메뉴 건너뛰기




Volumn 163, Issue 1, 2000, Pages 55-62

GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide

Author keywords

Cell culture; Dopaminergic cells; Free radicals; Neurotrophic factors; Oxidative stress; Parkinson's disease

Indexed keywords

FERRIC CHLORIDE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; IRON; LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENT; NEUROTROPHIC FACTOR; NEUROTROPHIN 4; NITROPRUSSIDE SODIUM;

EID: 0034024177     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7339     Document Type: Article
Times cited : (41)

References (40)
  • 3
    • 0029552813 scopus 로고
    • GDNF reduces apoptosis in dopaminergic neurons in vitro
    • Clarkson E. D., Zawada W. M., Freed C. R. GDNF reduces apoptosis in dopaminergic neurons in vitro. NeuroReport. 7:1995;145-149.
    • (1995) NeuroReport , vol.7 , pp. 145-149
    • Clarkson, E.D.1    Zawada, W.M.2    Freed, C.R.3
  • 5
    • 0022475372 scopus 로고
    • Lipid peroxidation as a cause of nigral cell death in Parkinson's disease
    • Dexter D. T, Carter C. J., Wells F. R. Lipid peroxidation as a cause of nigral cell death in Parkinson's disease. Lancet. 2:1986;639-640.
    • (1986) Lancet , vol.2 , pp. 639-640
    • Dexter, D.T.1    Carter, C.J.2    Wells, F.R.3
  • 6
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • Dexter D. T., Wells F. R., Lees A. J., Agid F., Agid Y., Jenner P., Marsden C. D. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52:1989;1830-1836.
    • (1989) J. Neurochem. , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3    Agid, F.4    Agid, Y.5    Jenner, P.6    Marsden, C.D.7
  • 7
    • 0030001780 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant therapy in Parkinson's disease
    • Ebadi M., Srinivasan S. K., Baxi M. D. Oxidative stress and antioxidant therapy in Parkinson's disease. Prog. Neurobiol. 48:1996;1-19.
    • (1996) Prog. Neurobiol. , vol.48 , pp. 1-19
    • Ebadi, M.1    Srinivasan, S.K.2    Baxi, M.D.3
  • 8
    • 0026042368 scopus 로고
    • The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia
    • Engele J., Bohn M. C. The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia. J. Neurosci. 11:1991;3070-3078.
    • (1991) J. Neurosci. , vol.11 , pp. 3070-3078
    • Engele, J.1    Bohn, M.C.2
  • 9
    • 0030008795 scopus 로고    scopus 로고
    • Growth factor-induced c-fos expression defines distinct subsets of midbrain dopaminergic neurons
    • Engele J., Schilling K. Growth factor-induced c-fos expression defines distinct subsets of midbrain dopaminergic neurons. Neuroscience. 73:1996;397-406.
    • (1996) Neuroscience. , vol.73 , pp. 397-406
    • Engele, J.1    Schilling, K.2
  • 10
    • 0026484388 scopus 로고
    • The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
    • Fahn S., Cohen G. The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it. Ann. Neurol. 32:1992;804-812.
    • (1992) Ann. Neurol. , vol.32 , pp. 804-812
    • Fahn, S.1    Cohen, G.2
  • 11
    • 0027937548 scopus 로고
    • Oxidative stress: Free radical production in neural degeneration
    • Götz M. E., Kunig G., Riederer P., Youdim M. B. Oxidative stress: Free radical production in neural degeneration. Pharmacol. Ther. 63:1994;37-122.
    • (1994) Pharmacol. Ther. , vol.63 , pp. 37-122
    • Götz, M.E.1    Kunig, G.2    Riederer, P.3    Youdim, M.B.4
  • 13
    • 0025791009 scopus 로고
    • Cytokine-induced synthesis of nitogen oxides in macrophages: A protective host response to Leishmania and other intracellular pathogens
    • Green S. J., Nacy C. A., Meltzer M. S. Cytokine-induced synthesis of nitogen oxides in macrophages: A protective host response to Leishmania and other intracellular pathogens. J. Leukocyte Biol. 50:1991;93-103.
