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Volumn 8, Issue 2, 2004, Pages 69-77

Fluconazole resistance in Candida albicans: A review of mechanisms

Author keywords

Antifungal resistance; Candida albicans; Ergosterol; Fluconazole

Indexed keywords

ABC TRANSPORTER; ANTIFUNGAL AGENT; ARGININE; ASPARTIC ACID; CYCLIC AMP; CYCLOSPORIN A; CYTOCHROME P450; ERGOSTEROL; FLUCONAZOLE; GLUTAMIC ACID; ISOLEUCINE; ITRACONAZOLE; KETOCONAZOLE; LANOSTEROL; LEUCINE; LINOLEOYL COENZYME A DESATURASE; LYSINE; MICONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; POSACONAZOLE; RAVUCONAZOLE; SQUALENE MONOOXYGENASE; STEROID DELTA ISOMERASE; STEROL 14ALPHA DEMETHYLASE; TACROLIMUS; VALINE; VORICONAZOLE;

EID: 3242659003     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (131)

References (83)
  • 1
    • 0025363182 scopus 로고
    • Fluconazole: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses
    • Grant SM, Clissold SP. Fluconazole: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs 1990; 39: 877-916.
    • (1990) Drugs , vol.39 , pp. 877-916
    • Grant, S.M.1    Clissold, S.P.2
  • 2
    • 0028324030 scopus 로고
    • Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: Persistence of Candida albicans strains with the same genotype
    • Millon L, Manteaux A, Reboux G. et al. Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype. J Clin Microbiol 1994; 32: 1115-1118.
    • (1994) J. Clin. Microbiol. , vol.32 , pp. 1115-1118
    • Millon, L.1    Manteaux, A.2    Reboux, G.3
  • 4
    • 0036090546 scopus 로고    scopus 로고
    • Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis
    • Perea S. Lopez-Ribot JL, Wickes BL, et al. Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob Agents Chemother 2002; 46: 1695-1703.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1695-1703
    • Perea, S.1    Lopez-Ribot, J.L.2    Wickes, B.L.3
  • 6
    • 0030838772 scopus 로고    scopus 로고
    • Point prevalence of oropharyngeal carriage of fluconazole-resistant Candida in human immunodeficiency virus-infected patients
    • Martins MD, Lozano-Chiu M, Rex JH. Point prevalence of oropharyngeal carriage of fluconazole-resistant Candida in human immunodeficiency virus-infected patients. Clin Infect Dis 1997; 25: 843-846.
    • (1997) Clin. Infect. Dis. , vol.25 , pp. 843-846
    • Martins, M.D.1    Lozano-Chiu, M.2    Rex, J.H.3
  • 7
    • 0032788359 scopus 로고    scopus 로고
    • National epidemiology of mycoses survey (NE-MIS): Variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units
    • Rangel-Frausto MS. Wiblin T, Blumberg HM, et al. National epidemiology of mycoses survey (NE-MIS): variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units. Clin Infect Dis 1999; 29: 253-258.
    • (1999) Clin. Infect. Dis. , vol.29 , pp. 253-258
    • Rangel-Frausto, M.S.1    Wiblin, T.2    Blumberg, H.M.3
  • 8
    • 0036550465 scopus 로고    scopus 로고
    • Non-albicans Candida spp. causing fungaemia: Pathogenicity and antifungal resistance
    • Krcmery V, Barnes AJ. Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance. J Hosp Infect 2002; 50: 243-260.
    • (2002) J. Hosp. Infect. , vol.50 , pp. 243-260
    • Krcmery, V.1    Barnes, A.J.2
  • 10
    • 0025738717 scopus 로고
    • Cytochrome P-450-dependent 14 alpha-sterol demethylase of Candida albicans and its interaction with azole antifungals
    • Hitchcock CA. Cytochrome P-450-dependent 14 alpha-sterol demethylase of Candida albicans and its interaction with azole antifungals. Biochem Soc Trans 1991; 19: 782-787.
    • (1991) Biochem. Soc. Trans. , vol.19 , pp. 782-787
    • Hitchcock, C.A.1
  • 12
    • 0030998109 scopus 로고    scopus 로고
    • Molecular mechanisms of azole resistance in fungi
    • Joseph-Horne T, Hollomon DW. Molecular mechanisms of azole resistance in fungi. FEMS Microbiol Lett 1997; 149: 141-149.
