Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation

Journal of Cell Biology

Volumn 154, Issue 2, 2001, Pages 345-354

  Grimm, Jan ^a   Sachs, Martin ^a   Britsch, Stefan ^a   Di Cesare, Silvana ^a   Schwarz Romond, Thomas ^a   Alitalo, Kari ^b   Birchmeier, Walter ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Docking proteins; Endothelia; Neural development; Signal transduction; Yeast two hybrid system

Indexed keywords

DOCKING PROTEIN; PROTEIN DOK 4; PROTEIN DOK 5; PROTEIN P 62 DOK; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EMBRYO; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NEURITES; NEURONS; ORGAN SPECIFICITY; PC12 CELLS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RAS GTPASE-ACTIVATING PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA;

EID: 0035939661     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200102032     Document Type: Article

References (64)

1. Grb2 binding to the different isoforms of Ret tyrosine kinase
2. Identification of Shc docking site on Ret tyrosine kinase
3. A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins
4. Developmental expression of the RET protooncogene
5. Functional interaction of β-catenin with the transcription factor LEF-1
6. Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-Ret receptor tyrosine kinase
7. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
8. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cγ
9. p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells
10. Characterization of a novel member of the dok family that binds and modulates Abl signaling
11. Molecular cloning and characterization of p56dok-2 defines a new family of Ras-GAP-binding proteins
12. Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC
13. Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain
14. Mutations of the RET protooncogene in Hirschsprung's disease
15. Expression of the RET receptor tyrosine kinase and GDNFR-α in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment
16. Differential expression of the RET gene in human acute myeloid leukemia
17. The RET receptor tyrosine kinase, but not its specific ligand, GDNF, is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation
18. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor
19. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling
20. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons
21. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary, thyroid carcinoma
22. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
23. The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
24. Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation
25. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
26. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling
27. Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities
28. RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
29. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
30. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life
31. Renal and neuronal abnormalities in mice lacking GDNF
32. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
33. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
34. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
35. Implication of expression of GDNF/Ret signalling components in differentiation of bone marrow haemopoietic cells
36. FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation
37. Tyrosine phosphorylarion of p62(Dok) induced by cell adhesion and insulin: Possible role in cell migration
38. Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system
39. Expression of the c-ret protooncogene during mouse embryogenesis
40. Defects in enteric innervation and kidney development in mice lacking GDNF
41. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila
42. Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B
43. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease
44. Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations
45. Essential role of Gab1 for signaling by the c-Met receptor in vivo
46. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
47. An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: Evidence for a ret-specific signaling pathway
48. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
49. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
50. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
51. Role of IRS-2 in insulin and cytokine signalling
52. p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction
53. Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line
54. Activation of a novel human transforming gene, ret, by DNA rearrangement
55. The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells
56. Characterization ofa multicomponent receptor for GDNF
57. Signal transduction by receptors with tyrosine kinase activity
58. Receptor protein-tyrosine kinases and their signal transduction pathways
59. Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement
60. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
61. Disruption of IRS-2 causes type 2 diabetes in mice
62. Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok
63. Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling