The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-α-induced expression of monocyte-chemoattractant protein-1 in endothelial cells

Blood

Volumn 93, Issue 3, 1999, Pages 857-865

  Goebeler, Matthias ^a   Kilian, Karin ^b   Gillitzer, Reinhard ^b   Kunz, Manfred ^b   Yoshimura, Teizo ^b   Bröcker, Eva B ^b   Rapp, Ulf R ^b   Ludwig, Stephan ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CHEMOKINE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE MIGRATION; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

EID: 0032936517     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.3.857.403k03_857_865     Document Type: Article

References (37)

1. Baggiolini M, Dewald B, Moser B: Human chemokines: An update. Annu Rev Immunol 15:675, 1997
2. Mantovani A, Bussolino F, Introna M: Cytokine regulation of endothelial cell function: From molecular level to the bedside. Immunol Today 18:231, 1997
3. Yla-Herttuala S, Lipton BA, Rosenfeld ME, Sarkioja T, Yoshimura T, Leonard EJ, Witztum JL, Steinberg D: Expression of monocyte chemoattractant protein-1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc Natl Acad Sci USA 88:5252, 1991
4. Nelken NA, Coughlin SR, Gordon D, Wilcox JN: Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest 88:1121, 1991
5. Takeya M, Yoshimura T, Leonard EJ, Takahashi K: Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody. Hum Pathol 24:534, 1993
6. Randolph GJ, Furie MB: A soluble gradient of endogenous monocyte chemoattractant protein-1 promotes the transendothelial migration of monocytes in vitro. J Immunol 155:3610, 1995
7. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA: Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci USA 91:3652, 1994
8. Rand ML, Warren JS, Mansour MK, Newman W, Ringler DJ: Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte-chemoattractant protein-1. Am J Pathol 148:855, 1996
9. Flory CM, Jones ML, Warren JS: Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein-1. Lab Invest 69:396, 1993
10. Mantovani A, Sozzani S, Proost P, van Damme J: The monocyte chemoattractant protein family, in Horuk R (ed): Chemoattractant Ligands and Their Receptors, Pharmacology and Toxicology: Basic and Clinical Aspects. Boca Raton, FL, CRC, 1996, p 169
11. Robinson MJ, Cobb MH: Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9:180, 1997
12. Daum G, Eisenmann-Tappe I, Fries HW, Troppmair J, Rapp UR: The ins and outs of Raf kinases. TIBS 19:474, 1994
13. Naumann U, Hoffmeyer A, Flory E, Rapp UR: Raf protein serine/threonine kinases, in Marks F (ed): Protein Phosphorylation. Weinheim, Germany, VCH Verlagsgesellschaft, 1996, p 203
14. Marshall CJ: Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179, 1995
15. Kyriakis JM, Avruch J: Protein kinase cascades activated by stress and inflammatory cytokines. BioEssays 18:567, 1996
16. Young P, McDonnell P, Dunnington D, Hand A, Laydon J, Lee J: Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents Actions 39:C67, 1993
17. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Keys JR, Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young PR: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739, 1994
18. Beyaert R, Cuenda A, Vanden Berghe W, Plaisance S, Lee JC, Haegeman G, Cohen P, Fiers W: The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor. EMBO J 15:1914, 1996
19. Kumar S, Orsini MJ, Lee JC, McDonnell PC, Debouck C, Young PR: MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein signal transduction pathway. J Biol Chem 271:30864, 1996
20. Cohen P: The search of physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 7:353, 1997
21. Ludwig S, Engel K, Hoffmeyer A, Sithanandam G, Neufeld B, Palm D, Gaestel M, Rapp UR: 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Mol Cell Biol 16:6687, 1996
22. Dorn P, DaSilva L, Martarano L, Derse D: Equine infectious anemia virus tat: Insights into the structure, function and evolution of Lentivirus trans-activator proteins. J Virol 64:1616, 1990
23. Raingeaud J, Whitmarsh AJ, Barrett T, Dérijard B, Davis RJ: MKK6-and MKK3-regulated gene expression is mediated by the p38 mitogen activated signal transduction pathway. Mol Cell Biol 16:1247, 1996
24. Huang S, Jiang Y, Li Z, Nishida E, Mathias P, Lin S, Ulevitch RJ, Nemerow GR, Han J: Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase 6b. Immunity 6:739, 1997
25. Karmann K, Min W, Fanslow WC, Pober JS: Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1. J Exp Med 184:173, 1996
26. Goebeler M, Roth J, Bröcker EB, Sorg C, Schulze-Osthoff K: Activation of nuclear factor-κB and gene expression in human endothelial cells by the common haptens nickel and cobalt. J Immunol 155:2459, 1995
27. Goebeler M, Schnarr B, Toksoy A, Kunz M, Bröcker EB, Duschl A, Gillitzer R: Interleukin-13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells. Involvement of IL-4Rα and Stat6 phosphorylation. Immunology 91: 450, 1997
28. Yoshimura T, Yuhki N, Moore SK, Apella E, Lerman MI, Leonard EJ: Human monocyte chemoattractant protein-1 (MCP-1): Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett 244:487, 1989
29. Ueda A, Ishigatsubo Y, Okubo T, Yoshimura T: Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-κB sites and NF-κB/Rel subunit specificity. J Biol Chem 272:31092, 1997
30. Pang L, Sawada T, Decker SJ, Saltiel AR: Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 270:13585, 1995
31. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC: SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364:229, 1995
32. Ludwig S, Hoffmeyer A, Goebeler M, Kilian K, Häfner H, Neufeld B, Han J, Rapp UR: The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. J Biol Chem 273:1917, 1998
33. Hoffmeyer A, Avots A, Flory E, Weber CK, Serfling E, Rapp UR: The GABP-responsive element of the interleukin-2 enhancer is regulated by JNK/SAPK-activating pathways in T lymphocytes. J Biol Chem 273:10112, 1998
34. Ueda A, Okuda K, Ohno S, Shirai A, Igarashi T, Matsunaga K, Fukushima J, Kawamoto S, Ishigatsubo Y, Okubo T: NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol 153:2052, 1994
35. Wesselborg S, Bauer MKA, Vogt M, Lienhard Schmitz M, Schulze-Osthoff K: Activation of transcription factor NF-κB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways. J Biol Chem 272:12422, 1997
36. Pietersma A, Tilly BC, Gaestel M, de Jong N, Lee JC, Koster JF, Sluiter W: p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level. Biochem Biophys Res Commun 230:44, 1997
37. Read MA, Whitley MZ, Gupta S, Pierce JW, Best J, Davis RJ, Collins T: Tumor necrosis factor α-induced E-selectin expression is activated by the nuclear factor-κB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways. J Biol Chem 272:2753, 1997