Retinoic acid receptors and cancers

Annual Review of Nutrition

Volumn 24, Issue , 2004, Pages 201-221

  Soprano, Dianne Robert ^a   Qin, Pu ^a   Soprano, Kenneth J ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Retinoic acid; Retinoic acid receptors; Retinoids

Indexed keywords

RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA;

CANCER; CARCINOGENESIS; CELL GROWTH; CHROMOSOME TRANSLOCATION; GENE SILENCING; GROWTH INHIBITION; HUMAN; LEUKEMOGENESIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN FUNCTION; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; NEOPLASMS; RECEPTORS, RETINOIC ACID; TRETINOIN;

ANIMALIA;

EID: 3142780491     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.24.012003.132407     Document Type: Review

References (123)

1. Alcalay M, Zangrilli D, Fagioli M, Pandolfi PP, Mencarelli A, et al. 1992. Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 89:4840-44
2. Arapshian A, Kuppumbatti YS, Miray-Lopez R. 2000. Methylation of conserved CpG sites neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells. Oncogene 19:4066-70
3. Arnould C, Philippe C, Bourdon V, Gregoire MJ, Berge R, Jonveaux P. 1999. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. Hum. Mol. Genet. 8:1741-49
4. Avvisati G, Ten Cate JW, Mandelli F. 1990. The coagulopathy in APL: DIC? In Hemostasis and Cancer, ed. L Muszbek, pp. 91-100. Boca Raton, FL: CRC
5. Benedetti L, Levin AA, Scicchitano BM, Grignani F, Allenby G, et al. 1997. Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells. Blood 90:1175-85
6. Bennett JM, Catowsky D, Daniel MT, Flandrin G, Galton DA, et al. 1976. Proposals for the classification of the acute leukaemias. French-American- British (FAB) co-operative group. Br. J. Haematol. 33:451-58
7. 4-like transgene. EMBO J. 13:5570-80
8. Berard J, Laboune F, Mukuma M, Masse S, Kothary R, Bradley WEC. 1996. Lung tumors in mice expressing an antisense RARβ2 transgene. FASEB J. 10:1091-97
9. Borrow J, Goddard AD, Sheer D, Solomon E. 1990. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249:1577-80
10. Bovenzi V, Le NL, Cote S, Sinnett D, Momparler LF, Momparler RL. 1999. DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of 5-aza-2′deoxycytidine. Anticancer Drugs 10:471-76
11. Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, et al. 1997. A PMLRARα transgene initiates marine promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 94: 2551-56
12. Chambon P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J. 10:940-54
13. Chang C-C, Ye BH, Chaganti RSK, Dalla-Favera R. 1996. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA 93:6947-52
14. Chen S-J, Zelent A, Tong J-H, Yu H-Q, Wang Z-Y, et al. 1993. Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. J. Clin. Invest. 91:2260-67
15. Chen Z, Brand NJ, Chen A, Chen S-J, Tong J-H, et al. 1993. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 12:1161-67
16. Chen ZX, Xue YQ, Zhang R, Tao RF, Xia XM, et al. 1991. A clinical and experimental study on all-trans-retinoic acid-treated acute promyelocytic leukemia patients. Blood 78:1413-19
17. Collins SJ. 2002. The role of retinoids and retinoic acid receptors in normal hematopoiesis. Leukemia 16:1896-905
18. Cote S, Momparler RL. 1997. Activation of the retinoic acid receptor beta gene by 5-aza-2′-deoxyctytidine in human DLD-1 colon carcinoma cells. Anticancer Drugs 8:56-61
19. Cote S, Sinnett D, Momparler RL. 1998. Demethylation by 5-aza-2′deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta gene in human colon carcinoma cells. Anticancer Drugs 9:743-50
20. Darwiche N, Scita G, Jones C, Rutberg S, Greenwald E, et al. 1996. Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression. Cancer Res. 56:4942-49
21. de The H, Chomienne C, Lanotte M, Degos L, Dejean A. 1990. The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature 347:558-61
22. Ding W, Li YP, Nobile LM, Grills G, Carrera I, et al. 1998. Leukemic cellular retinoic acid resistance and missense mutations in the PML-RARα fusion gene after relapse of all-trans-retinoic acid and intensive chemotherapy. Blood 92:1172-83
