Emerging chemical and biological approaches for the preparation of discovery libraries

Drug Discovery Today

Volumn 11, Issue 3-4, 2006, Pages 143-148

  Boldt, Grant E ^a   Dickerson, Tobin J ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NATURAL PRODUCTS AND THEIR SYNTHETIC DERIVATIVES; RECEPTOR;

COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; CONTINUOUS FLOW REACTOR; DRUG RESEARCH; HIGH THROUGHPUT SCREENING; MICROWAVE RADIATION; MOLECULAR LIBRARY; MOLECULAR SIZE; PHAGE DISPLAY; REACTION ANALYSIS; REVIEW;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN;

EID: 33644851859     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(05)03697-4     Document Type: Review

References (57)

1. Lundqvist T. The devil is still in the details - driving early drug discovery forward with biophysical experimental methods Curr. Opin. Drug Discov. Dev. 8 2005 513 519
2. Barbas C.F. III Phage display: A laboratory manual 2001 Cold Springs Harbor Laboratory Press
3. Service R.F. Surviving the blockbuster syndrome Science 303 2004 1796 1798
4. S. Fergus Assessment of structural diversity in combinatorial synthesis Curr. Opin. Chem. Biol. 9 2005 304 309
5. Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability J. Pharmacol. Toxicol. Methods 44 2000 235 249
6. Schneider G., Fechner U. Computer-based de novo design of drug-like molecules Nat. Rev. Drug Discov. 4 2005 649 663
7. Merrifield R.B. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide J. Am. Chem. Soc. 85 1963 2149 2154
8. Czarnik A.W. Solid-phase organic synthesis 2001 Wiley
9. Wilson S.R. Czarnik A.W. Combinatorial chemistry: Synthesis and application 1997 Wiley
10. D. Walsh Understanding the effects of the polymer support on reaction rates and kinetics: knowledge toward efficient synthetic design Curr. Opin. Chem. Biol. 7 2003 353 361
11. Gravert D.J., Janda K.D. Organic synthesis on soluble polymer supports: liquid-phase methodologies Chem. Rev. 97 1997 489 509
12. Dickerson T.J. Soluble polymers as scaffolds for recoverable catalysts and reagents Chem. Rev. 102 2002 3325 3344
13. Yoshida J., K. Itami Tag strategy for separation and recovery Chem. Rev. 102 2002 3693 3716
14. P.H. Toy, Janda K.D. Soluble polymer-supported organic synthesis Acc. Chem. Res. 33 2000 546 554
15. A. Studer, Curran D.P. A strategic alternative to solid phase synthesis: Preparation of a small isoxazoline library by "fluorous synthesis" Tetrahedron 53 1997 6681 6696
16. A. Studer Fluorous synthesis: Fluorous protocols for the Ugi and Biginelli multicomponent condensations J. Org. Chem. 62 1997 2917 2924
17. Burke M.D., Schreiber S.L. A planning strategy for diversity-oriented synthesis Angew. Chem. Int. Ed. Engl. 43 2004 46 58
18. D.S. Tan Diversity-oriented synthesis: exploring the intersections beween chemistry and biology Nat. Chem. Biol. 1 2005 74 84
19. Kappe C.O. Controlled microwave heating in modern organic synthesis Angew. Chem. Int. Ed. Engl. 43 2004 6250 6284
20. Westaway K.C., R. Gedye The question of specific activation of organic reactions by microwaves J. Microw. Power 30 1995 219 230
21. F. Langa Microwave irradiation: More than just a method for accelerating reactions Contemp. Org. Synth. 4 1997 373 386
22. Perreux L., A. Loupy A tentative rationalization of microwave effects in organic synthesis according to the reaction medium, and mechanistic considerations Tetrahedron 57 2001 9199 9223
23. Strauss C.R. Microwave-assisted reactions in organic synthesis - Are there any nonthermal microwave effects? Angew. Chem. Int. Ed. Engl. 41 2002 3589 3590
24. Baghurst D.R., Mingos D.M.P. Tilden Lecture. Applications of microwave dielectric heating effects to synthetic problems in chemistry Chem. Soc. Rev. 20 1991 1 47
25. S.V. Ley Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation J. Chem. Soc. Perkin Trans. 1 2000 3815 4196