    • (1991) J. Leukocyte Biol. , vol.50 , pp. 93-103
    • Green, S.J.1    Nacy, C.A.2    Meltzer, M.S.3
  • 17
    • 0027972545 scopus 로고
    • Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon
    • Hyman C., Juhasz M., Jackson C., Wright P., Ip N. Y., Lindsay R. M. Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J. Neurosci. 14:1994;335-347.
    • (1994) J. Neurosci. , vol.14 , pp. 335-347
    • Hyman, C.1    Juhasz, M.2    Jackson, C.3    Wright, P.4    Ip, N.Y.5    Lindsay, R.M.6
  • 18
    • 0028127755 scopus 로고
    • Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures
    • Hynes M. A., Poulsen K., Armanini M., Berkemeier L., Phillips H., Rosenthal A. Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. J. Neurosci. Res. 37:1994;144-154.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 144-154
    • Hynes, M.A.1    Poulsen, K.2    Armanini, M.3    Berkemeier, L.4    Phillips, H.5    Rosenthal, A.6
  • 19
    • 0026337175 scopus 로고
    • Oxidative stress as a cause of Parkinson's disease
    • Jenner P. Oxidative stress as a cause of Parkinson's disease. Acta Neurol. Scand. 84:1991;6-15.
    • (1991) Acta Neurol. Scand. , vol.84 , pp. 6-15
    • Jenner, P.1
  • 20
    • 0033212912 scopus 로고    scopus 로고
    • Iron as catalyst for oxydative stress in the pathogenesis of Parkonson's disease?
    • Kienzl E., Jellinger K., Stachelberger H., Linert W. Iron as catalyst for oxydative stress in the pathogenesis of Parkonson's disease? Life Sci. 65:1999;1973-1976.
    • (1999) Life Sci. , vol.65 , pp. 1973-1976
    • Kienzl, E.1    Jellinger, K.2    Stachelberger, H.3    Linert, W.4
  • 21
    • 0025265681 scopus 로고
    • Selective and nonselective stimulation of cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II
    • Knüsel B., Michel P. P., Schwaber J. S., Hefti F. Selective and nonselective stimulation of cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J. Neurosci. 10:1990;558-570.
    • (1990) J. Neurosci. , vol.10 , pp. 558-570
    • Knüsel, B.1    Michel, P.P.2    Schwaber, J.S.3    Hefti, F.4
  • 22
    • 0023610067 scopus 로고
    • MPTP: An industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson's disease
    • Kopin I. J. MPTP: An industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson's disease. Environ. Health Perspect. 75:1987;45-51.
    • (1987) Environ. Health Perspect. , vol.75 , pp. 45-51
    • Kopin, I.J.1
  • 24
    • 0028860775 scopus 로고
    • Trophic and protective effects of growth differentiation factor 5, a member of the transforming growth factor beta superfamily, on midbrain dopaminergic neurons
    • Krieglstein K., Suter-Crazzolara C., Hotten G., Pohl J., Unsicker K. Trophic and protective effects of growth differentiation factor 5, a member of the transforming growth factor beta superfamily, on midbrain dopaminergic neurons. J. Neurosci. Res. 42:1995;724-732.
    • (1995) J. Neurosci. Res. , vol.42 , pp. 724-732
    • Krieglstein, K.1    Suter-Crazzolara, C.2    Hotten, G.3    Pohl, J.4    Unsicker, K.5
  • 25
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin L. H., Doherty D. H., Lile J. D., Bektesh S., Collins F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260:1993;1130-1332.
    • (1993) Science , vol.260 , pp. 1130-1332
    • Lin, L.H.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 27
    • 0026684221 scopus 로고
    • Toxic effects of iron for cultured mesencephalic dopaminergic neurons derived from rat embryonic brains
    • Michel P. P, Vyas S., Agid Y. Toxic effects of iron for cultured mesencephalic dopaminergic neurons derived from rat embryonic brains. J. Neurochem. 59:1992;118-127.
    • (1992) J. Neurochem. , vol.59 , pp. 118-127
    • Michel, P.P.1    Vyas, S.2    Agid, Y.3
