13-cis-retinoic acid competitively inhibits 3α-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: A mechanism for its anti-androgenic effects in sebaceous glands?

Biochemical and Biophysical Research Communications

Volumn 303, Issue 1, 2003, Pages 273-278

  Karlsson, Teresa ^a   Vahlquist, Anders ^a   Kedishvili, Natalia ^b   Törmä, Hans ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Acne; Androgen; Enzyme kinetics; Epidermis; Isotretinoin; Retinoic acid; Retinoid; Retinol dehydrogenase; Skin

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; ADAPALENE; ALDEHYDE; ANDROSTANEDIOL; ANDROSTANEDIONE; ANDROSTANOLONE; ANDROSTERONE; DEHYDRORETINOL; ETRETIN; ISOTRETINOIN; RETINOID; RETINOL; RETINOL DEHYDROGENASE; 3(17) HYDROXYSTEROID DEHYDROGENASE; 3(17)-HYDROXYSTEROID DEHYDROGENASE; ALCOHOL DEHYDROGENASE; ANTIANDROGEN; HYDROXYSTEROID DEHYDROGENASE; OXYGEN; RECOMBINANT PROTEIN; RETINOIC ACID; TRANS RETINOL DEHYDROGENASE; TRANS-RETINOL DEHYDROGENASE;

ACNE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LIVER; OXIDATION; PRIORITY JOURNAL; SEBACEOUS GLAND; SEBUM SECRETION; SKIN; ANIMAL; BIOLOGICAL MODEL; CELL LINE; DOSE RESPONSE; DRUG EFFECT; EPIDERMIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSECT; KINETICS; METABOLISM; TIME;

ALCOHOL OXIDOREDUCTASES; ANDROGEN ANTAGONISTS; ANDROSTERONE; ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMIS; HYDROXYSTEROID DEHYDROGENASES; INSECTS; ISOTRETINOIN; KINETICS; MODELS, BIOLOGICAL; OXYGEN; RECOMBINANT PROTEINS; SEBACEOUS GLANDS; SKIN; TIME FACTORS; TRETINOIN;

EID: 0037470858     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00332-2     Document Type: Article

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