23. Early E, Moore MA, Kakizuka A, Nason-Burchenal K, Martin P, et al. 1996. Transgenic expression of PML/RARalpha impairs myelopoiesis. Proc. Natl. Acad. Sci. USA 93:7900-4
24. Faria TN, Mendelsohn C, Chambon P, Gudas LJ. 1999. The targeted disruption of both allelies of RARβ(2) in F9 cells results in the loss of retinoic acid-associated growth arrest. J. Biol. Chem. 274:26783-88
25. Frankel SR, Eardley A, Heller G, Berman E, Miller WH Jr, et al. 1994. All-trans-retinoic acid for acute promyeloctyic leukemia: results of the New York study. Ann. Intern. Med. 120:278-86
26. Fukutani H, Naoe T, Ohno R, Yoshida H, Miyawaki S, et al. 1995. Isoforms of PML-retinoic acid receptor alpha fused transcripts affect neither clinical features of acute promyelocytic leukemia nor prognosis after treatment with all-trans retinoic acid. The Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia 9:1478-82
27. Gebert JF, Moghal N, Frangioni JV, Sugarbaker DJ, Neel BG. 1991. High frequency of retinoic acid receptor beta abnormalities in human lung cancer. Oncogene 6:1859-68
28. Geisen C, Denk C, Gremm B, Baust C, Karger A, et al. 1997. High-level expression of the retinoic acid receptor beta gene in normal cells of the uterine cervix is regulated by the retinoic acid receptor alpha and is abnormally down-regulated in cervical carcinoma cells. Cancer Res. 57:1460-67
29. Grimwade D. 1999. The pathogenesis of acute promyelocytic leukemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease. Br. J. Haematol. 106:591-613
30. Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ. 1997. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood 89:376-87
31. Gu B-W, Xiong H, Zhou Y, Chen B, Wang L, et al. 2002. Variant-type PML-RARα fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RARα gene and identification of a new clinical subtype resistant to retinoic acid therapy. Proc. Natl. Acad. Sci. USA 99:7640-45
32. Gudas L, Sporn MB, Roberts AB. 1994. Cellular biology and biochemistry of the retinoids. In The Retinoids, ed. MB Sporn, AB Roberts, DS Goodman, pp. 443-520. New York: Raven. 2nd ed.
33. Guidez F, Huang W, Tong J-H, Dubois C, Balitrand N, et al. 1994. Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient. Leukemia 8:312-17
34. Gupta V, Tabak D, Keating A. 2003. Acute promyelocytic leukemia: a case-based review. Hematology 8:105-13
35. Han QX, Allegretto EA, Shao ZM, Kute TE, Ordonez J, et al. 1997. Elevated expression of retinoic acid receptor-alpha (RAR alpha) in estrogen-receptor- positive breast carcinomas as detected by immunohistochemistry. Diagn. Mol. Pathol. 6:42-48
36. Hart SM. 2002. Modulation of nuclear receptor dependent transcription. Biol. Res. 35:295-303
37. Hayashi K, Goodison S, Urquidi V, Tarin D, Lotan R, Tahara E. 2003. Differential effects of retinoic acid on the growth of isogenic metastatic and non-metastatic breast cancer cell lines and their association with distinct expression of retinoic acid receptor beta isoforms 2 and 4. Int. J. Oncol. 22:623-29
38. Hayashi K, Yokozaki H, Goodison S, Oue N, Suzuki T, et al. 2001. Inactivation of retinoic acid receptor beta by promoter CpG hypermethylation in gastric cancer. Differentiation 69:13-21
39. Hayashi K, Yokozaki H, Naka K, Yasui W, Lotan R, Tahara E. 2001. Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines. Jpn. J. Cancer Res. 92:42-50
40. He LZ, Bhaumik M, Tribioli C, Rego EM, Ivins S, et al. 2000. Two critical hits for promyelocytic leukemia. Mol. Cell. 6:1131-41
41. He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, et al. 1998. Distinction interactions of PML-RAR alpha and PLZF-RAR alpha with corepressors determine differential responses to RA in APL. Nat. Genet. 18:126-35
42. He LZ, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, et al. 1997. Acute leukemia with promyelocytic features in PML/RAR alpha transgenic mice. Proc. Natl. Acad. Sci. USA 94:5302-7
43. Hillestad LK. 1957. Acute promyelocytic leukemia. Acta Med. Scand. 159:189-94
44. Hong WK, Itri LM. 1994. Retinoids and human cancer. In The Retinoids, ed. MB Sporn, AB Roberts, DS Goodman, pp. 597-630. New York: Raven. 2nd ed.
