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Volumn 9, Issue 2, 2006, Pages 188-194

Netrins guide Drosophila commissural axons at short range

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; NETRIN;

EID: 31544468703     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1625     Document Type: Article
Times cited : (122)

References (50)
  • 1
    • 0035514195 scopus 로고    scopus 로고
    • Dynamic regulation of axon guidance
    • Yu, T.W. & Bargmann, C.I. Dynamic regulation of axon guidance. Nat. Neurosci. 4, 1169-1176 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 1169-1176
    • Yu, T.W.1    Bargmann, C.I.2
  • 2
    • 0037032812 scopus 로고    scopus 로고
    • Molecular mechanisms of axon guidance
    • Dickson, B.J. Molecular mechanisms of axon guidance. Science 298, 1959-1964 (2002).
    • (2002) Science , vol.298 , pp. 1959-1964
    • Dickson, B.J.1
  • 3
    • 0037817750 scopus 로고    scopus 로고
    • Signaling at the growth cone: Ligand-receptor complexes and the control of axon growth and guidance
    • Huber, A.B., Kolodkin, A.L., Ginty, D.D. & Cloutier, J.F. Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annu. Rev. Neurosci. 26, 509-563 (2003).
    • (2003) Annu. Rev. Neurosci. , vol.26 , pp. 509-563
    • Huber, A.B.1    Kolodkin, A.L.2    Ginty, D.D.3    Cloutier, J.F.4
  • 4
    • 0029959555 scopus 로고    scopus 로고
    • The molecular biology of axon guidance
    • Tessier-Lavigne, M. & Goodman, C.S. The molecular biology of axon guidance. Science 274, 1123-1133 (1996).
    • (1996) Science , vol.274 , pp. 1123-1133
    • Tessier-Lavigne, M.1    Goodman, C.S.2
  • 5
    • 0030606264 scopus 로고    scopus 로고
    • Direct and long-range action of a wingless morphogen gradient
    • Zecca, M., Basler, K. & Struhl, G. Direct and long-range action of a wingless morphogen gradient. Cell 87, 833-844 (1996).
    • (1996) Cell , vol.87 , pp. 833-844
    • Zecca, M.1    Basler, K.2    Struhl, G.3
  • 6
    • 0029894568 scopus 로고    scopus 로고
    • Direct and long-range action of a DPP morphogen gradient
    • Nellen, D., Burke, R., Struhl, G. & Basler, K. Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368 (1996).
    • (1996) Cell , vol.85 , pp. 357-368
    • Nellen, D.1    Burke, R.2    Struhl, G.3    Basler, K.4
  • 7
    • 0030663064 scopus 로고    scopus 로고
    • A hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    • Strigini, M. & Cohen, S.M. A hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697-4705 (1997).
    • (1997) Development , vol.124 , pp. 4697-4705
    • Strigini, M.1    Cohen, S.M.2
  • 8
    • 0033639077 scopus 로고    scopus 로고
    • Gradient formation of the TGF-beta homolog Dpp
    • Entchev, E.V., Schwabedissen, A. & Gonzalez-Gaitan, M. Gradient formation of the TGF-beta homolog Dpp. Cell 103, 981-991 (2000).
    • (2000) Cell , vol.103 , pp. 981-991
    • Entchev, E.V.1    Schwabedissen, A.2    Gonzalez-Gaitan, M.3
  • 9
    • 0033636094 scopus 로고    scopus 로고
    • Dpp gradient formation in the Drosophila wing imaginal disc
    • Teleman, A.A. & Cohen, S.M. Dpp gradient formation in the Drosophila wing imaginal disc. Cell 103, 971-980 (2000).
    • (2000) Cell , vol.103 , pp. 971-980
    • Teleman, A.A.1    Cohen, S.M.2
  • 10
    • 0034964445 scopus 로고    scopus 로고
    • A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube
    • Briscoe, J., Chen, Y., Jessell, T.M. & Struhl, G. A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. Mol. Cell 7, 1279-1291 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 1279-1291
    • Briscoe, J.1    Chen, Y.2    Jessell, T.M.3    Struhl, G.4
  • 11
    • 7944220146 scopus 로고    scopus 로고
    • Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo
    • Williams, P.H., Hagemann, A., Gonzalez-Gaitan, M. & Smith, J.C. Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo. Curr. Biol. 14, 1916-1923 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 1916-1923
    • Williams, P.H.1    Hagemann, A.2    Gonzalez-Gaitan, M.3    Smith, J.C.4
  • 12
    • 5444233782 scopus 로고    scopus 로고
    • Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans
    • Belenkaya, T.Y. et al. Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans. Cell 119, 231-244 (2004).
