A role for extracellular metallothioneins in CNS injury and repair

Neuroscience

Volumn 123, Issue 3, 2004, Pages 595-599

  Chung, R S ^a   West, A K ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Astrocyte; Brain injury; Cytokine; Inflammatory response; Regeneration

Indexed keywords

METALLOTHIONEIN;

ASTROCYTE; BRAIN CELL; BRAIN INJURY; CENTRAL NERVOUS SYSTEM; HUMAN; MOLECULAR MODEL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; WOUND HEALING;

EID: 0346099129     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2003.10.019     Document Type: Review

References (50)

1. Adlard P.A., West A.K., Vickers J.C. Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease. Neurobiol Dis. 5:1998;349-356.
2. Aschner M., Cherian M.G., Klaassen C.D., Palmiter R.D., Erickson J.C., Bush A.I. Metallothioneins in brain-the role in physiology and pathology. Toxicol Appl Pharmacol. 142:1997;229-242.
3. Borghesi L.A., Youn J., Olson E.A., Lynes M.A. Interactions of metallothionein with murine lymphocytes plasma membrane binding and proliferation . Toxicology. 108:1996;129-140.
4. Bremner I., Mehra R.K., Sato M. Metallothionein in blood, bile and urine. Experientia Suppl. 1987. 52:1987;507-517.
5. Campagne M.L., Thibodeaux H., van Bruggen N., Cairns B., Gerlai R., Palmer J.T., Williams S.P., Lowe D.G. Evidence for a protective role of metallothionein-1 in focal cerebral ischemia. Proceedings of the National Academy of Sciences, USA. 96:1999;12870-12875.
6. Canpolat E., Lynes M.A. In vivo manipulation of endogenous metallothionein with a monoclonal antibody enhances a T-dependent humoral immune response. Toxicol Sci. 62:2001;61-70.
7. Carrasco J., Penkowa M., Hadberg H., Molinero A., Hidalgo J. Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I+II-deficient mice. Eur J Neurosci. 12:2000;2311-2322.
8. Carrasco J., Penkowa M., Giralt M., Camats J., Molinero A., Campbell I.L., Palmiter R.D., Hidalgo J. Role of metallothionein-III following central nervous system damage. Neurobiol Dis. 13:2003;22-36.
9. Ceballos D., Lago N., Verdu E., Penkowa M., Carrasco J., Navarro X., Palmiter R.D., Hidalgo J. Role of metallothioneins in peripheral nerve function and regeneration. Cell Mol Life Sci. 60:2003;1209-1216.
10. Choudhuri S., McKim J.M. Jr, Klaassen C.D. Differential expression of the metallothionein gene in liver and brain of mice and rats. Toxicol Appl Pharmacol. 119:1993;1-10.
11. Choudhuri S., Kramer K.K., Berman N.E., Dalton T.P., Andrews G., Klaassen C.D. Constitutive expression of metallothionein genes in mouse brain. Toxicol Appl Pharmacol. 131:1995;144-154.
12. Chung R.S., Vickers J.C., Chuah M.I., Eckhardt B.L., West A.K. Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting. Exp Neurol. 178:2002;1-12.
13. Chung R.S., Vickers J.C., Chuah M.I., West A.K. Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury. J Neurosci. 23:2003;3336-3342.
14. Chung RS, Adlard PA, Dittmann J, Chuah MI, Vickers JC, West AK (2003b) Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury. J Neurochem, in press.
15. Crowthers K.C., Kline V., Giardina C., Lynes M.A. Augmented humoral immune function in metallothionein-null mice. Toxicol Appl Pharmacol. 166:2000;161-172.
16. Erickson J.C., Sewell A.K., Jensen L.T., Winge D.R., Palmiter R.D. Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Brain Res. 649:1994;297-304.
17. Friedman R.L., Manly S.P., McMahon M., Kerr I.M., Stark G.R. Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell. 38:1984;745-755.
18. Garvey J.S. Metallothionein structure/antigenicity and detection/quantitation in normal physiological fluids . Environ Health Prosp. 54:1984;117-127.
19. Giralt M., Penkowa M., Lago N., Molinero A., Hidalgo J. Metallothionein-1+2 protect the CNS after a focal brain injury. Exp Neurol. 173:2002;114-128.
20. Gong Y.H., Elliott J.L. Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosis. Exp Neurol. 162:2000;27-36.
21. Hidalgo J., Giralt M., Garvey J.S., Armario A. Physiological role of glucocorticoids on rat serum and liver metallothionein basal and stress conditions. Am J Physiol. 254:(E71-):1988;78.
22. Hidalgo J., Aschner M., Zatta P., Vasak M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull. 55:2001;133-145.
23. Hidalgo J., Penkowa M., Giralt M., Carrasco J., Molinero A. Metallothionein expression and oxidative stress in the brain. Methods Enzymol. 348:2002;238-249.
24. Holloway A.F., Stennard F.A., Dziegielewska K.M., Weller L., West A.K. Localisation and expression of metallothionein immunoreactivity in the developing sheep brain. Int J Dev Neurosci. 15:1997;195-203.