    • (1997) FEMS Microbiol. Lett. , vol.149 , pp. 141-149
    • Joseph-Horne, T.1    Hollomon, D.W.2
  • 13
    • 0030844294 scopus 로고    scopus 로고
    • International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections
    • Edwards JE Jr, Bodey GP, Bowden RA, et al. International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections. Clin Infect Dis 1997; 25: 43-59.
    • (1997) Clin. Infect. Dis. , vol.25 , pp. 43-59
    • Edwards Jr., J.E.1    Bodey, G.P.2    Bowden, R.A.3
  • 14
    • 0037878064 scopus 로고    scopus 로고
    • Shifting patterns in the epidemiology of nosocomial Candida infections
    • Snydman DR. Shifting patterns in the epidemiology of nosocomial Candida infections. Chest 2003; 123 (5 Suppl): 500S-503S.
    • (2003) Chest , vol.123 , Issue.5 SUPPL.
    • Snydman, D.R.1
  • 15
    • 0031054924 scopus 로고    scopus 로고
    • The mutation T315A in Candida albicans sterol 14α-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity
    • Lamb DC, Kelly DE, Schunck WH, et al. The mutation T315A in Candida albicans sterol 14α-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. J Biol Chem 1997; 272: 5682-5688.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5682-5688
    • Lamb, D.C.1    Kelly, D.E.2    Schunck, W.H.3
  • 16
    • 0034812585 scopus 로고    scopus 로고
    • Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients
    • Perea S, López-Ribot JL, Kirkpatrick WR, et al. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 2001; 45: 2676-2684.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2676-2684
    • Perea, S.1    López-Ribot, J.L.2    Kirkpatrick, W.R.3
  • 18
    • 0030812876 scopus 로고    scopus 로고
    • Molecular biological characterization of an azole-resistant Candida glabrata isolate
    • Marichal P, Vanden Bossche H. Odds FC, et al. Molecular biological characterization of an azole-resistant Candida glabrata isolate. Antimicrob Agents Chemother 1997; 41: 2229-2237.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2229-2237
    • Marichal, P.1    Vanden Bossche, H.2    Odds, F.C.3
  • 19
    • 0002968435 scopus 로고    scopus 로고
    • Resistance to antifungal drugs: Current status and clinical implications
    • Holmberg K, Stevens DA. Resistance to antifungal drugs: current status and clinical implications. Curr Opin Anti-Infective Invest Drugs 1999; 1: 306-317.
    • (1999) Curr. Opin. Anti-Infective Invest. Drugs , vol.1 , pp. 306-317
    • Holmberg, K.1    Stevens, D.A.2
  • 20
    • 0031755686 scopus 로고    scopus 로고
    • Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis
    • López-Ribot JL, McAtee RK, Lee NL, et al. Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob Agents Chemother 1998; 42: 2932-2937.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2932-2937
    • López-Ribot, J.L.1    McAtee, R.K.2    Lee, N.L.3
  • 21
    • 0030914272 scopus 로고    scopus 로고
    • Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient
    • White TC, Pfaller MA, Rinaldi RG, Smith J, Redding SW. Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient. Oral Dis 1997; 3: S102-S109.
    • (1997) Oral Dis. , vol.3
    • White, T.C.1    Pfaller, M.A.2    Rinaldi, R.G.3    Smith, J.4    Redding, S.W.5
  • 22
    • 0033807662 scopus 로고    scopus 로고
    • Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors
    • Henry KW, Nickels JT, Edlind TD. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother 2000; 44: 2693-2700.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2693-2700
    • Henry, K.W.1    Nickels, J.T.2    Edlind, T.D.3
  • 24
    • 0034780510 scopus 로고    scopus 로고
    • In vitro and in vivo effects of 14α-demethylase (ERG11) depletion in Candida glabrata
    • Nakayama H, Nakayama N, Arisawa M, Aoki Y. In vitro and in vivo effects of 14α-demethylase (ERG11) depletion in Candida glabrata. Antimicrob Agents Chemother 2001; 45: 3037-3045.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 3037-3045
    • Nakayama, H.1    Nakayama, N.2    Arisawa, M.3    Aoki, Y.4
  • 25
    • 0030792602 scopus 로고    scopus 로고
    • The presence of an R467K aminoacid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α-demethylase in Candida albicans
    • White TC. The presence of an R467K aminoacid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α-demethylase in Candida albicans. Antimicrob Agents Chemother 1997; 41: 1488-1494.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1488-1494
    • White, T.C.1
  • 26
    • 0031759244 scopus 로고    scopus 로고
    • Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
    • Franz R, Kelly SE, Lamb DC, Kelly DE, Ruhne M, Morschhäuser J. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob Agents Chemother 1998; 42: 3065-3072.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 3065-3072
    • Franz, R.1    Kelly, S.E.2    Lamb, D.C.3    Kelly, D.E.4    Ruhne, M.5    Morschhäuser, J.6
  • 27
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White TC, Marr KA, Bowden RA. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev 1998; 11: 382-402.
