C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor

Neuron

Volumn 32, Issue 1, 2001, Pages 25-38

  Hao, Joe ^a   Yu, Timothy ^a   Fujisawa, Kazuko ^b   Culotti, Joseph ^b   Gengyo Ando, Keiko ^c   Mitani, Shohei ^c   Moulder, Gary ^d   Barstead, Robert ^d   Tessier Lavigne, Marc ^a   Bargmann, Cornelia I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; NETRIN; PROTEIN; RECEPTOR; ROUNDABOUT RECEPTOR; SLIT PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CELL MIGRATION; CONTROLLED STUDY; DEVELOPMENT; EMBRYO; EPIDERMIS; INFORMATION; LARVA; MUSCLE; NERVE CELL; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN DEFECT;

EID: 17944370144     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(01)00448-2     Document Type: Article

References (50)

1. Repellent signaling by Slit requires the leucine-rich repeats
2. The genetics of Caenorhabditis elegans
3. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
4. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
5. The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans
6. Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis
7. Retinal ganglion cell axon guidance in the mouse optic chiasm: Expression and function of robos and slits
8. The unc-86 gene product couples cell lineage and cell identity in C. elegans
9. Identification of Caenorhabditis elegans genes required for neuronal differentiation and migration
10. A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division
11. Astray, a zebrafish roundabout homolog required for retinal axon guidance
12. Characterization of mutations induced by ethyl methanesulfonate, UV, and trimethylpsoralen in the nematode Caenorhabditis elegans
13. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans
14. Type IV collagen is detectable in most, but not all, basement membranes of Caenorhabditis elegans and assembles on tissues that do not express it
15. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
16. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
17. Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain
18. The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development
19. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors
20. Slit is the midline repellent for the Robo receptor in Drosophila
21. Neuropilin is a semaphorin III receptor
22. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans
23. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
24. Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain
25. Slit2-mediated chemorepulsion and collapse of developing forebrain axons
26. Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance
27. Expression of the vertebrate Slit gene family and their putative receptors, the Robo genes, in the developing murine kidney
28. Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
29. Crossing the midline: Roles and regulation of Robo receptors
30. Slit: An extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains
31. Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline
32. Change in chemoattractant responsiveness of developing axons at an intermediate target
33. Short-range and long-range guidance by Slit and its Robo receptors: A combinatorial code of Robo receptors controls lateral position
34. Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
35. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
36. Hierarchical organization of guidance receptors: Silencing of netrin attraction by slit through a Robo/DCC receptor complex
37. The embryonic cell lineage of the nematode Caenorhabditis elegans
38. MIG-13 positions migrating cells along the anteroposterior body axis of C. elegans
39. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
40. Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching
41. Wnt signaling system that specifies two patterns of cell migration in C. elegans
42. The structure of the ventral nerve cord of Caenorhabditis elegans
43. The structure of the nervous system of the nematode Caenorhabditis elegans
44. An actin-mediated two-step mechanism is required for ventral enclosure of the C. elegans hypodermis
45. Genetic analysis of the mechanisms controlling target selection: Complementary and combinatorial functions of netrins, semaphorins, and IgCAMs
46. Directional guidance of neuronal migration in the olfactory system by the protein Slit
47. The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
48. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
49. Genes required for axon pathfinding and extension in the C. elegans nerve ring