The RET receptor is linked to stress response pathways

Cancer Research

Volumn 64, Issue 13, 2004, Pages 4453-4463

  Myers, Shirley M ^a   Mulligan, Lois M ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN A1A; HEAT SHOCK PROTEIN A1B; HEAT SHOCK PROTEIN A1L; PROTEIN HSF1; PROTEIN RET; PROTEIN RET51; PROTEIN RET9; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINE; CELL MIGRATION; CELL TYPE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; EMBRYO; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NEUROSECRETORY CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STRESS; UPREGULATION;

CELL LINE, TRANSFORMED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; STRESS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 3042819506     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-3605     Document Type: Article

References (85)

1. Avantaggiato V, Dathan NA, Grieco M, et al. Developmental expression of the RET protooncogene. Cell Growth Differ 1994;5:305-11.
2. Pachnis V, Mankoo B, Costantini F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development (Camb) 1993;119:1005-17.
3. Attie-Bitach T, Abitbol M, Gerard M, et al. Expression of the RET proto-oncogene in human embryos. Am J Med Genet 1998;80:481-6.
4. Kitagawa H, Hayashi T, Mitsumoto Y, Koga N, Itoyama Y, Abe K. Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats. Stroke 1998;29: 1417-22.
5. Henderson C, Phillips H, Pollock R, et al. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science (Wash DC) 1994;266: 1062-4.
6. Mograbi B, Bocciardi R, Bourget I, et al. The sensitivity of activated Cys Ret mutants to glial cell line-derived neurotrophic factor is mandatory to rescue neuroectodermic cells from apoptosis. Mol Cell Biol 2001;21:6719-30.
7. Mograbi B, Bocciardi R, Bourget I, et al. Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells. J Biol Chem 2001;276:45307-19.
8. De Vita G, Melillo RM, Carlomagno F, et al. Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC 12 cell survival. Cancer Res 2000;60:3727-31.
9. Oppenheim RW, Houenou LJ, Parsadanian AS, Prevette D, Snider WD, Shen L. Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes. J Neurosci 2000;20: 5001-11.
10. Oppenheim RW, Houenou LJ, Johnson JE, et al. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature (Lond.) 1995; 373:344-6.
11. Lingor P, Unsicker K, Krieglstein K. GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. Exp Neurol 2000;163:55-62.
12. Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002;3:383-94.
13. Hansford JR, Mulligan LM. Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis. J Med Genet 2000;37:817-27.
14. Santoro M, Melillo RM, Carlomagno F, Fusco A, Vecchio G. Molecular mechanisms of RET activation in human cancer. Ann N Y Acad Sci 2002;963:116-21.
15. 2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene 1998;16: 2435-45.
16. Murakami H, Iwashita T, Asai N, et al. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation. Biochem Biophys Res Commun 1999;262:68-75.
17. Borrello MG, Alberti L, Arighi E, et al. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase C gamma. Mol Cell Biol 1996;16:2151-63.
18. Hayashi H, Ichihara M, Iwashita T, et al. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor. Oncogene 2000;19:4469-75.
19. Hayashi Y, Iwashita T, Murakamai H, et al. Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation. Biochem Biophys Res Commun 2001;281: 682-9.
20. Tahira T, Ishizaka Y, Itoh F, Sugimura T, Nagao M. Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. Oncogene 1990;5:97-102.
21. Rossel M, Pasini A, Chappuis S, et al. Distinct biological properties of two RET isoforms activated by MEN 2A/FMTC and MEN 2B mutations. Oncogene 1997;14: 265-75.
22. Ishiguro Y, Iwashita T, Murakami H, et al. The role of amino acids surrounding tyrosine 1062 in ret in specific binding of the shc phosphotyrosine-binding domain. Endocrinology 1999;140:3992-8.
23. de Graaff E, Srinivas S, Kilkenny C, et al. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev 2001;15: 2433-44.
24. Alberti L, Borrello MG, Ghizzoni S, Torriti F, Rizzetti MG, Pierotti MA. Grb2 binding to the different isoforms of Ret tyrosine kinase. Oncogene 1998;17:1079-1087.
25. Arighi E, Alberti L, Torriti F, et al. Identification of Shc docking site on Ret tyrosine kinase. Oncogene 1997;14:773-82.