    • (1998) Clin. Microbiol. Rev. , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 28
    • 0031938057 scopus 로고    scopus 로고
    • Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
    • Sanglard D, Ischer F, Koymans L, Bille J. Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrob Agents Chemother 1998; 42: 241-253.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 241-253
    • Sanglard, D.1    Ischer, F.2    Koymans, L.3    Bille, J.4
  • 29
    • 0032733078 scopus 로고    scopus 로고
    • Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem
    • Kelly SL, Lamb DC, Kelly DE. Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem. FEMS Microbiol Lett 1999; 180: 171-175.
    • (1999) FEMS Microbiol. Lett. , vol.180 , pp. 171-175
    • Kelly, S.L.1    Lamb, D.C.2    Kelly, D.E.3
  • 30
    • 0033986849 scopus 로고    scopus 로고
    • The R467K amino acid substitution in Candida albicans sterol 14α-demethylase causes drug resistance through reduced affinity
    • Lamb DC, Kelly DE, White TC, Kelly SE. The R467K amino acid substitution in Candida albicans sterol 14α-demethylase causes drug resistance through reduced affinity. Antimicrob Agents Chemother 2000; 44: 63-67.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 63-67
    • Lamb, D.C.1    Kelly, D.E.2    White, T.C.3    Kelly, S.E.4
  • 31
    • 0037130284 scopus 로고    scopus 로고
    • The genetic basis of fluconazole resistance development in Candida albicans
    • Morschhäuser J. The genetic basis of fluconazole resistance development in Candida albicans. Biochim Biophys Acta 2002; 1587: 240-248.
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 240-248
    • Morschhäuser, J.1
  • 32
    • 0032826408 scopus 로고    scopus 로고
    • Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
    • Marichal P, Koymans L, Willemsens S. et al. Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 1999; 145: 2701-2713.
    • (1999) Microbiology , vol.145 , pp. 2701-2713
    • Marichal, P.1    Koymans, L.2    Willemsens, S.3
  • 33
    • 0037284177 scopus 로고    scopus 로고
    • Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient
    • Maebashi K, Kudoh M, Nishiyama, et al. Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient. Microbiol Immunol 2003; 47: 117-124.
    • (2003) Microbiol. Immunol. , vol.47 , pp. 117-124
    • Maebashi, K.1    Kudoh, M.2    Nishiyama, A.3
  • 34
    • 0036841830 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: Correlation with reduction in CDR and ERG upregulation
    • Smith WL, Edlind TD. Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. Antimicrob Agents Chemother 2002; 46: 3532-3539.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3532-3539
    • Smith, W.L.1    Edlind, T.D.2
  • 35
    • 0036839691 scopus 로고    scopus 로고
    • Evaluation of differential gene expression in fluconazole-susceptible and - Resistant isolates of Candida albicans by cDNA microarray analysis
    • Rogers PD, Barker KS. Evaluation of differential gene expression in fluconazole-susceptible and - resistant isolates of Candida albicans by cDNA microarray analysis. Antimicrob Agents Chemother 2002; 46: 3412-3417.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3412-3417
    • Rogers, P.D.1    Barker, K.S.2
  • 36
    • 0037378017 scopus 로고    scopus 로고
    • Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates
    • Rogers PD, Barker KS. Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates. Antimicrob Agents Chemother 2003; 47: 1220-1227.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1220-1227
    • Rogers, P.D.1    Barker, K.S.2
  • 37
    • 0031687814 scopus 로고    scopus 로고
    • Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR
    • Marr KA, Lyons CN, Rustad TR, Bowden RA, White TC. Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. Antimicrob Agents Chemother 1998; 42: 2584-2589.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2584-2589
    • Marr, K.A.1    Lyons, C.N.2    Rustad, T.R.3    Bowden, R.A.4    White, T.C.5
  • 39
    • 0034101979 scopus 로고    scopus 로고
    • Genome-wide expression patterns in Saccharomyces cerevisiae: Comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol
    • Bammert GF, Fostel JM. Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol. Antimicrob Agents Chemother 2000; 44: 1255-1265.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 1255-1265
    • Bammert, G.F.1    Fostel, J.M.2
  • 40
    • 0036894215 scopus 로고    scopus 로고
    • Drug susceptibilities of yeast cells are affected by membrane lipid composition
    • Mukhopadhyay K, Kohli A, Prasad R. Drug susceptibilities of yeast cells are affected by membrane lipid composition. Antimicrob Agents Chemother 2002; 46: 3695-3705.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3695-3705
    • Mukhopadhyay, K.1    Kohli, A.2    Prasad, R.3
  • 41
    • 0032895836 scopus 로고    scopus 로고
    • Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix
    • Dimster-Denk D, Rine J, Phillips J, et al. Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix. J Lipid Res 1999; 40: 850-860.
