Microfluidics-based biochips: Technology issues, implementation platforms, and design-automation challenges

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems

Volumn 25, Issue 2, 2006, Pages 211-223

  Su, Fei ^a,b   Chakrabarty, Krishnendu ^a,b,c,d,e,f   Fair, Richard B ^a,b,g  

^a IEEE   (United States)

^b Duke University   (United States)

^c DUKE UNIVERSITY   (United States)

^d ACM   (United States)

^e ACM SIGDA   (United States)

^f Sigma Xi ^*  (United States)

^g ELECTROCHEMICAL SOCIETY   (United States)

Author keywords

Biochips; Design automation; Microfluidics; Reconfiguration; Synthesis; Testing

Indexed keywords

BIOCHIPS; DESIGN AUTOMATION; MICROFLUIDICS; RECONFIGURATION; SYNTHESIS;

ARRAYS; AUTOMATION; BIOASSAY; DIAGNOSIS; DNA SEQUENCES; MICROELECTRONICS; MOLECULAR BIOLOGY; RNA; TESTING;

BIOMEDICAL EQUIPMENT;

EID: 31344461624     PISSN: 02780070     EISSN: None     Source Type: Journal    
DOI: 10.1109/TCAD.2005.855956     Document Type: Article

References (56)

1. M. A. Burns et al., "An integrated nanoliter DNA analysis device," Science, vol. 282, no. 5388, pp. 484-487, Oct. 1998.
2. T. Zhang, K. Chakrabarty, and R. B. Fair, Microelectrofluidic Systems: Modeling and Simulation. Boca Raton, FL: CRC Press, 2002.
3. T. Thorsen, S. Maerkl, and S. Quake, "Microfluidic large-scale integration," Science, vol. 298, no. 5593, pp. 580-584, Oct. 2002.
4. E. Verpoorte and N. F. De Rooij, "Microfluidics meets MEMS," Proc. IEEE, vol. 91, no. 6, pp. 930-953, Jun. 2003.
5. T. H. Schulte, R. L. Bardell, and B. H. Weigl, "Microfluidic technologies in clinical diagnostics," Clin. Chim. Acta, vol. 321, no. 1-2, pp. 1-10, Jul. 2002.
6. V. Srinivasan, V. K. Pamula, and R. B. Fair, "An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids," Lab Chip, vol. 4, no. 4, pp. 310-315, Aug. 2004.
7. H. F. Hull, R. Danila, and K. Ehresmann, "Smallpox and bioterrorism: Public-health responses," J. Lab. Clin. Med., vol. 142, no. 4, pp. 221-228, Oct. 2003.
8. S. Venkatesh and Z. A. Memish, "Bioterrorism: A new challenge for public health," Int. J. Antimicrob. Agents, vol. 21, no. 2, pp. 200-206, Feb. 2003.
9. M. G. Pollack, R. B. Fair, and A. D. Shenderov, "Electrowetting-based actuation of liquid droplets for microfluidic applications," Appl. Phys. Lett., vol. 77, no. 11, pp. 1725-1726, Sep. 2000.
10. S. K. Cho, S. K. Fan, H. Moon, and C. J. Kim, "Toward digital microfluidic circuits: Creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation," in Proc. IEEE Micro Electro Mechanical Systems (MEMS) Conf., Las Vegas, NV, 2002, pp. 32-52.
11. International Technology Roadmap for Semiconductors (ITRS). [Online]. Available: http://public.itrs.net/Files/2003ITRS/Home2003.htm
12. Affymetrix GeneChip. [Online]. Available: http://www.affymetrix.com
13. Infineon Electronic DNA Chip. [Online]. Available: http://www.infineon.com
14. Nanogen NanoChip. [Online]. Available: http://www.nanogen.com
15. S. Mutlu et al., "Enhanced electro-osmosis pumping with liquid bridge and field effect flow rectification," in Proc. IEEE Micro Electro Mechanical Systems (MEMS) Conf., Maastricht, The Netherlands, 2004, pp. 850-853.
16. B. S. Gallardo et al., "Electrochemical principles for active control of liquids on submillimeter scales," Science, vol. 283, no. 5398, pp. 57-60, Jan. 1999.