    • (2004) Cell , vol.119 , pp. 231-244
    • Belenkaya, T.Y.1
  • 13
    • 0028138219 scopus 로고
    • The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
    • Serafini, T. et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424 (1994).
    • (1994) Cell , vol.78 , pp. 409-424
    • Serafini, T.1
  • 14
    • 0026481173 scopus 로고
    • UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans
    • Ishii, N., Wadsworth, W.G., Stern, B.D., Culotti, J.G. & Hedgecock, E.M. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873-881 (1992).
    • (1992) Neuron , vol.9 , pp. 873-881
    • Ishii, N.1    Wadsworth, W.G.2    Stern, B.D.3    Culotti, J.G.4    Hedgecock, E.M.5
  • 15
    • 0030220353 scopus 로고    scopus 로고
    • Guidance cues at the Drosophila CNS midline: Identification and characterization of two Drosophila Netrin/UNC-6 homologs
    • Harris, R., Sabatelli, L.M. & Seeger, M.A. Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs. Neuron 17, 217-228 (1996).
    • (1996) Neuron , vol.17 , pp. 217-228
    • Harris, R.1    Sabatelli, L.M.2    Seeger, M.A.3
  • 16
    • 0030220346 scopus 로고    scopus 로고
    • Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
    • Mitchell, K.J. et al. Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron 17, 203-215 (1996).
    • (1996) Neuron , vol.17 , pp. 203-215
    • Mitchell, K.J.1
  • 17
    • 0028061313 scopus 로고
    • Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
    • Kennedy, T.E., Serafini, T., de la Torre, J.R. & Tessier-Lavigne, M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435 (1994).
    • (1994) Cell , vol.78 , pp. 425-435
    • Kennedy, T.E.1    Serafini, T.2    De La Torre, J.R.3    Tessier-Lavigne, M.4
  • 18
    • 0029065329 scopus 로고
    • The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
    • Colamarino, S.A. & Tessier-Lavigne, M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621-629 (1995).
    • (1995) Cell , vol.81 , pp. 621-629
    • Colamarino, S.A.1    Tessier-Lavigne, M.2
  • 19
    • 0033517355 scopus 로고    scopus 로고
    • Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1
    • Hopker, V.H., Shewan, D., Tessier-Lavigne, M., Poo, M. & Holt, C. Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature 401, 69-73 (1999).
    • (1999) Nature , vol.401 , pp. 69-73
    • Hopker, V.H.1    Shewan, D.2    Tessier-Lavigne, M.3    Poo, M.4    Holt, C.5
  • 20
    • 0030592485 scopus 로고    scopus 로고
    • UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
    • Chan, S.S. et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87, 187-195 (1996).
    • (1996) Cell , vol.87 , pp. 187-195
    • Chan, S.S.1
  • 21
    • 0030592522 scopus 로고    scopus 로고
    • Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
    • Keino-Masu, K. et al. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87, 175-185 (1996).
    • (1996) Cell , vol.87 , pp. 175-185
    • Keino-Masu, K.1
  • 22
    • 0030592577 scopus 로고    scopus 로고
    • Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance
    • Kolodziej, P.A. et al. frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87, 197-204 (1996).
    • (1996) Cell , vol.87 , pp. 197-204
    • Kolodziej, P.A.1
  • 23
    • 0035831295 scopus 로고    scopus 로고
    • Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation
    • Stein, E., Zou, Y., Poo, M. & Tessier-Lavigne, M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science 291, 1976-1982 (2001).
    • (2001) Science , vol.291 , pp. 1976-1982
    • Stein, E.1    Zou, Y.2    Poo, M.3    Tessier-Lavigne, M.4
  • 24
    • 0026753387 scopus 로고
    • UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans
    • Leung-Hagesteijn, C. et al. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71, 289-299 (1992).
    • (1992) Cell , vol.71 , pp. 289-299
    • Leung-Hagesteijn, C.1
  • 25
    • 0027163671 scopus 로고
    • Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally
    • Hamelin, M., Zhou, Y., Su, M.W., Scott, I.M. & Culotti, J.G. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364, 327-330 (1993).
    • (1993) Nature , vol.364 , pp. 327-330
    • Hamelin, M.1    Zhou, Y.2    Su, M.W.3    Scott, I.M.4    Culotti, J.G.5
  • 26
    • 0030888324 scopus 로고    scopus 로고
    • Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors
    • Leonardo, E.D. et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833-838 (1997).
    • (1997) Nature , vol.386 , pp. 833-838
    • Leonardo, E.D.1
  • 27
    • 0030964393 scopus 로고    scopus 로고
    • The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein
    • Ackerman, S.L. et al. The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386, 838-842 (1997).
