메뉴 건너뛰기




Volumn 119, Issue 2, 2001, Pages 248-260

Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis

Author keywords

Apoptosis; Cytokines; EAE MS; Metallothionein (MT); Oxidative stress

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; METALLOTHIONEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0035479008     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(01)00357-5     Document Type: Article
Times cited : (70)

References (81)
  • 4
    • 0029845691 scopus 로고    scopus 로고
    • The functional significance of brain metallothioneins
    • (1996) FASEB J. , vol.10 , pp. 1129-1136
    • Aschner, M.1
  • 5
    • 0031934470 scopus 로고    scopus 로고
    • Astrocytic functions and physiological reactions to injury: The potential to induce and/or exacerbate neuronal dysfunction - A forum position paper
    • (1998) Neurotoxicol. , vol.19 , pp. 7-17
    • Aschner, M.1
  • 6
    • 0031714274 scopus 로고    scopus 로고
    • Metallothionein (MT) isoforms in the central nervous system (CNS): Regional and cell-specific distribution and potential functions as an antioxidant
    • (1998) Neurotoxicology , vol.19 , pp. 653-660
    • Aschner, M.1
  • 8
    • 0030970058 scopus 로고    scopus 로고
    • Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
    • (1997) J. Mol. Med. , vol.75 , pp. 165-173
    • Benveniste, E.N.1
  • 12
    • 0032077767 scopus 로고    scopus 로고
    • Transgenic mice and cytokine actions in the brain: Bridging the gap between structural and functional neuropathology
    • (1998) Brain Res. Rev. , vol.26 , pp. 327-336
    • Campbell, I.L.1
  • 14
    • 0032904412 scopus 로고    scopus 로고
    • An evaluation of the role of mitochondria in neurodegenerative diseases: Mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
    • (1999) Brain Res. Rev. , vol.29 , pp. 1-25
    • Cassarino, D.S.1    Bennett J.P., Jr.2
  • 23
    • 0029411144 scopus 로고
    • Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation
    • (1995) Mol. Med. , vol.1 , pp. 795-805
    • Gijbels, K.1    Brocke, S.2    Abrams, J.S.3    Steinman, L.4
  • 29
    • 0025820404 scopus 로고
    • Oligodendroglial cell death induced by oxygen radicals and its protection by catalase
    • (1991) J. Neurosci. , vol.29 , pp. 100-106
    • Kim, Y.S.1    Kim, S.U.2
  • 32
    • 0030902675 scopus 로고    scopus 로고
    • Effect of non-toxic mercury, zinc or cadmium pretreatment on the capacity of human monocytes to undergo lipopolysaccharide-induced activation
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 797-806
    • Koropatnick, J.1    Zalups, R.K.2
  • 46
    • 0034111307 scopus 로고    scopus 로고
    • IL-6 deficiency leads to reduced metallothionein I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment
    • (2000) Exp. Neurol. , vol.163 , pp. 72-84
    • Penkowa, M.1    Hidalgo, J.2
  • 47
    • 0033662509 scopus 로고    scopus 로고
    • Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis
    • (2000) Glia , vol.32 , pp. 247-263
    • Penkowa, M.1    Hidalgo, J.2
  • 48
    • 0034952985 scopus 로고    scopus 로고
    • Metallothionein treatment reduces proinflammatory cytokines IL-6 and TNF-α and apoptotic cell death during experimental autoimmune encephalomyelitis (EAE)
    • In press
    • (2001) Exp. Neurol. , vol.169
    • Penkowa, M.1    Hidalgo, J.2
  • 49
  • 73
    • 0021944046 scopus 로고
    • Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
    • (1985) Biochim. Biophys. Acta , vol.827 , pp. 36-44
    • Thornalley, P.J.1    Vasak, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.