메뉴 건너뛰기




Volumn 149, Issue 2, 1997, Pages 141-149

Molecular mechanisms of azole resistance in fungi

Author keywords

Azole antifungal; Demethylase inhibitor fungicide; Multi drug resistance; P450; Resistance

Indexed keywords

CYTOCHROME P450; DEMETHYLASE; ENZYME; ENZYME INHIBITOR; PYRROLE; STEROL; UNCLASSIFIED DRUG;

EID: 0030998109     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00043-8     Document Type: Review
Times cited : (148)

References (33)
  • 1
    • 0023687573 scopus 로고
    • Cytochrome P-450 of fungi: Primary target for azole antifungal agents
    • (McGinnis, M.R., Ed.) Springer-Verlag, New York
    • Yoshida, Y. (1988) Cytochrome P-450 of fungi: Primary target for azole antifungal agents. In: Current Topics in Mycology, Vol. 2 (McGinnis, M.R., Ed.) pp. 388-418. Springer-Verlag, New York.
    • (1988) In: Current Topics in Mycology , vol.2 , pp. 388-418
    • Yoshida, Y.1
  • 2
    • 0023134858 scopus 로고
    • 14dm purified from Saccharomyces cerevisiae microsomes
    • 14dm purified from Saccharomyces cerevisiae microsomes. Biochem. Pharmacol. 36, 229-235.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 229-235
    • Yoshida, Y.1    Aoyama, Y.2
  • 3
    • 0024441201 scopus 로고
    • Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P45014DM (lanosterol 14α-demethylase) from yeast. Evidence confirming the intermediate step of lanosterol 14α-demethylation
    • Aoyama, Y., Yoshida, Y., Sonado, Y. and Sato, Y. (1989) Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P45014DM (lanosterol 14α-demethylase) from yeast. Evidence confirming the intermediate step of lanosterol 14α-demethylation. J. Biol. Chem. 264, 18502-18505.
    • (1989) J. Biol. Chem. , vol.264 , pp. 18502-18505
    • Aoyama, Y.1    Yoshida, Y.2    Sonado, Y.3    Sato, Y.4
  • 4
    • 0020488323 scopus 로고
    • II phase promoting ability of sterols
    • II phase promoting ability of sterols. FEBS Lett. 143, 133-136.
    • (1982) FEBS Lett. , vol.143 , pp. 133-136
    • Gallay, J.1    De Kruijff, B.2
  • 6
    • 0027205567 scopus 로고
    • The structural requirements of sterols for membrane function in Saccharomyces cerevisiae
    • Nes, D.W., Janssen, G.G., Cromley, F.G., Kalinowska, M. and Akihisa, T. (1993) The structural requirements of sterols for membrane function in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 300, 724-733.
    • (1993) Arch. Biochem. Biophys. , vol.300 , pp. 724-733
    • Nes, D.W.1    Janssen, G.G.2    Cromley, F.G.3    Kalinowska, M.4    Akihisa, T.5
  • 7
    • 84907135003 scopus 로고
    • Isolation and analysis of ketoconazole resistant mutants of Saccharomyces cerevisiae
    • Watson, P.F., Rose, M.E. and Kelly, S.L. (1988) Isolation and analysis of ketoconazole resistant mutants of Saccharomyces cerevisiae. J. Med. Vet. Mycol. 26, 153-162.
    • (1988) J. Med. Vet. Mycol. , vol.26 , pp. 153-162
    • Watson, P.F.1    Rose, M.E.2    Kelly, S.L.3
  • 8
    • 0028985926 scopus 로고
    • Defective sterol Δ5(6)desaturase as a cause of azole resistance in Ustilago maydis
    • Joseph-Horne, T., Manning, N., Hollomon, D. and Kelly, S.L. (1995) Defective sterol Δ5(6)desaturase as a cause of azole resistance in Ustilago maydis. FEMS Microbiol. Lett. 127, 29-34.
    • (1995) FEMS Microbiol. Lett. , vol.127 , pp. 29-34
    • Joseph-Horne, T.1    Manning, N.2    Hollomon, D.3    Kelly, S.L.4
  • 9
    • 0020583026 scopus 로고
    • Requirement for a second sterol biosynthetic mutation for viability of a sterol C-14 demethylation defect in Saccharomyces cerevisiae
