Pathways of HERG inactivation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 1 46-1, 1999, Pages

  Kiehn, Johann ^a,b   Lacerda, Antonio E ^a,c   Brown, Arthur M ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c Rammelkamp Center   (United States)

Author keywords

Activation; Kinetics; Rapid repolarizing cardiac potassium current

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; POTASSIUM;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; ELECTROPHYSIOLOGY; GENE EXPRESSION; HEART MUSCLE CELL; HEART REPOLARIZATION; KINETICS; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; XENOPUS;

EID: 0032868168     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.1.h199     Document Type: Article

References (30)

1. Colquhoun, D., and B. Sakmann. Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J. Physiol. (Lond.) 369: 501-557, 1985.
2. Colquhoun, D., and F. J. Sigworth. Fitting and statistical analysis of single-channel records. In: Single-Channel Recording, edited by B. Sakmann and E. Neher. New York: Plenum, 1995, p. 483-587.
3. Curran, M. E., I. Splawski, K. W. Timothy, G. M. Vincent, E. D. Green, and M. T. Keating. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803, 1995.
4. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391: 85-100, 1981.
5. Horie, M., S. Hayashi, and C. Kawai. Two types of delayed rectifying K channels in atrial cells of guinea pig heart. Jpn. J. Physiol. 40: 479-490, 1990.
6. Hoshi, T., W. N. Zagotta, and R. W. Aldrich. Shaker potassium channel gating. I: Transitions near the open state. J. Gen. Physiol. 103: 249-278, 1994.
7. + channel in rabbit sinoatrial node cells. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H443-H452, 1995.
8. + current by dofetilide. Circ. Res. 72: 75-83, 1993.
9. Keating, M. T. The long QT syndrome. A review of recent molecular genetic and physiologic discoveries. Medicine (Baltimore) 75: 1-5, 1996.
10. Kiehn, J., C. Karle, D. Thomas, X. Yao, J. Brachmann, and W. Kubler. HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. J. Biol. Chem. 273: 25285-25291, 1998.
11. Kiehn, J., A. E. Lacerda, B. Wible, and A. M. Brown. Molecular physiology and pharmacology of HERG: single channel currents and block by dofetilide. Circulation 94: 2572-2579, 1996.
12. Kiehn, J., P. Villena, T. Beyer, and J. Brachmann. Differential effects of the new class III agent dofetilide on potassium currents in guinea pig cardiomyocytes. J. Cardiovasc. Pharmacol. 24: 566-572, 1994.
13. Liu, S., R. L. Rasmusson, D. L. Campbell, S. Wang, and H. C. Strauss. Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes. Biophys. J. 70: 2704-2715, 1996.
14. K(A) channels reopen during recovery from inactivation. Nature 353: 657-660, 1991.
15. Kr potassium channel. Cell 81: 299-307, 1995.
16. + current. J. Gen. Physiol. 96: 195-215, 1990.
17. Schonherr, R., and S. H. Heinemann. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J. Physiol. (Lond.) 493: 635-642, 1996.
18. Shibasaki, T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J. Physiol. (Lond.) 387: 227-250, 1987.
19. Smith, P. L., T. Baukrowitz, and G. Yellen. The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379: 833-836, 1996.
20. + channel. Open-channel block by methanesulfonanilides. Circ. Res. 78: 499-503, 1996.
21. Kr channel. J. Gen. Physiol. 107: 611-619, 1996.
22. + channels by reactive oxygen species. Proc. Natl. Acad. Sci. USA 94: 11698-11703, 1997.
23. Trudeau, M. C., J. W. Warmke, B. Ganetzky, and G. A. Robertson. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269: 92-95, 1995.
24. VanDongen, A. M. J. A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels. Biophys. J. 70: 1303-1315, 1996.
25. Veldkamp, M. W., A. C. G. vanGinneken, and L. N. Bouman. Single delayed rectifier channels of rabbit ventricular myocytes. Circ. Res. 72: 865-878, 1993.
26. Veldkamp, M. W., A. C. G. vanGinneken, T. Opthof, and L. N. Bouman. Delayed rectifier channels in human ventricular myocytes. Circulation 92: 3497-3504, 1995.
27. Wang, S., S. Liu, M. J. Morales, H. C. Strauss, and R. L. Rasmusson. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J. Physiol. (Lond.) 502: 45-60,1997.
28. Wang, Z., B. Fermini, and S. Nattel. Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc. Res. 28: 1540-1546, 1994.
29. + channels expressed in Xenopus oocytes. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1309-H1314, 1997.
30. + channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation. J. Physiol. (Lond.) 509: 129-137, 1998.