    • (1997) Nature , vol.386 , pp. 838-842
    • Ackerman, S.L.1
  • 28
    • 0035923748 scopus 로고    scopus 로고
    • Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    • Keleman, K. & Dickson, B.J. Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron 32, 605-617 (2001).
    • (2001) Neuron , vol.32 , pp. 605-617
    • Keleman, K.1    Dickson, B.J.2
  • 29
    • 0033603256 scopus 로고    scopus 로고
    • A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion
    • Hong, K. et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927-941 (1999).
    • (1999) Cell , vol.97 , pp. 927-941
    • Hong, K.1
  • 30
    • 0030582772 scopus 로고    scopus 로고
    • Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
    • Serafini, T. et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87, 1001-1014 (1996).
    • (1996) Cell , vol.87 , pp. 1001-1014
    • Serafini, T.1
  • 31
    • 0025332245 scopus 로고
    • The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
    • Hedgecock, E.M., Culotti, J.G. & Hall, D.H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61-85 (1990).
    • (1990) Neuron , vol.4 , pp. 61-85
    • Hedgecock, E.M.1    Culotti, J.G.2    Hall, D.H.3
  • 32
    • 0030062518 scopus 로고    scopus 로고
    • Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
    • Wadsworth, W.G., Bhatt, H. & Hedgecock, E.M. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16, 35-46 (1996).
    • (1996) Neuron , vol.16 , pp. 35-46
    • Wadsworth, W.G.1    Bhatt, H.2    Hedgecock, E.M.3
  • 33
    • 0032524324 scopus 로고    scopus 로고
    • Genetic analysis of the mechanisms controlling target selection: Complementary and combinatorial functions of netrins, semaphorins, and IgCAMs
    • Winberg, M.L., Mitchell, K.J. & Goodman, C.S. Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs. Cell 93, 581-591 (1998).
    • (1998) Cell , vol.93 , pp. 581-591
    • Winberg, M.L.1    Mitchell, K.J.2    Goodman, C.S.3
  • 34
    • 0029670680 scopus 로고    scopus 로고
    • Eagle, a member of the steroid receptor gene superfamily, is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in the Drosophila CNS
    • Higashijima, S., Shishido, E., Matsuzaki, M. & Saigo, K. eagle, a member of the steroid receptor gene superfamily, is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in the Drosophila CNS. Development 122, 527-536 (1996).
    • (1996) Development , vol.122 , pp. 527-536
    • Higashijima, S.1    Shishido, E.2    Matsuzaki, M.3    Saigo, K.4
  • 35
    • 0030609890 scopus 로고    scopus 로고
    • The differentiation of the serotonergic neurons in the Drosophila ventral nerve cord depends on the combined function of the zinc finger proteins Eagle and Huckebein
    • Dittrich, R., Bossing, T., Gould, A.P., Technau, G.M. & Urban, J. The differentiation of the serotonergic neurons in the Drosophila ventral nerve cord depends on the combined function of the zinc finger proteins Eagle and Huckebein. Development 124, 2515-2525 (1997).
    • (1997) Development , vol.124 , pp. 2515-2525
    • Dittrich, R.1    Bossing, T.2    Gould, A.P.3    Technau, G.M.4    Urban, J.5
  • 36
    • 0032707248 scopus 로고    scopus 로고
    • Clonal analysis of Drosophila embryonic neuroblasts: Neural cell types, axon projections and muscle targets
    • Schmid, A., Chiba, A. & Doe, C.Q. Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets. Development 126, 4653-4689 (1999).
    • (1999) Development , vol.126 , pp. 4653-4689
    • Schmid, A.1    Chiba, A.2    Doe, C.Q.3
  • 37
    • 0035823004 scopus 로고    scopus 로고
    • Argosomes: A potential vehicle for the spread of morphogens through epithelia
    • Greco, V., Hannus, M. & Eaton, S. Argosomes: a potential vehicle for the spread of morphogens through epithelia. Cell 106, 633-645 (2001).
    • (2001) Cell , vol.106 , pp. 633-645
    • Greco, V.1    Hannus, M.2    Eaton, S.3
  • 38
    • 18344378499 scopus 로고    scopus 로고
    • Lipoprotein particles are required for Hedgehog and Wingless signalling
    • Panakova, D., Sprang, H., Marois, E., Thiele, C. & Eaton, S. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435, 58-65 (2005).
