메뉴 건너뛰기




Volumn 9, Issue 3, 2004, Pages 87-94

Metallothioneins and brain injury: What transgenic mice tell us

Author keywords

Brain injury; Cytokines; Metallothionein; Oxidative stress; Transgenic mice

Indexed keywords

ANTIOXIDANT; GROWTH INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN; METALLOTHIONEIN; METALLOTHIONEIN 4; METALLOTHIONEIN I; METALLOTHIONEIN II; METALLOTHIONEIN III; UNCLASSIFIED DRUG;

EID: 3042785091     PISSN: 1342078X     EISSN: None     Source Type: Journal    
DOI: 10.1265/ehpm.9.87     Document Type: Review
Times cited : (14)

References (155)
  • 1
    • 33947463103 scopus 로고
    • A cadmium protein from equine kidney cortex
    • Margoshes M, Vallee BL. A cadmium protein from equine kidney cortex. J. Amer. Chem. Soc. 1957; 79: 4813-4814.
    • (1957) J. Amer. Chem. Soc. , vol.79 , pp. 4813-4814
    • Margoshes, M.1    Vallee, B.L.2
  • 2
    • 0001593597 scopus 로고
    • Metallothionein: A cadmium- and zinc-containing protein from equine renal cortex
    • Kägi JHR, Vallee BL. Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex. J. Biol. Chem. 1960; 235: 3460-3465.
    • (1960) J. Biol. Chem. , vol.235 , pp. 3460-3465
    • Kägi, J.H.R.1    Vallee, B.L.2
  • 3
    • 0343957243 scopus 로고
    • Metallothionein: A cadmium- and zinc-containing protein from equine renal cortex. II. Physicochemical properties
    • Kägi JHR, Valle BL. Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex. II. Physicochemical properties. J. Biol. Chem. 1961; 236: 2435-2442.
    • (1961) J. Biol. Chem. , vol.236 , pp. 2435-2442
    • Kägi, J.H.R.1    Valle, B.L.2
  • 5
    • 0023198489 scopus 로고
    • Interactions between metallothionein and trace elements
    • Bremner I. Interactions between metallothionein and trace elements. Prog. Food Nutr. Sci. 1987; 11: 1-37.
    • (1987) Prog. Food Nutr. Sci. , vol.11 , pp. 1-37
    • Bremner, I.1
  • 6
    • 0038406726 scopus 로고    scopus 로고
    • Metallothioneins: New functional and structural insights
    • Vašák M, Hasler DW. Metallothioneins: new functional and structural insights. Current Opinion Chem. Biol. 2000; 4: 177-183.
    • (2000) Current Opinion Chem. Biol. , vol.4 , pp. 177-183
    • Vašák, M.1    Hasler, D.W.2
  • 7
    • 0033990794 scopus 로고    scopus 로고
    • Regulation of metallothionein gene expression by oxidative stress and metal ions
    • Andrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem. Pharmacol. 2000; 59: 95-104.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 95-104
    • Andrews, G.K.1
  • 10
    • 0002599375 scopus 로고    scopus 로고
    • Metallothionein: Molecular evolution and classification
    • (ed. CD Klaassen). Birkhäuser Verlag, Basel
    • Binz P-A, Kägi JHR. (1999) Metallothionein: Molecular evolution and classification. In: Metallothionein IV (ed. CD Klaassen), pp 7-13. Birkhäuser Verlag, Basel.
    • (1999) Metallothionein IV , pp. 7-13
    • Binz, P.-A.1    Kägi, J.H.R.2
  • 12
    • 0028289610 scopus 로고
    • Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia
    • Quaife CJ, Findley SD, Erickson JC, et al. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry 1994; 33: 7250-7259.
    • (1994) Biochemistry , vol.33 , pp. 7250-7259
    • Quaife, C.J.1    Findley, S.D.2    Erickson, J.C.3
  • 14
  • 16
    • 0021929190 scopus 로고
    • Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids
    • Yagle MK, Palmiter RD. Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids. Mol. Cell. Biol. 1985; 5: 291-294.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 291-294
    • Yagle, M.K.1    Palmiter, R.D.2
  • 17
    • 0034661764 scopus 로고    scopus 로고
    • Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion
    • van Lookeren Campagne M, Thiobodeaux H, van Bruggen N, Cairns B, Lowe DG. Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. J. Neurosci. 2000; 20: 5200-5207.
    • (2000) J. Neurosci. , vol.20 , pp. 5200-5207
    • Van Lookeren Campagne, M.1    Thiobodeaux, H.2    Van Bruggen, N.3    Cairns, B.4    Lowe, D.G.5
  • 18
    • 0019483405 scopus 로고
    • Transcriptional regulation of the mouse metallothionein-I gene by heavy metals
    • Durnam DM, Palmiter RD. Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J. Biol. Chem. 1981; 256: 5712-5716.
    • (1981) J. Biol. Chem. , vol.256 , pp. 5712-5716
    • Durnam, D.M.1    Palmiter, R.D.2
  • 19
  • 20
    • 0023227114 scopus 로고
    • Isolation and characterization of a metallothionein-like protein from monkey brain
    • Gulati S, Paliwal VK, Sharma M, Gill KD, Nath R. Isolation and characterization of a metallothionein-like protein from monkey brain. Toxicology 1987; 45: 53-64.
    • (1987) Toxicology , vol.45 , pp. 53-64
    • Gulati, S.1    Paliwal, V.K.2    Sharma, M.3    Gill, K.D.4    Nath, R.5
  • 21
    • 0033113988 scopus 로고    scopus 로고
    • Localization of metallothioneins-I & -II and -III in the brain of aged dog
    • Kojima S, Shimada A, Morita T, Yamano Y, Umemura T. Localization of metallothioneins-I & -II and -III in the brain of aged dog. J. Vet. Med. Sci. 1999; 61: 343-349.
    • (1999) J. Vet. Med. Sci. , vol.61 , pp. 343-349
    • Kojima, S.1    Shimada, A.2    Morita, T.3    Yamano, Y.4    Umemura, T.5
  • 24
    • 0026078083 scopus 로고
    • Bacterial endotoxin-induced expression of metallothionein genes in rat brain, as revealed by in situ hybridization
    • Itano Y, Noji S, Koyama E, et al. Bacterial endotoxin-induced expression of metallothionein genes in rat brain, as revealed by in situ hybridization. Neurosci. Lett. 1991; 124: 13-16.
    • (1991) Neurosci. Lett. , vol.124 , pp. 13-16
    • Itano, Y.1    Noji, S.2    Koyama, E.3
  • 26
    • 0027994282 scopus 로고
    • Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles
    • Masters BA, Quaife CJ, Erickson JC, et al. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles. J. Neurosci. 1994; 14: 5844-5857.
    • (1994) J. Neurosci , vol.14 , pp. 5844-5857
    • Masters, B.A.1    Quaife, C.J.2    Erickson, J.C.3
  • 27
    • 0032192504 scopus 로고    scopus 로고
    • Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6
    • Carrasco J, Hernández J, González B, Campbell IL, Hidalgo J. Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6. Exp. Neurol. 1998; 153: 184-194.
