A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in parkinsonian cerebrospinal fluid

Annals of Neurology

Volumn 40, Issue 1, 1996, Pages 119-122

  Maruyama, Wakako ^a   Abe, Takashi ^b   Tohgi, Hideo ^b   Dostert, Philippe ^c   Naoi, Makoto ^d  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c PFIZER INC   (United States)

^d NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; HOMOVANILLIC ACID; NEUROTOXIN; SALSOLINOL;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; ENANTIOMER; ENZYME ACTIVITY; FEMALE; HUMAN; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; SHY DRAGER SYNDROME;

EID: 0029891783     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410400120     Document Type: Article

References (15)

1. Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983;219:979-980
2. Tipton KF, Singer TP. Advances in our understanding of the mechanism of the neurotoxicity of MPTP and related compounds. J Neurochem 1993;61:1191-1206
3. Ung-Chhun N, Cheng BY, Pronger DA, et al. Alkaloid adducts in human brain: coexistence of 1-carboxylated and noncarboxylated isoquinolines and β-carbolines in alcoholics and nonalcoholics. In: Collins MA, ed. Aldehyde adducts in alcoholism. New York: Alan R Liss, 1985:125-136
4. Niwa T, Takeda N, Yoshizumi H, et al. Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6-7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains. Biochem Biophys Res Commun 1991;177:603-609
5. Naoi M, Maruyama W, Dostert P, et al. Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rats: biochemical, pathological and behavioral studies. Brain Res 1996;709:285-295
6. Dostert P, Strolin Benedetti M, Dordain G, Vernay D. Enantiometric composition of urinary salsolinol in parkinsonian patients after Madopar. J Neural Transm [P-D Sect] 1989;1: 269-278
7. Naoi M, Maruyama W, Acworth IN, et al. Multi-electrode detection system for determination of neurotransmitters. In: Parvez H, Naoi M, Nagatsu T, Parvez S, eds. Methods in neurotransmitter and neuropeptide research, vol I Amsterdam: Elsevier, 1993:1-39
8. Deng Y, Maruyama W, Dostert P, et al. Determination of (R)-and (S)-enantiomer of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid Chromatographic column. J Chromatogr B Biomed Appl 1995;670-47-54
9. Strolin Benedetti M, Bellotti V, Pianezola E, et al. Ratio of the R and S enantiomers of salsolinol in food and human urine. J Neural Transm 1989;77:47-53
10. Maruyama W, Nakahara D, Ota M, et al. N-Methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study. J Neurochem 1992;59:395-400
11. Takahashi T, Deng Y, Maruyama W, et al. Uptake of a neurotoxin candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cell by dopamine transport system. J Neural Transm [Gen Sect] 1994;98:107-118
12. Naoi M, Maruyama W, Zhang JH, et al. Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion. Life Sci 1995;57:1061-1066
13. Maruyama W, Dostert P, Naoi M. Dopamine-derived N-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: in vivo and in vitro studies. J Neurochem 1995;64:2635-2643
14. Maruyama W, Dostert P, Matsubara K, Naoi M. N-Methyl-(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity. Free Radic Biol Med 1995;19:67-75
15. Naoi M, Maruyama W, Dostert P. Binding of 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion to melanin: effects of ferrous and ferric ion on the binding. Neurosci Lett 1994;171: 9-12