The dispersal of replication proteins after etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway

Cancer Research

Volumn 66, Issue 3, 2006, Pages 1675-1683

  Rossi, Rossella ^a   Lidonnici, Maria Rosa ^a   Soza, Samuela ^a   Biamonti, Giuseppe ^a   Montecucco, Alessandra ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; CYCLINE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; NIBRIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; REPLICATION PROTEIN A; SINGLE STRANDED DNA BINDING PROTEIN;

ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE PROTEINS; CHROMATIN; DNA LIGASES; DNA REPLICATION; ETOPOSIDE; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REPLICATION PROTEIN A; S PHASE;

EID: 32944479182     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2741     Document Type: Article

References (37)

1. Zhou B-BS, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000;408:433-9.
2. Bell S, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem 2002;71:333-74.
3. Santocanale C, Diffley JF. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 1998;395:615-8.
4. Abraham R. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001;15:2177-96.
5. Osborn A, Elledge S, Zou L. Checking on the fork: the DNA replication stress-response pathway. Trends Cell Biol 2002;12:509-16.
6. Kastan M, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004;432:316-23.
7. Bartek J, Lukas C, Lukas J. Checking on DNA damage in S phase. Nat Rev Mol Cell Biol 2004;5:792-804.
8. Difilippantonio S, Celeste A, Fernandez-capetillo O, et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol 2005;7:675-85.
9. Stiff T, Reis C, Alderton G, Woodbine L, O'Driscoll M, Jeggo P. Nbs1 is required for ATR-dependent phosphorylation events. EMBO J 2005;24:199-208.
10. Hozak P, Jackson DA, Cook PR. Replication factories and nuclear bodies: the ultrastructural characterization of replication sites during the cell cycle. Cell 1994;107:2191-202.
11. Jackson DA, Pombo A. Replicon clusters are stable units of chromosome structure: Evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. J Cell Biol 1998;140:1285-95.
12. O'Keefe RT, Henderson SC, Spector DL. Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific α-satellite DNA sequences. J Cell Biol 1992;116:1095-110.
13. Frouin I, Montecucco A, Spadari S, Maga G. DNA replication: a complex matter. EMBO Rep 2003;4:666-70.
14. Montecucco A, Rossi R, Levin DS, et al. DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. EMBO J 1998;17:3786-95.
15. Rossi R, Villa A, Negri C, et al. The replication factory targeting sequence/PCNA-binding site is required in G(I) to control the phosphorylation status of DNA ligase I. EMBO J 1999;18:5745-54.
16. Ferrari G, Rossi R, Arosio D, Vindigni A, Biamonti G, Montecucco A. Cell cycle-dependent phosphorylation of human DNA ligase I at the cyclin-dependent kinase sites. J Biol Chem 2003;278:37761-7.
17. Dimitrova DS, Gilbert DM. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis. Nat Cell Biol 2000;2:686-94.
18. Feijoo C, Hall-Jackson C, Wu R, et al. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol 2001;154:913-24.
19. Montecucco A, Rossi R, Ferrari G, Scovassi AI, Prosperi E, Biamonti G. Etoposide induces the dispersal of DNA ligase I from replication factories. Mol Biol Cell 2001;12:2109-18.
20. Kaufmann S. Cell death induced by topoisomerase-targeted drugs: more questions than answer. Biochim Biophys Acta 1998;1400:195-211.
21. 2 arrests induced by Topoisomerase I poisons are dependent on ATR kinase function. J Biol Chem 2002;277:1599-606.
22. Costanzo V, Shechter D, Lupardus P, Cimprich K, Gottesman M, Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 2003;11:203-13.
23. Cliby WA, Roberts CJ, Cimprich KA, et al. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J 1998;17:159-69.
24. Stewart G, Maser R, Stankovic T, et al. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 1999;99:577-87.
25. Montecucco A, Savini E, Weighardt F, et al. The N-terminal domain of human DNA ligase I contains the nuclear localisation signal and directs the enzyme to sites of DNA replication. EMBO J 1995;14:5379-86.
26. Lidonnici M, Rossi R, Paixao S, et al. Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle. J Cell Sci 2004;117:5221-31.
27. Skoufias D, Lacroix F, Andreassen P, Wilson L, Margolis R. Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase. Mol Cell 2004;15:977-90.
28. Lees-Miller S, Godbout R, Chan D, et al. Absence of p350 subunit of DNA-activated protein kinase from radiosensitive human cell line. Science 1995;267:1183-5.
29. Sharma S, Otterlei M, Sommers J, et al. WRN helicase and FEN-1 form a complex on replication arrest and together process branch-migrating DNA structures associated with the replication fork. Mol Biol Cell 2004;15:734-50.
30. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004;73:39-85.
31. Groves P, Yu L, Schwarz J, et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem 2000;275:5600-5.
32. Wang X, Guan J, Hu B, Weiss RS, Iliakis G, Wang Y. Involvement of Hus1 in the chain elongation step of DNA replication after exposure to champtothecin or ionizing radiation. Nucleic Acids Res 2004;32:767-75.
33. Lucas I, Germe T, Chevrier-Miller M, Hyrien O. Topoisomerase II can unlink replicating DNA by precatenane removal. EMBO J 2001;20:6509-19.
34. Maser RS, Zinkel R, Petrini JHJ. An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Nat Genet 2001;27:417.
35. Matsuura S, Kobayashi J, Tauchi H, Komatsu K. Nijmegen Breakage Syndrome and DNA double strand break repair by NBS1 complex Adv Biophys 2004;38:65-80.
36. Robinson J, Lu L, Dixon K, Bissler J. DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. J Biol Chem 2005;280:12927-34.
37. Legarkova M, Svetlova E, Giacca M, Falaschi A, Razin S. DNA loop anchorage region colocalizes with the replication origin located downstream to the human gene encoding lamin B2. J Cell Biochem 1998;69:13-8.