17. K. Ichimura, S. Oh, and M. Nakagawa, "Light-driven motion of liquids on a photoresponsive surface," Science, vol. 288, no. 5471, pp. 1624-1626, Jun. 2000.
18. T. S. Sammarco and M. A. Burns, "Thermocapillary pumping of discrete droplets in microfabricated analysis devices," AIChe J., vol. 45, no. 2, pp. 350-366, 1999.
19. G. N. Somero, "Proteins and temperature," Annu. Rev. Physiol., vol. 57, pp. 43-68, 1995.
20. A. Wixforth, and J. Scriba, Nanopumps for Programmable Biochips. [Online]. Available: http://www.advalytix.de
21. M. Washizu, "Electrostatic actuation of liquid droplets for microreactor applications," IEEE Trans. Ind. Appl., vol. 34, no. 4, pp. 732-737, Jul./Aug. 1998.
22. T. B. Jones et al., "Dielectrophoretic liquid actuation and nanodroplet formation," J. Appl. Phys., vol. 89, no. 3, pp. 1441-1448, Feb. 2001.
23. J. Vykoukal et al., "A programmable dielectric fluid processor for droplet-based chemistry," in Micro Total Analysis Systems, Monterey, CA, 2001, pp. 72-74.
24. A DEP Primer. [Online]. Available: http://www.dielectrophoresis.org
25. T. B. Jones, K. L. Wang, and D. J. Yao, "Frequency-dependent electromechanics of aqueous liquids: Electrowetting and dielectrophoresis, " Langmuir, vol. 20, no. 7, pp. 2813-2818, Mar. 2004.
26. M. Pollack, "Electrowetting-based microactuation of droplets for digital microfluidics," Ph.D. thesis, Dept. Elect. Comput. Eng., Duke Univ., Durham, NC, 2001.
27. M. G. Pollack, A. D. Shenderov, and R. B. Fair, "Electrowetting-based actuation of droplets for integrated microfluidics," Lab Chip, vol. 2, no. 1, pp. 96-101, 2002.
28. V. Srinivasan, V. K. Pamula, M. G. Pollack, and R. B. Fair, "A digital microfluidic biosensor for multianalyte detection," in Proc. IEEE Micro Electro Mechanical Systems (MEMS) Conf., Kyoto, Japan, 2003, pp. 327-330.
29. _, "Clinical diagnostics on human whole blood, plasma, serum, urine, saliva, sweat, and tears on a digital microfluidic platform," in Proc. μT AS, Squaw Valley, CA, 2003, pp. 1287-1290.
30. V. Srinivasan, "A digital microfluidic lab-on-a-chip for clinical diagnostic applications," Ph.D. thesis, Dept. Elect. Comput. Eng., Duke Univ., Durham, NC, 2005.
31. S. Senturia, "Microfabricated structures for the measurement of mechanical properties and adhesion of thin films," in Proc. Int. Conf. Solid-State Sensors and Actuators (Transducers), Tokyo, Japan, 1987, pp. 11-16.
32. G. K. Fedder and Q. Jing, "A hierarchical circuit-level design methodology for microelectromechinal system," IEEE Trans. Circuits Syst. II, Analog Digit. Signal Process., vol. 46, no. 10, pp. 1309-1315, Oct. 1999.
33. S. K. De and N. R Aluru, "Physical and reduced-order dynamic analysis of MEMS," in Proc. IEEE/ACM Int. Conf. Computer-Aided Design, San Jose, CA, 2003, pp. 270-273.
34. T. Mukherjee and G. K. Fedder, "Design methodology for mixed-domain systems-on-a-chip [MEMS design]," in Proc. IEEE VLSI System Level Design, Orlando, FL, 1998, pp. 96-101.
35. A. B. Kahng et al., "Evaluation of placement techniques for DNA probe array layout," in Proc. IEEE/ACM Int. Conf. Computer-Aided Design, San Jose, CA, 2003, pp. 262-269.
36. A. N. Chatterjee and N. R. Aluru, "Combined circuit/device modeling and simulation of integrated microfluidic systems," J. Microelectromech. Syst., vol. 14, no. 1, pp. 81-95, Feb. 2005.