    • (1998) Exp. Neurol. , vol.153 , pp. 184-194
    • Carrasco, J.1    Hernández, J.2    González, B.3    Campbell, I.L.4    Hidalgo, J.5
  • 28
    • 0033119327 scopus 로고    scopus 로고
    • CNS wound healing is severely depressed in metallothionein I- and II-deficient mice
    • Penkowa M, Carrasco J, Giralt M, Moos T, Hidalgo J. CNS wound healing is severely depressed in metallothionein I- and II-deficient mice. J. Neurosci. 1999; 19: 2535-2545.
    • (1999) J. Neurosci. , vol.19 , pp. 2535-2545
    • Penkowa, M.1    Carrasco, J.2    Giralt, M.3    Moos, T.4    Hidalgo, J.5
  • 29
    • 0026265241 scopus 로고
    • Glial immunoreactivity for metallothionein in the rat brain
    • Young JK, Garvey JS, Huang PC. Glial immunoreactivity for metallothionein in the rat brain. Glia 1991; 4: 602-610.
    • (1991) Glia , vol.4 , pp. 602-610
    • Young, J.K.1    Garvey, J.S.2    Huang, P.C.3
  • 31
    • 84940139156 scopus 로고
    • Glial metallothionein
    • Young JK. Glial metallothionein. Biol. Signals 1994; 3: 169-175.
    • (1994) Biol. Signals , vol.3 , pp. 169-175
    • Young, J.K.1
  • 32
    • 0029257277 scopus 로고
    • Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes
    • Penkowa M, Moos T. Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes. Glia 1995; 13: 217-227.
    • (1995) Glia , vol.13 , pp. 217-227
    • Penkowa, M.1    Moos, T.2
  • 33
    • 0029044550 scopus 로고
    • Immunochemical detection of metallothionein in brain
    • Nakajima K, Suzuki K. Immunochemical detection of metallothionein in brain. Neurochem. Int. 1995; 27: 73-87.
    • (1995) Neurochem. Int. , vol.27 , pp. 73-87
    • Nakajima, K.1    Suzuki, K.2
  • 34
    • 0031038551 scopus 로고    scopus 로고
    • An immunohistochemical study on the tissue-specific localization of metallothionein in dogs
    • Shimada A, Yanagida M, Umemura T. An immunohistochemical study on the tissue-specific localization of metallothionein in dogs. J. Comp. Pathol. 1997; 116: 1-11.
    • (1997) J. Comp. Pathol. , vol.116 , pp. 1-11
    • Shimada, A.1    Yanagida, M.2    Umemura, T.3
  • 35
    • 0032750633 scopus 로고    scopus 로고
    • Immunohistochemical analysis in a case of idiopathic Lennox-Gastaut syndrome
    • Kawashima T, Adachi T, Tokunaga Y, et al. Immunohistochemical analysis in a case of idiopathic Lennox-Gastaut syndrome. Clin. Neuropathol. 1999; 18: 286-292.
    • (1999) Clin. Neuropathol. , vol.18 , pp. 286-292
    • Kawashima, T.1    Adachi, T.2    Tokunaga, Y.3
  • 36
    • 0034069770 scopus 로고    scopus 로고
    • Metallothioneins are upregulated in symptomatic mice with astrocyte-targeted expression of tumor necrosis factor-α
    • Carrasco J, Giralt M, Penkowa M, Stalder AK, Campbell IL, Hidalgo J. Metallothioneins are upregulated in symptomatic mice with astrocyte-targeted expression of tumor necrosis factor-α. Exp. Neurol. 2000; 163: 46-54.
    • (2000) Exp. Neurol. , vol.163 , pp. 46-54
    • Carrasco, J.1    Giralt, M.2    Penkowa, M.3    Stalder, A.K.4    Campbell, I.L.5    Hidalgo, J.6
  • 37
    • 0345086470 scopus 로고    scopus 로고
    • Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: Astroglial response and metallothionein expression
    • Acarin L, González B, Hidalgo J, Castro AJ, Castellano B. Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: astroglial response and metallothionein expression. Neuroscience 1999; 92: 827-839.
    • (1999) Neuroscience , vol.92 , pp. 827-839
    • Acarin, L.1    González, B.2    Hidalgo, J.3    Castro, A.J.4    Castellano, B.5
  • 38
    • 0035058876 scopus 로고    scopus 로고
    • Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner
    • Nagano S, Satoh M, Sumi H, et al. Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner. Eur. J. Neurosci. 2001; 13: 1363-1370.
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 1363-1370
    • Nagano, S.1    Satoh, M.2    Sumi, H.3
  • 39
    • 0035872463 scopus 로고    scopus 로고
    • Roles of the metallothionein family of proteins in the central nervous system
    • Hidalgo J, Aschner M, Zatta P, Vašák M. Roles of the metallothionein family of proteins in the central nervous system. Brain. Res. Bull. 2001; 55: 133-145.
    • (2001) Brain. Res. Bull. , vol.55 , pp. 133-145
    • Hidalgo, J.1    Aschner, M.2    Zatta, P.3    Vašák, M.4
  • 40
    • 0025768860 scopus 로고
    • The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
    • Uchida Y, Takio K, Titani K, Ihara Y, Tomonaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron 1991; 7: 337-347.
    • (1991) Neuron , vol.7 , pp. 337-347
    • Uchida, Y.1    Takio, K.2    Titani, K.3    Ihara, Y.4    Tomonaga, M.5
  • 41
    • 0027048685 scopus 로고
    • Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease
    • Tsuji S, Kobayashi H, Uchida Y, Ihara Y, Miyatake T. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. Embo. J. 1992; 11: 4843-4850.
    • (1992) Embo. J. , vol.11 , pp. 4843-4850
    • Tsuji, S.1    Kobayashi, H.2    Uchida, Y.3    Ihara, Y.4    Miyatake, T.5
  • 42
    • 0027172593 scopus 로고
    • Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system
    • Kobayashi H, Uchida Y, Ihara Y, et al. Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system. Mol. Brain Res. 1993; 19: 188-194.
    • (1993) Mol. Brain Res. , vol.19 , pp. 188-194
    • Kobayashi, H.1    Uchida, Y.2    Ihara, Y.3
  • 43
    • 0030802387 scopus 로고    scopus 로고
    • Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma
    • Hoey JG, Garrett SH, Sens MA, Todd JH, Sens DA. Expression of MT-3 mRNA in human kidney, proximal tubule cell cultures, and renal cell carcinoma. Toxicol. Lett. 1997; 92: 149-160.
    • (1997) Toxicol. Lett. , vol.92 , pp. 149-160
    • Hoey, J.G.1    Garrett, S.H.2    Sens, M.A.3    Todd, J.H.4    Sens, D.A.5
  • 44
    • 0031818254 scopus 로고    scopus 로고
    • Expression of the gene encoding metallothionein-3 in organs of the reproductive system
    • Moffatt P, Séguin C. Expression of the gene encoding metallothionein-3 in organs of the reproductive system. DNA Cell Biol. 1998; 17: 501-510.
    • (1998) DNA Cell Biol. , vol.17 , pp. 501-510
    • Moffatt, P.1    Séguin, C.2
  • 46
    • 0032707806 scopus 로고    scopus 로고
    • Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines
    • Garrett SH, Sens MA, Shukla D, et al. Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines. Prostate 1999; 41: 196-202.
    • (1999) Prostate , vol.41 , pp. 196-202
    • Garrett, S.H.1    Sens, M.A.2    Shukla, D.3
  • 47
    • 0035403880 scopus 로고    scopus 로고
    • Metallothionein isoform 3 overexpression is associated with breast cancers having a poor prognosis
    • Sens MA, Somji S, Garrett SH, Beall CL, Sens DA. Metallothionein isoform 3 overexpression is associated with breast cancers having a poor prognosis. Am. J. Pathol. 2001; 159: 21-26.
