메뉴 건너뛰기




Volumn 172, Issue 4 I, 2004, Pages 1399-1403

Dihydrotestosterone and the prostate: The scientific rationale for 5α-reductase inhibitors in the treatment of benign prostatic hyperplasia

Author keywords

Dihydrotestosterone; Finasteride; GG 745; Prostate; Prostatic hyperplasia

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; DUTASTERIDE; FINASTERIDE; PLACEBO; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE;

EID: 4544285381     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000139539.94828.29     Document Type: Article
Times cited : (238)

References (20)
  • 1
    • 0035528888 scopus 로고    scopus 로고
    • The role of 5α-reduction in steroid hormone physiology
    • Wilson, J. D.: The role of 5α-reduction in steroid hormone physiology. Reprod Fertil Dev, 13: 673, 2001
    • (2001) Reprod Fertil Dev , vol.13 , pp. 673
    • Wilson, J.D.1
  • 2
    • 0032588595 scopus 로고    scopus 로고
    • Differences in steroid 5alpha-reductase iso-enzyme expression between normal and pathological human prostate tissue
    • Iehle, C., Radvanyi, F., Gil Diez de Medina, S., Ouafik, L. H., Gerard, H., Chopin, D. et al: Differences in steroid 5alpha-reductase iso-enzyme expression between normal and pathological human prostate tissue. J Steroid Biochem Mol Biol, 68: 189, 1999
    • (1999) J Steroid Biochem Mol Biol , vol.68 , pp. 189
    • Iehle, C.1    Radvanyi, F.2    Gil Diez De Medina, S.3    Ouafik, L.H.4    Gerard, H.5    Chopin, D.6
  • 3
    • 0030816596 scopus 로고    scopus 로고
    • Pharmacological and molecular evidence for the expression of the two steroid 5alpha-reductase isozymes in normal and hyperplastic human prostatic cells in culture
    • Berthaut, I., Mestayer, C., Portois, M. C., Cussenot, O. and Mowszowicz, I.: Pharmacological and molecular evidence for the expression of the two steroid 5 alpha-reductase isozymes in normal and hyperplastic human prostatic cells in culture. Prostate, 32: 155, 1997
    • (1997) Prostate , vol.32 , pp. 155
    • Berthaut, I.1    Mestayer, C.2    Portois, M.C.3    Cussenot, O.4    Mowszowicz, I.5
  • 4
    • 0023680233 scopus 로고
    • Kinetic parameters of 5 alpha-reductase activity in stroma and epithelium of normal, hyperplastic, and carcinomatous human prostates
    • Bruchovsky, N., Rennie, P. S., Batzold, F. H., Goldenberg, S. L., Fletcher, T. and McLoughlin, M. G.: Kinetic parameters of 5 alpha-reductase activity in stroma and epithelium of normal, hyperplastic, and carcinomatous human prostates. J Clin Endocrinol Metab, 67: 806, 1988
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 806
    • Bruchovsky, N.1    Rennie, P.S.2    Batzold, F.H.3    Goldenberg, S.L.4    Fletcher, T.5    McLoughlin, M.G.6
  • 6
    • 0141988845 scopus 로고    scopus 로고
    • 5α-Reductase type 1 immunostaining is enhanced in some prostate cancers compared with benign prostatic hyperplasia epithelium
    • Thomas, L. N., Douglas, R. C., Vessey, J. P., Gupta, R., Fontaine, D., Norman, R. W. et al: 5α-Reductase type 1 immunostaining is enhanced in some prostate cancers compared with benign prostatic hyperplasia epithelium. J Urol, 170: 2019, 2003
    • (2003) J Urol , vol.170 , pp. 2019
    • Thomas, L.N.1    Douglas, R.C.2    Vessey, J.P.3    Gupta, R.4    Fontaine, D.5    Norman, R.W.6
  • 7
    • 0037989860 scopus 로고    scopus 로고
    • The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis
    • Habib, F. K., Ross, M., Bayne, C. W., Bollina, P., Grigor, K. and Chapman, K.: The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis. Clin Cancer Res, 9: 1815, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 1815
    • Habib, F.K.1    Ross, M.2    Bayne, C.W.3    Bollina, P.4    Grigor, K.5    Chapman, K.6
  • 8
    • 0033305674 scopus 로고    scopus 로고
    • Androgen-induced regrowth in the castrated rat ventral prostate: Role of 5alpha-reductase
    • Wright, A. S., Douglas, R. C., Thomas, L. N., Lazier, C. B. and Rittmaster, R. S.: Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase. Endocrinology, 140: 4509, 1999
    • (1999) Endocrinology , vol.140 , pp. 4509
    • Wright, A.S.1    Douglas, R.C.2    Thomas, L.N.3    Lazier, C.B.4    Rittmaster, R.S.5
  • 12
    • 0028907599 scopus 로고
    • Effect of testosterone on bone density and bone metabolism in adolescent male hypogonadism
    • Arisaka, O., Arisaka, M., Nakayama, Y., Fujiwara, S. and Yabuta, K.: Effect of testosterone on bone density and bone metabolism in adolescent male hypogonadism. Metabolism, 44: 419, 1995
