The role of epigenetic modifications in retinoic acid receptor β2 gene expression in human prostate cancers

Laboratory Investigation

Volumn 81, Issue 7, 2001, Pages 1049-1057

  Nakayama, Tsuyoshi ^a   Watanabe, Masatoshi ^a   Yamanaka, Mikio ^a   Hirokawa, Yoshifumi ^a   Suzuki, Hiroyoshi ^b   Ito, Haruo ^b   Yatani, Ryuichi ^a   Shiraishi, Taizo ^a  

^a MIE UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; HISTONE H4; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHROMOSOME 3P; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR SUPPRESSOR GENE;

EID: 0034932724     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780316     Document Type: Article

References (37)

1. Methylation of conserved CpG sites neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells
2. Different ligand responsiveness of human retinoic-acid-receptor beta-gene transcription in tumorigenic and non-tumorigenic cervical-carcinoma-derived cell lines is mediated through a large retinoic-acid-response domain
3. Methylation-induced repression: Belts, braces, and chromatin
4. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
5. A decade of molecular biology of retinoic acid receptors
6. Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene
7. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
8. CpG islands in vertebrate genomes
9. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
10. Effects of fixation on RNA extraction and amplification from laser capture microdissected tissue
11. Expression and function of angiopoietin-1 in breast cancer
12. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
13. Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1)in primary and metastatic prostate cancer
14. The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression
15. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
16. Cytidine methylation of regulatory sequences near the piclass glutathione S-transferase gene accompanies human prostatic carcinogenesis
17. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin
18. Differential expression of nuclear retinoid receptors in normal and malignant prostates
19. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
20. Epigenetic regulation of androgen receptor gene expression in human prostate cancers
21. Methylation of the 5′ CpG island of the endothelin B receptor gene is common in human prostate cancer
22. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
23. Expression of retinoid receptor genes and proteins in non-small-cell lung cancer
24. Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis
25. Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter
26. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
27. Parent-of-origin specific histone acetylation and reactivation of a key imprinted gene locus in Prader-Willi syndrome
28. Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells
29. Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells
30. The language of covalent histone modifications
31. Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition
32. Genomic organization of the human retinoic acid receptor β2
33. Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas
34. Mi-2 complex couples DNA methylation to chromatin remodelling and histone
35. Methylation and silencing of the retinoic acid receptor-β2 gene in breast cancer
36. Co-repressor complexes and remodelling chromatin for repression
37. Progressive decrease in nuclear retinoic acid receptor beta messenger RNA level during breast carcinogenesis