    • Taylor, F.R., Rodreguez, R.J. and Parks, L.W. (1983) Requirement for a second sterol biosynthetic mutation for viability of a sterol C-14 demethylation defect in Saccharomyces cerevisiae. J. Bacteriol. 155, 64-68.
    • (1983) J. Bacteriol. , vol.155 , pp. 64-68
    • Taylor, F.R.1    Rodreguez, R.J.2    Parks, L.W.3
  • 10
    • 0023498489 scopus 로고
    • Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiae
    • Kalb, V.F., Woods, C.W., Turi, T.G., Dey, C.R., Sutter, T.R. and Loper, J.C. (1987) Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiae. DNA 6, 549-556.
    • (1987) DNA , vol.6 , pp. 549-556
    • Kalb, V.F.1    Woods, C.W.2    Turi, T.G.3    Dey, C.R.4    Sutter, T.R.5    Loper, J.C.6
  • 11
    • 0023808897 scopus 로고
    • Isolation of the gene for cytochrome P450 L1A1 (lanosterol 14αdemethylase) from Candida albicans
    • Kirsch, D.R., Lai, M.H. and O'Sullivan, J. (1988) Isolation of the gene for cytochrome P450 L1A1 (lanosterol 14αdemethylase) from Candida albicans. Gene 68, 229-237.
    • (1988) Gene , vol.68 , pp. 229-237
    • Kirsch, D.R.1    Lai, M.H.2    O'Sullivan, J.3
  • 12
    • 0024114790 scopus 로고
    • Primary structure of the cytochrome P450 lanosterol 14αdemethylase gene from Candida albicans
    • Chen, C., Kalb, V.F., Turi, T.G. and Loper, J.C. (1988) Primary structure of the cytochrome P450 lanosterol 14αdemethylase gene from Candida albicans. DNA 7, 617-626.
    • (1988) DNA , vol.7 , pp. 617-626
    • Chen, C.1    Kalb, V.F.2    Turi, T.G.3    Loper, J.C.4
  • 13
    • 0029896322 scopus 로고    scopus 로고
    • Isolation of an Ustilago maydis ERG 11 gene and its expression in a mutant deficient in sterol 14αdemethylase activity
    • Hargreaves, J.A. and Keon, J.P.R. (1996) Isolation of an Ustilago maydis ERG 11 gene and its expression in a mutant deficient in sterol 14αdemethylase activity. FEMS Microbiol. Lett. 139, 203-207.
    • (1996) FEMS Microbiol. Lett. , vol.139 , pp. 203-207
    • Hargreaves, J.A.1    Keon, J.P.R.2
  • 14
    • 0029882092 scopus 로고    scopus 로고
    • Isolation and molecular characterisation of the gene encoding eburicol 14αdemethylase (CYP51) from Penicillium italicum
    • Nistelrooy, J.G.M., van der Brink, J.M., van Kan, J.A.L., van Gorcom, R.F.M. and de Waard, M.A. (1996) Isolation and molecular characterisation of the gene encoding eburicol 14αdemethylase (CYP51) from Penicillium italicum. Mol. Gen. Genet. 250, 725-733.
    • (1996) Mol. Gen. Genet. , vol.250 , pp. 725-733
    • Nistelrooy, J.G.M.1    Van Der Brink, J.M.2    Van Kan, J.A.L.3    Van Gorcom, R.F.M.4    De Waard, M.A.5
  • 15
    • 0027937190 scopus 로고
    • Modelling cytochrome P450 14αdemethylase (Candida albicans) from P450cam
    • Boscott, P.E. and Grant, G.H. (1994) Modelling cytochrome P450 14αdemethylase (Candida albicans) from P450cam. J. Mol. Graph. 12, 185-193.
    • (1994) J. Mol. Graph. , vol.12 , pp. 185-193
    • Boscott, P.E.1    Grant, G.H.2
  • 16
    • 0343520738 scopus 로고
    • Structural and molecular properties of Candida albicans cytochrome P450 sterol 14α-demethylase
    • (Dixon, G.K., Copping, L.G. and Hollomon, D.W., Eds.), Bios Scientific, Oxford
    • Lamb, D.C., Boscott, P., Richards, W.G., Baldwin, B.C., Kelly, D.E. and Kelly, S.L. (1995) Structural and molecular properties of Candida albicans cytochrome P450 sterol 14α-demethylase. In: Antifungal Agents: Discovery and Mode of Action (Dixon, G.K., Copping, L.G. and Hollomon, D.W., Eds.), pp. 271-274, Bios Scientific, Oxford.