    • (2001) Am. J. Pathol. , vol.159 , pp. 21-26
    • Sens, M.A.1    Somji, S.2    Garrett, S.H.3    Beall, C.L.4    Sens, D.A.5
  • 48
    • 0035191940 scopus 로고    scopus 로고
    • Expression and regulation of metallothioneins in the rat epididymis
    • Cyr DG, Dufresne J, Pillet S, Alfieri TJ, Hermo L. Expression and regulation of metallothioneins in the rat epididymis. J. Androl. 2001; 22: 124-135.
    • (2001) J. Androl. , vol.22 , pp. 124-135
    • Cyr, D.G.1    Dufresne, J.2    Pillet, S.3    Alfieri, T.J.4    Hermo, L.5
  • 49
    • 0036828144 scopus 로고    scopus 로고
    • Identification of cell-specific messenger ribonucleic acids in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization
    • Yamashita M, Glasgow E, Zhang BJ, Kusano K, Gainer H. Identification of cell-specific messenger ribonucleic acids in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization. Endocrinology 2002; 143: 4464-4476.
    • (2002) Endocrinology , vol.143 , pp. 4464-4476
    • Yamashita, M.1    Glasgow, E.2    Zhang, B.J.3    Kusano, K.4    Gainer, H.5
  • 50
    • 0028243055 scopus 로고
    • Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain
    • Pountney DL, Fundel SM, Faller P, Birchler NE, Hunziker P, Vasak M. Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain. FEBS Lett. 1994; 345: 193-197.
    • (1994) FEBS Lett. , vol.345 , pp. 193-197
    • Pountney, D.L.1    Fundel, S.M.2    Faller, P.3    Birchler, N.E.4    Hunziker, P.5    Vasak, M.6
  • 51
    • 0029013734 scopus 로고
    • Temporalspatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid-induced seizures
    • Dalton T, Pazdernik TL, Wagner J, Samson F, Andrews GK. Temporalspatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid-induced seizures. Neurochem. Int. 1995; 27: 59-71.
    • (1995) Neurochem. Int. , vol.27 , pp. 59-71
    • Dalton, T.1    Pazdernik, T.L.2    Wagner, J.3    Samson, F.4    Andrews, G.K.5
  • 52
    • 0029804668 scopus 로고    scopus 로고
    • Identification and characterization of metallothionein III (growth inhibitory factor) from porcine brain
    • Chen CF, Wang SH, Lin LY. Identification and characterization of metallothionein III (growth inhibitory factor) from porcine brain. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 1996; 115: 27-32.
    • (1996) Comp. Biochem. Physiol. B Biochem. Mol. Biol. , vol.115 , pp. 27-32
    • Chen, C.F.1    Wang, S.H.2    Lin, L.Y.3
  • 53
    • 0032044202 scopus 로고    scopus 로고
    • Molecular cloning and expression of the canine metallothionein-III gene
    • Kojima S, Shimada A, Kodan A, et al. Molecular cloning and expression of the canine metallothionein-III gene. Can. J. Vet. Res. 1998; 62: 148-151.
    • (1998) Can. J. Vet. Res. , vol.62 , pp. 148-151
    • Kojima, S.1    Shimada, A.2    Kodan, A.3
  • 54
    • 0036645710 scopus 로고    scopus 로고
    • Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III
    • Chung RS, Holloway AF, Eckhardt BL, et al. Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III. Biochem. J. 2002; 365: 323-328.
    • (2002) Biochem. J. , vol.365 , pp. 323-328
    • Chung, R.S.1    Holloway, A.F.2    Eckhardt, B.L.3
  • 55
    • 0002450099 scopus 로고
    • Growth inhibitory factor in brain
    • (eds. Kt Suzuki, N Imura, M Kimura). Birkhäuser Verlag, Basel
    • Uchida Y. Growth inhibitory factor in brain. In: Metallothionein III (eds. Kt Suzuki, N Imura, M Kimura), pp. 315-328. Birkhäuser Verlag, Basel, 1993.
    • (1993) Metallothionein III , pp. 315-328
    • Uchida, Y.1
  • 56
    • 0029013735 scopus 로고
    • Expression of growth inhibitory factor (GIF) in normal and injured rat brains
    • Anezaki T, Ishiguro H, Hozumi I, et al. Expression of growth inhibitory factor (GIF) in normal and injured rat brains. Neurochem. Int. 1995; 27: 89-94.
    • (1995) Neurochem. Int. , vol.27 , pp. 89-94
    • Anezaki, T.1    Ishiguro, H.2    Hozumi, I.3
  • 57
    • 0029130554 scopus 로고
    • Expression of growth inhibitory factor mRNA following cortical injury
    • Yuguchi T, Kohmura E, Yamada K, et al. Expression of growth inhibitory factor mRNA following cortical injury. J. Neurotrauma 1995; 12: 299-306.
    • (1995) J. Neurotrauma , vol.12 , pp. 299-306
    • Yuguchi, T.1    Kohmura, E.2    Yamada, K.3
  • 58
    • 0028831497 scopus 로고
    • Changes in growth inhibitory factor mRNA expression compared with those in c-jun mRNA expression following facial nerve transection
    • Yuguchi T, Kohmura E, Yamada K, et al. Changes in growth inhibitory factor mRNA expression compared with those in c-jun mRNA expression following facial nerve transection. Mol. Brain Res. 1995; 28: 181-185.
    • (1995) Mol. Brain Res. , vol.28 , pp. 181-185
    • Yuguchi, T.1    Kohmura, E.2    Yamada, K.3
  • 59
    • 0028978526 scopus 로고
    • Chemical modulation of metallothionein I and III mRNA in mouse brain
    • Zheng H, Berman NE, Klaassen CD. Chemical modulation of metallothionein I and III mRNA in mouse brain. Neurochem. Int. 1995; 27: 43-58.
    • (1995) Neurochem. Int. , vol.27 , pp. 43-58
    • Zheng, H.1    Berman, N.E.2    Klaassen, C.D.3
  • 61
    • 0030799225 scopus 로고    scopus 로고
    • Expression of growth inhibitory factor mRNA after focal ischemia in rat brain
    • Yuguchi T, Kohmura E, Sakaki T, et al. Expression of growth inhibitory factor mRNA after focal ischemia in rat brain. J. Cereb. Blood Flow Metab. 1997; 17: 745-752.
    • (1997) J. Cereb. Blood Flow Metab. , vol.17 , pp. 745-752
    • Yuguchi, T.1    Kohmura, E.2    Sakaki, T.3
  • 62
    • 0032526171 scopus 로고    scopus 로고
    • Interleukin-6 and tumor necrosis factor-alpha type 1 receptor deficient mice reveal a role of IL-6 and TNF-alpha on brain metallothionein-I and -III regulation
    • Carrasco J, Hernández J, Bluethmann H, Hidalgo J. Interleukin-6 and tumor necrosis factor-alpha type 1 receptor deficient mice reveal a role of IL-6 and TNF-alpha on brain metallothionein-I and -III regulation. Mol. Brain Res. 1998; 57: 221-234.