26. Lorenzo MJ, Gish GD, Houghton C, et al. RET alternative splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2. Oncogene 1997;14:763-71.
27. Borrello MG, Pelicci G, Arighi E, et al. The oncogenic versions of the ret and trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Oncogene 1994;9:1661-8.
28. Grimm J, Sachs M, Britsch S, et al. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol 2001;154:345-54.
29. Melillo RM, Carlomagno F, De Vita G, et al. The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret. Oncogene 2001;20:209-18.
30. Melillo RM, Santoro M, Ong SH, et al. Docking protein frs2 links the protein tyrosine kinase ret and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol 2001;21:4177-87.
31. Myers SM, Eng C, Ponder BAJ, Mulligan LM. Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: a novel C terminus for RET. Oncogene 1995;11:2039-45.
32. Sanicola M, Hession C, Worley D, et al. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci USA 1997;94:6238-43.
33. Myers S, Worley D, Cote G, Mulligan L. Analysis of GFRalpha1 polymorphism and splice variants; effect on GFRalpha1/GDNF/RET complexes. Am J Hum Genet 1999;65:A377.
34. Kato M, Takeda K, Kawamoto Y, et al. Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res 2002; 62:2414-22.
35. Forster T, Roy D, Ghazal P. Experiments using microarray technology: limitations and standard operating procedures. J Endocrinol 2003;178:195-204.
36. Knudsen S, Workman C, Sicheritz-Ponten T, Friis C. GenePublisher: automated analysis of DNA microarray data. Nucleic Acids Res 2003;31:3471-6.
37. Bernard PS, Wittwer CT. Real-time PCR technology for cancer diagnostics. Clin Chem 2002;48:1178-85.
38. Manie S, Santoro M, Fusco A, Billaud M. The RET receptor: function in development and dysfunction in congenital malformation. TIG 2001;17:580-9.
39. Milner CM, Campbell RD. Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 1990;32:242-51.
40. Spies T, Blanck G, Bresnahan M, Sands J, Strominger JL. A new cluster of genes within the human major histocompatibility complex. Science (Wash DC) 1989;243: 214-7.
41. Nollen EA, Morimoto RI. Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci 2002;115:2809-16.
42. Hohfeld J, Cyr DM, Patterson C. From the cradle to the grave: molecular chaperones that may choose between folding and degradation. EMBO Rep 2001;2:885-90.
43. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. Biochem Biophys Res Commun 2001;281:706-13.
44. Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G. Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. J Biol Chem 2003;278:29106-14.
45. Heinemeyer T, Wingender E, Reuter I, et al. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res 1998;26:362-7.
46. Colucci-D'Amato GL, D'Alessio A, Califano D, et al. Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK. J Biol Chem 2000;275:19306-14.
47. van Puijenbroek AA, van Weering DH, van den Brink CE, et al. Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation Oncogene 1997;14:1147-57.
48. Watanabe T, Ichihara M, Hashimoto M, et al. Characterization of gene expression induced by RET with MEN2A or MEN2B mutation. Am J Pathol 2002;161:249-56.
49. Melillo RM, Barone MV, Lupoli G, et al. Ret-mediated mitogenesis requires Src kinase activity. Cancer Res 1999;59:1120-6.
50. Califano D, Monaco C, De Vita G, et al. Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells. Oncogene 1995;11: 107-12.
51. Califano D, D'Alessio A, Colucci-D'Amato GL, et al. A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells. Proc Natl Acad Sci USA 1996;93:7933-7.
52. Califano D, Rizzo C, D'Alessio A, et al. Signaling through Ras is essential for Ret oncogene-induced cell differentiation in PC12 cells. J Biol Chem 2000;275:19297-305.
53. Xing S, Furminger TL, Tong Q, Jhiang SM. Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells. J Biol Chem 1998;273: 4909-14.
54. D'Alessio A, De Vita G, Cali G, et al. Expression of the RET oncogene induces differentiation of SK-N-BE neuroblastoma cells. Cell Growth Differ 1995;6:1387-94.
55. Kurokawa K, Kawai K, Hashimoto M, Ito Y, Takahashi M. Cell signalling and gene expression mediated by RET tyrosine kinase. J Intern Med 2003;253:627-33.
56. Ivanchuk SM, Eng C, Cavenee WK, Mulligan LM. The expression of RET and its multiple splice forms in developing human kidney. Oncogene 1997;14:1811-8.
