An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1

EMBO Reports

Volumn 4, Issue 9, 2003, Pages 906-911

  Gerber, Jana ^a   Mühlenhoff, Ulrich ^a   Lill, Roland ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTATHIONINE GAMMA LYASE; FERROUS ION; FRATAXIN; IRON BINDING PROTEIN; IRON SULFUR PROTEIN; MATRIX PROTEIN; MITOCHONDRIAL PROTEIN; NFS1 PROTEIN; PROTEIN ISU1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOGENESIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; FRIEDREICH ATAXIA; FUNGAL STRAIN; GENE CLUSTER; GENE FUNCTION; GENETIC ANALYSIS; IN VIVO STUDY; IRON BINDING CAPACITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; COMPLEX FORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

IRON-BINDING PROTEINS; IRON-SULFUR PROTEINS; PRECIPITIN TESTS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0141623560     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.embor918     Document Type: Article

References (28)

1. Adamec, J., Rusnak, F., Owen, W.G., Naylor, S., Benson, L.M., Gacy, A.M. & Isaya, G. (2000) Iron-dependent self-assembly of recombinant yeast frataxin: implications for Friedreich ataxia. Am. J. Hum. Genet., 67, 549-562.
2. Adinolfi, S., Trifuoggi, M., Politou, A.S., Martin, S. & Pastore, A. (2002) A structural approach to understanding the iron-binding properties of phylogenetically different frataxins. Hum. Mol. Genet., 11, 1865-1877.
3. Agar, J.N., Yuvaniyama, P., Jack, R.F., Cash, V.L., Smith, A.D., Dean, D.R. & Johnson, M.K. (2000) Modular organization and identification of a mononuclear iron-binding site within the NifU protein. J. Biol. Inorg. Chem., 5, 167-177.
4. Babcock, M., De Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M. & Kaplan, J. (1997) Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin. Science, 276, 1709-1712.
5. Cavadini, P., O'Neill, H.A., Benada, O. & Isaya, G. (2002) Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia. Hum. Mol. Genet., 11, 217-227.
6. Chen, O.S., Hemenway, S. & Kaplan, J. (2002) Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis. Proc. Natl Acad. Sci. USA, 99, 12321-12326.
7. Craig, E.A. & Marszalek, J. (2002) A specialized mitochondrial molecular chaperone system: a role in formation of Fe/S centers. Cell. Mol. Life Sci., 59, 1658-1665.
8. Dutkiewicz, R., Schilke, B., Kneiszner, H., Walter, W., Craig, E.A. & Marszalek, J. (2003) Ssq1, a mitochondrial Hsp70 involved in iron-sulfur (Fe/S) center biogenesis: similarities to and differences from its bacterial counterpart. J. Biol. Chem. (in the press ).
9. Foury, F. (1999) Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain. FEBS Lett., 456, 281-284.
10. Foury, F. & Cazzalini, O. (1997) Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria. FEBS Lett., 411, 373-377.
11. Foury, F. & Talibi, D. (2001) Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. J. Biol. Chem., 276, 7762-7768.
12. Frazzon, J. & Dean, D.R. (2003) Formation of iron-sulphur clusters in bacteria - an emerging field in bioinorganic chemistry. Curr. Opin. Chem. Biol., 6, 166-173.
13. Gerber, J. & Lill, R. (2002) Biogenesis of iron-sulfur proteins in eukaryotes: components, mechanism and pathology. Mitochondrion, 2, 71-86.
14. Lange, H., Kispal, G., Kaut, A. & Lill, R. (2000) A mitochondrial ferredoxin is essential for biogenesis of intra- and extra-mitochondrial Fe/S proteins. Proc. Natl Acad. Sci. USA, 97, 1050-1055.
15. Lill, R. & Kispal, G. (2000) Maturation of cellular Fe/S proteins: the essential function of mitochondria. Trends Biochem. Sci., 25, 352-356.
16. Lutz, T., Westermann, B., Neupert, W. & Herrmann, J.M. (2001) The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria. J. Mol. Biol., 307, 815-825.
17. Mühlenhoff, U. & Lill, R. (2000) Biogenesis of iron-sulfur proteins in eukaryotes: a novel task of mitochondria that is inherited from bacteria. Biochim. Biophys. Acta, 1459, 370-382.
18. Mühlenhoff, U., Richhardt, N., Ristow, M., Kispal, G. & Lill, R. (2002a) The yeast frataxin homologue Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum. Mol. Genet., 11, 2025-2036.
19. Mühlenhoff, U., Richhardt, N., Gerber, J. & Lill, R. (2002b) Characterization of iron-sulfur protein assembly in isolated mitochondria: a requirement for ATP, NADH and reduced iron. J. Biol. Chem., 277, 29810-29816.
20. Mühlenhoff, U., Richhardt, N., Gerber, J. & Lill, R. (2003) Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p. EMBO J., in the press.
21. Mumberg, D., Müller, R. & Funk, M. (1995) Yeast vectors for controlled expression of heterologous proteins in different genetic backgrounds. Gene, 156, 119-122.
22. Nuth, M., Yoon, T. & Cowan, J.A. (2002) Iron-sulfur cluster biosynthesis: characterization of iron nucleation sites for assembly of the [2Fe-2S]2+ cluster core in IscU proteins. J. Am. Chem. Soc., 124, 8774-8775.
23. Puccio, H. & Koenig, M. (2002) Friedreich ataxia: a paradigm for mitochondrial diseases. Curr. Opin. Genet. Dev., 12, 272-277.
24. Puccio, H., Simon, D., Cossee, M., Criqui-Filipe, P., Tiziano, F., Melki, J., Hindelang, C., Matyas, R., Rustin, P. & Koenig, M. (2001) Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nature Genet., 27, 181-186.
25. Rötig, A., de Lonlay, P., Chretien, D., Foury, F., Koenig, M., Sidi, D., Munnich, A. & Rustin, P. (1997) Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nature Genet., 17, 215-217.
26. Wilson, R.B. (2003) Frataxin and frataxin deficiency in Friedreich's ataxia. J. Neurol. Sci., 207, 103-105.
27. Wilson, R.B. & Roof, D.M. (1997) Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue. Nature Genet., 16, 352-357.
28. Yoon, T. & Cowan, J.A. (2003) Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in Isu-type proteins. J. Am. Chem. Soc., 125, 6078-6084.