Glycine transporters: Essential regulators of neurotransmission

Trends in Biochemical Sciences

Volumn 30, Issue 6, 2005, Pages 325-333

  Eulenburg, Volker ^a   Armsen, Wencke ^a   Betz, Heinrich ^a   Gomeza, Jesús ^b  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); GLYCINE; NEUROTRANSMITTER RECEPTOR;

AMINO ACID SEQUENCE; CARBOXY TERMINAL SEQUENCE; EXCITABLE MEMBRANE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GABAERGIC TRANSMISSION; GEL ELECTROPHORESIS; HUMAN; LONG TERM POTENTIATION; MOLECULAR CLONING; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS REGULATION; RECEPTOR DENSITY; REVIEW; SIGNAL TRANSDUCTION; STOICHIOMETRY; STRUCTURE ANALYSIS; SYNAPTIC EFFICACY; SYNAPTIC TRANSMISSION;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; HYPERGLYCEMIC HYPEROSMOLAR NONKETOTIC COMA; MICE; MICE, KNOCKOUT; MOVEMENT DISORDERS; NEUROTRANSMITTER AGENTS; STARTLE REACTION; SYNAPTIC TRANSMISSION;

ANIMALIA; VERTEBRATA;

EID: 20444391684     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2005.04.004     Document Type: Review

References (71)