    • (1999) J. Lipid Res. , vol.40 , pp. 850-860
    • Dimster-Denk, D.1    Rine, J.2    Phillips, J.3
  • 42
    • 0037047077 scopus 로고    scopus 로고
    • Population genomics of drug resistance in Candida albicans
    • Cowen LE, Nantel A, Whiteway MS. et al. Population genomics of drug resistance in Candida albicans. Proc Natl Acad Sci U S A 2002; 99: 9284-9289.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9284-9289
    • Cowen, L.E.1    Nantel, A.2    Whiteway, M.S.3
  • 43
    • 0024468971 scopus 로고
    • Defective sterol C5-6 desaturation and azole resistance: A new hypothesis for the mode of action of azole antifungals
    • Watson PF, Rose ME, Ellis SW, England H, Kelly SL. Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochem Biophys Res Commun 1989; 164: 1170-1175.
    • (1989) Biochem. Biophys. Res. Commun. , vol.164 , pp. 1170-1175
    • Watson, P.F.1    Rose, M.E.2    Ellis, S.W.3    England, H.4    Kelly, S.L.5
  • 44
    • 0031024163 scopus 로고    scopus 로고
    • Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation
    • Kelly SL, Lamb DC, Kelly DE, et al. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation. FEBS Lett 1997; 400: 80-82.
    • (1997) FEBS Lett. , vol.400 , pp. 80-82
    • Kelly, S.L.1    Lamb, D.C.2    Kelly, D.E.3
  • 45
    • 0141788145 scopus 로고    scopus 로고
    • Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole
    • Jackson CJ, Lamb DC, Manning NJ, Kelly DE, Kelly SL. Mutations in Saccharomyces cerevisiae sterol C5-desaturase conferring resistance to the CYP51 inhibitor fluconazole. Biochem Biophys Res Commun 2003; 309: 999-1004.
    • (2003) Biochem. Biophys. Res. Commun. , vol.309 , pp. 999-1004
    • Jackson, C.J.1    Lamb, D.C.2    Manning, N.J.3    Kelly, D.E.4    Kelly, S.L.5
  • 46
    • 0043270593 scopus 로고    scopus 로고
    • Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents
    • Sanglard D, Ischer F, Parkinson T, Falconer D, Bille J. Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. Antimicrob Agents Chemother 2003; 47: 2404-2412.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2404-2412
    • Sanglard, D.1    Ischer, F.2    Parkinson, T.3    Falconer, D.4    Bille, J.5
  • 47
    • 0028928549 scopus 로고
    • Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
    • Prasad R, De Wergifosse P, Goffeau A, Balzi E. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr Genet 1995; 27: 320-329.
    • (1995) Curr. Genet. , vol.27 , pp. 320-329
    • Prasad, R.1    De Wergifosse, P.2    Goffeau, A.3    Balzi, E.4
  • 48
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother 1995; 39: 2378-2386.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.L.4    Monod, M.5    Bille, J.6
  • 49
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
    • Sanglard D, Ischer F, Monod M, Bille J. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 1997; 143: 405-416.
    • (1997) Microbiology , vol.143 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 50
    • 0032888237 scopus 로고    scopus 로고
    • Molecular aspects of fluconazole resistance development in Candida albicans
    • Franz R, Ruhnke M, Morschhäuser J. Molecular aspects of fluconazole resistance development in Candida albicans. Mycoses 1999; 42: 453-458.
