Induction, expression and maintenance of cytochrome P450 isoforms in long-term cultures of primary human hepatocytes

Altex

Volumn 21, Issue SUPPL. 3, 2004, Pages 3-11

  Yuan, Jing ^a   Liu, Liegang ^a   Shimada, Masashi ^a   Wang, Aiguo ^a   Ruhnke, Maren ^b   Heeckt, Peter ^c   Muller, Andrea R ^a,b   Nussler, Natascha C ^a   Neuhaus, Peter ^a   Nussler, Andreas ^a,d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c Fresenius Proserve GmbH   (Germany)

^d Fresenius Biotech   (Germany)

Author keywords

Cytochrome P450; Drug screening; Human hepatocytes; Toxicology

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; ALBUMIN; AMINOTRANSFERASE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; ETHOXYRESORUFIN DEETHYLASE; GLUCOSE; GLUCURONOSYLTRANSFERASE; ISOPROTEIN; PHENOBARBITAL; RIFAMPICIN; TESTOSTERONE DERIVATIVE; UREA;

ARTICLE; BIOASSAY; CELL CULTURE; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG METABOLISM; DRUG SCREENING; ENZYME ACTIVITY; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; PROTEIN EXPRESSION; QUALITY CONTROL; TOXICOLOGY; UREA CYCLE; WESTERN BLOTTING;

ALBUMINS; ANIMAL TESTING ALTERNATIVES; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOTTING, WESTERN; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; GLUCOSE; HEPATOCYTES; HUMANS; ISOENZYMES; L-LACTATE DEHYDROGENASE; LACTIC ACID; LIVER; TESTOSTERONE; TOXICOLOGY; UREA;

EID: 3242794283     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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