25. Karin M., Imbra R.J., Heguy A., Wong G. Interleukin 1 regulates human metallothionein gene expression. Mol Cell Biol. 5:1985;2866-2869.
26. Kikuchi Y., Irie M., Kasahara T., Sawada J., Terao T. Induction of metallothionein in a human astrocytoma cell line by interleukin-1 and heavy metals. FEBS Lett. 317:1993;22-26.
27. Lynes M.A., Borghesi L.A., Youn J., Olson E.A. Immunomodulatory activities of extracellular metallothionein I. Metallothionein effects on antibody production . Toxicology. 85:1993;161-177.
28. Masters B.A., Quaife C.J., Erickson J.C., Kelly E.J., Froelick G.J., Zambrowicz B.P., Brinster R.L., Palmiter R.D. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles. J Neurosci. 14:1994;5844-5857.
29. Montoliu C., Monfort P., Carrasco J., Palacios O., Capdevila M., Hidalgo J., Felipo V. Metallothionein-III prevents glutamate and nitric oxide neutroxicity in primary cultures of cerebellar neurons. J Neurochem. 75:2000;266-273.
30. Nakajima K., Suzuki K., Otaki N., Kimura M. Detection of metallothionein in brain. Methods Enzymol. 205:1991;387-395.
31. Nakajima K., Suzuki K. Immunochemical detection of metallothionein in brain. Neurochem Int. 27:1995;73-87.
32. Nishimura N., Nishimura H., Ghaffar A., Tohyama C. Localization of metallothionein in the brain of rat and mouse. J Histochem Cytochem. 40:1992;309-315.
33. Palmiter R.D., Findley S.D., Whitmore T.E., Durnam D.M. MT-III, a brain-specific member of the metallothionein gene family. PNAS. 89:1992;6333-6337.
34. Palmiter R.D. The elusive function of metallothioneins. PNAS. 95:1998;8428-8430.
35. Penkowa M., Carrasco J., Giralt M., Moos T., Hidalgo J. CNS wound healing is severely depressed in metallothionein I- and II-deficient mice. J Neurosci. 19:1999;2535-2545.
36. Penkowa M., Giralt M., Moos T., Thomsen P.S., Hernandez J., Hidalgo J. Impaired inflammatory response to glial cell death in genetically metallothionein-I- and -II-deficient mice. Exp Neurol. 156:1999;149-164.
37. Penkowa M., Giralt M., Carrasco J., Hadberg H., Hidalgo J. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia. 32:2000;271-285.
38. Penkowa M., Hidalgo J. Metallothionein treatment reduces proinflammatory cytokines IL-6 and TNF-α and apoptotic cell death during experimental autoimmune encephalomyelitis (EAE). Exp Neurol. 170:2001;1-14.
39. Penkowa M., Giralt M., Camats J., Hidalgo J. Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide. J Comp Neurol. 444:2002;174-189.
40. Sato M., Sasaki M., Hojo H. Tissue specific induction of metallothionein synthesis by tumor necrosis factor-alpha. Res Commun Chem Pathol Pharmacol. 75:1992;159-172.
41. Schroeder J.J., Cousins R.J. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. PNAS. 87:1990;3137-3141.
42. Trayhurn P., Duncan J.S., Wood A.M., Beattie J.H. Regulation of metallothionein gene expression and secretion in rat adipocytes differentiated from preadipocytes in primary culture. Horm Metab Res. 32:2000;542-547.
43. Trendelenburg G., Prass K., Priller J., Kapinya K., Polley A., Muselmann C., Ruscher K., Kannbley U., Schmitt A.O., Castell S., Wiegand F., Meisel A., Rosenthal A., Dirnagl U. Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. J Neurosci. 22:2002;5879-5888.
44. Uchida Y., Takio K., Titani K., Ihara Y., Tomonaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron. 7:1991;337-347.
45. Uchida Y., Gomi F., Masumizu T., Miura Y. Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. J Biol Chem. 277:2002;32353-32359.
46. Yamada M., Hayashi S., Hozumi I., Inuzuka T., Tsuji S., Takahashi H. Subcellular localization of growth inhibitory factor in rat brain light and electron microscopic immunohistochemical studies . Brain Res. 735:1996;257-264.
47. Youn J., Borghesi L.A., Olson E.A., Lynes M.A. Immunomodulatory activities of extracellular metallothionein II. Effects on macrophage functions . J Toxicol Environ Health. 45:1995;397-413.
48. Youn J., Lynes M.A. Metallothionein-induced suppression of cytotoxic T lymphocyte function an important immunoregulatory control . Toxicol Sci. 52:1999;199-208.
49. Yuguchi T., Kohmura E., Sakaki T., Nonaka M., Yamada K., Yamashita T., Kishiguchi T., Sakaguchi T., Hayakawa T. Expression of growth inhibitory factor mRNA after focal ischemia in rat brain. J Cereb Blood Flow Metab. 17:1997;745-752.
50. Zheng H., Berman N.E., Klaassen C.D. Chemical modulation of metallothionein I and III mRNA in mouse brain. Neurochem Int. 27:1995;43-58.