High-level expression of the retinoic acid receptor β gene in normal cells of the uterine cervix is regulated by the retinoic acid receptor α and is abnormally down-regulated in cervical carcinoma cells

Cancer Research

Volumn 57, Issue 8, 1997, Pages 1460-1467

  Geisen, Caroline ^a   Denk, Claudia ^a   Gremm, Birgit ^b   Baust, Corinna ^a   Karger, Achim ^a   Bollag, Werner ^c   Schwarz, Elisabeth ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR SUBUNIT; RETINOIC ACID RECEPTOR;

ARTICLE; CARCINOGENESIS; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR DOWN REGULATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CARCINOMA;

BLOTTING, NORTHERN; CERVIX UTERI; DOWN-REGULATION; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; HYBRID CELLS; KERATINOCYTES; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; UTERINE CERVICAL NEOPLASMS;

EID: 0030902017     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Gudas, L. J., Sporn, M. B., and Roberts, A. B. Cellular biology and biochemistry of the retinoids. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), The Retinoids: Biology, Chemistry and Medicine, pp. 443-520. New York: Raven Press, 1994.
2. Hofmann, C., and Eichele, G. Retinoids in development. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), The Retinoids: Biology, Chemistry and Medicine, 2nd Ed., pp. 387-442. New York: Raven Press, 1994.
3. Bollag, W., Apfel, C., and LeMotte, P. Retinoids: achievements, prospectives and future goals. In: S. Waxman (ed.), Differentiation Therapy, Challenges of Modern Medicine, Vol. 10, pp. 285-302. Rome: Ares-Serono Symposia Publications, 1995.
4. Bollag, W., Isnardi, L., Jablonska, S., Klaus, M., Majewski, S., Pirson, W., and Toma, S. Links between pharmacological properties of retinoids and nuclear retinoid receptors. Int. J. Cancer, 70: 470-472, 1997.
5. Bollag, W. Retinoids and Interferon α in the prevention and treatment of preneoplastic and neoplastic diseases: a review. Retinoids, Today and Tomorrow, 40: 26-31, 1995.
6. Hong, W. K., and Itri, L. M. Retinoids and human cancer. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), The Retinoids: Biology, Chemistry and Medicine, pp. 597-630. New York: Raven Press, 1994.
7. Leid, M., Kastner, P., and Chambon, P. Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem. Sci., 17: 427-433, 1992.
8. Chambon, P. The retinoid signaling pathway: molecular and genetic analyses. Semin. Cell Biol., 5: 115-125, 1994.
9. Mangelsdorf, D. J., Umesono, K., and Evans, R. M. The retinoid receptors. In: M. B. Sporn, A. B., Roberts, and D. S. Goodman (eds.), The Retinoid Receptors: Biology, Chemistry, and Medicine, pp. 319-349. New York: Raven Press, 1994.
10. Evans, R. M. The steroid and thyroid hormone receptor superfamily. Science (Washington DC), 240: 889-895, 1988.
11. Green, S., and Chambon, P. Nuclear receptors enhance our understanding of transcription regulation. Trends Genet., 4: 309-314, 1988.
12. Perlmann, T., and Vennström, B. The sound of silence. Nature (Lond.), 377: 387-388, 1995.
13. Heyman, R. A., Mangelsdorf, D., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., and Thaller, C. 9-cis-retinoic acid is a high-affinity ligand for the retinoic X receptor. Cell, 68: 397-406, 1992.
14. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberger, M., Lovey, A., and Grippo, J. F. 9-cis-retinoic acid stereoisomer binds and activates the nuclear receptor RXR-α. Nature (Lond.), 355: 359-361, 1992.
15. de Thé, H., Marchio, A., Tiollais, P., and Dejean, A. Differential expression and ligand regulation of the retinoic acid receptor α and β genes. EMBO J., 8: 429-433, 1989.
16. de Thé, H., Vivanco Ruiz, M. D. M., Tiollais, P., Stunnenberg, H., and Dejean, A. Identification of a retinoic responsive element in the retinoic acid receptor β gene. Nature (Lond.), 343: 177-180, 1990.
17. Hoffmann, B., Lehmann, J. M., Zhang, X-K., Hermann, T., Husmann, M., Graupner, G., and Pfahl, M. A retinoic acid receptor-specific element controls the retinoic acid receptor-β promoter. Mol. Endocrinol., 4: 1727-1736, 1990.
18. Sucov, H. M., Murakami, K. K., and Evans, R. M. Characterisation of an autoregulated response element in the mouse retinoic acid receptor β gene. Proc. Natl. Acad. Sci. USA, 87: 5392-5396, 1990.
19. Dejean, A., Bougueleret, L., Grzeschik, K-H., and Tiollais, P. Hepatitis B virus DNA integration in a sequence homologous to c-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature (Lond.), 322: 70-72, 1986.
20. Gebert, J. F., Moghal, N., Frangioni, J. V., Sugarbaker, D. J., and Neel, B. G. High frequency of retinoic acid receptor β abnormalities in human lung cancer. Oncogene, 6: 1859-1868, 1991.
21. Houle, B., Leduc, F., and Bradley, W. E. C. Implications of the RARβ in epidermoid (squamous) lung cancer. Genes Chromosomes Cancer, 3: 358-366, 1991.
22. Nervi, C., Vollberg, T. M., George, M. D., Zelent, A., Chambon, P., and Jetten, A. M. Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells. Exp. Cell Res., 195: 163-170, 1991.