26. S.V. Ley, Baxendale I.R. New tools and concepts for modern organic synthesis Nat. Rev. Drug Discov. 1 2002 573 586
27. Kirschning A. The "resin-capture-release" hybrid technique: A merger between solid- and solution-phase synthesis Chemistry 6 2000 4445 4450
28. Tzschucke C.C. Modern separation techniques for the efficient workup in organic synthesis Angew. Chem. Int. Ed. Engl. 41 2002 3964 4000
29. Vaino A.R., Janda K.D. Solid-phase organic synthesis: A critical understanding of the resin J. Comb. Chem. 2 2000 579 596
30. S.V. Ley A polymer-supported thionating reagent J. Chem. Soc., Perkin Trans. 1 4 2001 358 361
31. W-B. Yeh Combinatorial synthesis of biheterocyclic benzimidazoles by microwave irradiation Comb. Chem. High Throughput Screen 7 2004 251 255
32. C-L. Tung, Sun C-M. Liquid phase synthesis of chiral quinoxalinones by microwave irradiation Tetrahedron Lett. 45 2004 1159 1162
33. W. Zhang, Chen C.H-T. Fluorous synthesis of biaryl-substituted proline analogs by 1,3-dipolar cycloaddition and Suzuki coupling reactions Tetrahedron Lett. 46 2005 1807 1810
34. W-B. Yeh, Sun C-M. Soluble polymer-supported synthesis of thioxotetrapyrimidinone by focused microwave irradiation J. Comb. Chem. 6 2004 279 282
35. W. Zhang A highly efficient microwave-assisted Suzuki coupling reaction of aryl perfluorooctylsulfonates with boronic acids Org. Lett. 6 2004 1473 1476
36. Alcázar J. Reproducibility across microwave instruments: Preparation of a set of 24 compounds on a multiwell plate under temperature-controlled conditions J. Comb. Chem. 7 2005 353 355
37. A. Loupy Microwaves in Organic Synthesis 2002 Wiley
38. B. Yan Looking for quality Modern Drug Discovery 7 2004 30 34
39. G. Jas, Kirschning A. Continuous flow techniques in organic synthesis Chemistry 9 2003 5708 5723
40. Jönsson D. Automated flow-through synthesis of heterocyclic thioethers J. Comb. Chem. 6 2004 584 595
41. Cheeseman J.D. Receptor-assisted combinatorial chemistry: Thermodynamics and kinetics in drug discovery Chem. Eur. J. 11 2005 1708 1716
42. Krasiñski A. In situ selection of lead compounds by Click Chemistry: Target-guided optimization of acetylcholinesterase inhibitors J. Am. Chem. Soc. 127 2005 6686 6692
43. I. Huc, Lehn J-M. Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly Proc. Natl. Acad. Sci. U. S. A. 94 1997 2106 2110
44. Siuzdak G. The expanding role of mass spectrometry in biotechnology 2003 MCC Press
45. R. Nguyen, Huc I. Using an enzyme's active site to template inhibitors Angew. Chem. Int. Ed. Engl. 40 2001 1774 1776
46. H.C. Kolb, Sharpless K.B. The growing impact of click chemistry on drug discovery Drug Disc. Today 8 2003 1128 1137
47. M. Li Applications of display technology in protein analysis Nat. Biotechnol. 18 2000 1251 1256
48. Griffiths A.D. isolation of high affinity human antibodies directly from large synthetic repertoires EMBO J. 13 1994 3245 3260
49. Brenner S., Lerner R.A. Encoded combinatorial chemistry Proc. Natl. Acad. Sci. U. S. A. 89 1992 5381 5383
50. Frankel A. Encodamers: Unnatural peptide oligomers encoded in RNA Chem. Biol. 10 2003 1043 1050
51. Halpin D.R., Harbury P.B. DNA display I. Sequence encoded routing of DNA populations PLoS Biol. 2 2004 E173
52. X. Li Translation of DNA into synthetic N-acyloxazolidines J. Am. Chem. Soc. 126 2004 5090 5092
53. S. Melkko Encoded self-assembling chemical libraries Nat. Biotechnol. 22 2004 568 574
54. Woiwode T.F. Synthetic compound libraries displayed on the surface of encoded bacteriophage Chem. Biol. 10 2003 847 858
55. Fellouse F., Deshayes K. Bacteriophage that display small molecules Chem. Biol. 10 2003 783 784
56. J. Yin Phagemid encoded small molecules for high throughput screening of chemical libraries J. Am. Chem. Soc. 126 2004 13570 13571
57. H. Yin, Hamilton A.D. Strategies for targeting protein-protein interactions with synthetic agents Angew. Chem. Int. Ed. Engl. 44 2005 4130 4163