    scopus 로고
    • The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing
    • Yogev-Falach M, Amit T, Bar-Am O, Youdim MB. 2003. The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing. FASEB J 17:2325-2327.
    • (2003) FASEB J , vol.17 , pp. 2325-2327
    • Yogev-Falach, M.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4
  • 71
    • 0345308381 scopus 로고    scopus 로고
    • Rasagiline; an anti-Parkinson drug with neuroprotective activity
    • Youdim MB. 2003. Rasagiline; an anti-Parkinson drug with neuroprotective activity. Exp Rev Neurotherapeutics 3:737-749.
    • (2003) Exp Rev Neurotherapeutics , vol.3 , pp. 737-749
    • Youdim, M.B.1
  • 72
    • 0642345197 scopus 로고    scopus 로고
    • The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline
    • Youdim MB, Amit T, Yogev-Falach M, Bar-Am O, Maruyama W, Naoi M. 2003. The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline. Biochem Pharmacol 66:1635-1641.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1635-1641
    • Youdim, M.B.1    Amit, T.2    Yogev-Falach, M.3    Bar-Am, O.4    Maruyama, W.5    Naoi, M.6
  • 73
    • 0035130289 scopus 로고    scopus 로고
    • Rasagiline [N-propargyl-1R(+)aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
    • Youdim MB, Gross A, Finberg JP. 2001a. Rasagiline [N-propargyl-1R(+) aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol 132:500-506.
    • (2001) Br J Pharmacol , vol.132 , pp. 500-506
    • Youdim, M.B.1    Gross, A.2    Finberg, J.P.3
  • 74
    • 0034941767 scopus 로고    scopus 로고
    • The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo
    • Youdim MB, Wadia A, Tatton W, Weinstock M. 2001b. The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo. Ann N Y Acad Sci 939:450-458.
    • (2001) Ann N Y Acad Sci , vol.939 , pp. 450-458
    • Youdim, M.B.1    Wadia, A.2    Tatton, W.3    Weinstock, M.4
  • 75
    • 0035568344 scopus 로고    scopus 로고
    • Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]
    • Youdim MB, Weinstock M. 2001. Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol 21:555-573.
    • (2001) Cell Mol Neurobiol , vol.21 , pp. 555-573
    • Youdim, M.B.1    Weinstock, M.2
  • 76
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan J, Yankner BA. 2000. Apoptosis in the nervous system. Nature 407:802-809.
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 77
    • 0032580361 scopus 로고    scopus 로고
    • Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins
    • Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G. 1998. Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene 16:2265-2282.
    • (1998) Oncogene , vol.16 , pp. 2265-2282
    • Zamzami, N.1    Brenner, C.2    Marzo, I.3    Susin, S.A.4    Kroemer, G.5


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