Loss of Retinoic Acid Receptor β gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines

Cancer Research

Volumn 62, Issue 14, 2002, Pages 3945-3949

  Suh, Young Ah ^a   Lee, Ho Young ^a   Virmani, Arvind ^b   Wong, Jiemin ^c   Mann, Koren K ^d   Miller, Wilson H ^d   Gazdar, Adi ^b   Kurie, Jonathan M ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; HISTONE H3; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA;

ACETYLATION; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA HISTONE INTERACTION; HUMAN; HUMAN CELL; LUNG CANCER; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFECT; PROTEIN EXPRESSION; RECEPTOR GENE; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ACETYLATION; ANTINEOPLASTIC AGENTS; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; HISTONES; HUMANS; LUNG NEOPLASMS; PROMOTER REGIONS (GENETICS); RECEPTORS, RETINOIC ACID; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0037099516     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. The retinoid receptors
2. The "dark side" of chromatin remodeling: Repressive effects on transcription
3. Increasing the complexity of coacrivation in nuclear receptor signaling
4. Human lung cancer cell lines exhibit resistance to retinoic acid treatment
5. Suppression of retinoic acid receptor β in non-small-cell lung cancer in vivo: Implications for lung cancer development
6. Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancer
7. A specific defect in the retinoic acid response associated with human lung cancer cell lines
8. Promoter methylation and silencing of the retinoic acid receptor-β gene in lung carcinomas
9. DNA methylation, chromatin inheritance, and cancer
10. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
11. NCI-Navy Medical Oncology Branch cell line data base
12. Demethylation by 5-aza-2′-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor β gene in human colon carcinoma cells
13. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
14. Stress pathway activation induces phosphorylation of retinoid X receptor
15. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3
16. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
17. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor
18. SNF2β-BRGI is essential for the viability of F9 murine embryonal carcinoma cells
19. The yeast Ada complex mediated the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors
20. Nuclear receptor coactivators and corepressors
21. The SMRT corepressor is a target of phosphorylation by protein kinase CK2 (casein kinase II)
22. CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box
23. Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization
24. A CBP integrator complex mediated transcriptional activation and AP-1 inhibition by nuclear receptors
25. AIB I. A steroid receptor coactivator amplified in breast and ovarian cancer
26. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
27. DNA methylation is linked to deacetylation of histone H3, but not H4 on the imprinted genes Snrpn and U2afl-rsl
28. Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation
29. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
30. Regulation of chromatin structure by site-sepcific histone H3 methyltransferases