45. Huang M, Ye Y, Chen R, Chai J, Lu J, et al. 1988. The use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567-72
46. Imaizumi M, Suzuki H, Yoshinari M, Sato A, Saito T, et al. 1998. Mutations in the E-domain of RARα portion of the PML/RARα chimeric gene may confer clinical resistance to all-trans-retinoic acid in acute promyelocytic leukemia. Blood 92:374-82
47. Jensen K, Shiels C, Freemont PS. 2001. PML protein isoforms and the RBCC/TRIM motif. Oncogene 20:7223-33
48. Jepsen K, Rosenfeld MG. 2002. Biological roles and mechanistic actions of corepressor complexes. J. Cell Sci. 115:689-98
49. Katsetos CD, Stadnicka I, Boyd JC, Ehya H, Zheng S, et al. 1998. Cellular distribution of retinoic acid receptor-α protein in serious adenocarcinomas of ovarian, tubal and peritoneal origin. Am. J. Pathol. 153:469-80
50. Khuri FR, Lotan R, Kemp BL, Lippman SM, Wu H, et al. 2000. Retinoic acid receptor-beta as a prognostic indicator in stage I non-small-cell lung cancer. J. Clin. Oncol. 18:2798-804
51. Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, et al. 2002. UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 99:3806-11
52. Kogan SC, Brown DE, Schultz DB, Truong BT, Lallemand-Breitenbach V, et al. 2001. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptorα chimeric protein (PMLRARα) to block neutrophilic differentiation and initiate acute leukemia. J. Exp. Med. 193:531-43
53. Koken MHM, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz C, et al. 1994. The t(15;17) translocation alters a nuclear body in a retinoic acid reversible fashion. EMBO J. 13:1073-83
54. Klaassen I, Brakenhoff RH, Smeets SJ, Snow GB, Braakhuis BJ. 2001. Expression of retinoic acid receptor gamma correlated with retinoic acid sensitivity and metabolism in head and neck squamous cell carcinoma cell lines. Int. J. Cancer 92:661-65
55. 4 in a unique F9 teratocarcinoma cell system. Submitted
56. Le Q, Dawson MI, Soprano DR, Soprano KJ. 2000. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene 19:1457-65
57. Le Q, Soprano DR, Soprano KJ. 2002. Profiling of retinoid mediated gene expression in synchronized human SCC cells using Atlas™ human cDNA expression arrays. J. Cell. Physiol. 190:345-55
58. Le Beau MM, Bitts S, Davis EM, Kogan SC. 2002. Recurring chromosomal abnormalities in leukemia in PML-RARα transgenic mice parallel human acute promyelocytic leukemia. Blood 99:2985-91
59. Li JY, English MA, Ball HJ, Yeyati PL, Waxman S, Licht JD. 1997. Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein. J. Biol. Chem. 272:22447-55
60. Li M, Song S, Lippman SM, Zhang XK, Liu X, et al. 2002. Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene 21:411-18
61. Li Y, Dawson MI, Agadir A, Lee MO, Jong L, et al. 1998. Regulation of RAR beta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction. Int. J. Cancer 75:88-95
62. Li YP, Andersen J, Zelent A, Rao S, Paietta E, et al. 1997. RARalpha1/ RARalpha2-PML mRNA expression in acute promyelocytic leukemia cells: a molecular and laboratory-clinical correlative study. Blood 90:306-12
63. Lin B, Chen G, Xiao D, Lolluri SK, Cao X, et al. 2000. Orphan receptor COUP-TF is required for induction of retinoic acid receptor β, growth inhibition and apoptosis by retinoic acid in cancer cells. Mol. Cell Biol. 20:957-70
64. Lin RH, Nagy L, Inoue S, Shao W, Miller WH, Evans RM. 1998. Role of the histone deactylase complex in acute promyelocytic leukaemia. Nature 391:811-14
65. Lin RJ, Evans RM. 2000. Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers. Mol. Cell. 5: 821-30
66. Longo L, Pandolfi PP, Biondi A, Rambaldi A, Mencarelli A, et al. 1990. Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias. J. Exp. Med. 172:1571-75
67. Lotan R, Xu XC, Lippman SM, Ro JY, Lee JS, et al. 1995. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. N. Engl. J. Med. 332:1405-10
68. Lotan Y, Xu XC, Shalev M, Lotan R, Williams R, et al. 2000. Differential expression of nuclear retinoid receptors in normal and malignant prostates. J. Clin. Oncol. 18:116-21
69. McGregor F, Wagner E, Felix D, Soutar D, Parkinson K, Harrison PR. 1997. Inappropriate retinoic acid receptor-beta expression in oral dysplasias: correlation with acquisition of the immortal phenotype. Cancer Res. 57:3886-89
70. 3 sensitive relapse acute promyelocytic leukemia. Haematologica 84:963-68
71. Maurer AB, Wichmann C, Gross A, Kunkel H, Heinzel T, et al. 2002. The Stat5-RARα fusion protein represses transcription and differentiation through interaction with a corepressor complex. Blood 99:2647-52
72. Melnick A, Licht JC. 1999. Deconstructing a disease: RAR alpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93:3167-215
73. Miller WH, Warrell RP, Frankel SR, Jakubowski A, Gabrilove JG, et al. 1990. Novel retinoic acid receptor-alpha transcripts in acute promyelocytic leukemia responsive to all-trans-retinoic acid. J. Natl. Cancer Inst. 82:1932-33
74. Moon RC, Mehta RG, Rao KVN. 1994. Retinoids and cancer in experimental animals. In The Retinoids, ed. MB Sporn, AB Roberts, DS Goodman, pp. 573-595. New York: Raven. 2nd ed.
75. Nakayama T, Watanabe M, Yamanaka M, Hirokawa Y, Suzuki H, et al. 2001. The role of epigenetic modifications in retinoic acid receptor beta2 gene expression in human prostrate cancers. Lab. Invest. 81:1049-57
76. Nason-Burchenal K, Dmitrovsky E. 1999. The retinoids: cancer therapy and prevention mechanisms. In Retinoids. The Biochemical and Molecular Basis of Vitamin A and Retinoid Action (Handbook of Experimental Pharmacology), ed. H Nau, W Blaner, vol. 139, pp. 301-22. Berlin: Springer-Verlag
77. Oshita F, Sekiyama A, Suzuki R, Ikehara M, Yamada K, et al. 2003. Detection of occult tumor cells in peripheral blood from patients with small cell lung cancer by promoter methylation and silencing of the retinoic acid receptor-beta. Oncol. Rep. 10:105-8
78. Pandolfi PP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, et al. 1992. Genomic variability and alternative splicing generate multiple PML/RARα transcripts that encode aberrant PML proteins and PML-RARα isoforms in acute promyelocytic leukaemia. EMBO J. 11:1397-407
79. Park DJ, Vuong PT, de Vos S, Douer D, Koeffler HP. (July 31, 2003.) Comparative analysis of genes regulated by PML/RARα and PLZF/RARα in response to retinoic acid using oligonucleotide arrays. Blood 10.1182/blood-2003-02-0412
80. Perez A, Kastner P, Sethi S, Lutz Y, Reibel C, Chambon P. 1993. PML-RAR homodimers: distinct DNA binding proteins and heteromeric interactions with RXR. EMBO J. 12:3171-82
81. Petti MC, Fazi F, Gentile M, Diverio D, DeFabritis P, et al. 2002. Complete remission through blast cell differentiation in PLZF-RARα positive acute promyelocytic leukemia: in vitro and in vivo studies. Blood 100:1065-67
82. Phan VT, Shultz DB, Truong BT, Blake TJ, Brown AL, et al. 2003. Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation. Mol. Cell Biol. 23:4573-85
