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Yan B., Yan H. Combination of single bead FTIR and chemometrics in combinatorial chemistry: application of the multivariate calibration method in monitoring solid-phase organic synthesis. J. Comb. Chem. 3:2001;78-84.
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Determination of functional group distribution within Rasta resins utilizing optical analysis
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0035903620
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Spatially resolved single bead analysis: Homogeneity, diffusion, and adsorption in cross-linked polystyrene
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A thorough study using fluorescence microscopy (confocal and non-confocal) as well as IR microscopy. Studied the effects of bead size and diffusion and particularly highlights adsorption's effect on reaction progress. Importantly, confirms functional site homogeneity throughout the resin
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Rademann J., Barth M., Brock R., Egelhaaf H.J., Jung G. Spatially resolved single bead analysis: homogeneity, diffusion, and adsorption in cross-linked polystyrene. Chem. Eur. J. 7:2001;3884-3889 A thorough study using fluorescence microscopy (confocal and non-confocal) as well as IR microscopy. Studied the effects of bead size and diffusion and particularly highlights adsorption's effect on reaction progress. Importantly, confirms functional site homogeneity throughout the resin.
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Study showing essentially uniform site distribution in dry and swollen aminomethylated polystyrene resin beads using scanning confocal Raman spectroscopy
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Diffusion of reagents in macrobeads
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Measured diffusion rates in macro beads simply and effectively using an acylation reaction stopped at various time points. Beads were stained to detect the extent of diffusion and the stained versus unstained areas were measured to calculate the diffusion rate. Highlights many factors that aid in diffusion rates
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Use d PS-DVB resins with a range of cross-linker content to determine the effect of cross-linking on the reaction kinetics. Drastic rate enhancements were seen as a function of cross-linking content, as well as some surprising results regarding increased cross-linker content giving increased product purity
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A novel method is reported in the study of solid-support reagent interactions and the effect of solvent on solid-support reactivity for various solid supports. The method determined Hammett relationships for the displacement of a solid-supported pentafluorophenyl ester with four para-substituted anilines (p-MeO, p-Me, p-F, p-Cl) and aniline
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Novel method that rapidly determines the reaction kinetics of the release of a fluorescent dye from a resin-bound active ester into solution upon treatment with benzylamine using in situ fluorescence measurements. Studied a broad range of commercially available resins in various common solvents and showed the considerable effects of these factors on rate
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0001242088
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