Reduction of glial glutamate transporters in the parietal cortex and hippocampus of the EL mouse

Journal of Neurochemistry

Volumn 79, Issue 3, 2001, Pages 564-575

  Ingram, Esther M ^a,c   Wiseman, John W ^b   Tessler, Shoshi ^a   Emson, Piers C ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

EL mouse; GLAST; GLT1; Hippocampus; Parietal cortex

Indexed keywords

GLUTAMATE TRANSPORTER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; EPILEPTIC DISCHARGE; EPILEPTOGENESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; SEIZURE; TISSUE LEVEL;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPILEPSY, TEMPORAL LOBE; EXCITATORY AMINO ACID TRANSPORTER 2; GLUTAMIC ACID; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; NEUROGLIA; PARIETAL LOBE; RNA, MESSENGER;

ANIMALIA;

EID: 0034759553     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00612.x     Document Type: Article

References (57)

1. Expression of glial glutamate transporters GLT1 and GLAST is unchanged in the hippocampus in fully kindled rats
2. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat
3. Functional comparisons of 3 glutamate transporter subtypes cloned from human motor cortex
4. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
5. Firing pattens of human limbic neurons during stereoencephalography (SEEG) and clinical temporal-lobe seizures
6. Glutamate, GABA and epilepsy
7. Biochemical correlates of epilepsy in the El mouse - Analysis of glial fibrillary acidic protein and gangliosides
8. Seizure related elevations of extracellular amino acids in human focal epilepsy
9. Bench to bedside - The glutamate connection
10. +] coupled L-glutamate transporter purified from rat brain is located in glial cell processes
11. 3+-induced epileptogenesis
12. Extracellular hippocampal glutamate and sponaneous seizure in the conscious human brain
13. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
14. Enhanced aspartate release related to epilepsy in (El) mice
15. New seizure frequency QTL and the complex genetics of epilepsy in EL mice
16. Large frequency potentiation induced by 2 Hz stimulation in the hippocampus of epileptic El mice
17. Brain glutamate transporter proteins form homomultimers
18. Aspartic acid release from cerebral cortical slices of El mice with high seizure susceptibility
19. Regional excitatory and inhibitory amino-acid levels in epileptic El mouse brain
20. The epilepsy-like abnormalities in a strain of mouse
21. Glial glutamate transporter mRNAs in the genetically absence epilepsy rat from Strasbourg
22. Epileptic seizure of El mouse initiates at the parietal cortex - Depth EEG observation in freely moving condition using buffer amplifier
23. Primary structure and functional characterization of a high-affinity glutamate transporter
24. The neuronal and epithelial human high-affinity glutamate transporter - Insights into structure and mechanism of transport
25. Mechanism of transport and storage of neurotransmitters
26. Effect of amygdaloid kindling on the content and release of amino acids from the amygdaloid complex: In vivo and in vitro studies
27. NMDA and kainate-evoked release of nitric oxide and classical neurotransmitters in the rat striatum: In vivo evidence that nitric oxide may play a neuroprotective role
28. Mouse excitatory amino acid transporter EAAT2 - Isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2
29. 3H] D-aspartate uptake and glutamate metabolism in rats
30. Differential expression of 2 glial glutamate transporters in the rat brain - Quantitative and immunocytochemical observations
31. +] Coupled L-glutamate transporter purified from rat brain confirms glial cell localization
32. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy
33. Alterations in glutamate transporter protein levels in kindling induced epilepsy
34. Molecular cloning of 2 glutamate transporter subtypes from mouse brain
35. Depth EEG in mutant epileptic El mice - Demonstration of secondary generalization of the seizure from the hippocampus
36. The release and uptake of excitatory amino acids
37. Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure
38. Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice
39. Cloning and expression of a rat-brain L-glutamate transporter
40. Genes for epilepsy mapped in the mouse
41. Glutamate release in severe brain ischaemia is mainly by reversed uptake
42. Localization of neuronal and glial glutamate transporters
43. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
44. Experimental models of multifactorial epilepsies: The EL mouse and mice susceptible to audiogenic seizures
45. Dynamic changes in expression of glutamate transporter mRNAs in developing brain
46. Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity
47. +-dependent glutamate aspartate transporter from rat brain
48. Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS
49. Local cerebral glucose utilization in epileptic seizures of the mutant El mouse
50. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake
51. Cloning and expression of a glutamate transporter from mouse brain
52. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT1
53. Expression of glutamate transporters in human temporal lobe epilepsy
54. Bilateral seizure related changes of extracellular glutamate concentration in hippocampi during development of amygdaloid kindling
55. 3+-induced epileptogenesis
56. Collapse of extracellular glutamate regulation during epileptogenesis: Down-regulation ad functional failure of glutamate transporter function in rats with chronic seizures indiced by kainic acid
57. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice