Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation

Biochemical and Biophysical Research Communications

Volumn 281, Issue 3, 2001, Pages 682-689

  Hayashi, Yasuhito ^a   Iwashita, Toshihide ^a   Murakamai, Hideki ^a   Kato, Yutaka ^b   Kawai, Kumi ^a   Kurokawa, Kei ^a   Tohnai, Iwai ^a   Ueda, Minoru ^a   Takahashi, Masahide ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

BMK1; GDNF; MEF2C transcription factor; MEN2A mutation; RET

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR; WORTMANNIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; MUTANT; NONHUMAN; ONCOGENE RET; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SIPPLE SYNDROME;

EID: 0034816526     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4338     Document Type: Article

References (24)

1. Cloning and expression of the ret protooncogene encoding a tyrosine kinase with two potential transmembrane domains
2. cDNA cloning of mouse ret protooncogene and its sequence similarity to the cadherin superfamily
3. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
4. GDNF family neurotrophic factor signaling: Four masters, one servant?
5. RET proto-oncogene in the development of human cancer
6. Mechanism of activation of ret proto-oncogene by multiple endocrine neoplasia 2A mutation
7. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
8. Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation
9. Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma
10. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor
11. Transforming activity of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
12. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
13. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cγ
14. A mutation at tyrosine 1062 in MEN2A-RET and MEN2B-RET impairs their transforming activity and association with Shc adaptor proteins
15. A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations
16. Primary structure of BMK1: A new mammalian MAP kinase
17. Components of a new human protein kinase signal transduction pathway
18. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase
19. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
20. Characterization of the promoter region of the human RFP gene
21. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
22. MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway
23. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases
24. Big mitogen-activated kinase regulates multiple members of the MEF2C protein family