Ensuring the operational health of droplet-based microelectrofluidic biosensor systems

IEEE Sensors Journal

Volumn 5, Issue 4, 2005, Pages 763-772

  Su, Fei ^a   Ozev, Sule ^a   Chakrabarty, Krishnendu ^a  

^a Duke University   (United States)

Author keywords

Microelectrofluidic biosensor systems; Reliability; Testing for manufacturing and operational defects

Indexed keywords

ANTIGENS; CHEMICAL WARFARE; COMPUTER SIMULATION; DNA; FLUIDICS; HEALTH; MONTE CARLO METHODS; RELIABILITY; TOXIC MATERIALS;

MICROELECTROFLUIDIC BIOSENSOR SYSTEMS; PARAMETER VARIATIONS; POLYMERASE CHAIN REACTIONS (PCR); TESTING FOR MANUFACTURING AND OPERATIONAL DEFECTS;

BIOSENSORS;

EID: 23844489125     PISSN: 1530437X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSEN.2005.848127     Document Type: Article

References (29)

1. S. Venkatesh and Z. A. Memish, "Bioterrorism: a new challenge for public health," Int. J. Antimicrob. Agents, vol. 21, pp. 200-206, 2003.
2. J. Paul, "Bioterrorism and biodefence," J. Infection, vol. 44, pp. 59-66, 2002.
3. H. F. Hull, R. Danila, and K. Ehresmann, "Smallpox and bioterrorism: public-health responses," J. Lab. Clin. Med., vol. 142, pp. 221-228, 2003.
4. M. G. Pollack, R. B. Fair, and A. D. Shenderov, "Electrowetting- based actuation of liquid droplets for microfluidic applications," Appl. Phys. Lett., vol. 77, pp. 1725-1726, 2000.
5. T. Zhang, K. Chakrabarty, and R. B. Fair, Microelectrofluidic Systems: Modeling and Simulation. Boca Raton, FL: CRC, 2002.
6. S. K. Cho, S. K. Fan, H. Moon, and C. J. Kim, "Toward digital microfluidic circuits: creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation," in Proc. IEEE Conf. MEMS, Las Vegas, NV, Jan. 2002, pp. 32-52.
7. V. Srinivasan, V. K. Pamula, M. G. Pollack, and R. B. Fair, "A digital microfluidic biosensor for multianalyte detection," in Proc. IEEE Conf. MEMS, Kyoto, Japan, Jan. 2003, pp. 327-330.
8. M. G. Pollack, P. Y. Paik, A. D. Shenderov, V. K. Pamula, F. S. Dietrich, and R. B. Fair, "Investigation of electrowetting-based microfluidics for real-time PCR applications," in Proc. μ TAS, Squaw Valley, CA, Oct. 2003, pp. 619-622.
9. V. Srinivasan, V. K. Pamula, M. G. Pollack, and R. B. Fair, "Clinical diagnostics on human whole blood, plasma, serum, urine, saliva, sweat, and tears on a digital microfluidic platform," in Proc. μTAS, Squaw Valley, CA, Oct. 2003, pp. 1287-1290.
10. D. J. Holme and H. Peck, Analytical Biochemistry, 2nd ed. Essex, U.K.: Longman, 1993.
11. International Technology Roadmap for Semiconductors (ITRS) [On-line]. Available: http://public.itrs.net/Files/2003ITRS/Home2003.htm
12. J. L. Jackel, S. Hackwood, J. J. Veslka, and G. Beni, "Electrowetting switch for multimode optical fibers," Appl. Opt., vol. 22, pp. 1765-1770, 1999.
13. R. Yates, C. Williams, C. Shearwood, and P. Mellor, "A micromachined rotating yaw rate sensor," in Proc. Micromachined Devices and Components II, SPIE Meeting, Austin, TX, Oct. 1996, pp. 161-168.
14. M. G. Pollack, "Electrowetting-based microactuation of droplets for digital microfluidics," Ph.D. dissertation, Dept. Elect. Comput. Eng., Duke Univ., Durham, NC, 2001.
15. S. K. De and N. R Aluru, "Physical and reduced-order dynamic analysis of MEMS," in Proc. IEEE/ACM ICCAD , San Jose, CA, Nov. 2003, pp. 270-273.
16. G. K. Fedder and Q. Jing, "A hierarchical circuit-level design methodology for microelectromechanical systems," IEEE Trans. Circuits Syst. II, Analog Digit. Signal Process., vol. 46, no. 9, pp. 1309-1315, Sep. 1999.
17. A. Kolpekwar and R. D. Blanton, "Development of a MEMS testing methodology" (in Nov.), in Proc. ITC, Washington, DC, 1997, pp. 923-993.
18. N. Deb and R. D. Blanton, "Analysis of failure sources in surface-micromachined MEMS," in Proc. ITC, Atlantic City, NJ, Oct. 2000, pp. 739-749.
19. H. G. Kerkhoff, "Testing philosophy behind the micro analysis system," Proc. SPIE, vol. 3680, pp. 78-83, 1999.
20. H. G. Kerkhoff and H. P. A. Hendriks, "Fault modeling and fault simulation in mixed micro-fluidic microelectronic systems," J. Electron. Test.: Theory Appl., vol. 17, pp. 427-437, 2001.
21. H. G. Kerkhoff and M. Acar, "Testable design and testing of microelectro-fluidic arrays," in Proc. IEEE VTS, Napa Valley, CA, Apr. 2003, pp. 403-409.
22. A. Jee and F. J. Ferguson, "Carafe: an inductive fault analysis tool for CMOS VLSI circuits," in Proc. IEEE VTS, Atlantic City, NJ, Apr. 1993, pp. 92-98.
23. J. Ding, K. Chakrabarty, and R. B. Fair, "Scheduling of microfluidic operations for reconfigurable two-dimensional electrowetting arrays," IEEE Trans. Comput.-Aided Design Integr. Circuits Syst., vol. 20, pp. 1463-1468, Dec. 2001.
24. H. Ren, R. B. Fair, M. G. Pollack, and E. J. Shaughnessy, "Dynamics of electro-wetting droplet transport," Sens. Actuators B, vol. 87, pp. 201-206, 2002.
25. S. D. Nigam and J. U. Turner, "Review of statistical approaches to tolerance analysis," Comput.-Aided Design, vol. 27, pp. 6-25, 1995.
26. J. R. Johnson, "Development of polymerase chain reaction-based assays for bacterial gene detection," J. Microbiol. Meth., vol. 41, pp. 201-209, 2000.
27. T. Zhang, K. Chakrabarty, and R. B. Fair, "Behavioral modeling and performance evaluation of microelectrofluidics-based PCR systems using SystemC," IEEE Trans. Comput.-Aided Design Integr. Circuits Syst., vol. 23, pp. 843-858, 2004.
28. CRC Handbook of Chemistry and Physics, 84th ed. Boca Raton, FL: CRC.
29. Silicone Fluid Brochure From Gelest, Inc. [Online], Available: http://www.gelest.com/Library/SiFluids.pdf