CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: Modulation by FTY720

Journal of Experimental Medicine

Volumn 194, Issue 12, 2001, Pages 1875-1881

  Henning, Golo ^a   Ohl, Lars ^a   Junt, Tobias ^b   Reiterer, Phillip ^c   Brinkmann, Volker ^d   Nakano, Hideki ^e   Hohenberger, Werner ^a   Lipp, Martin ^c   Förster, Reinhold ^a,f  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d NOVARTIS PHARMA AG   (Switzerland)

^e TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

B cell; Chemokine receptor; Lymphocyte migration; Lymphoid organs; T cell

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR7; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PERTUSSIS TOXIN; RANTES; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; IMMUNOHISTOLOGY; IMMUNOMODULATION; LYMPHOCYTE HOMING; LYMPHOCYTE MIGRATION; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VENULE;

ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CHEMOKINES, CC; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROPYLENE GLYCOLS; RECEPTORS, CHEMOKINE; SPHINGOSINE;

EID: 0035905398     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.12.1875     Document Type: Article

References (21)

1. Naive and memory T cells show distinct pathways of lymphocyte recirculation
2. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
3. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
4. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
5. A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4
6. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7
7. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
8. FTY720: A novel transplantation drug that modulates lymphocyte traffic rather than activation
9. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing
10. Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols
11. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory
12. FTY720, a novel immunosuppressant, prolongs rat skin allograft survival by decreasing T-cell infiltration into grafts
13. Donor-derived IP-10 initiates development of acute allograft rejection
14. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
15. Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis
16. Opiate receptor-mediated chemotaxis of human monocytes
17. EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue
18. CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection
19. Human cytomegalovirus latency and reactivation - A delicate balance between the virus and its host's immune system
20. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
21. Skewed maturation of memory HIV-specific CD8 T lymphocytes