    • (1995) In: Antifungal Agents: Discovery and Mode of Action , pp. 271-274
    • Lamb, D.C.1    Boscott, P.2    Richards, W.G.3    Baldwin, B.C.4    Kelly, D.E.5    Kelly, S.L.6
  • 18
    • 84907127080 scopus 로고
    • Genetic and physiological analysis of azole sensitivity in Saccharomyces cerevisiae
    • Kenna, S., Bligh, H.F.J., Watson, P.F. and Kelly, S.L. (1989) Genetic and physiological analysis of azole sensitivity in Saccharomyces cerevisiae. J. Med. Vet. Mycol. 27, 397-406.
    • (1989) J. Med. Vet. Mycol. , vol.27 , pp. 397-406
    • Kenna, S.1    Bligh, H.F.J.2    Watson, P.F.3    Kelly, S.L.4
  • 19
    • 0023656001 scopus 로고
    • Characterisation of a cytochrome P450 deficient mutant of Candida albicans
    • Bard, M., Lees, N.D., Barbuch, R.J. and Sanglard, D. (1987) Characterisation of a cytochrome P450 deficient mutant of Candida albicans. Biochem. Biophys. Res. Commun. 147, 794-800.
    • (1987) Biochem. Biophys. Res. Commun. , vol.147 , pp. 794-800
    • Bard, M.1    Lees, N.D.2    Barbuch, R.J.3    Sanglard, D.4
  • 20
    • 0020455412 scopus 로고
    • A sterol C-14 demethylation deficient mutant of Ustilago maydis: Characteristics and sensitivity to inhibitors of ergosterol biosynthesis
    • Walsh, R.C. and Sisler, H.D. (1982) A sterol C-14 demethylation deficient mutant of Ustilago maydis: characteristics and sensitivity to inhibitors of ergosterol biosynthesis. Pestic. Biochem. Physiol. 18, 122-131.
    • (1982) Pestic. Biochem. Physiol. , vol.18 , pp. 122-131
    • Walsh, R.C.1    Sisler, H.D.2
  • 21
    • 0028807725 scopus 로고
    • Altered P450 activity associated with direct selection for fungal azole resistance
    • Joseph-Horne, T., Hollomon, D., Loeffler, R.S.T. and Kelly, S.L. (1995) Altered P450 activity associated with direct selection for fungal azole resistance. FEBS Lett. 374, 174-178.
    • (1995) FEBS Lett. , vol.374 , pp. 174-178
    • Joseph-Horne, T.1    Hollomon, D.2    Loeffler, R.S.T.3    Kelly, S.L.4
  • 22
    • 0343653119 scopus 로고
    • Suitability of an azole resistant mutant of Ustilago maydis for sterol 14αdemethylase complementation studies
    • (Lyr, H., Russell, P.E. and Sisler, H.D., Eds.), Intercept, Andover
    • Butters, J.A. and Hollomon, D.W. (1995) Suitability of an azole resistant mutant of Ustilago maydis for sterol 14αdemethylase complementation studies. In: Modern Fungicides and Antifungal Compounds (Lyr, H., Russell, P.E. and Sisler, H.D., Eds.), pp. 313-318. Intercept, Andover.
    • (1995) In: Modern Fungicides and Antifungal Compounds , pp. 313-318
    • Butters, J.A.1    Hollomon, D.W.2
  • 23
    • 0002358572 scopus 로고    scopus 로고
    • Molecular genetics of resistance in fungi to azole fungicides
    • (Brown, T.M. Ed.), American Chemical Society, Washington, DC
    • De Waard, M.A. (1996) Molecular genetics of resistance in fungi to azole fungicides. In: Molecular Genetics and Evolution of Pesticide Resistance (Brown, T.M. Ed.), pp 62-71. American Chemical Society, Washington, DC.
    • (1996) In: Molecular Genetics and Evolution of Pesticide Resistance , pp. 62-71
    • De Waard, M.A.1
  • 24
    • 0023653283 scopus 로고
    • Isolation of the Candida tropicalis gene for P450 lanosterol demethylase and its expression in Saccharomyces cerevisiae
    • Chen, C., Turi, T.G., Sanglard, D. and Loper, J.C. (1987) Isolation of the Candida tropicalis gene for P450 lanosterol demethylase and its expression in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 146, 1311-1317.
