Impaired response of UCP family to cold exposure in diabetic (db/db) mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 279, Issue 4 48-4, 2000, Pages

  Masaki, Takayuki ^a   Yoshimatsu, Hironobu ^a   Chiba, Seiichi ^a   Sakata, Toshiie ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

db db mice; Free fatty acids; Uncoupling protein family

Indexed keywords

LIPOPROTEIN LIPASE; MUSCLE PROTEIN; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; DIABETES MELLITUS; FATTY ACID BLOOD LEVEL; LIPOLYSIS; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE ADIPOSE TISSUE;

EID: 0033695668     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2000.279.4.r1305     Document Type: Article

References (30)

1. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue
2. Tissue-dependent upregulation of rat uncoupling protein- 2 expression in response to fasting or cold
3. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
4. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
5. Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins
6. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
7. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
8. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
9. Effects of cold exposure on cyclic AMP concentration in plasma, liver, and brown and white adipose tissues in cold-acclimated rats
10. Streptozotocin treatment upregulates uncoupling protein 3 expression in the rat heart
11. Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats
12. Brown adipose tissue thermogenesis in obese animals
13. Thermogenesis in brown adipose tissue as an energy buffer. Implications for obesity
14. A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: Reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding
15. Tumor necrosis factor-α regulates in vivo expression of the rat UCP family differentially
16. Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone
17. Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: Their gene expression in rats fed high-fat diet
18. Thermogenic mechanism in brown fat
19. Fatty acid control of lipoprotein lipase: A link between energy metabolism and lipid transport
20. Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid beta-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis
21. Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition: A link with insulin resistance
22. Leptin induction of UCP1 gene expression is dependent on sympathetic innervation
23. Alterations of brown adipose tissue in genetically obese (ob/ob) mice. I. Demonstration of loss of metabolic response to nerve stimulation and catecholamine and its partial recovery after fasting or cold adaptation
24. Thermoregulation in the diabetic-obese (db/db) mouse. The role of non-shivering thermogenesis in energy balance
25. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system
26. Thermogenic defect in pre-obese ob/ob mice
27. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
28. Simplified high throughput protocol for Northern hybridization
29. Positional cloning of the mouse obese gene and its human homologue
30. Induction by leptin of uncoupling protein- 2 and enzymes of fatty acid oxidation