    • (1999) Mycoses , vol.42 , pp. 453-458
    • Franz, R.1    Ruhnke, M.2    Morschhäuser, J.3
  • 51
    • 0034081664 scopus 로고    scopus 로고
    • Targeted gene disruption in Candida albicans wild-type strains: The role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates
    • Wirsching S, Michel S, Morschhäuser J. Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates. Mol Microbiol 2000; 36: 856-865.
    • (2000) Mol. Microbiol. , vol.36 , pp. 856-865
    • Wirsching, S.1    Michel, S.2    Morschhäuser, J.3
  • 52
    • 0029820482 scopus 로고    scopus 로고
    • Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    • Sanglard D, Ischer F, Monod M, Bille J. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother 1996; 40: 2300-2305.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2300-2305
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 53
    • 0030761555 scopus 로고    scopus 로고
    • Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation
    • Marr KA, White TC, van Burik JA, Bowden RA. Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation. Clin Infect Dis 1997; 25: 908-910.
    • (1997) Clin. Infect. Dis. , vol.25 , pp. 908-910
    • Marr, K.A.1    White, T.C.2    van Burik, J.A.3    Bowden, R.A.4
  • 54
    • 0037085683 scopus 로고    scopus 로고
    • ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators
    • Smriti, Krishnamurthy S, Dixit BL, Gupta CM, Milewski S, Prasad R. ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators. Yeast 2002; 19: 303-318.
    • (2002) Yeast , vol.19 , pp. 303-318
    • Smriti, A.1    Krishnamurthy, S.2    Dixit, B.L.3    Gupta, C.M.4    Milewski, S.5    Prasad, R.6
  • 55
    • 0033616421 scopus 로고    scopus 로고
    • Asymmetric distribution of phosphatidylethanolamine in C. albicans: Possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily
    • Dogra S, Krishnamurthy S, Gupta V. et al. Asymmetric distribution of phosphatidylethanolamine in C. albicans: possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily. Yeast 1999; 15: 111-121.
    • (1999) Yeast , vol.15 , pp. 111-121
    • Dogra, S.1    Krishnamurthy, S.2    Gupta, V.3
  • 56
    • 0036208102 scopus 로고    scopus 로고
    • In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry
    • Kohli A, Smriti, Mukhopadhyay K, Rattan A, Prasad R. In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry. Antimicrob Agents Chemother 2002; 46: 1046-1052.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1046-1052
    • Kohli, A.1    Smriti, A.2    Mukhopadhyay, K.3    Rattan, A.4    Prasad, R.5
  • 57
    • 0034870709 scopus 로고    scopus 로고
    • Biofilm formation by the fungal pathogen Candida albicans: Development, architecture, and drug resistance
    • Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormick T, Ghannoum MA. Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. J Bacteriol 2001; 183: 5385-5394.
    • (2001) J. Bacteriol. , vol.183 , pp. 5385-5394
    • Chandra, J.1    Kuhn, D.M.2    Mukherjee, P.K.3    Hoyer, L.L.4    McCormick, T.5    Ghannoum, M.A.6
  • 58
    • 0035018512 scopus 로고    scopus 로고
    • Antifungal resistance of candidal biofilms formed on denture acrylic in vitro
    • Chandra J, Mukherjee PK, Leidich SD, et al. Antifungal resistance of candidal biofilms formed on denture acrylic in vitro. J Dent Res 2001; 80: 903-908.
    • (2001) J. Dent. Res. , vol.80 , pp. 903-908
    • Chandra, J.1    Mukherjee, P.K.2    Leidich, S.D.3
  • 59
    • 0036151240 scopus 로고    scopus 로고
    • Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces
    • Kuhn DM, Chandra J, Mukherjee PK, Ghannoum MA. Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces. Infect Immun 2002; 70: 878-888.
    • (2002) Infect. Immun. , vol.70 , pp. 878-888
    • Kuhn, D.M.1    Chandra, J.2    Mukherjee, P.K.3    Ghannoum, M.A.4
  • 60
    • 0041764578 scopus 로고    scopus 로고
    • Mechanism of fluconazole resistance in Candida albicans biofilms: Phase-specific role of efflux pumps and membrane sterols
    • Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect Immun 2003; 71: 4333-4340.