  • 29
    • 0025440265 scopus 로고
    • Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice
    • Otto D., Unsicker K. Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice. J. Neurosci. 10:1990;1912-1821.
    • (1990) J. Neurosci. , vol.10 , pp. 1912-1821
    • Otto, D.1    Unsicker, K.2
  • 30
    • 0028430953 scopus 로고
    • FGF-2 in the MPTP model of Parkinson's disease: Effects on astroglial cells
    • Otto D., Unsicker K. FGF-2 in the MPTP model of Parkinson's disease: Effects on astroglial cells. Glia. 11:1994;47-56.
    • (1994) Glia , vol.11 , pp. 47-56
    • Otto, D.1    Unsicker, K.2
  • 31
    • 0030948029 scopus 로고    scopus 로고
    • Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization
    • Pochon N. A., Menoud A., Tseng J. L., Zurn A. D., Aebischer P. Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization. Eur. J. Neurosci. 9:1997;463-471.
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 463-471
    • Pochon, N.A.1    Menoud, A.2    Tseng, J.L.3    Zurn, A.D.4    Aebischer, P.5
  • 32
    • 0030898725 scopus 로고    scopus 로고
    • Is differential regulation of mitochondrial transcripts in Parkinson's disease related to apoptosis?
    • Ruberg M., Brugg B., Prigent A., Hirsch E., Brice A., Agid Y. Is differential regulation of mitochondrial transcripts in Parkinson's disease related to apoptosis? J. Neurochem. 68:1997;2098-2110.
    • (1997) J. Neurochem. , vol.68 , pp. 2098-2110
    • Ruberg, M.1    Brugg, B.2    Prigent, A.3    Hirsch, E.4    Brice, A.5    Agid, Y.6
  • 34
    • 0029047329 scopus 로고
    • Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion
    • Sauer H., Rosenblad C., Bjorklund A. Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc. Natl. Acad. Sci. USA. 92:1995;8935-8939.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8935-8939
    • Sauer, H.1    Rosenblad, C.2    Bjorklund, A.3
  • 35
    • 0025935041 scopus 로고
    • Cytotoxic effect of brain macrophages on developing neurons
    • Thery C., Chamak B., Mallat M. Cytotoxic effect of brain macrophages on developing neurons. Eur. J. Neurosci. 3:1991;1155-1164.
    • (1991) Eur. J. Neurosci. , vol.3 , pp. 1155-1164
    • Thery, C.1    Chamak, B.2    Mallat, M.3
  • 36
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • Tomac A., Lindqvist E., Lin L. F., Ogren S. O., Young D., Hoffer B. J., Olson L. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. 373:1995;335-339.
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.F.3    Ogren, S.O.4    Young, D.5    Hoffer, B.J.6    Olson, L.7
  • 37
    • 0030915959 scopus 로고    scopus 로고
    • Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS
    • Trupp M., Belluardo N., Funakoshi H., Ibanez C. F. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17:1997;3554-3567.
    • (1997) J. Neurosci. , vol.17 , pp. 3554-3567
    • Trupp, M.1    Belluardo, N.2    Funakoshi, H.3    Ibanez, C.F.4
  • 38
    • 0027953105 scopus 로고
    • Growth factors in Parkinson's disease
    • Unsicker K. Growth factors in Parkinson's disease. Prog. Growth Factor Res. 5:1994;73-87.
    • (1994) Prog. Growth Factor Res. , vol.5 , pp. 73-87
    • Unsicker, K.1
  • 39
    • 0030330849 scopus 로고    scopus 로고
    • Growth factor function in the development and maintenance of midbrain dopaminergic neurons: Concepts, facts and prospects for TGF-beta
    • Unsicker K., Suter-Crazzolara C., Krieglstein K. Growth factor function in the development and maintenance of midbrain dopaminergic neurons: Concepts, facts and prospects for TGF-beta. Ciba Found. Symp. 196:1996;70-80.
    • (1996) Ciba Found. Symp. , vol.196 , pp. 70-80
    • Unsicker, K.1    Suter-Crazzolara, C.2    Krieglstein, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.