The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties

Blood

Volumn 95, Issue 8, 2000, Pages 2683-2690

  Redner, Robert L ^a   Chen, J Don ^b   Rush, Elizabeth A ^b   Li, Hui ^b   Pollock, Sheri L ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOPHOSMIN; RAC PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ACUTE MYELOBLASTIC LEUKEMIA; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CHROMOSOME TRANSLOCATION 5; CONTROLLED STUDY; GENE FUSION; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

EID: 0034656067     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.8.2683     Document Type: Article

References (49)

1. de The H, Chomienne C, Lanotte M, Degos L, Dejean A. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature. 1990;347:558.
2. Warrell R Jr, de The H, Wang ZY, Degos L. Acute promyelocytic leukemia. N Engl J Med. 1993;329: 177.
3. Evans R. The steroid and thyroid hormone receptor superfamily. Nature. 1988;240:889.
4. Leid M, Kastner P, Lyons R, et al. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell. 1992;68:377.
5. Yu VC, Delsert C, Andersen B, et al. RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 1991;67:1251.
6. Umesono K, Murakami KK, Thompson CC, Evans RM. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell. 1991;65:1255.
7. de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell. 1991;66:675.
8. Kakizuka A, Miller WJ, Umesono K, et al. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor PML. Cell. 1991;66:663.
9. Brown D, Kogan S, Lagasse E, et al. A PML-RARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1997;94:2551.
10. Early E, Moore MA, Kakizuka A, et al. Transgenic expression of PML/RARalpha impairs myelopoiesis. Proc Natl Acad Sci U S A. 1996;93:7900.
11. Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood. 1997;89:376.
12. He LZ, Tribioli C, Rivi R, et al. Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A. 1997; 94:5302.
13. Pandolfi PP, Grignani F, Alcalay M, et al. Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene. 1991;6:1285.
14. Perez A, Kastner P, Setni S, Lutz Y, Reibel C, Chambon P. PMLRAR homodimers: distinct DNA binding properties and heterodimeric interactions with RXR. EMBO J. 1993;12:3171.
15. Lin RJ, Nagy L, Inoue S, Shao WL, Miller WH, Evans RM. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature. 1998;391:811.
16. Grignani F, Dematteis S, Nervi C, et al. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature. 1998;391:815.
17. Guidez F, Ivins S, Zhu J, Soderstrom M, Waxman S, Zelent A. Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to pml-and plzf-rar-alpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia Blood. 1998;91:2634.
18. He LZ, Guidez F, Tribioli C, et al. Distinct interactions of pml-rar-alpha and plzf-rar-alpha with corepressors determine differential responses to ra in apl. Nat Genet. 1998;18:126.
19. Weis K, Rambaud S, Lavau C, et al. Retinoic acid regulates aberrant nudear localization of PML-RARa in acute promyelocytic leukemia cells. Cell. 1994; 76:345.
20. Dyck JA, Gerd GG, Miller WH, Chen JD, Kakizuka A, Evans RM. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell. 1994;76:333.
21. Mu ZM, Chin KV, Lozano G, Liu JH, Chang KS. A growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol. 1994;14:6858.
22. Chen Z, Brand NJ, Chen A, et al. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 1993;12:1161.
23. Licht JD, Chomienne C, Goy A, et al. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood. 1995;85:1083.
24. Chen Z, Guidez F, Rousselot P, et al. PLZF-RARa fusion proteins generated from the variant t(11; 17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent trasactivation of wild-type retinoic acid receptors. Proc Natl Acad Sci U S A. 1994;91:1178.
25. Ruthardt M, Testa U, Nervi C, et al. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling. Mol Cell Biol. 1997;17:4859.
26. Brunel V, Sainty D, Carbuccia N, et al. Unbalanced translocation t(5;17) in an atypical acute promyelocytic leukemia. Genes Chromosomes Cancer. 1995;14:307.
27. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood. 1996;87:882.
28. Redner RL, Corey SJ, Rush EA. Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid. Leukemia. 1997; 11:1014.
29. Ausubel FM, Brent R, Kingston RE, et al. Current Protocols in Molecular Biology. New York, NY: John Wiley & Sons; 1995.
30. de The H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A. Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature. 1990;343:177.
31. Sucov HM, Murakami KK, Evans RM. Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proc Natl Acad Sci U S A. 1990;87:5392.
32. Steinman RA, Huang J, Yaroslavskiy B, Goff JP, Ball ED, Nguyen A. Regulation of p21/waf-1 during myeloid differentiation. Blood. 1998;91:4531.
33. Li H, Chen JD. The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation. J Biol Chem. 1998;273:5948.
34. Umesono K, Giguere V, Glass CK, Rosenfeld MG, Evans RM. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature. 1988;336:262.
35. Zelent A, Krust A, Petkovich M, Kastner P, Chambon P. Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature. 1989;339: 714.
36. Smith WC, Nakshatri H, Leroy P, Rees J, Chambon P. A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. EMBO J. 1991;10:2223.
37. Mendelsohn C, Ruberte E, LeMeur M, Morriss-Kay G, Chambon P. Developmental analysis of the retinoic acid-inducible RAR-beta 2 promoter in transgenic animals. Development. 1991;113: 723.
38. Leroy P, Nakshatri H, Chambon P. Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element. Proc Natl Acad Sci U S A. 1991;88:10, 138.
39. Durand B, Saunders M, Leroy P, Leid M, Chambon P. All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs. Cell. 1992;71:73.
40. Mader S, Chen JY, Chen Z, White J, Chambon P, Gronemeyer H. The patterns of binding of RAR, RXR and TR homo-and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains. EMBO J. 1993;12: 5029.
41. Redner RL, Wang J, Liu JM. Chromatin remodeling and leukmia: new therapeutic paradigms. Blood. 1999;94:417.
42. Li H, Gomes PJ, Chen JD. RAC3, a steroid/ nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc Natl Acad Sci U S A. 1997;94:8479.
43. Park EJ, Schroen DJ, Yang M, Li H, Li L, Chen JD. SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor compressor. Proc Natl Acad Sci U S A. 1999;96:3519.
44. Licht JD, Shaknovitch R, English MA, et al. Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor - a chimera generated in t(11;17)-associated acute promyelocytic leukemia. Oncogene. 1996; 12:323.
45. Rastinejad F, Perlmann T, Evans RM, Sigler PB. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature. 1995;375:203.
46. Liu QR, Chan PK. Formation of nucleophosmin/ B23 oligomers requires both the amino- and the carboxyl-terminal domains of the protein. Eur J Biochem. 1991;200:715.
47. Warrell RP, He LZ, Richon V, Calleja E, Pandolfi PP. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J Natl Cancer Inst. 1998;90: 1621.
48. Nagy L, Kao HY, Chakravarti D, et al. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell. 1997;89:373.
49. Grignani F, Testa U, Rogaia D, et al. Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains. EMBO J. 1996;15:4949.