    • (1998) Mol. Brain Res. , vol.57 , pp. 221-234
    • Carrasco, J.1    Hernández, J.2    Bluethmann, H.3    Hidalgo, J.4
  • 63
    • 0033113988 scopus 로고    scopus 로고
    • Localization of metallothioneins-I & -II and -III in the brain of aged dog
    • Kojima S, Shimada A, Morita T, Yamano Y, Umemura T. Localization of metallothioneins-I & -II and -III in the brain of aged dog. J. Vet. Med. Sci. 1999; 61: 343-349.
    • (1999) J. Vet. Med. Sci. , vol.61 , pp. 343-349
    • Kojima, S.1    Shimada, A.2    Morita, T.3    Yamano, Y.4    Umemura, T.5
  • 64
    • 0033559447 scopus 로고    scopus 로고
    • The distribution of zinc selenite and expression of metallothionein-III mRNA in the spinal cord and dorsal root ganglia of the rat suggest a role for zinc in sensory transmission
    • Velázquez RA, Cai Y, Shi Q, Larson AA. The distribution of zinc selenite and expression of metallothionein-III mRNA in the spinal cord and dorsal root ganglia of the rat suggest a role for zinc in sensory transmission. J. Neurosci. 1999; 19: 2288-2300.
    • (1999) J. Neurosci. , vol.19 , pp. 2288-2300
    • Velázquez, R.A.1    Cai, Y.2    Shi, Q.3    Larson, A.A.4
  • 65
    • 0032944167 scopus 로고    scopus 로고
    • Expression of growth inhibitory factor (metallothionein-III) mRNA and protein following excitotoxic immature brain injury
    • Acarin L, Carrasco J, González B, Hidalgo J, Castellano B. Expression of growth inhibitory factor (metallothionein-III) mRNA and protein following excitotoxic immature brain injury. J. Neuropathol. Exp. Neurol. 1999; 58: 389-397.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 389-397
    • Acarin, L.1    Carrasco, J.2    González, B.3    Hidalgo, J.4    Castellano, B.5
  • 66
    • 0033557201 scopus 로고    scopus 로고
    • Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice
    • Penkowa M, Moos T, Carrasco J, et al. Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice. Glia 1999; 25: 343-357.
    • (1999) Glia , vol.25 , pp. 343-357
    • Penkowa, M.1    Moos, T.2    Carrasco, J.3
  • 67
    • 0011392304 scopus 로고    scopus 로고
    • Metallothionein expression is altered in a transgenic murine model of familial amyotrophic latyeral sclerosis
    • Gong YH, Elliott JL. Metallothionein expression is altered in a transgenic murine model of familial amyotrophic latyeral sclerosis. Exp. Neurol. 2000; 162: 27-36.
    • (2000) Exp. Neurol. , vol.162 , pp. 27-36
    • Gong, Y.H.1    Elliott, J.L.2
  • 68
    • 0037728629 scopus 로고    scopus 로고
    • Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment
    • Kim D, Kim EH, Kim C, et al. Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment. Neuroreport 2003; 14: 679-682.
    • (2003) Neuroreport , vol.14 , pp. 679-682
    • Kim, D.1    Kim, E.H.2    Kim, C.3
  • 69
    • 0030574080 scopus 로고    scopus 로고
    • Subcellular localization of growth inhibitory factor in rat brain: Light and electron microscopic immunohistochemical studies
    • Yamada M, Hayashi S, Hozumi I, Inuzuka T, Tsuji S, Takahashi H. Subcellular localization of growth inhibitory factor in rat brain: light and electron microscopic immunohistochemical studies. Brain Res. 1996; 735: 257-264.
    • (1996) Brain Res. , vol.735 , pp. 257-264
    • Yamada, M.1    Hayashi, S.2    Hozumi, I.3    Inuzuka, T.4    Tsuji, S.5    Takahashi, H.6
  • 70
    • 0030601960 scopus 로고    scopus 로고
    • Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds-an immunocytochemical study using confocal laser scan microscope
    • Hozumi I, Inuzuka T, Ishiguro H, Hiraiwa M, Uchida Y, Tsuji S. Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds-an immunocytochemical study using confocal laser scan microscope. Brain Res. 1996; 741: 197-204.
    • (1996) Brain Res. , vol.741 , pp. 197-204
    • Hozumi, I.1    Inuzuka, T.2    Ishiguro, H.3    Hiraiwa, M.4    Uchida, Y.5    Tsuji, S.6
  • 71
    • 0032747632 scopus 로고    scopus 로고
    • Metallothionein (MT)-III: Generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains
    • Carrasco J, Giralt M, Molinero A, Penkowa M, Moos T, Hidalgo J. Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains. J. Neurotrauma. 1999; 16: 1115-1129.
    • (1999) J. Neurotrauma , vol.16 , pp. 1115-1129
    • Carrasco, J.1    Giralt, M.2    Molinero, A.3    Penkowa, M.4    Moos, T.5    Hidalgo, J.6
  • 73
    • 0034007406 scopus 로고    scopus 로고
    • Neuron death and glial response in pontosubicular necrosis. The role of the growth inhibition factor
    • Isumi H, Uchida Y, Hayashi T, Furukawa S, Takashima S. Neuron death and glial response in pontosubicular necrosis. The role of the growth inhibition factor. Clin. Neuropathol. 2000; 19: 77-84.
    • (2000) Clin. Neuropathol. , vol.19 , pp. 77-84
    • Isumi, H.1    Uchida, Y.2    Hayashi, T.3    Furukawa, S.4    Takashima, S.5
  • 74
    • 0035056140 scopus 로고    scopus 로고
    • Zinc or copper deficiency-induced impaired inflammatory response to brain trauma may be caused by the concomitant metallothionein changes
    • Penkowa M, Giralt M, Thomsen P, Carrasco J, Hidalgo J. Zinc or copper deficiency-induced impaired inflammatory response to brain trauma may be caused by the concomitant metallothionein changes. J. Neurotrauma 2001; 18: 447-463.
    • (2001) J. Neurotrauma , vol.18 , pp. 447-463
    • Penkowa, M.1    Giralt, M.2    Thomsen, P.3    Carrasco, J.4    Hidalgo, J.5
  • 75
    • 0033556215 scopus 로고    scopus 로고
    • Ischemia induces metallothionein III expression in neurons of rat brain
    • Yanagitani S, Miyazaki H, Nakahashi Y, et al. Ischemia induces metallothionein III expression in neurons of rat brain. Life Sci. 1999; 64: 707-715.
    • (1999) Life Sci. , vol.64 , pp. 707-715
    • Yanagitani, S.1    Miyazaki, H.2    Nakahashi, Y.3
  • 77
    • 0344394903 scopus 로고    scopus 로고
    • Zinc released from metallothionein-III may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury
    • Lee JY, Kim JH, Palmiter RD, Koh JY. Zinc released from metallothionein-III may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury. Exp. Neurol. 2003; 184: 337-347.
    • (2003) Exp. Neurol. , vol.184 , pp. 337-347
    • Lee, J.Y.1    Kim, J.H.2    Palmiter, R.D.3    Koh, J.Y.4
  • 80
    • 0032127594 scopus 로고    scopus 로고
    • Metallothioneins are highly expressed in astrocytes and microcapillaries in Alzheimer's disease
    • Zambenedetti P, Giordano R, Zatta P. Metallothioneins are highly expressed in astrocytes and microcapillaries in Alzheimer's disease. J. Chem. Neuroanat. 1998; 15: 21-26.