57. Murakami H, Iwashita T, Asai N, lwata Y, Narumiya S, Takahashi M. Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase. Oncogene 1999;18:1975-82.
58. Romano A, Wong WT, Santoro M, Wirth PJ, Thorgeirsson SS, DiFiore PP. The high transforming potency of erbB-2 and ret is associated with phosphorylation of paxillin and a 23 kDa protein. Oncogene 1994;9:2923-33.
59. Kim LT, Fleming JB, Lopez-Guzman C, Nwariaku F, Focal adhesions and associated proteins in medullary thyroid carcinoma cells. J Surg Res 2003;111:177-84.
60. Wang CY, Yang F, He XP, et al. Regulation of neuromuscular synapse development by glial cell line-derived neurotrophic factor and neurturin. J Biol Chem 2002;277: 10614-25.
61. Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature (Lond.) 1994;367:380-3.
62. Meng X, Lindahl M, Hyvonen ME, et al. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science (Wash DC) 2000;287:1489-93.
63. Durbec PL, Larsson-Blomberg LB, Schuchardt A, Costantini F, Pachnis V. Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development (Camb) 1996;122:349-58.
64. Lan MS, Russell EK, Lu J, Johnson BE, Notkins AL. IA-1, a new marker for neuroendocrine differentiation in human lung cancer cell lines. Cancer Res 1993;53: 4169-71.
65. Martinerie C, Perbal B, Expression of a gene encoding a novel potential IGF binding protein in human tissues. C R Acad Sci III 1991;313:345-51.
66. Oremek GM, Sapoutzis N. Pro-gastrin-releasing peptide (Pro-GRP), a tumor marker for small cell lung cancer. Anticancer Res 2003;23:895-8.
67. Trougakos IP, Gonos ES. Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol 2002;34:1430-48.
68. Jolly C, Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst (Bethesda) 2000;92:1564-72.
69. Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG. The cellular inhibitor of the PKR protein kinase, P58 (IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. J Biol Chem 1999;274: 3797-803.
70. Arvidsson A, Kokaia Z, Airaksinen MS, Saarma M, Lindvall O. Stroke induces widespread changes of gene expression for glial cell line-derived neurotrophic factor family receptors in the adult rat brain. Neuroscience 2001;106:27-41.
71. Sarabi A, Chang CF, Wang Y, Tomac AC, Hoffer BJ, Morales M. Differential expression of the cell line-derived neurotrophic factor (GDNF) receptor GFRalpha1 in heterozygous Gfralpha1 null-mutant mice after stroke. Neurosci Lett 2003;341: 241-5.
72. Wang Y, Chang CF, Morales M, Chiang YH, Hoffer J. Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury. Ann N Y Acad Sci 2002; 962:423-37.
73. Newfry GA, Jones KJ. Differential effects of facial nerve transection on heat shock protein 70 expression in the developing and adult hamster facial nucleus. Metab Brain Dis 1998;13:253-7.
74. Naveilhan P, ElShamy WM, Ernfors P. Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFR alpha after sciatic nerve lesion in the mouse. Eur J Neurosci 1997;9:1450-60.
75. Trupp M, Belluardo N, Funakoshi H, Ibáñez CF. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-α indicates multiple mechanisms of trophic actions in the adult rat CNS. J Neurosci 1997;17:3554-67.
76. Mosser DD, Caron AW, Bourget L, Denis-Larose C, Massie B. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 1997;17:5317-27.
77. Buzzard KA, Giaccia AJ, Killender M, Anderson RL. Heat shock protein 72 modulates pathways of stress-induced apoptosis. J Biol Chem 1998;273:17147-53.
78. Bordeaux MC, Forcet C, Granger L, et al. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J 2000;19:4056-63.
79. Jaattela M. Escaping cell death: survival proteins in cancer. Exp Cell Res 1999;248: 30-43.
80. Jaattela M. Heat shock proteins as cellular lifeguards. Ann Med 1999;31:261-71.
81. Devouassoux-Shisheboran M, Mauduit C, Tabone E, Droz JP, Benahmed M. Growth regulatory factors and signalling proteins in testicular germ cell tumours. APMIS 2003;111:212-24.
82. Futami H, Egawa S, Takasaki K, Tsukada T, Shiraishi M, Yamaguchi K. Allelic loss of DNA locus of the RET proto-oncogene in small cell lung cancer. Cancer Lett 2003;195:59-65.
83. Pirkkala L, Nykanen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 2001;15:1118-31.
84. Xiao X, Zuo X, Davis AA, et al. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 1999;18:5943-52.
85. Tsui-Pierchala BA, Ahrens RC, Crowder RJ, Milbrandt J, Johnson EM Jr. The long and short isoforms of Ret function as independent signaling complexes. J Biol Chem 2002;277:34618-25.