37. B. Shapiro et al., "Modeling of electrowetted surface tension for addressable microfluidic systems: Dominant physical effects, material dependences, and limiting phenomena," in Proc. IEEE Micro Electro Mechanical Systems (MEMS) Conf., Kyoto, Japan, 2003, pp. 201-205.
38. J. Zeng and F. T. Korsmeyer, "Principles of droplet electrohydrodynamics for lab-on-a-chip," Lab Chip, vol. 4, no. 4, pp. 265-277, 2004.
39. CoventorWare. [Online]. Available: http://www.coventor.com
40. F. Su and K. Chakrabarty, "Architectural-level synthesis of digital microfluidics-based biochips," in Proc. IEEE Int. Conf. Computer-Aided Design, San Jose, CA, 2004, pp. 223-228.
41. _, "Design of fault-tolerant and dynamically-reconfigurable microfluidic biochips," in Proc. Design, Automation and Test Eur. (DATE) Conf., Munich, Germany, 2005, pp. 1202-1207.
42. F. Su, S. Ozev, and K. Chakrabarty, "Test planning and test resource optimization for droplet-based microfluidic systems," in Proc. Eur. Test Symp., Corsica, France, 2004, pp. 72-77.
43. _, "Concurrent testing of droplet-based microfluidic systems for multiplexed biomedical assays," in Proc. IEEE Int. Test Conf., Charlotte, NC, 2004, pp. 883-892.
44. G. De Micheli, Synthesis and Optimization of Digital Circuits. New York: McGraw-Hill, 1994.
45. R. Camposano, "Behavioral synthesis," in Proc. IEEE/ACM Design Automation Conf., Las Vegas, NV, 1996, pp. 33-34.
46. A. Kolpekwar and R. D. Blanton, "Development of a MEMS testing methodology," in Proc. Int. Test Conf., Washington, DC, 1997, pp. 923-937.
47. N. Deb and R. D. Blanton, "Analysis of failure sources in surface-micromachined MEMS," in Proc. Int. Test Conf., Atlantic City, NJ, 2000, pp. 739-749.
48. H. G. Kerkhoff, "Testing philosophy behind the micro analysis system," in Proc. SPIE, Paris, France, 1999, vol. 3680, pp. 78-83.
49. H. G. Kerkhoff and H. P. A. Hendriks, "Fault modeling and fault simulation in mixed micro-fluidic microelectronic systems," J. Electron. Test.: Theory Appl., vol. 17, no. 5, pp. 427-437, Oct. 2001.
50. H. G. Kerkhoff and M. Acar, "Testable design and testing of microelectro-fluidic arrays," in Proc. IEEE VLSI Test Symp., Napa, CA, 2003, pp. 403-409.
51. A. Jee and F. J. Ferguson, "Carafe: An inductive fault analysis tool for CMOS VLSI circuits," in Proc. IEEE VLSI Test Symp., Atlantic City, NJ, 1993, pp. 92-98.
52. F. Su, S. Ozev, and K. Chakrabarty, "Testing of droplet-based microelectrofluidic systems," in Proc. IEEE Int. Test Conf., Charlotte, NC, 2003, pp. 1192-1200.
53. _, "Ensuring the operational health of droplet-based microelectrofluidic biosensor systems," IEEE Sensors J., vol. 5, no. 4, pp. 763-773, Aug. 2005.
54. F. Su, K. Chakrabarty, and V. K. Pamula, "Yield enhancement of digital microfluidics-based biochips using space redundancy and local reconfiguration," in Proc. Design Automation and Test in Europe (DATE) Conf., Munich, Germany, 2005, pp. 1196-1201.
55. F. Su and K. Chakrabarty, "Defect tolerance for gracefully-degradable mocrofluidics-based chips," in Proc. IEEE VLSI Test Symp., Palm Springs, CA, 2005, pp. 321-326.
56. T. Mukherjee, "MEMS design and verification," in Proc. IEEE Int. Text Conf., Charlotte, NC, 2003, pp. 681-690.