83. Picard E, Seguin C, Momhoven N, Rochette-Egly C, Siat J, et al. 1999. Expression of retinoid receptor genes and proteins in non-small-cell lung cancer. J. Natl. Cancer Inst. 91:1059-66
84. Pollock JL, Westervelt P, Kurichety AK, Pelicci PG, Grisolano JL, Ley TJ. 1999. A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 96:15103-8
85. Qiu H, Lotan R, Lippman SM, Xu XC. 2000. Lack of correlation between expression of retinoic acid receptor beta and loss of heterozygosity on chromosome band 3p24 in esophageal cancer. Genes Chromosomes Cancer 28:196-202
86. Qiu H, Zhang W, El-Naggar AK, Lippman SM, Lin P, et al. 1999. Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis. Am. J. Pathol. 155:1519-23
87. Reddy BA, Etkin LD, Freemont PS. 1992. A novel zinc finger coiled-coil domain in a family of nuclear proteins. Trends Biochem. Sci. 17:344-45
88. Redner RL, Chen JD, Rush EA, Li H, Pollock SL. 2000. The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties. Blood 95:2683-90
89. Redner RL, Rush EA, Faas S, Rudert WA, Corey ST. 1996. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood 87:882-86
90. Reiter A, Saussele S, Grimwade D, Wiemels JL, Segal MR, et al. 2003. Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia. Genes Chromosomes Cancer 36:175-88
91. Ruthardt M, Testa U, Nervi C, Ferrucci PF, Grignani F, et al. 1997. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signaling. Mol. Cell Biol. 17:4859-69
92. Salomoni P, Pandolfi PP. 2002. The role of PML in tumor suppression. Cell 108:165-70
93. Seewaldt VL, Johnson BS, Parker MB, Collins SJ, Swisshelm K. 1995. Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. Cell Growth Differ. 6:1077-88
94. Sessarego M, Fugazza G, Balleari E, Bruzzone R, Ballestrero A, Patrone F. 1997. High frequency of trisomy 8 in acute promyelocytic leukemia: a fluorescence in situ hybridization study. Cancer Genet. Cytogenet. 97:161-64
95. 4 protein in human breast tumor cells with nuclear and cytoplasmic localization. Proc. Natl. Acad. Sci. USA 96:8651-56
96. Soprano DR, Chen LX, Wu S, Donigan AM, Borghaei RC, Soprano KJ. 1996. Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition. Oncogene 12:577-84
97. Soprano DR, Soprano KJ. 2003. Role of RARs and RXRs in mediating the molecular mechanism of action of Vitamin A. In Molecular Nutrition, ed. J Zempleni, H Daniel, pp 135-49. Cambridge, MA: CABI
98. Sun Y-A, Lee H-Y, Virmani A, Wong J, Mann KK, et al. 2003. Loss of retinoic acid receptor β gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines. Cancer Res. 62:3945-49
99. Sun SY, Wan H, Yue P, Hong WK, Lotan R. 2000. Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition. J. Biol. Chem. 275:17149-53
100. Swisshelm K, Ryan K, Lee X, Tsou HC, Peacocke M, Sager R. 1994. Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ. 5:133-41
101. Takayama N, Kizaki M, Hida T, Kinjo K, Ikeda Y. 2001. Novel mutation in the PML/RARα chimeric gene exhibits dramatically decreased ligand-binding activity and confers acquired resistance to retinoic acid in acute promyelocytic leukemia. Exp. Hematol. 29:864-72
102. Wei L-N. 2003. Retinoid receptors and their coregulators. Annu. Rev. Pharmacol.Toxicol. 43:47-72
103. Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, et al. 1994. Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells. Cell 76:345-56
104. Wells RA, Catzavelos C, Kamel-Reid S. 1997. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Nat. Genet. 17:109-13