    • (2003) Infect. Immun. , vol.71 , pp. 4333-4340
    • Mukherjee, P.K.1    Chandra, J.2    Kuhn, D.M.3    Ghannoum, M.A.4
  • 61
    • 0022349044 scopus 로고
    • Candida albicans and a phosphorylated glucomannan-protein fraction of its cell wall induce production of immune interferon by human peripheral blood mononuclear cells
    • Spagnoli GC, Ausiello C, Casalinuovo I, Antonelli G, Dianzani F, Cassone A. Candida albicans and a phosphorylated glucomannan-protein fraction of its cell wall induce production of immune interferon by human peripheral blood mononuclear cells. IRCS Med Sci 1985; 13: 1190-1191.
    • (1985) IRCS Med. Sci. , vol.13 , pp. 1190-1191
    • Spagnoli, G.C.1    Ausiello, C.2    Casalinuovo, I.3    Antonelli, G.4    Dianzani, F.5    Cassone, A.6
  • 62
    • 84907125848 scopus 로고
    • Biochemical and antigenic characterization of mannoprotein constituents released from yeast and mycelial forms of Candida albicans
    • Torosantucci A, Gomez MJ, Bromuro C, Casalinuovo I, Cassone A. Biochemical and antigenic characterization of mannoprotein constituents released from yeast and mycelial forms of Candida albicans. J Med Vet Mycol 1991; 29: 361-372.
    • (1991) J. Med. Vet. Mycol. , vol.29 , pp. 361-372
    • Torosantucci, A.1    Gomez, M.J.2    Bromuro, C.3    Casalinuovo, I.4    Cassone, A.5
  • 63
    • 0036090545 scopus 로고    scopus 로고
    • Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance
    • Angiolella L, Micocci MM, D'Alessio S, Girolamo A, Maras B, Cassone A. Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance. Antimicrob Agents Chemother 2002; 46: 1688-1694.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1688-1694
    • Angiolella, L.1    Micocci, M.M.2    D'Alessio, S.3    Girolamo, A.4    Maras, B.5    Cassone, A.6
  • 64
    • 0033971070 scopus 로고    scopus 로고
    • Influence of fluconazole at subinhibitory concentrations on cell surface hydrophobicity and phagocytosis of Candida albicans
    • Hazen KC, Mandell G, Coleman E, Wu G. Influence of fluconazole at subinhibitory concentrations on cell surface hydrophobicity and phagocytosis of Candida albicans. FEMS Microbiol Lett 2000; 183: 89-94.
    • (2000) FEMS Microbiol. Lett. , vol.183 , pp. 89-94
    • Hazen, K.C.1    Mandell, G.2    Coleman, E.3    Wu, G.4
  • 65
    • 0027515402 scopus 로고
    • The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients
    • Pujol C, Reynes J, Renaud F, et al. The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients. Proc Natl Acad Sci U S A 1993; 90: 9456-9459.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9456-9459
    • Pujol, C.1    Reynes, J.2    Renaud, F.3
  • 67
    • 0032987324 scopus 로고    scopus 로고
    • Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans
    • Perepnikhatka V, Fischer FJ, Niimi M, et al. Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans. J Bacteriol 1999; 181: 4041-4049.
    • (1999) J. Bacteriol. , vol.181 , pp. 4041-4049
    • Perepnikhatka, V.1    Fischer, F.J.2    Niimi, M.3
  • 68
    • 0037378010 scopus 로고    scopus 로고
    • Drug resistance is not directly affected by mating type locus zygosity in Candida albicans
    • Pujol C, Messer SA, Pfaller M, Soll DR. Drug resistance is not directly affected by mating type locus zygosity in Candida albicans. Antimicrob Agents Chemother 2003; 47: 1207-1212.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1207-1212
    • Pujol, C.1    Messer, S.A.2    Pfaller, M.3    Soll, D.R.4
  • 69
    • 0036232109 scopus 로고    scopus 로고
    • Homozygosity at the Candida albicans MTL locus associated with azole resistance
    • Rustad TR, Stevens DA, Pfaller MA, White TC. Homozygosity at the Candida albicans MTL locus associated with azole resistance. Microbiology 2002; 148: 1061-1072.
    • (2002) Microbiology , vol.148 , pp. 1061-1072
    • Rustad, T.R.1    Stevens, D.A.2    Pfaller, M.A.3    White, T.C.4
  • 70
    • 0141594783 scopus 로고    scopus 로고
    • Progress in functional genomics approaches to antifungal drug target discovery
    • De Backer MD, Van Duck P. Progress in functional genomics approaches to antifungal drug target discovery. Trends Microbiol 2003; 11: 470-478.