    • (1998) J. Chem. Neuroanat. , vol.15 , pp. 21-26
    • Zambenedetti, P.1    Giordano, R.2    Zatta, P.3
  • 81
    • 0032413587 scopus 로고    scopus 로고
    • Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease
    • Adlard PA, West AK, Vickers JC. Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease. Neurobiol. Dis. 1998; 5: 349-356.
    • (1998) Neurobiol. Dis. , vol.5 , pp. 349-356
    • Adlard, P.A.1    West, A.K.2    Vickers, J.C.3
  • 82
    • 0033597547 scopus 로고    scopus 로고
    • Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice
    • Chuah MI, Getchell ML. Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice. Neuroreport 1999; 10: 1919-1924.
    • (1999) Neuroreport , vol.10 , pp. 1919-1924
    • Chuah, M.I.1    Getchell, M.L.2
  • 83
    • 0026781415 scopus 로고
    • Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis
    • Sillevis Smitt PA, Blaauwgeers HG, Troost D, de Jong JM. Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis. Neurosci. Lett. 1992; 144: 107-110.
    • (1992) Neurosci. Lett. , vol.144 , pp. 107-110
    • Sillevis Smitt, P.A.1    Blaauwgeers, H.G.2    Troost, D.3    De Jong, J.M.4
  • 85
    • 0030272622 scopus 로고    scopus 로고
    • Expression of different metallothionein messenger ribonucleic acids in motor cortex, spinal cord and liver from patients with amyotrophic lateral sclerosis
    • Blaauwgeers HG, Anwar Chand M, van den Berg FM, Vianney de Jong JM, Troost D. Expression of different metallothionein messenger ribonucleic acids in motor cortex, spinal cord and liver from patients with amyotrophic lateral sclerosis. J. Neurol. Sci. 1996; 142: 39-44.
    • (1996) J. Neurol. Sci. , vol.142 , pp. 39-44
    • Blaauwgeers, H.G.1    Anwar Chand, M.2    Van Den Berg, F.M.3    Vianney De Jong, J.M.4    Troost, D.5
  • 86
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C, Hermans G, Pedotti R, et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002; 8: 500-508.
    • (2002) Nat. Med. , vol.8 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3
  • 88
    • 0025024263 scopus 로고
    • Endotoxin induction of murine metallothionein gene expression
    • De SK, McMaster MT, Andrews GK. Endotoxin induction of murine metallothionein gene expression. J. Biol. Chem. 1990; 265: 15267-15274.
    • (1990) J. Biol. Chem. , vol.265 , pp. 15267-15274
    • De, S.K.1    McMaster, M.T.2    Andrews, G.K.3
  • 89
    • 0025469698 scopus 로고
    • Liver, brain, and heart metallothionein induction by stress
    • Hidalgo J, Borras M, Garvey JS, Armario A. Liver, brain, and heart metallothionein induction by stress. J. Neurochem. 1990; 55: 651-654.
    • (1990) J. Neurochem. , vol.55 , pp. 651-654
    • Hidalgo, J.1    Borras, M.2    Garvey, J.S.3    Armario, A.4
  • 90
    • 0028105293 scopus 로고
    • Regulation of metallothionein-I+II levels in specific brain areas and liver in the rat: Role of catecholamines
    • Gasull T, Giralt M, García A, Hidalgo J. Regulation of metallothionein-I+II levels in specific brain areas and liver in the rat: role of catecholamines. Glia 1994; 12: 135-143.
    • (1994) Glia , vol.12 , pp. 135-143
    • Gasull, T.1    Giralt, M.2    García, A.3    Hidalgo, J.4
  • 91
    • 0032804191 scopus 로고    scopus 로고
    • Induction of metallothionein by stress and its molecular mechanisms
    • Jacob ST, Ghoshal K, Sheridan JF. Induction of metallothionein by stress and its molecular mechanisms. Gene Expr. 1999; 7: 301-310.
    • (1999) Gene Expr. , vol.7 , pp. 301-310
    • Jacob, S.T.1    Ghoshal, K.2    Sheridan, J.F.3
  • 93
    • 0032484651 scopus 로고    scopus 로고
    • Alterations of metallothionein II and apolipoprotein J mRNA levels in kainate-treated rats
    • Montpied P, de Bock F, Baldy Moulinier M, Rondouin G. Alterations of metallothionein II and apolipoprotein J mRNA levels in kainate-treated rats. Neuroreport 1998; 9: 79-83.
    • (1998) Neuroreport , vol.9 , pp. 79-83
    • Montpied, P.1    De Bock, F.2    Baldy Moulinier, M.3    Rondouin, G.4
  • 94
    • 0033931868 scopus 로고    scopus 로고
    • Enhanced seizures and hippocampal neurodegeneration following kainic acid induced seizures in metallothionein-I+II deficient mice
    • Carrasco J, Penkowa M, Hadberg H, Molinero A, Hidalgo J. Enhanced seizures and hippocampal neurodegeneration following kainic acid induced seizures in metallothionein-I+II deficient mice. Eur. J. Neurosci. 2000; 12: 2311-2322.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 2311-2322
    • Carrasco, J.1    Penkowa, M.2    Hadberg, H.3    Molinero, A.4    Hidalgo, J.5
  • 95
    • 0036460425 scopus 로고    scopus 로고
    • Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia
    • Tang Y, Lu A, Aronow BJ, Wagner KR, Sharp FR. Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur. J. Neurosci. 2002; 15: 1937-1952.
    • (2002) Eur. J. Neurosci. , vol.15 , pp. 1937-1952
    • Tang, Y.1    Lu, A.2    Aronow, B.J.3    Wagner, K.R.4    Sharp, F.R.5
  • 96
    • 0029885593 scopus 로고    scopus 로고
    • Immunocytochemically detectable metallothionein is expressed by astrocytes in the ischaemic human brain
    • Neal JW, Singhrao SK, Jasani B, Newman GR. Immunocytochemically detectable metallothionein is expressed by astrocytes in the ischaemic human brain. Neuropathol. Appl. Neurobiol. 1996; 22: 243-247.
    • (1996) Neuropathol. Appl. Neurobiol. , vol.22 , pp. 243-247
    • Neal, J.W.1    Singhrao, S.K.2    Jasani, B.3    Newman, G.R.4
  • 98
    • 0037101619 scopus 로고    scopus 로고
    • Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia
    • Trendelenburg G, Prass K, Priller J, et al. Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. J. Neurosci. 2002; 22: 5879-5888.
    • (2002) J. Neurosci. , vol.22 , pp. 5879-5888
    • Trendelenburg, G.1    Prass, K.2    Priller, J.3
  • 99
    • 0035783937 scopus 로고    scopus 로고
    • Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice
    • Fukada K, Nagano S, Satoh M, et al. Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice. Eur. J. Neurosci. 2001; 14: 2032-2036.
    • (2001) Eur. J. Neurosci. , vol.14 , pp. 2032-2036
    • Fukada, K.1    Nagano, S.2    Satoh, M.3
  • 100
    • 0037109771 scopus 로고    scopus 로고
    • Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins
    • Puttaparthi K, Gitomer WL, Krishnan U, Son M, Rajendran B, Elliott JL. Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins. J. Neurosci. 2002; 22: 8790-8796.
    • (2002) J. Neurosci. , vol.22 , pp. 8790-8796
    • Puttaparthi, K.1    Gitomer, W.L.2    Krishnan, U.3    Son, M.4    Rajendran, B.5    Elliott, J.L.6
  • 101
    • 0033662509 scopus 로고    scopus 로고
    • Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis
    • Penkowa M, Hidalgo J. Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis. Glia 2000; 32: 247-263.