23. Zhang, X-K., Liu, Y., Lee, M-O., and Pfahl, M. A specific defect in the retinoic acid response associated with human lung cancer cell lines. Cancer Res., 54: 5663-5669, 1994.
24. Caliaro, M. J., Marmouget, C., Guichard, S., Mazars, P., Valette, A., Moisand, A., Bugat R., and Jozan, S. Response of four ovarian carcinoma cell lines to all-trans retinoic acid: relationship with induction of differentiation and retinoic acid receptor expression. Int. J. Cancer, 56: 743-748, 1994.
25. Hu, L., Crowe, D. L., Rheinwald, J. G., Chambon, P., and Gudas, L. J. Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines. Cancer Res., 57: 3972-3981, 1991.
26. Swisshelm, K., Ryan, K., Lee, X., Tsou, H. C., Peacocke, M., and Sager, R. Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth & Differ., 5: 133-141, 1994.
27. Xu, X-C., Ro, J. Y., Lee, J. S., Shin, D. M., Hong, W. K., and Lotan, R. Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues. Cancer Res., 54: 3580-3587, 1994.
28. Lotan, R., Xu, X-C., Lippman, S. M., Ro, J. Y., Lee, J. S., Lee, J. J., and Hong, W. K. Suppression of retinoic acid receptor-β in premalignant oral lesions and its up-regulation by isotretinoin. N. Engl. J. Med., 332: 1405-1410, 1995.
29. Houle, B., Rochette-Egly, C., and Bradley, W. E. C. Tumor-suppressive effect of the retinoic acid receptor β in human epidermoid lung cancer cells. Proc. Natl. Acad. Sci. USA, 90: 985-989, 1993.
30. Bartsch, D., Boye, B., Baust, C., zur Hausen, H., and Schwarz, E. Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor β gene in non-tumorigenic and tumorigenic HeLa hybrid cells. EMBO J., 11: 2283-2291, 1992.
31. Baust, C., Redpath, L., and Schwarz, E. Different ligand responsiveness of human retinoic acid receptor β gene transcription in tumorigenic and non tumorigenic cervical carcinoma-derived cell lines is mediated through a large retinoic acid response domain. Int. J. Cancer, 67: 409-416, 1996.
32. Stanbridge, E. J., Der, C. J., Doersen, C-J., Nishimi, R. Y., Peehl, D. M., Weissman, B. E., and Wilkinson, J. E. Human cell hybrids: analysis of transformation and tumorigenicity. Science (Washington DC), 275: 252-259, 1982.
33. Stanley, M. A., Browne, H. M., Appleby, M., and Minson, A. C. Properties of a non-tumorigenic human cervical keratinocyte cell line. Int. J. Cancer, 43: 672-676, 1989.
34. Wu, Y. J., Parker, L. M., Binder, N. E., Beckett, M. A., Sinard, J. H., Griffiths, C. T., and Rheinwald, J. G. The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell, 31: 693-703, 1982.
35. Geisen, C., Delius, H., Lichter, P., and Kahn, T. A transcribed human sequence related to the mouse HCl and the human papillomavirus type 18 E5 genes is located at chromosome 7pl3-14. Hum. Mol. Genet., 4: 1337-1345, 1995.
36. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
37. Chen, C., and Okayama, H. High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7: 2745-2752, 1987.
38. Franke, W. W., Moll, R., Achtstaetter, T., and Kuhn, C. Cell typing of epithelia and carcinomas of the female genital tract using cytoskeletal proteins as markers. In: R. Peto and H. zur Hausen (eds.), Viral Etiology of Cervical Cancer, Banbury Report, pp. 121-148. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1986.
39. Schutt, A., Rosenberger, M., Lovey, A., Apfel, C., and Hsu, M-C. Receptor specificity in the antiproliferative response of breast carcinoma cell lines to retinoids. Proc. Am. Assoc. Cancer Res., 37: 225, 1996.
40. Apfel C., Bauer, F., Crettaz, M., Form, L., Kamber, M., Kaufmann, F., LeMotte, P., Pirson, W., and Klaus, M. A retinoic acid receptor α antagonist selectively counter-acts retinoic acid effects. Proc. Natl. Acad. Sci. USA, 89: 7129-7133, 1992.
41. Liu, Y., Lee, M-O., Wang, H-G., Li, Y., Hashimoto, Y., Klaus, M., Reed, J. C., and Zhang, X-K. Retinoic acid receptor β mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol. Cell. Biol., 16: 1138-1149, 1996.
42. Frangioni, J. V., Moghal, N., Stuart-Tilley, A., Neel, B. G., and Alper, S. L. The DNA binding domain of retinoic acid receptor β is required for ligand-dependent suppression of proliferation. J. Cell Sci., 107: 827-838, 1994.
43. Lee, X., Si, S. P., Tsou, H. C., and Peacocke, M. Cellular aging and transformation suppression: a role for retinoic acid receptor β2. Exp. Cell Res., 275: 296-304, 1995.
44. Chiba, H., Muramatsu, M., Nomoto, A., and Kato, H. Two homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. Nucleic Acids Res., 22: 1815-1820, 1994.
45. Le Douarin, B., Zechel, C., Garnier, J-M., Lutz, Y., Tora, L., Pierrat, B., Heery, D., Gronemeyer, H., Chambon, P., and Losson, R. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18, EMBO J., 14: 2020-2033, 1995.
46. vom Baur, E., Zechel, C., Heery, D., Heine, M. J. S., Garnier, J. M., Vivat, V., Le Douarin, B., Gronemeyer, H., Chambon, P., and Losson, R. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1 EMBO J., 15: 110-124, 1996.