105. Westin S, Rosenfeld MG, Glass CK. 2000. Nuclear receptor coactivators. Adv. Pharmacol. 47:89-112
106. Widschwendter M, Berger J, Daxenbichler G, Muller-Holzner E, Widschwendter A, et al. 1997. Loss of retinoic acid receptor β expression in breast cancer and morphologically normal adjacent tissues but not in the normal breast tissue distant from the cancer. Cancer Res. 57:4156-61
107. Widschwendter M, Berger J, Hermann M, Muller HM, Amberger A, et al. 2000. Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. J. Natl. Cancer Inst. 92:826-32
108. Wu Q, Li Y, Liu R, Agadir A, Lee MO, et al. 1997. Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nurr77 and COUP TF and their heterodimerization. EMBO J. 16:1656-69
109. Wu S, Donigan A, Platsoucas CD, Jung W, Soprano DR, Soprano KJ. 1997. All-trans retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G-1. Exp. Cell Res. 232:277-86
110. Wu S, Zhang D, Donigan A, Dawson MI, Soprano DR, Soprano KJ. 1998. Effects of conformationally restricted synthetic retinoids on ovarian tumor cell growth. J Cell. Biochem. 68:378-88
111. Wu S, Zhang D, Zhang ZP, Soprano DR, Soprano KJ. 1998. Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid. Oncogene 17:2839-49
112. Xu XC, Liu X, Tahara E, Lippman SM, Lotan R. 1999. Expression and up-regulation of retinoic acid receptor-beta is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines. Cancer Res. 59:2477-83
113. Xu XC, Ro JY, Lee JS, Shin DM, Hong WK, Lotan R. 1994. Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues. Cancer Res. 54:3580-87
114. Xu XC, Sneige N, Liu X, Nandagiri R, Lee JJ, et al. 1997. Progressive decrease in nuclear retinoic acid receptor beta messenger RNA level during breast carcinogenesis. Cancer Res. 57:4992-96
115. Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, et al. 1997. Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development. J. Natl. Cancer Inst. 89:624-29
116. Xu XC, Wong WY, Goldberg L, Baer SC, Wolf JE, et al. 2001. Progressive decreases in nuclear retinoid receptors during skin squamous carcinogenesis. Cancer Res. 61:4306-10
117. Yang Q, Sakurai T, Yoshimura G, Mori I, Nakamura M, et al. 2001. Hypermethylation does not account for the frequent loss of the retinoic acid receptor beta2 in breast carcinoma. Anticancer Res. 21:1829-33
118. Zelent A, Guidez F, Melnick A, Waxman S, Licht JD. 2001. Translocations of the RARα gene in acute promyelocytic leukemia. Oncogene 20:7186-203
119. Zhang XK, Liu Y, Lee MO, Pfahl M. 1994. A specific defect in the retinoic acid response associated with human lung cancer cell lines. Cancer Res. 54:5663-69
120. Zhou DC, Kim SH, Ding W, Schultz C, Warrell RP, Gallagher RE. 2002. Frequent mutations in the ligand-binding domain of PML-RARα after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deactylase inhibitors in vitro and in vivo. Blood 99:1356-63
121. Zimonjic DB, Pollock JL, Westervelt P, Popescu NC, Ley TJ. 2000. Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. Proc. Natl. Acad. Sci. USA 97: 13306-11
122. Zochbauer-Muller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD. 2001. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res. 61:249-55
123. Zou CP, Youssef EM, Zou CC, Carey TE, Lotan R. 2001. Differential effects of chromosome 3p deletion on the expression of the putative tumor suppressor RAR beta and on retinoid resistance in human squamous carcinoma cells. Oncogene 20:6820-27