    • (2000) Glia , vol.32 , pp. 247-263
    • Penkowa, M.1    Hidalgo, J.2
  • 102
    • 0035934271 scopus 로고    scopus 로고
    • Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis
    • Espejo C, Carrasco J, Hidalgo J, et al. Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis. Neuroscience 2001; 105: 1055-1065.
    • (2001) Neuroscience , vol.105 , pp. 1055-1065
    • Espejo, C.1    Carrasco, J.2    Hidalgo, J.3
  • 103
    • 0035479008 scopus 로고    scopus 로고
    • Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis
    • Penkowa M, Espejo C, Martínez-Cáceres EM, Poulsen CB, Montalban X, Hidalgo J. Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2001; 119: 248-260.
    • (2001) J. Neuroimmunol. , vol.119 , pp. 248-260
    • Penkowa, M.1    Espejo, C.2    Martínez-Cáceres, E.M.3    Poulsen, C.B.4    Montalban, X.5    Hidalgo, J.6
  • 104
    • 0031558662 scopus 로고    scopus 로고
    • Increased astrocytic expression of metallothioneins I+II in brainstem of adult rats treated with 6-aminonicotinamide
    • Penkowa M, Hidalgo J, Moos T. Increased astrocytic expression of metallothioneins I+II in brainstem of adult rats treated with 6-aminonicotinamide. Brain Res. 1997; 774: 256-259.
    • (1997) Brain Res. , vol.774 , pp. 256-259
    • Penkowa, M.1    Hidalgo, J.2    Moos, T.3
  • 105
    • 0032994517 scopus 로고    scopus 로고
    • Impaired inflammatory response to glial cell death in genetically metallothionein-I- and -II-deficient mice
    • Penkowa M, Giralt M, Moos T, Thomsen PS, Hernández J, Hidalgo J. Impaired inflammatory response to glial cell death in genetically metallothionein-I- and -II-deficient mice. Exp. Neurol. 1999; 156: 149-164.
    • (1999) Exp. Neurol. , vol.156 , pp. 149-164
    • Penkowa, M.1    Giralt, M.2    Moos, T.3    Thomsen, P.S.4    Hernández, J.5    Hidalgo, J.6
  • 106
    • 0034111307 scopus 로고    scopus 로고
    • IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment
    • Penkowa M, Hidalgo J. IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment. Exp. Neurol. 2000; 163: 72-84.
    • (2000) Exp. Neurol. , vol.163 , pp. 72-84
    • Penkowa, M.1    Hidalgo, J.2
  • 107
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle J, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993; 262: 689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.1    Puttfarcken, P.2
  • 108
    • 0028800715 scopus 로고
    • Cytokines and the nervous system. I: Expression and recognition
    • Hopkins S, Rothwell N. Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci. 1995; 18: 83-88.
    • (1995) Trends Neurosci. , vol.18 , pp. 83-88
    • Hopkins, S.1    Rothwell, N.2
  • 109
    • 0028869476 scopus 로고
    • Cytokines and the nervous system II: Actions and mechanisms of action
    • Rothwell NJ, Hopkins SJ. Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurol. Sci. 1995; 18: 130-136.
    • (1995) Trends Neurol. Sci. , vol.18 , pp. 130-136
    • Rothwell, N.J.1    Hopkins, S.J.2
  • 110
    • 0345195968 scopus 로고    scopus 로고
    • Experimental strategies to promote axonal regeneration after traumatic central nervous system injury
    • Stichel C, Verner Müller H. Experimental strategies to promote axonal regeneration after traumatic central nervous system injury. Progr. Neurobiol. 1998; 56: 119-148.
    • (1998) Progr. Neurobiol. , vol.56 , pp. 119-148
    • Stichel, C.1    Verner Müller, H.2
  • 111
    • 0031766138 scopus 로고    scopus 로고
    • Novel pharmacologic strategies in the treatment of experimental traumatic brain injury
    • McIntosh T, Juhler M, Wieloch T. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury. J. Neurotrauma 1998; 15: 731-769.
    • (1998) J. Neurotrauma , vol.15 , pp. 731-769
    • McIntosh, T.1    Juhler, M.2    Wieloch, T.3
  • 112
    • 0027433102 scopus 로고
    • Neurologic disease in transgenic mice by cerebral overexpression of interleukin 6
    • Campbell IL, Abraham CR, Masliah E, et al. Neurologic disease in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA 1993; 90: 10061-10065.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10061-10065
    • Campbell, I.L.1    Abraham, C.R.2    Masliah, E.3
  • 113
    • 0031656782 scopus 로고    scopus 로고
    • Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor
    • Stalder AK, Carson MJ, Pagenstecher A, et al. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. Am. J. Pathol. 1998; 153: 767-783.
    • (1998) Am. J. Pathol. , vol.153 , pp. 767-783
    • Stalder, A.K.1    Carson, M.J.2    Pagenstecher, A.3
  • 114
    • 17044453671 scopus 로고    scopus 로고
    • Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice
    • Hernández J, Molinero A, Campbell IL, Hidalgo J. Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice. Brain. Res. Mol. Brain. Res. 1997; 48: 125-131.
    • (1997) Brain. Res. Mol. Brain. Res. , vol.48 , pp. 125-131
    • Hernández, J.1    Molinero, A.2    Campbell, I.L.3    Hidalgo, J.4
  • 115
    • 0035075017 scopus 로고    scopus 로고
    • Astrocyte-targeted expression of interleukin-3 and interferon-a causes specific changes in metallothionein expression in the brain
    • Giralt M, Carrasco J, Penkowa M, et al. Astrocyte-targeted expression of interleukin-3 and interferon-a causes specific changes in metallothionein expression in the brain. Exp. Neurol. 2001; 168: 334-346.
    • (2001) Exp. Neurol. , vol.168 , pp. 334-346
    • Giralt, M.1    Carrasco, J.2    Penkowa, M.3
  • 116
    • 0027533507 scopus 로고
    • Oxygen free radicals and metallothionein
    • Sato M, Bremner I. Oxygen free radicals and metallothionein. Free Radical Biol. Med. 1993; 14: 325-337.
    • (1993) Free Radical Biol. Med. , vol.14 , pp. 325-337
    • Sato, M.1    Bremner, I.2
  • 117
    • 0029845691 scopus 로고    scopus 로고
    • The functional significance of brain metallothioneins
    • Aschner M. The functional significance of brain metallothioneins. Faseb J. 1996; 10: 1129-1136.
    • (1996) Faseb J. , vol.10 , pp. 1129-1136
    • Aschner, M.1
  • 118
    • 0032952723 scopus 로고    scopus 로고
    • Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression
    • Lee DK, Carrasco J, Hidalgo J, Andrews GK. Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. Biochem. J. 1999; 337: 59-65.
    • (1999) Biochem. J. , vol.337 , pp. 59-65
    • Lee, D.K.1    Carrasco, J.2    Hidalgo, J.3    Andrews, G.K.4
  • 119
    • 0027182948 scopus 로고
    • Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice
    • Palmiter RD, Sandgren EP, Koeller DM, Brinster RL. Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol. Cell. Biol. 1993; 13: 5266-5275.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5266-5275
    • Palmiter, R.D.1    Sandgren, E.P.2    Koeller, D.M.3    Brinster, R.L.4
  • 120
    • 0027204069 scopus 로고
    • Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse
    • Michalska AE, Choo KH. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. USA 1993; 90: 8088-8092.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8088-8092
    • Michalska, A.E.1    Choo, K.H.2
  • 122
    • 0037022717 scopus 로고    scopus 로고
    • Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide
    • Penkowa M, Giralt M, Camats J, Hidalgo J. Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide. J. Comp. Neurol. 2002; 444: 174-189.