    • (2003) Trends Microbiol. , vol.11 , pp. 470-478
    • De Backer, M.D.1    Van Duck, P.2
  • 71
    • 0141924879 scopus 로고    scopus 로고
    • Cyclic AMP signaling pathway modulates susceptibility of Candida species and Saccharomyces cerevisiae to anti-fungal azoles and other sterol biosynthesis inhibitors
    • Jain P, Akula I, Edlind I. Cyclic AMP signaling pathway modulates susceptibility of Candida species and Saccharomyces cerevisiae to anti-fungal azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother 2003; 47: 3195-3201.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 3195-3201
    • Jain, P.1    Akula, I.2    Edlind, I.3
  • 72
    • 0037083792 scopus 로고    scopus 로고
    • Calcineurin is essential for survival during membrane stress in Candida albicans
    • Cruz MC, Goldstein AL, Blankenship JR. et al. Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J 2002; 21: 546-559.
    • (2002) EMBO J. , vol.21 , pp. 546-559
    • Cruz, M.C.1    Goldstein, A.L.2    Blankenship, J.R.3
  • 73
    • 0345489076 scopus 로고    scopus 로고
    • Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei
    • Onyewu C, Blankenship JR, Del Poeta M, Heitman J. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrob Agents Chemother 2003; 47: 956-964.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 956-964
    • Onyewu, C.1    Blankenship, J.R.2    Del Poeta, M.3    Heitman, J.4
  • 74
    • 0037659374 scopus 로고    scopus 로고
    • Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes
    • Marchetti O, Moreillon P, Entenza JM, et al. Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes. Antimicrob Agents Chemother 2003; 47: 1565-1570.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1565-1570
    • Marchetti, O.1    Moreillon, P.2    Entenza, J.M.3
  • 75
    • 0027980317 scopus 로고
    • Combined effect of fluconazole and thymosin alpha 1 on systemic candidiasis in mice immuno-suppressed by morphine treatments
    • Di Francesco P, Gaziano R, Casalinuovo IA, et al. Combined effect of fluconazole and thymosin alpha 1 on systemic candidiasis in mice immuno-suppressed by morphine treatments. Clin Exp Immunol 1994; 97: 347-352.
    • (1994) Clin. Exp. Immunol. , vol.97 , pp. 347-352
    • Di Francesco, P.1    Gaziano, R.2    Casalinuovo, I.A.3
  • 76
    • 0036266003 scopus 로고    scopus 로고
    • In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance
    • Bachmann SP, Patterson TF, Lopez-Ribot JL. In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance. J Clin Microbiol 2002; 40: 2228-2230.
    • (2002) J. Clin. Microbiol. , vol.40 , pp. 2228-2230
    • Bachmann, S.P.1    Patterson, T.F.2    Lopez-Ribot, J.L.3
  • 78
    • 0032882718 scopus 로고    scopus 로고
    • Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
    • Ghannoum MA, Rice LB. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev 1999; 12: 501-517.
    • (1999) Clin. Microbiol. Rev. , vol.12 , pp. 501-517
    • Ghannoum, M.A.1    Rice, L.B.2
  • 79
    • 0036828026 scopus 로고    scopus 로고
    • Antifungal resistance in pathogenic fungi
    • Perea S, Patterson TF. Antifungal resistance in pathogenic fungi. Clin Infect Dis 2002; 35: 1073-1080.
    • (2002) Clin. Infect. Dis. , vol.35 , pp. 1073-1080
    • Perea, S.1    Patterson, T.F.2
  • 80
    • 0036858135 scopus 로고    scopus 로고
    • Clinical relevance of mechanisms of antifungal drug resistance in yeasts
    • Sanglard D. Clinical relevance of mechanisms of antifungal drug resistance in yeasts. Enferm Infecc Microbiol Clin 2002; 20: 462-469.
    • (2002) Enferm. Infecc. Microbiol. Clin. , vol.20 , pp. 462-469
    • Sanglard, D.1
  • 82
    • 0036488166 scopus 로고    scopus 로고
    • Resistance of Candida species to antifungal agents: Molecular mechanisms and clinical consequences
    • Sanglard D, Odds FC. Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences. Lancet Infect Dis 2002; 2: 73-85.
    • (2002) Lancet Infect. Dis. , vol.2 , pp. 73-85
    • Sanglard, D.1    Odds, F.C.2


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