The HERG K+ channel: Progress in understanding the molecular basis of its unusual gating kinetics

European Biophysics Journal

Volumn 33, Issue 2, 2004, Pages 89-97

  Vandenberg, Jamie I ^a,b   Torres, Allan M ^c   Campbell, Terence J ^a,b   Kuchel, Philip W ^c  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL HERG; SCORPION VENOM; VOLTAGE GATED POTASSIUM CHANNEL;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING ASSAY; BINDING KINETICS; CHANNEL GATING; GENE FUNCTION; GENE IDENTIFICATION; HEART ARRHYTHMIA; HEART REPOLARIZATION; KINETICS; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; SCORPION VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP;

SCORPIONES;

EID: 3342961787     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-003-0338-3     Document Type: Article

References (71)

1. Abbott GW et al (1999) MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97:175-187
2. Anumonwo JM et al (1999) Proton and zinc effects on HERG currents. Biophys J 77:282-298
3. Aydar E, Palmer C (2001) Functional characterization of the C-terminus of the human ether-a-go-go-related gene K(+) channel (HERG). J Physiol 534:1-14
4. Baukrowitz T, Yellen G (1995) Modulation of K + current by frequency and external [K+]: a tale of two inactivation mechanisms. Neuron 15:951-960
5. Chen J et al (1999) Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. J Biol Chem 274:10113-10118
6. Corona M et al (2002) A large number of novel Ergtoxin-like genes and ERG K + -channels blocking peptides from scorpions of the genus Centruroides. FEBS Lett 532:121-126
7. Cui J et al (2001) Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2. J Biol Chem 276:17244-17251
8. Curran ME et al (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80:795-803
9. Doyle DA et al (1998) The structure of the potassium channel: molecular basis of K + conduction and selectivity. Science 280:69-77
10. Emmi A et al (2000) Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes. J Neurosci 20:3915-3925
11. Fan JS et al (1999) Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel. Biophys J 76:3128-3140
12. Ficker E et al (1998). Molecular determinants of dofetilide block of HERG K + channels. Circ Res 82:386-395
13. Fozzard HA (2000) Channel-specific therapy of cardiac arrhythmias in our time? J Cardiovasc Electrophysiol 11:369-370
14. Gross A, MacKinnon R (1996) Agitoxin footprinting the shaker potassium channel pore. Neuron 16:399-406
15. Gullo F et al (2003) ERG K + channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J 17:330-332
16. Herzberg IM et al (1998) Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. J Physiol 511:3-14
17. Hidalgo P, MacKinnon R (1995) Revealing the architecture of a K + channel pore through mutant cycles with a peptide inhibitor. Science 268:307-310
18. Hoshi T et al (1991) Two types of inactivation in Shaker K + channels: effects of alterations in the carboxy-terminal region. Neuron 7:547-556
19. Jiang M et al (1999) Mechanism for the effects of extracellular acidification on HERG-channel function. Am J Physiol 277: H1283-H1292
20. Jiang Y et al (2002) The open pore conformation of potassium channels. Nature 417:523-526
21. Jiang Y et al (2003) The principle of gating charge movement in a voltage-dependent K + channel. Nature 423:42-48
22. Keating MT, Sanguinetti MC (2001). Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104:569-580
23. Kiehn J et al (1999). Pathways of HERG inactivation. Am J Physiol 277:H199-H210
24. Koradi, R., Billeter, M., and Wuthrich, K. (1996) MOLMOL: a program for display and analysis of macromolecular structures. J Mol Graph 14:51-55
25. Korolkova YV et al (2002) New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1. J Biol Chem 277:43104-43109
26. Korolokova YV et al (2003) Probing the unique structure of HERG's outer vestibule using mutant cycle analysis. Biophys J 84:8a (abstract)
27. Kupershmidt S et al (2002). Defective human Ether-a-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus. J Biol Chem 277:27442-27448
28. Lanigan MD et al (2002) Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.Biochemistry. 41:11963-11971
29. Liu J et al (2002) Structural and functional role of the extracellular S5-P linker in the HERG potassium channel J Gen Physiol 120:723-737
30. Liu J et al (2003) Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes. J Gen Physiol 121:599-614
31. Loots E, Isacoff EY (1998) Protein rearrangements underlying slow inactivation of the Shaker K + channel. J Gen Physiol. 112:377-389