    • (2002) J. Comp. Neurol. , vol.444 , pp. 174-189
    • Penkowa, M.1    Giralt, M.2    Camats, J.3    Hidalgo, J.4
  • 123
    • 0037067511 scopus 로고    scopus 로고
    • Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain
    • Asanuma M, Miyazaki I, Higashi Y, et al. Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. Neurosci. Lett. 2002; 327: 61-65.
    • (2002) Neurosci. Lett. , vol.327 , pp. 61-65
    • Asanuma, M.1    Miyazaki, I.2    Higashi, Y.3
  • 124
    • 0037278676 scopus 로고    scopus 로고
    • Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis
    • Penkowa M, Espejo C, Martinez-Cáceres EM, Montalban X, Hidalgo J. Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis. Cell. Mol. Life Sci. 2003; 60: 185-197.
    • (2003) Cell. Mol. Life Sci. , vol.60 , pp. 185-197
    • Penkowa, M.1    Espejo, C.2    Martinez-Cáceres, E.M.3    Montalban, X.4    Hidalgo, J.5
  • 125
    • 0033871715 scopus 로고    scopus 로고
    • Altered central nervous system cytokine-growth factor expression profiles and angiogenesis in metallothionein-I+II deficient mice
    • Penkowa M, Carrasco J, Giralt M, et al. Altered central nervous system cytokine-growth factor expression profiles and angiogenesis in metallothionein-I+II deficient mice. J. Cereb. Blood Flow Metab. 2000; 20: 1174-1189.
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 1174-1189
    • Penkowa, M.1    Carrasco, J.2    Giralt, M.3
  • 126
    • 0036148593 scopus 로고    scopus 로고
    • Metallothionein-1+2 protect the CNS after a focal brain injury
    • Giralt M, Penkowa M, Lago N, Molinero A, Hidalgo J. Metallothionein-1+2 protect the CNS after a focal brain injury. Exp. Neurol. 2002; 173: 114-128.
    • (2002) Exp. Neurol. , vol.173 , pp. 114-128
    • Giralt, M.1    Penkowa, M.2    Lago, N.3    Molinero, A.4    Hidalgo, J.5
  • 127
    • 0036237140 scopus 로고    scopus 로고
    • Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6
    • Giralt M, Penkowa M, Hernández J, et al. Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiol. Dis. 2002; 9: 319-338.
    • (2002) Neurobiol. Dis. , vol.9 , pp. 319-338
    • Giralt, M.1    Penkowa, M.2    Hernández, J.3
  • 128
    • 0037342555 scopus 로고    scopus 로고
    • Metallothionein-1 overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6
    • Molinero A, Penkowa M, Hernández J, et al. Metallothionein-1 overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. J. Neuropathol. Exp. Neurol. 2003; 62: 315-328.
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 315-328
    • Molinero, A.1    Penkowa, M.2    Hernández, J.3
  • 129
    • 0038407699 scopus 로고    scopus 로고
    • Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression
    • Penkowa M, Camats J, Giralt M, et al. Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia 2003; 42: 287-306.
    • (2003) Glia , vol.42 , pp. 287-306
    • Penkowa, M.1    Camats, J.2    Giralt, M.3
  • 130
    • 0037911433 scopus 로고    scopus 로고
    • Treatment with metallothionein prevents demyelination and axonal damage and increases oliogodendrocyte precursors and tissue reapir during experimental autoimmune encephalomyelitis (EAE)
    • Penkowa M, Hidalgo J. Treatment with metallothionein prevents demyelination and axonal damage and increases oliogodendrocyte precursors and tissue reapir during experimental autoimmune encephalomyelitis (EAE). J. Neurosci. Res. 2003; 72: 574-586.
    • (2003) J. Neurosci. Res. , vol.72 , pp. 574-586
    • Penkowa, M.1    Hidalgo, J.2
  • 131
    • 0037996720 scopus 로고    scopus 로고
    • Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury
    • Chung RS, Vickers JC, Chuah MI, West AK. Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury. J. Neurosci. 2003; 23: 3336-3342.
    • (2003) J. Neurosci. , vol.23 , pp. 3336-3342
    • Chung, R.S.1    Vickers, J.C.2    Chuah, M.I.3    West, A.K.4
  • 132
    • 0028263925 scopus 로고
    • Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)
    • Erickson JC, Sewell AK, Jensen LT, Winge DR, Palmiter RD. Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Brain Res. 1994; 649: 297-304.
    • (1994) Brain Res. , vol.649 , pp. 297-304
    • Erickson, J.C.1    Sewell, A.K.2    Jensen, L.T.3    Winge, D.R.4    Palmiter, R.D.5
  • 134
    • 84940629830 scopus 로고
    • Growth-inhibitory factor, metallothionein-like protein, and neurodegenerative diseases
    • Uchida Y. Growth-inhibitory factor, metallothionein-like protein, and neurodegenerative diseases. Biol. Signals 1994; 3: 211-215.
    • (1994) Biol. Signals , vol.3 , pp. 211-215
    • Uchida, Y.1
  • 135
    • 0030723805 scopus 로고    scopus 로고
    • Developmental immunohistochemistry of growth inhibitory factor in normal brains and brains of patients with Down syndrome
    • Arai Y, Uchida Y, Takashima S. Developmental immunohistochemistry of growth inhibitory factor in normal brains and brains of patients with Down syndrome. Pediatr. Neurol. 1997; 17: 134-138.
    • (1997) Pediatr. Neurol. , vol.17 , pp. 134-138
    • Arai, Y.1    Uchida, Y.2    Takashima, S.3
  • 136
    • 0029096205 scopus 로고
    • Changes of growth inhibitory factor after stab wounds in rat brain
    • Hozumi I, Inuzuka T, Hiraiwa M, et al. Changes of growth inhibitory factor after stab wounds in rat brain. Brain Res. 1995; 688: 143-148.
    • (1995) Brain Res. , vol.688 , pp. 143-148
    • Hozumi, I.1    Inuzuka, T.2    Hiraiwa, M.3
  • 137
    • 0030050959 scopus 로고    scopus 로고
    • Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats
    • Inuzuka T, Hozumi I, Tamura A, Hiraiwa M, Tsuji S. Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats. Brain Res. 1996; 709: 151-153.
    • (1996) Brain Res. , vol.709 , pp. 151-153
    • Inuzuka, T.1    Hozumi, I.2    Tamura, A.3    Hiraiwa, M.4    Tsuji, S.5
  • 139
    • 0031016825 scopus 로고    scopus 로고
    • Disruption of the metallothionein-III gene in mice: Analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures
    • Erickson JC, Hollopeter G, Thomas SA, Froelick GJ, Palmiter RD. Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J. Neurosci. 1997; 17: 1271-1281.
    • (1997) J. Neurosci. , vol.17 , pp. 1271-1281
    • Erickson, J.C.1    Hollopeter, G.2    Thomas, S.A.3    Froelick, G.J.4    Palmiter, R.D.5
  • 140
    • 0034047740 scopus 로고    scopus 로고
    • Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons
    • Montoliu C, Monfort P, Carrasco J, et al. Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons. J. Neurochem. 2000; 75: 266-273.
