Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat

Neuroscience Letters

Volumn 318, Issue 3, 2002, Pages 137-140

  Rossato, Janine I ^a   Zeni, Gilson ^a   Mello, Carlos F ^a   Rubin, Maribel A ^a   Rocha, João B T ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Antioxidant; Ebselen; Lipid peroxidation; Quinolinic acid; Seizures

Indexed keywords

DIZOCILPINE; EBSELEN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUINOLINIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN HOMOGENATE; CIRCLING BEHAVIOR; CONTROLLED STUDY; CONVULSION; CORPUS STRIATUM; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; LIPID PEROXIDATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULATION;

EID: 84984569420     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02504-6     Document Type: Article

References (20)

1. The quinolinic acid hypothesis in Huntington's chorea
2. Melatonin reduces oxidative neurotoxicity due to quinolinic acid: In vitro and in vivo findings
3. Ebselen as a peroxynitrite scavenger in vitro and ex vivo
4. The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat
5. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid
6. A microdialysis study of striatal dopamine release in the circling rat, a genetic model with spontaneous lateralized rotational behavior
7. The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site
8. Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms
9. The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease
10. A novel biologically active seleno-organic compound-I: Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (ebselen)
11. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
12. Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons
13. Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum
14. MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum
15. Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
16. Neuropharmacology of quinolinic and kynurenic acids
17. Quinolinic acid: A potent endogenous excitant amino acid receptor in CNS
18. Neuroprotective efficacy of ebselen, an antioxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion
19. Change in calcium permeability caused by quinolinic acid in cultured rat hippocampal neurons
20. Ebselen in acute ischemic stroke: A placebo-controlled, double-blind clinical trial