1. - neurotransmitter transporters J. Neurochem. 71 1998 1785 1803
2. S. Ebihara Gene structure and alternative splicing of the mouse glycine transporter type-2 Biochem. Biophys. Res. Commun. 317 2004 857 864
3. R.H. Adams Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents J. Neurosci. 15 1995 2524 2532
4. B. Borowsky, and B.J. Hoffman Analysis of a gene encoding two glycine transporter variants reveals alternative promoter usage and a novel gene structure J. Biol. Chem. 273 1998 29077 29085
5. J.G. Hanley GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1 J. Biol. Chem. 275 2000 840 846
6. L. Olivares Carboxyl terminus of the glycine transporter GLYT1 is necessary for correct processing of the protein J. Biol. Chem. 269 1994 28400 28404
7. L. Olivares The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter J. Biol. Chem. 270 1995 9437 9442
8. I. Poyatos Polarized distribution of glycine transporter isoforms in epithelial and neuronal cells Mol. Cell. Neurosci. 15 2000 99 111
9. R. Martinez-Maza The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2 J. Biol. Chem. 276 2001 2168 2173
10. K. Ohno The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1 Mol. Cell. Neurosci. 26 2004 518 529
11. --coupled neurotransmitter transporters Eur. J. Pharmacol. 479 2003 229 236
12. F. Kilic, and G. Rudnick Oligomerization of serotonin transporter and its functional consequences Proc. Natl. Acad. Sci. U. S. A. 97 2000 3106 3111
13. M. Horiuchi Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes Proc. Natl. Acad. Sci. U. S. A. 98 2001 1448 1453
14. P. Scholze Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1 J. Biol. Chem. 277 2002 43682 43690
15. B. Lopez-Corcuera Hydrodynamic properties and immunological identification of the sodium- and chloride-coupled glycine transporter J. Biol. Chem. 268 1993 2239 2243
16. M.J. Roux, and S. Supplisson Neuronal and glial glycine transporters have different stoichiometries Neuron 25 2000 373 383
17. S. Supplisson, and M.J. Roux Why glycine transporters have different stoichiometries FEBS Lett. 529 2002 93 101
18. J. Ponce Transmembrane domain III plays an important role in ion binding and permeation in the glycine transporter GLYT2 J. Biol. Chem. 275 2000 13856 13862
19. B. Lopez-Corcuera Substrate-induced conformational changes of extracellular loop 1 in the glycine transporter GLYT2 J. Biol. Chem. 276 2001 43463 43470
20. F. Jursky, and N. Nelson Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor J. Neurochem. 64 1995 1026 1033
21. F. Jursky, and N. Nelson Developmental expression of the glycine transporters GLYT1 and GLYT2 in mouse brain J. Neurochem. 67 1996 336 344
22. J. Gomeza Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition Neuron 40 2003 785 796
23. J. Gomeza Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality Neuron 40 2003 797 806
24. L. Gabernet Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression Neurosci. Lett. 373 2005 79 84
25. G. Tsai Gene knockout of glycine transporter 1: characterization of the behavioral phenotype Proc. Natl. Acad. Sci. U. S. A. 101 2004 8485 8490
26. S. Supplisson, and C. Bergman Control of NMDA receptor activation by a glycine transporter co-expressed in Xenopus oocytes J. Neurosci. 17 1997 4580 4590
27. S. Ahmadi Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine Science 300 2003 2094 2097
28. A. Bradaia Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord J. Physiol. 559 2004 169 186
29. M. Martina Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels J. Physiol. 557 2004 489 500
30. Y. Nong Glycine binding primes NMDA receptor internalization Nature 422 2003 302 307
31. F. Zafra Arachidonic acid inhibits glycine transport in cultured glial cells Biochem. J. 271 1990 237 242
32. R.J. Pearlman Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a J. Neurochem. 84 2003 592 601
33. K.R. Aubrey Molecular basis for proton regulation of glycine transport by glycine transporter subtype 1b Mol. Pharmacol. 58 2000 129 135
34. B. Laube Potentiation of inhibitory glycinergic neurotransmission by Zn2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors Eur. J. Neurosci. 16 2002 1025 1036
35. P. Ju Zn2+ inhibits glycine transport by glycine transporter subtype 1b J. Biol. Chem. 279 2004 22983 22991
36. A. Geerlings Calcium- and syntaxin 1-mediated trafficking of the neuronal glycine transporter GLYT2 J. Biol. Chem. 276 2001 17584 17590
37. J. Gomeza Regulation by phorbol esters of the glycine transporter (GLYT1) in glioblastoma cells Biochim. Biophys. Acta 1233 1995 41 46
38. A. Fornes The second intracellular loop of the glycine transporter 2 contains crucial residues for glycine transport and phorbol ester-induced regulation J. Biol. Chem. 279 2004 22934 22943
39. K. Sato Modulation of a recombinant glycine transporter (GLYT1b) by activation of protein kinase C J. Neurochem. 65 1995 1967 1973
40. A. Geerlings Characterization of the interactions between the glycine transporters GLYT1 and GLYT2 and the SNARE protein syntaxin 1A FEBS Lett. 470 2000 51 54
41. Horiuchi, M. et al. Cellular localization and subcellular distribution of Ulip6, a brainspecific protein of the CRMP family that interacts with the neuronal glycine transporter 2. J. Neurochem. (in press)
42. T. Nishimura CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth Nat. Cell Biol. 5 2003 819 826
43. D.A. Applegarth, and J.R. Toone Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis Mol. Genet. Metab. 74 2001 139 146
44. Y. Sakata Structure and expression of the glycine cleavage system in rat central nervous system Brain Res. Mol. Brain Res. 94 2001 119 130
45. J.W. Lynch Molecular structure and function of the glycine receptor chloride channel Physiol. Rev. 84 2004 1051 1095
46. M.N. Vergouwe Hyperekplexia-like syndromes without mutations in the GLRA1 gene Clin. Neurol. Neurosurg. 99 1997 172 178
47. K.J. Whitehead Positive N-methyl-D-aspartate receptor modulation by selective glycine transporter-1 inhibition in the rat dorsal spinal cord in fvo Neuroscience 126 2004 381 390
48. R. Lim Blockade of glycine transporter-1 (GLYT-1) potentiates NMDA-receptor mediated synaptic transmission in hypoglossal motorneurons J. Neurophysiol. 92 2004 2530 2537
49. J.D. Jentsch, and R.H. Roth The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia Neuropsychopharmacology 20 1999 201 225
50. D.C. Javitt Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists Neuropsychopharmacology 29 2003 300 307
51. L. Chen Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in ftro and in fvo J. Neurophysiol. 89 2003 691 703
52. C. Sur, and G.G. Kinney The therapeutic potential of glycine transporter-1 inhibitors Expert Opin. Investig. Drugs 13 2004 515 521
53. G.G. Kinney The glycine transporter type 1 inhibitor N-[3-(4′- fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in fvo and produces an antipsychotic profile in rodent behavior J. Neurosci. 23 2003 7586 7591
54. R.J. Harvey GlyRα3: an essential target for spinal PGE2-mediated inflammatory pain sensitization Science 304 2004 884 887
55. P. Legendre The glycinergic inhibitory synapse Cell. Mol. Life Sci. 58 2001 760 793
56. C.A. Hubner Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition Neuron 30 2001 515 524
57. A.J. Berger Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses J. Neurophysiol. 80 1998 3336 3340
58. J.E. Chatterton Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits Nature 415 2002 793 798
59. F. Zafra Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS Eur. J. Neurosci. 7 1995 1342 1352
60. B. Cubelos Localization of the GLYT1 Glycine Transporter at Glutamatergic Synapses in the Rat Brain Cereb. Cortex 15 2005 448 459
61. D.V. Pow, and A.E. Hendrickson Distribution of the glycine transporter glyt-1 in mammalian and nonmammalian retinae Vis. Neurosci. 16 1999 231 239
62. F. Zafra Glycine transporters are differentially expressed among CNS cells J. Neurosci. 15 1995 3952 3969
63. S. Mahendrasingam Two approaches to double post-embedding immunogold labeling of freeze-substituted tissue embedded in low temperature Lowicryl HM20 resin Brain Res. Brain Res. Protoc. 11 2003 134 141
64. R. Gammelsaeter Glycine, GABA and their transporters in pancreatic islets of Langerhans: evidence for a paracrine transmitter interplay J. Cell Sci. 117 2004 3749 3758
65. L.G. Harsing Jr The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study Pharmacol. Biochem. Behav. 74 2003 811 825
66. E. Nunez Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters Br. J. Pharmacol. 129 2000 200 206
67. K.K. Ho 2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors Bioorg. Med. Chem. Lett. 14 2004 545 548
68. M. Isaac 5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors Bioorg. Med. Chem. Lett. 11 2001 1371 1373
69. J. Abramson Structure and mechanism of the lactose permease of Escherichia coli Science 301 2003 610 615
70. Y. Huang Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli Science 301 2003 616 620
71. D. Yernool Structure of a glutamate transporter homologue from Pyrococcus horikoshii Nature 431 2004 752 753