    • (1987) Biochem. Biophys. Res. Commun. , vol.146 , pp. 1311-1317
    • Chen, C.1    Turi, T.G.2    Sanglard, D.3    Loper, J.C.4
  • 25
    • 0030595053 scopus 로고    scopus 로고
    • Increased resistance to 14α-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14αdemethylase (cyp51) and the A. niger cytochrome P450 reductase (cpr A) genes
    • van den Brink, H.J.M., van Nistelrooy, J.G.M., de Waard, M.A., van den Hondel, C.A.M.J.J. and van Gorcom, R.F.M. (1996) Increased resistance to 14α-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14αdemethylase (cyp51) and the A. niger cytochrome P450 reductase (cpr A) genes. J. Biotech. 49, 13-18.
    • (1996) J. Biotech. , vol.49 , pp. 13-18
    • Van Den Brink, H.J.M.1    Van Nistelrooy, J.G.M.2    De Waard, M.A.3    Van Den Hondel, C.A.M.J.J.4    Van Gorcom, R.F.M.5
  • 27
    • 0022999746 scopus 로고
    • Progress in the understanding of multidrug resistance
    • Stark, G. (1986) Progress in the understanding of multidrug resistance. Nature 324, 407-408.
    • (1986) Nature , vol.324 , pp. 407-408
    • Stark, G.1
  • 28
    • 84987057688 scopus 로고
    • Accumulation of SBI fungicides in wild-type and fenarimol-resistant isolates of Penicillium italicum
    • De Waard, M.A. and Van Nistelrooy, J.G.M. (1988) Accumulation of SBI fungicides in wild-type and fenarimol-resistant isolates of Penicillium italicum. Pestic. Sci. 22, 371-382.
    • (1988) Pestic. Sci. , vol.22 , pp. 371-382
    • De Waard, M.A.1    Van Nistelrooy, J.G.M.2
  • 29
    • 0000826173 scopus 로고
    • Characterisation of energy dependent efflux of imazalil and fenarimol in isolates of Penicillium italicum with a low, medium and high degree of resistance to DMI-fungicides
    • Guan, J., Kapteyn, J.C., Kerkenaar, A. and De Waard, M.A. (1992) Characterisation of energy dependent efflux of imazalil and fenarimol in isolates of Penicillium italicum with a low, medium and high degree of resistance to DMI-fungicides. Netherlands J. Plant Pathol. 98, 313-324.
    • (1992) Netherlands J. Plant Pathol. , vol.98 , pp. 313-324
    • Guan, J.1    Kapteyn, J.C.2    Kerkenaar, A.3    De Waard, M.A.4
  • 30
    • 0028082188 scopus 로고
    • PDR5, a novel yeast multidrug resistant conferring transporter controlled by the transcription regulator PDR1
    • Balzi, E., Wang, M., Leterme, S., Van Dyck, L. and Goffeau, A. (1994) PDR5, a novel yeast multidrug resistant conferring transporter controlled by the transcription regulator PDR1. J. Biol. Chem. 269, 2206-2214.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2206-2214
    • Balzi, E.1    Wang, M.2    Leterme, S.3    Van Dyck, L.4    Goffeau, A.5
  • 31
    • 0028928549 scopus 로고
    • Molecular cloning and characterisation of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
    • Prasad, R., De Wergifosse, P., Goffeau, A. and Balzi, E. (1995) Molecular cloning and characterisation of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27, 320-329.
    • (1995) Curr. Genet. , vol.27 , pp. 320-329
    • Prasad, R.1    De Wergifosse, P.2    Goffeau, A.3    Balzi, E.4
  • 33
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard, D., Kuchler, K., Ischer, F., Pagani, J.-L., Monod, M. and Bille, J. (1995) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39, 2378-2386.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.-L.4    Monod, M.5    Bille, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.