    • (2005) Nature , vol.435 , pp. 58-65
    • Panakova, D.1    Sprang, H.2    Marois, E.3    Thiele, C.4    Eaton, S.5
  • 39
    • 0037418830 scopus 로고    scopus 로고
    • The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance
    • Charron, F., Stein, E., Jeong, J., McMahon, A.P. & Tessier-Lavigne,, M. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113, 11-23 (2003).
    • (2003) Cell , vol.113 , pp. 11-23
    • Charron, F.1    Stein, E.2    Jeong, J.3    McMahon, A.P.4    Tessier-Lavigne, M.5
  • 40
    • 0033199552 scopus 로고    scopus 로고
    • BMPs as mediators of roof plate repulsion of commissural neurons
    • Augsburger, A., Schuchardt, A., Hoskins, S., Dodd, J. & Butler, S. BMPs as mediators of roof plate repulsion of commissural neurons. Neuron 24, 127-141 (1999).
    • (1999) Neuron , vol.24 , pp. 127-141
    • Augsburger, A.1    Schuchardt, A.2    Hoskins, S.3    Dodd, J.4    Butler, S.5
  • 41
    • 0038242149 scopus 로고    scopus 로고
    • A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons
    • Butler, S.J. & Dodd, J. A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron 38, 389-401 (2003).
    • (2003) Neuron , vol.38 , pp. 389-401
    • Butler, S.J.1    Dodd, J.2
  • 42
    • 17944370144 scopus 로고    scopus 로고
    • C. elegans Slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor
    • Hao, J.C. et al. C. elegans Slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor. Neuron 32, 25-38 (2001).
    • (2001) Neuron , vol.32 , pp. 25-38
    • Hao, J.C.1
  • 43
    • 23644449576 scopus 로고    scopus 로고
    • Centrosome localization determines neuronal polarity
    • de Anda, F.C. et al. Centrosome localization determines neuronal polarity. Nature 436, 704-708 (2005).
    • (2005) Nature , vol.436 , pp. 704-708
    • De Anda, F.C.1
  • 44
    • 0034674713 scopus 로고    scopus 로고
    • Gene targeting by homologous recombination in Drosophila
    • Rong, Y.S. & Golic, K.G. Gene targeting by homologous recombination in Drosophila. Science 288, 2013-2018 (2000).
    • (2000) Science , vol.288 , pp. 2013-2018
    • Rong, Y.S.1    Golic, K.G.2
  • 45
    • 0037097866 scopus 로고    scopus 로고
    • Targeted mutagenesis by homologous recombination in D. melanogaster
    • Rong, Y.S. et al. Targeted mutagenesis by homologous recombination in D. melanogaster. Genes Dev. 16, 1568-1581 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 1568-1581
    • Rong, Y.S.1
  • 46
    • 0028722641 scopus 로고
    • Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos
    • eds. Goldstein, L.S.B. & Fyrberg, E.A. Academic Press, San Diego
    • Patel, N.H. Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos. in Drosophila Melanogaster: Practical Uses in Cell and Molecular Biology (eds. Goldstein, L.S.B. & Fyrberg, E.A.) 445-487 (Academic Press, San Diego, 1994).
    • (1994) Drosophila Melanogaster: Practical Uses in Cell and Molecular Biology , pp. 445-487
    • Patel, N.H.1
  • 47
    • 0027481755 scopus 로고
    • Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline
    • Seeger, M., Tear, G., Ferres-Marco, D. & Goodman, C.S. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10, 409-426 (1993).
    • (1993) Neuron , vol.10 , pp. 409-426
    • Seeger, M.1    Tear, G.2    Ferres-Marco, D.3    Goodman, C.S.4
  • 48
    • 0027232876 scopus 로고
    • Genes that control neuromuscularspecificity in Drosophila
    • Van Vactor, D., Sink, H., Fambrough, D., Tsoo, R. & Goodman, C.S. Genes that control neuromuscularspecificity in Drosophila. Cell 73, 1137-1153 (1993).
    • (1993) Cell , vol.73 , pp. 1137-1153
    • Van Vactor, D.1    Sink, H.2    Fambrough, D.3    Tsoo, R.4    Goodman, C.S.5
  • 49
    • 0026036279 scopus 로고
    • Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster
    • Bopp, D., Bell, L.R., Cline, T.W. & Schedl, P. Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster. Genes Dev. 5, 403-415 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 403-415
    • Bopp, D.1    Bell, L.R.2    Cline, T.W.3    Schedl, P.4
  • 50
    • 0028246732 scopus 로고
    • The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling
    • Bossing, T. & Technau, G.M. The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling. Development 120, 1895-1906 (1994).
    • (1994) Development , vol.120 , pp. 1895-1906
    • Bossing, T.1    Technau, G.M.2


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