Molecular mechanisms of RET activation in human cancer

Annals of the New York Academy of Sciences

Volumn 963, Issue , 2002, Pages 116-121

  Santoro, Massimo ^a   Melillo, Rosa Marina ^a   Carlomagno, Francesca ^a   Fusco, Alfredo ^a   Vecchio, Giancarlo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Carcinoma; Chromosome; Endocrine; Kinase; Oncogene; Papillary; Receptor; Thyroid

Indexed keywords

CYSTEINE; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN SHC; PROTEIN TYROSINE KINASE; TYROSINE KINASE RECEPTOR;

AUTOPHOSPHORYLATION; CANCER CELL; CANCER SURVIVAL; CARCINOGENESIS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; GENE REARRANGEMENT; GENETIC TRANSFORMATION; HUMAN; MITOGENESIS; NEUROFIBROMATOSIS; ONCOGENE; POINT MUTATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SIPPLE SYNDROME; TUMOR DIFFERENTIATION;

EID: 0036295515     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04102.x     Document Type: Conference Paper

References (17)

1. Cloning and expression of the ret protooncogene encoding a tyrosine kinase with two potential transmembrane domains
2. The GDNF-RET signalling partnership
3. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
4. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
5. Molecular characterization of RET/PTC3: A novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma
6. Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A
7. The WHO histological classification of thyroid tumors: A commentary on the second edition
8. RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes
9. RET/PTC oncogene activation is an early event in thyroid carcinogenesis
10. Radiation-induced thyroid cancer
11. Thyroid cancer risk to children calculated
12. Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident
13. The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line
14. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas
15. Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice
16. RET mutations in human disease
17. Germ-line mutations of MEN2A and MEN2B activate RET as a dominant transforming gene by different molecular mechanisms