    • (2000) J. Neurochem. , vol.75 , pp. 266-273
    • Montoliu, C.1    Monfort, P.2    Carrasco, J.3
  • 141
    • 0037008050 scopus 로고    scopus 로고
    • S-Nitrosothiols React Preferentially with Zinc Thiolate Clusters of Metallothionein III through Transnitrosation
    • Chen Y, Irie Y, Keung WM, Maret W. S-Nitrosothiols React Preferentially with Zinc Thiolate Clusters of Metallothionein III through Transnitrosation. Biochemistry 2002; 41: 8360-8367.
    • (2002) Biochemistry , vol.41 , pp. 8360-8367
    • Chen, Y.1    Irie, Y.2    Keung, W.M.3    Maret, W.4
  • 142
    • 0035814479 scopus 로고    scopus 로고
    • Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals
    • Ren H, Ji Q, Liu Y, Ru B. Different protective roles in vitro of alpha- and beta-domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals. Biochim. Biophys. Acta 2001; 1568: 129-134.
    • (2001) Biochim. Biophys. Acta , vol.1568 , pp. 129-134
    • Ren, H.1    Ji, Q.2    Liu, Y.3    Ru, B.4
  • 143
    • 0034811882 scopus 로고    scopus 로고
    • Metallothionein-III antagonizes the neurotoxic and neurotrophic effects of amyloid beta peptides
    • Irie Y, Keung WM. Metallothionein-III antagonizes the neurotoxic and neurotrophic effects of amyloid beta peptides. Biochem. Biophys. Res. Commun. 2001; 282: 416-420.
    • (2001) Biochem. Biophys. Res. Commun. , vol.282 , pp. 416-420
    • Irie, Y.1    Keung, W.M.2
  • 144
    • 0037449446 scopus 로고    scopus 로고
    • Anti-amyloid beta activity of metallothionein-III is different from its neuronal growth inhibitory activity: Structure-activity studies
    • Irie Y, Keung WM. Anti-amyloid beta activity of metallothionein-III is different from its neuronal growth inhibitory activity: structure-activity studies. Brain Res. 2003; 960: 228-234.
    • (2003) Brain Res. , vol.960 , pp. 228-234
    • Irie, Y.1    Keung, W.M.2
  • 145
    • 0037200013 scopus 로고    scopus 로고
    • Growth inhibitory factor prevents neurite extension and death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging
    • Uchida Y, Gomi F, Masumizu T, Miura Y. Growth inhibitory factor prevents neurite extension and death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. J. Biol. Chem. 2002; 277: 32353-32359.
    • (2002) J. Biol. Chem. , vol.277 , pp. 32353-32359
    • Uchida, Y.1    Gomi, F.2    Masumizu, T.3    Miura, Y.4
  • 146
    • 0037412035 scopus 로고    scopus 로고
    • Interactions of growth inhibitory factor with hydroxyl and superoxide radicals
    • Shi Y, Wang W, Mo J, Du L, Yao S, Tang W. Interactions of growth inhibitory factor with hydroxyl and superoxide radicals. Biometals 2003; 16: 383-389.
    • (2003) Biometals , vol.16 , pp. 383-389
    • Shi, Y.1    Wang, W.2    Mo, J.3    Du, L.4    Yao, S.5    Tang, W.6
  • 147
    • 0041525416 scopus 로고    scopus 로고
    • Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3
    • Roschitzki B, Vasak M. Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3. Biochemistry 2003; 42: 9822-9828.
    • (2003) Biochemistry , vol.42 , pp. 9822-9828
    • Roschitzki, B.1    Vasak, M.2
  • 148
    • 85026146143 scopus 로고    scopus 로고
    • Growth inhibitory factor prevents degeneration of injured adult rat motoneurons
    • Sakamoto T, Kawazoe Y, Uchida Y, Hozumi I, Inuzuka T, Watabe K. Growth inhibitory factor prevents degeneration of injured adult rat motoneurons. Neuroreport 2003; 14: 2147-2151.
    • (2003) Neuroreport , vol.14 , pp. 2147-2151
    • Sakamoto, T.1    Kawazoe, Y.2    Uchida, Y.3    Hozumi, I.4    Inuzuka, T.5    Watabe, K.6
  • 149
    • 0038399723 scopus 로고    scopus 로고
    • Role of metallothionein-III following central nervous system damage
    • Carrasco J, Penkowa M, Giralt M, et al. Role of metallothionein-III following central nervous system damage. Neurobiol. Dis. 2003; 13: 22-36.
    • (2003) Neurobiol. Dis. , vol.13 , pp. 22-36
    • Carrasco, J.1    Penkowa, M.2    Giralt, M.3
  • 150
    • 0033635904 scopus 로고    scopus 로고
    • Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system
    • Bibel M, Barde Y-A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes & Develop. 2000; 14: 2919-2937.
    • (2000) Genes & Develop , vol.14 , pp. 2919-2937
    • Bibel, M.1    Barde, Y.-A.2
  • 151
    • 0031027044 scopus 로고    scopus 로고
    • GAP-43: An intrinsec determinant of neuronal development and plasticity
    • Benowitz LI, Routtenberg A. GAP-43: an intrinsec determinant of neuronal development and plasticity. Trends. Neurosci. 1997; 20: 84-91.
    • (1997) Trends. Neurosci. , vol.20 , pp. 84-91
    • Benowitz, L.I.1    Routtenberg, A.2
  • 152
    • 0028932454 scopus 로고
    • Bioactivity of metallothionein-3 correlates with its novel beta domain sequence rather than metal binding properties
    • Sewell AK, Jensen LT, Erickson JC, Palmiter RD, Winge DR. Bioactivity of metallothionein-3 correlates with its novel beta domain sequence rather than metal binding properties. Biochemistry 1995; 34: 4740-4747.
    • (1995) Biochemistry , vol.34 , pp. 4740-4747
    • Sewell, A.K.1    Jensen, L.T.2    Erickson, J.C.3    Palmiter, R.D.4    Winge, D.R.5
  • 153
    • 0036445576 scopus 로고    scopus 로고
    • Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting
    • Chung RS, Vickers JC, Chuah MI, Eckhardt BL, West AK. Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting. Exp. Neurol. 2002; 178: 1-12.
    • (2002) Exp. Neurol. , vol.178 , pp. 1-12
    • Chung, R.S.1    Vickers, J.C.2    Chuah, M.I.3    Eckhardt, B.L.4    West, A.K.5
  • 154
    • 0346099129 scopus 로고    scopus 로고
    • A role for extracellular metallothioneins in CNS injury and repair
    • Chung RS, West AK. A role for extracellular metallothioneins in CNS injury and repair. Neuroscience 2004; 123: 595-599.
    • (2004) Neuroscience , vol.123 , pp. 595-599
    • Chung, R.S.1    West, A.K.2
  • 155
    • 0038385516 scopus 로고    scopus 로고
    • Role of metallothioneins in peripheral nerve function and regeneration
    • Ceballos D, Lago N, Verdu E, et al. Role of metallothioneins in peripheral nerve function and regeneration. Cell. Mol. Life Sci. 2003; 60: 1209-1216.
    • (2003) Cell. Mol. Life Sci. , vol.60 , pp. 1209-1216
    • Ceballos, D.1    Lago, N.2    Verdu, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.