    • (1995) Metabolism , vol.44 , pp. 419
    • Arisaka, O.1    Arisaka, M.2    Nakayama, Y.3    Fujiwara, S.4    Yabuta, K.5
  • 13
    • 1442278883 scopus 로고    scopus 로고
    • Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone
    • Amory, J. K., Watts, N. B., Easley, K. A., Sutton, P. R., Anawalt, B. D., Matsumoto, A. M. et al: Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. J Clin Endocrinol Metab, 89: 503, 2004
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 503
    • Amory, J.K.1    Watts, N.B.2    Easley, K.A.3    Sutton, P.R.4    Anawalt, B.D.5    Matsumoto, A.M.6
  • 14
    • 0036754256 scopus 로고    scopus 로고
    • Efficacy and safety of dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia
    • Roehrborn, C. G., Boyle, P., Nickel, J. C., Hoefner, K., Andriole, G. and the ARIA3001 ARIA3002 and ARIA3003 Study Investigators: Efficacy and safety of dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia. Urology, 60: 434, 2002
    • (2002) Urology , vol.60 , pp. 434
    • Roehrborn, C.G.1    Boyle, P.2    Nickel, J.C.3    Hoefner, K.4    Andriole, G.5
  • 15
    • 0006075228 scopus 로고    scopus 로고
    • The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia
    • McConnell, J. D., Bruskewitz, R., Walsh, P., Andriole, G., Lieber, M., Holtgrewe, H. L. et al: The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. N Engl J Med, 338: 557, 1998
    • (1998) N Engl J Med , vol.338 , pp. 557
    • McConnell, J.D.1    Bruskewitz, R.2    Walsh, P.3    Andriole, G.4    Lieber, M.5    Holtgrewe, H.L.6
  • 16
    • 0037213171 scopus 로고    scopus 로고
    • The effect of finasteride on the expression of vascular endothelial growth factor and microvessel density: A possible mechanism for decreased prostatic bleeding in treated patients
    • Pareek, G., Shevchuk, M., Armenakas, N. A., Vasjovic, L., Hochberg, D. A., Basillote, J. B. et al: The effect of finasteride on the expression of vascular endothelial growth factor and microvessel density: a possible mechanism for decreased prostatic bleeding in treated patients. J Urol, 169: 20, 2003
    • (2003) J Urol , vol.169 , pp. 20
    • Pareek, G.1    Shevchuk, M.2    Armenakas, N.A.3    Vasjovic, L.4    Hochberg, D.A.5    Basillote, J.B.6
  • 17
    • 0038311875 scopus 로고    scopus 로고
    • Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia
    • Andriole, G. L. and Kirby, R.: Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia. Eur Urol, 44: 82, 2003
    • (2003) Eur Urol , vol.44 , pp. 82
    • Andriole, G.L.1    Kirby, R.2
  • 18
    • 0032843781 scopus 로고    scopus 로고
    • Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men
    • Overstreet, J. W., Fuh, V. L., Gould, J., Howards, S. S., Lieber, M. M., Hellstrom, W. et al: Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men. J Urol, 162: 1295, 1999
    • (1999) J Urol , vol.162 , pp. 1295
    • Overstreet, J.W.1    Fuh, V.L.2    Gould, J.3    Howards, S.S.4    Lieber, M.M.5    Hellstrom, W.6
  • 19
    • 0036223551 scopus 로고    scopus 로고
    • The long-term effect of specific type II 5α-reductase inhibition with finasteride on bone mineral density in men: Results of a 4-year placebo-controlled trial
    • Matsumoto, A. M., Tenover, L., McClung, M., Mobley, D., Geller, J., Sullivan, M. et al: The long-term effect of specific type II 5α-reductase inhibition with finasteride on bone mineral density in men: results of a 4-year placebo-controlled trial. J Urol, 167: 2105, 2002
    • (2002) J Urol , vol.167 , pp. 2105
    • Matsumoto, A.M.1    Tenover, L.2    McClung, M.3    Mobley, D.4    Geller, J.5    Sullivan, M.6
  • 20
    • 85030823070 scopus 로고    scopus 로고
    • Potent DHT suppression by the novel dual 5α-reductase inhibitor dutasteride does not affect bone density, bone metabolism or lipid profiles in healthy men
    • Madrid, Spain, March 12-15
    • Clark, R. V., Huffman, C. S., Swerdloff, R. S., Wang, C., Matsumoto, A. and Bremner, W.: Potent DHT suppression by the novel dual 5α-reductase inhibitor dutasteride does not affect bone density, bone metabolism or lipid profiles in healthy men. Presented at XVIIIth Congress of European Association of Urology, Madrid, Spain, March 12-15, 2003
    • (2003) XVIIIth Congress of European Association of Urology
    • Clark, R.V.1    Huffman, C.S.2    Swerdloff, R.S.3    Wang, C.4    Matsumoto, A.5    Bremner, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.