32. Lu Y et al (2001) Effects of premature stimulation on HERG K(+) channels. J Physiol. 537:843-851
33. Meyer R, Heinemann SH (1997) Temperature and pressure dependence of Shaker K + channel N- and C-type inactivation. Eur Biophys J. 26:433-445
34. Mitcheson JS et al (2001) A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA 97:12329-12333
35. Mohler PJ et al (2003) Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature 421:634-639
36. Morais Cabral JH et al (1998) Crystal structure and functional analysis of the HERG potassium channel N-terminus: a eukaryotic PAS domain. Cell 95:649-655
37. Nakajima T et al (1998) Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation. Circ Res 83:415-422
38. Pardo-Lopez L et al (2002) Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule. J Biol Chem 277:16403-16411
39. Perozo E et al (1993). Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K + channels. Neuron 11:353-358
40. Piper et al (2003) HERG channel gating currents. Biophys J 84:543a (abstract)
41. Ponting CP, Aravind L (1997) PAS: a multifunctional domain family comes to light. Curr Biol. 7:R674-R677
42. Proks P et al (2001) Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel. J Gen Physiol 118:341-353
43. Ranganathan R et al (1996) Spatial localization of the K + channel selectivity filter by mutant cycle-based structure analysis. Neuron 16:131-139
44. Rosati B et al (2000) Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and release. FASEB J 14:2601-2610
45. Sanguinetti MC, Xu QP (1999) Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J Physiol 514:667-675
46. Sanguinetti MC et al (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81:299-307
47. Schonherr R, Heinemann SH (1996) Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J Physiol 493:635-642
48. Seoh SA et al (1996) Voltage-sensing residues in the S2 and S4 segments of the Shaker K + channel. Neuron 16:1159-1167
49. Shoeb F et al (2003) Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K + channel. Potential role of a conserved amino acid substitution in the S4 region. J Biol Chem 278:2503-2514
50. Smith PL, Yellen G (2002) Fast and slow voltage sensor movements in HERG potassium channels. J Gen Physiol 119:275-293
51. Smith PL et al (1996) The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379:833-836
52. Spector PS et al (1996) Fast inactivation causes rectification of the IKr channel. J Gen Physiol 107:611-619
53. Splawski I et al (1997) Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nat Genet 17:338-340
54. Splawski I et al (2000) Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and-KCNE2. Circulation 102:1178-1185
55. Terlau H et al (1997). Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment. J Physiol 502:537-543
56. Thompson JD et al (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680
57. Torres et al (2003) Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin. FEBS Lett 539:138-142
58. Tristani-Firouzi M et al (2002) Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K + channels. J Biol Chem 277:18994-19000
59. Trudeau MC et al (1995) HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269:92-95
60. Tseng GN (2001) I(Kr): the hERG channel. J Mol Cell Cardiol 33:835-849
61. Vandenberg JI et al (2001) HERG K + channels: friend and foe. Trends Pharmacol Sci 22:240-246
62. Wang J et al (1998) Regulation of deactivation by an amino terminal domain in human ether-a-go-go-related gene potassium channels. J Gen Physiol 112:637-647
63. Wang J et al (2000) Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels. J Gen Physiol 115:749-758
64. Wang Q et al (1995)SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80:805-811
65. Wang Q et al (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12:17-23
66. Wang S et al (1997) A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J Physiol 502:45-60
67. Warmke JW, Ganetzky B (1994) A family of potassium channel genes related to eag in Drosophila and mammals.Proc Natl Acad Sci USA 91:3438-3442
68. Yellen G (1998) The moving parts of voltage-gated ion channels. Q Rev Biophys 31:239-295
69. Yifrach O, MacKinnon R (2002) Energetics of pore opening in a voltage-gated K(+) channel. Cell 111(2):231-239
70. Zhou Z et al (1998) Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys J 74:230-241
71. Zou A et al (1998) A mutation in the pore region of HERG K + channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation. J Physiol 509:129-137